Advances in medicinal drug discovery. Medical search. Frequent questions

MedChemica - Extracting and exploiting medicinal chemistry ADMET knowledge au. (slideshare.net)

You'll be taught by academic researchers including pharmacologists, cell biologists, and medicinal and pharmaceutical chemists, whose own research is in pharmacology and drug discovery. (uea.ac.uk)
It supports medicinal chemists and other discovery scientists, escalating success rates and advancing small molecule drug discovery. (optibrium.com)
The Frontiers Meeting attracts a highly targeted audience composed of experts in drug discovery and development, in particular medicinal and synthetic chemists, together with scientists active in the fields of computer assisted drug design, biology, DMPK, pharmacology, early toxicology, as well as chemical and pharmaceutical development. (ldorganisation.com)
Chemists with a good understanding of the biosciences and an ability to apply their chemistry knowledge to biological and medicinal problems are in high demand. (bradford.ac.uk)
Many of the most important recent discoveries have been made at the interfaces of chemistry and biology, and chemists are needing to become well versed in both biological and medicinal chemistry. (bradford.ac.uk)
This masters programme, provided by the XJTLU Wisdom Lake Academy of Pharmacy, integrates academic development strategies with industry needs for high-quality medicinal chemists. (xjtlu.edu.cn)
Natural products have been a boon for both organic as well as medicinal chemists and practitioners of traditional medicine in exploring new biosynthetic pathways, charting novel synthesis strategies, and finding cures for human diseases. (selectbiosciences.com)
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd. (wikipedia.org)

This new course will provide an introduction to the small-molecule drug discovery process. (concordia.ca)
Thrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning and artificial intelligence (AI) as applied to small molecule drug discovery. (novartis.com)
Numerate is a privately held biotechnology company that applies machine-learning algorithms, at cloud scale, to overcome major challenges in small molecule drug discovery. (cbinsights.com)

ASMC'13 Moscow is being organized by the European Federation for Medicinal Chemistry (EFMC) and ChemBridge Corporation , as part of the series of events which started with ASMC'04 Moscow, followed by two editions in St. Petersburg (ASMC'07, ASMC'11) and one in Kiev (ASMC'09). (ldorganisation.com)
The Frontiers in Medicinal Chemistry symposium is co-organised on a biennial basis, as a collaboration between the ACS (American Chemical Society) and the EFMC (European Federation for Medicinal Chemistry). (ldorganisation.com)

For example, in practical classes you'll gain experience of synthetic medicinal chemistry as well as techniques in current molecular pharmacology - the techniques used in the discovery of new medicines. (uea.ac.uk)
Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility. (novartis.com)
These synthetic biology platforms will lead to transformative advances in natural product discovery, drug development, and production. (aiche.org)
You'll examine key aspects of inorganic, organic, physical, analytical, synthetic and computational chemistry, before specialising across a series of advanced topics as your degree develops. (imperial.ac.uk)

Journal of Medicinal Chemistry. (wikipedia.org)
Journal of Medicinal Chemistry 2010 , 53 (15) , 5549-5557. (acs.org)
Journal of Medicinal Chemistry 2009 , 52 (21) , 6768-6781. (acs.org)
Journal of Medicinal Chemistry 2008 , 51 (24) , 8048-8056. (acs.org)
Journal of Medicinal Chemistry 2008 , 51 (11) , 3322-3325. (acs.org)

Collaborating with a multidisciplinary group of scientists, you will be at the forefront of crafting inventive solutions to the most pressing drug discovery challenges, forging new paths toward groundbreaking medicines. (novartis.com)
PharmEnable is a Cambridge (UK) based AI-enabled drug discovery company mapping unexplored chemical space to develop innovative medicines. (bioindustry.org)
Medicinal plants are very popular in different traditional systems of medicines due to their diverse pharmacological potentials and lesser side effects in biological systems. (researchgate.net)
Medicinal plants used by traditional medical practitioners (TMP) to treat cancers are considered safe when used alone or combined with conventional therapy to ensure their effectiveness and eliminate the toxic effects of orthodox medicines. (who.int)
Advanced Therapy Medicinal Products (ATMP) are medicines that are based on cells, tissues or genes. (lu.se)

Frontiers in Anti-Infective Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Infective drug design and discovery. (benthamscience.com)
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. (benthamscience.com)

