Aedes arthropod proteins. Medical search. Frequent questions

In 2006, the A226V mutation enabled chikungunya to be transmitted by a new species of mosquito that is prevalent on Reunion Island (Aedes albopictus, or the tiger mosquito). (pasteur.fr)
This compound showed antiviral activity against wild-type DENV2 in both Hela and BHK-21 cells, but not in the C6/36 cell line derived from the mosquito Aedes albopictus. (bris.ac.uk)
Aedes albopictus is widely distributed across tropical and sub-tropical regions and is associated with the transmission of several arboviruses. (biomedcentral.com)
Our proteomic approach allowed the identification of two different trypsin-like serine peptidases and one chymotrypsin in protein spots of the alkaline region in 2DE map of the A. albopictus female midgut. (biomedcentral.com)
Aedes (Stegomyia) albopictus (Skuse) has a wide geographic distribution, covering all tropical and subtropical regions of the world, and is a vector for the viruses responsible for yellow fever and dengue [ 1 ]. (biomedcentral.com)
Chikungunya fever (CHIKF) is a viral disease transmitted by mainly two species of mosquitoes - Aedes aegypti and A. albopictus . (actascientific.com)
The reported occurrences of ZIKV infections are thought to be transmitted mainly by the mosquito species Aedes aegypti and Aedes albopictus . (frontiersin.org)
Bishop, C. & Asgari, S. (2021) Altered gene expression profile of Wolbachia pipientis w AlbB strain following transinfection from its native host Aedes albopictus to Aedes aegypti cells. (insect-host-pathogen.org)
albopictus mosquitoes transmit arthropod-borne illnesses across the globe, inflicting ~ 700,000 deaths annually. (icn2018.com)

D7 proteins are among the most abundant components of the saliva of blood-feeding arthropods. (bvsalud.org)

Since, ILHV circulation has been documented through all Latin America, encompassing a variety of hosts, from mosquitoes of the Aedes and Culex genus to birds, equines, buffaloes, sloths and non-human primates. (fapesp.br)
Previous analysis of the salivary gland transcriptome of Culex quinquefasciatus showed the potential presence of an endonuclease with sequence similarities to shrimp, crab and two tsetse salivary proteins. (silverchair.com)
Professor Attardo, who maintains a lab website on Vector Biology and Reproductive Biology at http://attardo-lab.com, and chairs the Designated Emphasis in the Biology of Vector-Borne Diseases (DEBVBD), will display some of his mosquito images, including a blood-fed Aedes aegypti, and a female and male Culex tarsalis . (ucanr.edu)

Background: The female Aedes aegypti mosquito is a vector of several arthropod-borne viruses, such as Mayaro, Dengue, Chikungunya, Yellow Fever, and Zika. (eurekaselect.com)
This female Aedes aegypti mosquito is shown after landing on a human host. (medscape.com)

It turns out that Wolbachia prevents these viruses from reproducing in Aedes aegypti mosquitoes that spread them. (phys.org)

The inotocin/receptor couple can also be found in the recently sequenced genome from the parasitic wasp Nasonia vitripennis but not in any other holometabolous insect with a completely sequenced genome (12 Drosophila species, the malaria mosquito Anopheles gambiae, the yellow fever mosquito Aedes aegypti, the silk worm Bombyx mori, and the honey bee Apis mellifera), suggesting that this neuropeptide system is confined to basal holometabolous insects. (lu.se)
In mosquitoes, the vast majority of described promoters are from Anopheles and Aedes mosquitoes. (psu.edu)
2007. An insight into immmunogenic proteins of Anopheles gambiae in African cildren. (knepublishing.com)
2007. Antibody Response Against Saliva Antigens of Anopheles gambiae and Aedes aegypti in Travellers in Tropical Africa. (knepublishing.com)

