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  • class
  • Fluoroquinolones were selected because this highly effective antimicrobial class is recent compared to others and it deserves a specific approach when it comes to companion animals. (elsevier.com)
  • The fluoroquinolone class of agents has been plagued by a number of compounds that have undergone an extensive clinical evaluation and have achieved distinctive clinical results but were not introduced into the market because of unacceptable safety and tolerability. (asmscience.org)
  • rupture
  • Because multiple studies showed higher rates of about twice the risk of aortic aneurysm rupture and dissection in those taking fluoroquinolones, FDA determined the warnings were warranted to alert health care professionals and patients. (fda.gov)
  • potentially
  • Etminan directed a study published in April in The Journal of the American Medical Association showing that the risk of suffering a potentially blinding retinal detachment was nearly fivefold higher among current users of fluoroquinolones, compared with nonusers. (telegram.com)
  • aortic
  • We reviewed cases reported to FDA* and four published observational studies 1,2,3,4 that showed an increased risk of aortic aneurysm or dissection associated with fluoroquinolone use (see Data Summary). (fda.gov)
  • however, taken together, the results of all four studies provide consistent evidence of an association between fluoroquinolone use and aortic aneurysm or dissection. (fda.gov)
  • bacterial
  • However, for serious acute cases of pyelonephritis or bacterial prostatitis where the person may need to be hospitalised, fluoroquinolones are recommended as first-line therapy. (wikipedia.org)
  • therapy
  • Within the REQUEST Group, experts strongly believe that when the decision is reached to use fluoroquinolones for therapy, veterinarians should strive to optimize therapeutic efficacy and minimize resistance to protect public and animal health. (elsevier.com)
  • Compliance
  • In addition, they designed a composite index that encapsulates Efficacy, Safety, Convenience and Compliance to assess the different fluoroquinolones according to prescribers' needs. (elsevier.com)
  • advise
  • I strongly advise you to educate yourself about the risks of fluoroquinolones, and refuse any prescription for these drugs unless absolutely necessary . (mercola.com)
  • known
  • Due to people with sickle-cell disease being at increased risk for developing osteomyelitis from the Salmonella , fluoroquinolones are the "drugs of choice" due to their ability to enter bone tissue without chelating it, as tetracyclines are known to do. (wikipedia.org)
  • common
  • It's important, nonetheless, to be cognizant of additional unexpected antibiotic-related adverse effects and to recognize those that do not fit the common profiles or even make common sense to the intuitive mind. (lww.com)
  • Allergic interstitial nephritis (AIN) is thought to be the most common form of fluoroquinolone nephrotoxicity and is attributed to a type III hypersensitivity reaction. (asmscience.org)