The fireside chat, titled "Computational Biology in Drug Discovery with Gain Therapeutics (GANX) CTO & Two Experts," will take place on Wednesday, March 29, 2023 at 12:00 pm ET. (cbinsights.com)
August 31, 2023 09:00 AM Eastern Daylight Time POLARISqb, the first company in the world to develop a drug discovery engine that utilizes the optimization power of quantum computing, announced that it has signed an MOU with Syntekabio (KOSDAQ: 226330), an Artificial Intelligence (AI) based drug development company. (cbinsights.com)
ACS medicinal chemistry letters 2023 8 14 (8): 1041-1042. (cdc.gov)

The Pharmacology Drug Discovery programme is the only MSci of its type in the UK and is innovative in its multidisciplinary approach. (uea.ac.uk)
The scientific programme for Frontiers 2015 will feature a plenary session, followed by sessions covering the latest advances in medicinal chemistry. (ldorganisation.com)
This research-oriented masters programme trains and cultivates top Medicinal Chemistry professionals with sound theoretical knowledge, practical problem-solving capabilities, innovative thinking, and effective communication skills developed within an international outlook. (xjtlu.edu.cn)
This project originated from DND i 's successful GHIT-funded NTD Drug Discovery Booster programme which, following further development in collaboration with Takeda, identified and advanced novel compounds against visceral leishmaniasis, resulting in the S07 lead chemical series of compounds that show promising efficacy and safety profiles. (dndi.org)

These are just some of the challenges you'll explore on our pharmacology and drug discovery degree. (uea.ac.uk)
Our research-rich environment is pivotal to the Pharmacology and Drug Discovery course, which has been designed to prepare you for a career at the forefront of pharmaceutical research. (uea.ac.uk)
Pharmacology is the study of drugs and their effects on living organisms. (uea.ac.uk)
You'll be introduced to medicinal chemistry, principles of pharmacology and neuropharmacology, drug delivery and pharmacokinetics. (uea.ac.uk)
These members are all experienced pharmaceutical industry veterans with expertise in drug discovery & design, medicinal chemistry, drug formulation, pharmacology, toxicology, FDA regulatory strategy, clinical development, business development, biotechnology company entrepreneurship and drug product commercialization. (rochester.edu)
Investigators will also receive expert assistance in de novo drug design, medicinal chemistry, pre-clinical testing, drug formulation, pharmacology and safety testing to advance candidate drugs through the various phase of pre-clinical testing to the first-in-human (IND stage) clinical trials. (rochester.edu)
The origin of many modern drugs is derived from ethnopharmacology, traditional medicine, and reverse pharmacology. (selectbiosciences.com)

Medicinal plants are useful as a natural therapy to treat minor illnesses, as gastrointestinal disorders or as topic antiinflammatories. (eurekaselect.com)
A previous population study gave us information on the consumption of medicinal plants in 73 pharmacies of the Buenos Aires province, in Argentina. (eurekaselect.com)
Based in the most consumed medicinal plants in our region, we reviewed the risks of such plants and the precautions that should be taken for a rational use. (eurekaselect.com)
Plants are a rich source of unique scaffolds, including 25% of natural-product-derived drugs. (aiche.org)
Advanced Pharmacological Uses of Medicinal Plants and Natural Products provides emerging research exploring the theoretical and practical aspects of drug discovery from natural sources that allow for the effective treatment of human health problems without any side effects, toxicity, or drug resistance. (credoreference.com)
The geographic information system for global medicinal plants(GMPGIS) system, MaxEnt model, and Thiessen polygon method were used to analyze the potential suitable areas for P. ginseng globally. (bvsalud.org)
Using cytotoxic and antioxidant studies, the study attempted to assess some of the commonly used medicinal plants used to cure cancer among Yoruba people in Ogun, Oyo, Osun, and Lagos (South-West, Nigeria). (who.int)
The antimicrobial activity of medicinal plants has shown better pharmacological action when such plants are loaded into a drug delivery system than when they are not loaded. (who.int)