Chikungunya virus (CHIKV) is an arthropod-borne RNA virus of the genus Alphavirus, family Togaviridae . (cdc.gov)
These results contribute to the gene annotation in this species of unknown genome and represent a small but important step toward the protein-level functional and localization assignment of trypsin-like serine peptidase genes in the Aedes genus. (biomedcentral.com)
CHIKV is a small (60 - 70 nm) spherical enveloped virus with single- stranded positive sense RNA molecule and belongs to the genus Alphavirus, which included more than 30 species of arthropod borne viruses [1], and the family Togaviridae (Figure 1). (actascientific.com)
ZIKV is transmitted by arthropods (mosquitoes genus Aedes ) as it happens for YFV, West Nile virus (WNV), Japanese encephalitic virus (JEV) and DENV. (biomedicineandprevention.com)
It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
It is transmitted from human to human through the bite of mosquitoes of the genus Aedes [ 2 ]. (hindawi.com)
The Flavivirus genus is composed of more than 70 arthropod-transmitted viruses, of which 30 are known to cause human disease. (medscape.com)

We applied both programs to the 29 proteins that express the five groups of arboviruses studied, and we calculated for each of them their Polarity Index Method ® profile and their intrinsic disorder predisposition. (eurekaselect.com)
Once the "fingerprint" of each group of arboviruses was obtained, these "fingerprints" were searched among the 559228 "reviewed" proteins from the UniProt database. (eurekaselect.com)
Results: In total, 1736 proteins were identified from the 559228 "reviewed" proteins from the UniProt database, with similar "PIM ® profile" to the 29 mutated proteins that express the five groups of arboviruses. (eurekaselect.com)
McCall, P.J. Aedes Mosquitoes and aedes-borne arboviruses in Africa: current and future threats. (eurekaselect.com)
One of them, Aedes aegypti, is the primary vector of several widely spread arboviruses such as Zika, dengue and West Nile viruses, and for most of them, human-licensed vaccines do not exist or are suboptimal. (sbir.gov)
It has been shown that many salivary proteins enhance infectivity and pathogenesis of arboviruses by modulating immune responses at the bite site. (sbir.gov)
On the other hand, we propose that the modulation of other proteins like transferrin, hsp60 and alpha glucosidase, may favour virus survival, replication and transmission, suggesting a subversion of the insect cell metabolism by the arboviruses. (hal.science)
Arboviruses ("arthropod-borne viruses") are a global health issue. (fapesp.br)
Arthropod vectors control the replication of arboviruses through their innate antiviral immune responses. (mdpi.com)
Zika belongs to a class of viruses known as Arboviruses, which are essentially any virus transmitted from blood-sucking arthropods, like mosquitoes and ticks, to vertebrates like humans. (todayifoundout.com)
A promising candidate for arbovirus control and prevention relies on replacing arbovirus-susceptible Aedes aegypti populations with mosquitoes that have been colonized by the intracellular bacterium Wolbachia and thus have a reduced capacity to transmit arboviruses. (geneconvenevi.org)
Unlike arboviruses, which have a dual-host tropism by cycling between vertebrate hosts and arthropod vectors, ISVs replicate exclusively in arthropod populations, causing a persistent viral infection, as such they are mainly maintained in nature by vertical transmission route. (encyclopedia.pub)

They are transmitted by hematophagous arthropods, primarily mosquitoes. (sbir.gov)
The saliva of hematophagous arthropods contains a complex mixture of biologically active proteins. (knepublishing.com)

Both viruses caused an increase of proteins involved in the generation of reactive oxygen species, energy production, and carbohydrate and lipid metabolism. (hal.science)
Although this protocol is specific for transgenic Aedes aegypti, the protocol may also be used for other mosquito species or other experimental treatment conditions, with the caveat that certain biological contexts may require special adaptations. (bvsalud.org)
That is one of the surprise discoveries made by a pair of Vanderbilt biologists when they sequenced the genome of a virus that attacks Wolbachia, a bacterial parasite that has successfully infected not only black widow spiders but more than half of all arthropod species, which include insects, spiders and crustaceans. (phys.org)
Occasionally, other mosquito types (eg, Coquillettidia perturbans and the ubiquitous Aedes canadensis species) may act as bridges in the horse-to-human transmission. (medscape.com)
By focusing our phylogenetic analysis to p53/p63/p73 and MDM proteins from phyla that retain the interaction domains TAD and p53/p63/p73BD, we built phylogenetic trees of p53/p63/p73 and MDM based on both vertebrate and invertebrate species. (biomedcentral.com)
Wolbachia are maternally inherited endosymbionts that infect nearly half of all arthropod species. (nature.com)
The adult females of most species have tube-like mouthparts (called a proboscis) that can pierce the skin of a host and feed on blood, which contains protein and iron needed to produce eggs. (itsolutionnest.com)
other infectious subtypes include the Aedes and Coquillettidia species. (medscape.com)

