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  • bioluminescence
  • The sensitivity of aequorin is due to the fact that bioluminescence is a rare phenomenon in nature and, therefore, it does not suffer from autofluorescence, which contributes to background emission. (valpo.edu)
  • This is the first time that aequorin variants incorporating non-canonical amino acids have shown to be active in vivo and useful as reporters in bioluminescence imaging. (valpo.edu)
  • In this study, using Drosophila and taking advantage of an in vivo bioluminescence Ca 2+ -imaging technique in combination with genetic and pharmacological tools, first we show that the GFP-aequorin Ca 2+ sensor is sensitive enough to detect odor-induced responses of various durations. (biologists.org)
  • Quincy Bioscience
  • Aequorin has proven to be neuroprotective in pre-clinical studies performed at the University of Wisconsin-Milwaukee and has shown to be effective at improving aspects of cognition such as spatial working memory and executive function in human studies conducted by Quincy Bioscience. (bio-medicine.org)
  • A company called Quincy Bioscience sells a product containing aequorin (Prevagen) that it promotes as "the first supplement to address aging through the restoration of calcium-binding proteins. (thecamreport.com)
  • vivo
  • Aequorin was also genetically linked to a VEGFA targeting molecule, a DARPin designated as MP0112, for the imaging of neovascularization in vivo using a wet age-related macular degeneration model in mice induced by laser exposure. (miami.edu)