Natural Products as Tools for Neuroscience: Discovery and Development of Novel Agents to Treat Drug Abuse. (acs.org)
The grant will support drug development of AgeneBio's novel GABA A discovery program to treat mild cognitive impairment due to Alzheimer's disease (MCI due to AD) and delay the onset of Alzheimer's dementia. (prnewswire.com)
AgeneBio's GABA A discovery program is a novel approach to delaying the onset of Alzheimer's dementia by targeting the marked hippocampal overactivity that is present during MCI due to AD," said Sharon Rosenzweig-Lipson, PhD , AgeneBio's Vice President of Research and Development and the Primary Investigator on studies supported by this grant. (prnewswire.com)
Our aim is to identify medically important pathways and targets related to human disease that will serve as the basis for the discovery and development of novel, highly differentiated new therapeutics. (rochester.edu)
Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2011). (eurekaselect.com)
This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. (benthamscience.com)
This discipline focuses on the discovery, development and utilisation of leading compounds by studying the mechanism of drug actions in vivo and in vitro as well as their metabolic process in the human body. (xjtlu.edu.cn)
Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. (biospace.com)
It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. (hindawi.com)
Therefore, molecular imaging plays an important role in earlier detection, accurate diagnosis, and drug development and discovery [ 5 - 7 ]. (hindawi.com)
The methodology in which Recursion uses artificial intelligence (AI) in drug discovery, could be one of the most disruptive technologies of our time," said Juergen Eckhardt, M.D., Member of the Executive Committee of Bayer's Pharmaceuticals Division, Head of Business Development, Licensing & Open Innovation and Head of Leaps by Bayer. (worldpharmanews.com)
Bayer's strategic approach in oncology is based on precision drug development which enables fast identification of the most promising targets and commercially viable programs. (worldpharmanews.com)
Evotec OAI has established itself as the partner of choice for drug discovery and development services for the world's premier pharmaceutical and biotechnology companies, maintaining its leadership role through innovation and unmatched customer service. (evotec.com)
Evotec OAI leverages this discovery engine in providing assay development and screening through to compound optimisation and drug manufacturing services to a broad and well-established net work of customers. (evotec.com)
Axxima Pharmaceuticals AG is a drug discovery and development company, pioneering the revolutionary approach of generating a "Signal Transduction Firewallâ" to combat infections, related disorders and diseases, such as inflammation. (evotec.com)
In the drug discovery sector, automated systems have become common use in areas such as high throughput screening, liquid handling, and are now routinely used across discovery and development workflows. (ddw-online.com)
Advanced medicinal chemistry expertise guides the development of synthesizable, complex and 3-dimensional small molecules, increasing specificity and reducing off-target effects. (bioindustry.org)
Medicinal Chemistry stands as a cornerstone in the fascinating world of drug discovery and development. (japanchemicaldaily.com)
Many barriers do exist for the discovery and development of natural product based drugs. (selectbiosciences.com)
Drug Metabolism and Pharmacokinetics (DMPK) is a scientific discipline once primarily associated with safety evaluation in drug development that has, in the last two decades, become a core discipline within drug discovery, development and even post-marketing. (europeanpharmaceuticalreview.com)
The front loading of DMPK to drug discovery can be attributed to a widely used but extremely misleading statistic from an analysis of compounds in clinical development between 1964-1985 in UK companies, where approximately 40 percent of drug attrition was attributed to sub-optimal PK properties. (europeanpharmaceuticalreview.com)
The Drugs for Neglected Diseases initiative (DND i ) welcomes renewed support from Japan's Global Health Innovative Technology Fund (GHIT Fund) for its drug discovery and early-stage development programmes pursuing new drug candidates for the treatment of leishmaniasis and Chagas disease. (dndi.org)
Syntekabio is a genomic big data and AI-driven drug discovery & development company. (cbinsights.com)
The partnership, which will combine the companies' vanguard drug research platforms, will provide a collaborative drug development service as well as develop new molecular leads. (cbinsights.com)
POLARISqb is a quantum computing-based drug development company in Durham, North Carolina. (cbinsights.com)
Once a compound has proved its value in these tests, the process of drug development starts prior to the clinical trials. (pharmacy180.com)
Nevertheless, recent advances in understanding the roles of class II PI3 kinases in different pathological contexts is leading to an increased interest in the development of specific inhibitors that can provide potential novel pharmacological tools. (lu.se)
In relation to The international pharmacopoeia , the Committee recommended the use and development of further basic tests for quick screening of drugs, for example at ports of entry, especially for antimalarial and antituberculosis drugs. (who.int)
Lund University is establishing a university-wide development center for advanced therapies, LU-ATMP. (lu.se)
We want to contribute to the vision of Sweden becoming a world leader in the development and availability of advanced therapies," says Erik Renström, Chancellor of Lund University. (lu.se)
Natural products and drug development : proceedings of the Alfred Benzon Symposium 20 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen 7-11 August 1983 / edited by P. Krogsgaard-Larsen, S. Brogger Christensen, Helmer Kofod. (who.int)
Drugs of natural origin : economic and policy aspects of discovery, development, and marketing / Anthony Artuso. (who.int)