Once Wolbachia infect a host arthropod, it wraps itself in a layer of the arthropod's membrane. (phys.org)
We suspect it makes pores in the membranes of the arthropod cells that surround Wolbachia, thereby allowing the phage to overcome both the bacterial and arthropod membranes that surround it. (phys.org)
Field trials and modelling studies suggest that elimination of dengue transmission may be possible through widespread release of Aedes aegypti mosquitoes infected with the insect bacterium Wolbachia pipientis (wMel strain), in conjunction with routine dengue control activities. (geneconvenevi.org)
BACKGROUND: Introgression of the bacterial endosymbiont Wolbachia into Aedes aegypti populations is a biocontrol approach being used to reduce arbovirus transmission. (geneconvenevi.org)
Previously, we created an Aedes aegypti Aag2 cell line (Aag2.wAlbB) transinfected with the wAlbB strain of Wolbachia and a matching tetracycline-cured Aag2.tet cell line. (geneconvenevi.org)
Hussain, M, Bradshaw, T., Lee, M. & Asgari, S. (2022) The involvement of atlastin in dengue virus and Wolbachia infection in Aedes aegypti and its regulation by aae-miR-989. (insect-host-pathogen.org)
Bishop, C., Hussain, M., Hugo, L.E. & Asgari, S. (2022) Analysis of Aedes aegypti microRNAs in response to Wolbachia w AlbB infection and their potential role in mosquito longevity. (insect-host-pathogen.org)
S. (2021) Transcriptional response of Wolbachia to dengue virus infection in the mosquito Aedes aegypti cells. (insect-host-pathogen.org)
Wolbachia are endosymbiont micro organism recognized to contaminate arthropods inflicting completely different results, resembling cytoplasmic incompatibility and pathogen blocking in Aedes aegypti. (cellgenetherapy.com)

Arthropod vectors - Arthropod vectors are mainly insect vectors that transmit disease through their blood-feeding abilities at all or some points in their life cycles . (biologyonline.com)
Examples of immunology vectors: mosquito (arthropod) and rodent. (biologyonline.com)
Arthropod vectors are cold-blooded (ectothermic) and thus especially sensitive to climatic factors. (slideshare.net)
Arthropod-borne Viruses Arthropod-borne viruses (arbovirus) are viruses that can be transmitted to man by arthropod vectors. (slideshare.net)

The objective of this study was to examine individual human sera response against protein extracts from salivary gland of Ae aegypti that mediate the infection of dengue viruses. (knepublishing.com)
Therefore, these immunogenic salivary proteins may serve as indicators for the immune response in human against protein from salivary gland of Ae. (knepublishing.com)

In Phase I, a proof-of-principle has been established for a novel strategy of prophylaxis, targeting one salivary protein secreted in A. aegypti saliva, AgBR1, in which passively and actively immunized immunocompromised murine models were partially protected against Zika virus transmitted via mosquito bites. (sbir.gov)
We will develop a vaccine candidate based on the A. aegypti salivary protein AgBR1 to control Zika virus infection and other related flaviviruses in the mouse model and in other rodent models such as guinea pigs and hamsters, which better resemble the human disease. (sbir.gov)
Importantly, this "recognition pocket" is found not only in RVF virus but also in the envelope proteins of other viral families transmitted by arthropods, such as the dengue, Zika and chikungunya viruses, which have caused major worldwide epidemics in recent years. (pasteur.fr)
Researchers from the Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health have made an important finding about Aedes aegypti mosquitoes-;one that could one day lead to better methods for reducing the mosquito-to-human transmission of dengue, yellow fever, Zika, and other harmful and sometimes deadly viruses. (news-medical.net)
mosquitoes transmit 'arthropod-borne' or 'arbo-' viruses including dengue virus, yellow fever virus, Zika virus, chikungunya virus, and Mayaro virus. (news-medical.net)
There is no known cure for the Zika Virus, which is primarily transmitted by the Aedes mosquito . (ansi.org)
As for more specifically what the Zika virus does to your body, once infected, Zika appears to fight your immune system by interfering with how your body's cells use signaling proteins to call on your immune system to react to a specific infection. (todayifoundout.com)

Based on partial sequences of the envelope protein E1, CHIKV strains can be grouped into 3 distinct genetic lineages, which share a common ancestor in tropical Africa ( 9 ). (cdc.gov)
Chikungunya virus (CHIKV) contamination due to an arthropod-borne virus turned into first found in Africa, CHIK-Virus additionally constrained in Southeast Asia. (ijpsr.com)

Abstract Background: Arthropod borne virus infections cause several emerging and resurgent infectious diseases. (hal.science)
ABSTRACT Dengue is one of the most important arthropod-borne viral diseases. (who.int)

Methodology and Principal Findings: Using a proteomics differential approach with two-Dimensional Differential in-Gel Electrophoresis (2D-DIGE), we defined the protein modulations in the midgut of Aedes aegypti that were triggered seven days after an oral infection (7 DPI) with dengue 2 (DENV-2) and chikungunya (CHIKV) viruses. (hal.science)
CHIKV infection produced an increase of proteins involved in detoxification. (hal.science)
It shows that the differentially regulated proteins in response to viral infection include structural, redox, regulatory proteins, and enzymes for several metabolic pathways. (hal.science)
We also investigated the role of D7 salivary proteins in Plasmodium gallinaceum infection and transmission. (bvsalud.org)
Dai, Z., Etebari, K. & Asgari, S. (2022) N6-methyladenosine modification of the Aedes aegypti transcriptome and its alteration upon dengue virus infection in Aag2 cell line. (insect-host-pathogen.org)
Leitner, M., Etebari, K. & Asgari, S. (2022) Transcriptional response of Aedes aegypti mosquito cells to dengue virus at early stages of infection. (insect-host-pathogen.org)

Conclusion: We propose that the "PIM ® profile" of characterization of proteins might be useful for the identification of proteins expressed by arthropod-borne viruses transmitted by Aedes aegypti mosquito. (eurekaselect.com)
Thangamani, S. An overview of animal models for arthropod-borne Viruses. (eurekaselect.com)
Dengue virus (DENV) is an important human arthropod-borne virus with a major impact on public health. (bris.ac.uk)
Yellow fever is an acute febrile infectious disease, caused by arthropod vector-borne virus that has two epidemiological different transmission cycles: wild and urban. (bvsalud.org)
[ 4 ] This article focuses on EEE, which is caused by an arthropod-borne alphavirus. (medscape.com)
Dengue viruses (DENVs), serotypes 1-4, are arthropod-borne viruses transmitted to humans by mosquitoes, primarily Aedes aegypti. (cdc.gov)
Introduction: Genetic modification, or transgenesis, is a powerful technique to investigate the molecular interactions between vector-borne pathogens and their arthropod hosts, as well as a potential novel approach for vector-borne disease control. (psu.edu)
Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)

The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)
These proteins may modify hemostatic responses and induce both cellular immunity and the production of specific antibodies, and thus influence the transmission of its pathogens from arthropods vector to human host. (knepublishing.com)

protein, Argonaute 2, has a key role-;via several biological mechanisms-;in keeping mosquitoes healthy and active despite these infections. (news-medical.net)

along with some invertebrates, primarily other arthropods. (itsolutionnest.com)
Males primarily drink nectar while the females often feed on blood, since they need the protein and iron found in blood to make eggs . (ansi.org)
The detection restrict of this digital methodology for N protein was 33.28 pg/mL, which was 300 instances decrease than conventional double-antibody sandwich primarily based enzyme-linked immunosorbent assay (ELISA). (humgen.org)