From your very first day as a student in chemistry, you will be taught by scientists working in the School of Chemistry and Biosciences who are actively involved in discovering new drugs and understanding complex biological processes and disease mechanisms. (bradford.ac.uk)
Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)
The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Infective drug design and discovery. (benthamscience.com)
The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. (benthamscience.com)
Automated systems have become a prominent feature throughout drug discovery, helping scientists save time and assisting in reproducible experiments for more verifiable results. (ddw-online.com)
Every year this event bring together about 200 drug discovery scientists together at a platform to discuss and share drug discovery related research and facilitates collaborations amongst scientists from across the globe. (selectbiosciences.com)
However, that is not denying the tremendous progress DMPK scientists have made in understanding absorption, distribution, metabolism and excretion (ADME) processes, contributing to enhanced drug design and the avoidance of DDIs, especially when set against a background of rising commercial, societal, regulatory and budgetary pressures. (europeanpharmaceuticalreview.com)

Cerella's AI platform is proven to overcome limitations in drug discovery data, confidently delivering results and seamlessly integrating with your med chem software platforms. (optibrium.com)

The introduction of deuterated drug candidates that began in the 1970s evolved from earlier work with deuterated metabolites. (wikipedia.org)
The talk will answer these questions through project examples where MMPA has been applied and how this led to drug candidates. (slideshare.net)
Artificial intelligence and the use of machine learning methods allow the processing of enormous amounts of data - including high-resolution imaging - and offers unprecedented potential for the discovery of new drug candidates for cancer and other complex diseases. (worldpharmanews.com)
Under the terms of the drug discovery contract Evotec OAI will apply its integrated medicinal chemistry platform to optimise initial screening hits already identified by Axxima and rapidly progress them towards novel clinical candidates for clinical trials. (evotec.com)
The professionalism of their integrated medicinal chemistry platform qualifies Evotec OAI as an ideal long-term drug discovery partner to support us in progressing selected projects into promising clinical drug candidates. (evotec.com)
In addition, the Company engages in selected discovery programmes itself to develop drug candidates for early out-licensing. (evotec.com)
Approximately 20 years ago, sub-optimal DMPK properties were recognised as a contributor to the failure of potential new therapies in early clinical trials and this precipitated the realignment of DMPK within discovery to assist in selecting optimal drug candidates to enter clinical trials. (europeanpharmaceuticalreview.com)
However, the predictive capability of allometry is limited for low clearance compounds, a requirement for oral drug candidates, as it does not account for species differences in metabolism. (europeanpharmaceuticalreview.com)
The objective of this new collaboration is to screen the chemical library of the University of Tokyo's Drug Discovery Initiative (DDI) against Leishmania donovani to identify hit series for progression as candidates for hit-to-lead optimization - the first GHIT-supported project screening a Japanese academic chemical library of this size and complexity. (dndi.org)
It also specializes in co-developing drug response biomarkers of existing drug candidates, which allows improvement of the likelihood of successful clinical trials, biomarker-driven indication expansion, and enhanced understanding of the drug's mechanism of action. (cbinsights.com)
In addition, POLARISqb has recently developed Quantum-Aided Drug Design (QuADD), a platform for generating new drug candidates using quantum annealing from exceptionally large molecular libraries. (cbinsights.com)
This process of drug discovery involves the identiﬁcation of the candidates, synthesis, characterization, screening, and assays for its therapeutic efﬁcacy. (pharmacy180.com)

Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse talents to redefine the way Biomedical Research discovery teams validate and develop new targets. (novartis.com)
The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. (benthamscience.com)
This strategic shift will enable Bayer to utilize Recursion's capabilities to initiate and advance the identification of novel therapeutic targets for challenging oncology indications with high unmet need. (worldpharmanews.com)
PharmEnable's proprietary drug discovery platform provides a powerful engine for generating novel chemical entities against challenging biological targets. (bioindustry.org)
PharmEnable models targets to identify their key molecular interactions and use AI to identify and expand the most relevant parts of chemical space for drugging that specific target. (bioindustry.org)
Numerate is using this platform to develop a pipeline of drug programs in the cardiovascular, metabolic and neurodegenerative disease areas, focused on targets not typically addressed by computer-aided drug discovery. (cbinsights.com)
Information on the human genome, its sequence, and what it encodes has been hailed as a potential windfall for drug discovery, promising to virtually eliminate the bottlenecks in therapeutic targets that have been one of the limiting factors on the rate of therapeutic discovery. (pharmacy180.com)
It is directed to the extent of background information available on a target, in particular, functional information and does not imply that the mechanism of the action of drugs that are thought to act through particular established targets is fully understood. (pharmacy180.com)
In general, 'new targets' are those targets that are not 'established targets', but which have been or are the subject of drug discovery campaigns. (pharmacy180.com)
The majority of the targets currently selected for drug discovery efforts are proteins. (pharmacy180.com)
PARP enzymes are drug targets: Drugs that inhibit PARP activity are already in use today in treatment of certain forms of cancer. (lu.se)