Gel profile comparisons showed that the level of 18 proteins was modulated by DENV-2 only and 12 proteins were modulated by CHIKV only. (hal.science)
There are three structural (C, E1, E2) and four non structural proteins in CHIKV [2]. (actascientific.com)

The Yukl lab studies bacterial proteins that mediate zinc import and nitric oxide / oxidative stress sensing. (nmsu.edu)

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. (bris.ac.uk)

ASTM E939-94(2012) - Standard Test Method of Field Testing Topical Applications of Compounds as Repellents for Medically Important and Pest Arthropods (Including Insects, Ticks, and Mites): Mosquitoes provides testing guidelines to determine the resiliency of potential mosquito-repelling compounds that have already undergone some laboratory testing. (ansi.org)

Here, we generated two knockout (KO) mosquito lines by CRISPR/Cas9 to functionally characterize D7L1 and D7L2, two abundantly expressed salivary proteins from the yellow fever mosquito vector Aedes aegypti. (bvsalud.org)
Aedes aegypti, the vector of yellow fever and dengue, expresses two D7 long-form salivary proteins: D7L1 and D7L2. (bvsalud.org)
Travelers with contraindications to the yellow fever vaccine (children under 9 months of age, pregnant or lactating women, persons with severe hypersensitivity to egg protein and severe immunodeficiency) or older than 60 years should consult their health care provider for risk-benefit careful evaluation. (bvsalud.org)

A proteomic approach was undertaken to characterize the key virus/vector interactions and host protein modifications that happen in the midgut for viral transmission to eventually take place. (hal.science)
Aedes aegypti is the main vector for transmission of dengue viruses into human. (knepublishing.com)
Viruses maintained in nature principally, or to an important extent, through biological transmission between susceptible vertebrate hosts by haematophagus arthropods or through trans ovarian and possibly venereal transmission in arthropods. (slideshare.net)

aegypti salivary proteins with Dengue disease severity. (knepublishing.com)

Conclusion/Significance: Our study constitutes the first analysis of the protein response of Aedes aegypti's midgut infected with viruses belonging to different families. (hal.science)
We hypothesize that the absence of D7 proteins in the midgut of KO mosquitoes might be responsible for creating a harsh environment for the parasite. (bvsalud.org)
In the present work, we further analyzed the peptidase expression in the midgut of sugar-fed females using 1DE-substrate gel zymography, two-dimensional electrophoresis (2DE), mass spectrometry (MS), and protein identification based on similarity. (biomedcentral.com)
100 kDa) that are usually linked to the plasma membrane of the midgut epithelium and hydrolyze the ends of small proteins and peptides (N-terminus or C-terminus) [ 10 ]. (biomedcentral.com)

In the homologous protein of the chikungunya virus, the scientists pinpointed one of the residues of the recognition pocket as amino acid 226. (pasteur.fr)

Structural proteins of CHIK-Virus with T and B cells had been used for immuno-informatic approach. (ijpsr.com)
The single Open Reading Frame (ORF) encodes for three structural proteins, E (envelope glycoproteins), C (capsid protein) and M (membrane protein) 6 and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5), which carry out crucial functions in assembly and replication. (biomedicineandprevention.com)

To get ultra-technical, it blocks translation of type 1 interferon, and the phosphorylation of the immune regulatory proteins STAT 1 and STAT 2. (todayifoundout.com)

Identification of these protein coding genes was achieved by similarity to the A. aegypti genome sequences using Mascot and OMSSA search engines. (biomedcentral.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)
Based on a comparative analysis of BPH and SBPH after transfer, the genes associated with sugar transporters and heat-shock proteins showed similar variation. (biomedcentral.com)

The ability for promoter sequences to drive expression of green fluorescent protein (GFP) in vivo was investigated using transgenic Drosophila melanogaster. (psu.edu)

In conclusion, we have identified a new DENV inhibitor, SDM25N, which restricts genomic RNA replication by - directly or indirectly - targeting the viral NS4B protein. (bris.ac.uk)

Thus, the ubiquitous presence of both proteins suggests that they were present in the common ancestor of all present-day animals, and we thus refer to these proteins as p53/p63/p73 ancestor and MDM ancestor , respectively. (biomedcentral.com)

Endopeptidases are relatively small molecules (~25-30 kDa) that can pass through peritrophic membrane pores and endoperitrophic spaces in insects, where they cleave large protein complexes. (biomedcentral.com)

These proteins bind and counteract hemostatic agonists such as biogenic amines and leukotrienes. (bvsalud.org)

Up to date, there are no effective prophylactic measures that would prevent the contact and bite of this arthropod and, therefore, its consequential contagion. (eurekaselect.com)

2011. Implication of haematophagous arthropod salivary proteins in host-vector interactions. (knepublishing.com)
Arthropod-Plant Interactions. (rothamsted.ac.uk)

This information was then compared with analogous information for other protein groups, such as proteins from bacteria, fungi, viruses, and cell-penetrating peptides from the UniProt database, and a set of intrinsically disordered proteins. (eurekaselect.com)

Scientists from the Institut Pasteur and the CNRS, working with the University of Göttingen, have characterized the mechanism used by the virus to insert one of its envelope proteins into the host cell membrane, thereby enabling it to infect the cell. (pasteur.fr)
They have demonstrated that the viral envelope protein has a "pocket" that specifically recognizes a category of lipids in the cell membrane. (pasteur.fr)

tory testing to the Arbovirus Diagnostic Laboratory at the Over the next 20 years, several ZIKV isolates were Centers for Disease Control and Prevention (CDC, Fort obtained from Aedes spp. (folkhalsomyndigheten.se)

We identified a single amino acid substitution (F164L) in the NS4B protein that confers resistance to SDM25N. (bris.ac.uk)

The gene CPLCG5 encodes a cuticle protein that plays an important role in pyrethroid resistance. (biomedcentral.com)

Objective: The objective of the present study was to search for the regularities of the proteins expressed by these five viruses, at residues level, and obtain a "bioinformatic fingerprint" to select them. (eurekaselect.com)

The cytokine CXCL10 (or interferon-³ induced protein 10, "IP-10") has been described as a potential treatment target in infectious diseases for its pro-inflammatory properties, especially regarding CXCR3-expressing cells. (fapesp.br)

2007. IgE and IgG4 Antibody Responses to Aedes Saliva in African Children. (knepublishing.com)

Scientists in the Structural Virology Unit (Institut Pasteur/CNRS) directed by Félix Rey, in collaboration with the University of Göttingen, characterized the mechanism used by the virus to insert one of its surface proteins into the host cell membrane and drive fusion. (pasteur.fr)
2005. Haematophagous arthropod saliva and host defense system: a tale of tear and blood. (knepublishing.com)

Anatomy3

Organisms34

Diseases5

Chemicals and Drugs8

Psychiatry and Psychology2

Phenomena and Processes14

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Health Care8

Albopictus9

Blood-feeding ar1

Culex3

Female Aedes aegypti mosquito2

Reproducing in Aedes aegypti1

Anopheles4

Genus7

Arboviruses12

Hematophagous arthropods2

Species8

Wolbachia9

Vectors4

Salivary gland2

Zika7

Africa2

Abstract2

Infection6

Borne8

Pathogens2

Infections1

Primarily3

CHIKV2

Bacterial1

Dengue virus1

Ticks1

Yellow Fever3

Transmission3

Aegypti salivary1

Midgut4

Chikungunya virus1

Structural proteins2

Regulatory proteins1

Genes3

Transgenic1

DENV1

Ubiquitous1

Insects1

Hemostatic1

Bite1

Interactions2

Peptides1

Envelope2

Arbovirus1

Amino acid1

Encodes1

Residues1

Infectious1

Responses1

Host2