The concept of replacing hydrogen with deuterium is an example of bioisosterism, whereby similar biological effects to a known drug are produced in an analog designed to confer superior properties. (wikipedia.org)
Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. (mdpi.com)
This course presents the concepts, tools and common instrumental techniques employed in modern bioanalytical chemistry for the quantitative analysis of drugs, metabolites, toxins, environmental contaminants, biomarkers, proteins, biotherapeutics and/or DNA in biological samples. (concordia.ca)
We will give you hands-on experience across a range of disciplines, even including areas such as computational chemistry to solve medicinal and biological chemistry problems. (bradford.ac.uk)
The third year we will introduce you to specialist content in medicinal chemistry and biological chemistry, including topics such as bioorganic and bioinorganic chemistry. (bradford.ac.uk)
Master's-level training focuses on developing a depth of knowledge within medicinal and biological chemistry that is linked to real-world problems. (bradford.ac.uk)
Medicinal Chemistry MRes combines life science, chemistry, medicine and computational science in order to study the structure and biological activity of drugs. (xjtlu.edu.cn)
Our bachelor's degree in medicinal chemistry is the only program of its kind in Illinois and one of just a handful in the country, offering students the opportunity to study the application of biological, chemical, and data science to computer-aided design, synthesis, evaluation, and analysis of structurally diverse drugs for the detection, treatment, and cure of human diseases. (iit.edu)
Study the application of biological, chemical, and data science to computer-aided design, synthesis, evaluation, and analysis of structurally diverse drugs for the detection, treatment, and cure of human diseases. (iit.edu)
Recursion's drug discovery platform navigates over five trillion biological and chemical relationships within one of the world's largest proprietary datasets. (worldpharmanews.com)
BioFocus and the Usher III Initiative began their collaboration in July 2010 with BioFocus performing an integrated drug discovery program encompassing medicinal chemistry, ADME and biological sciences, aiming at a small-molecule therapy for Usher syndrome type III. (labbulletin.com)
Discussion Topics Merits of a combination of knowledge-based approaches (ML) and physics-based approaches Big Pharma perspective: technological solutions to discover, design, and develop therapeutics Mixed solvents MD (MDmix) simulations in structure-based drug discovery and GANX's proprietary site-directed enzyme enhancement therapy (See-Tx™) platform to discover new allosteric binding sites Alignment of computation and biological experiments, e.g. (cbinsights.com)
The wealth of chemical diversity that has evolved with biological diversity is underrepresented in the commercial chemical library offerings, but needs to be expanded to strategically cover available chemical space and include drug-like compounds with improved pharmacologic, pharmacodynamic, and pharmacokinetic properties as compared to their current nitrogen-rich counterparts. (selectbiosciences.com)
Despite the advances in technology and understanding of the biological systems, drug discovery is still a long process with a low rate of new therapeutic discoveries. (pharmacy180.com)
is known to be of high nutritional and medicinal importance and has been demonstrated to possess a variety of biological activities. (bvsalud.org)

His patents range from areas in biochemistry, medicinal chemistry, and organic synthesis. (auburn.edu)
The course will focus primarily on the rational design and synthesis of drugs that employ multidisciplinary approaches to satisfy a multitude of specificity and safety requirements. (concordia.ca)
There will be a focus on organic synthesis within the special context of medicinal chemistry that illustrates the challenges involved in leveraging the opportunities presented by high throughput, parallel and/or combinatorial synthesis in light of physical limitations imposed by processing large numbers of compounds. (concordia.ca)
Rauter, A. P. Nucleoside analogues: N-glycosylation methodologies, synthesis of antiviral and antitumor drugs and potential against drug-resistant bacteria and Alzheimer's disease. (beilstein-journals.org)
However, the discovery, synthesis, and overall material supply chains for sourcing plant natural products and their derivatives remain ad hoc, biased, and tedious. (aiche.org)

Numerate's drug design platform combines advances in computer science and statistics with traditional medicinal chemistry approaches to address, in parallel, the factors that determine the success and failure of a drug candidate. (cbinsights.com)

Computational prediction of in vivo properties can also be used to improve design during drug discovery, help select compounds with better properties, and reduce the number of in vivo experiments. (optibrium.com)
The central role of DMPK in drug discovery is to contribute to the optimisation of compounds for man by balancing the properties associated with drug gastrointestinal absorption (for orally delivered therapies), distribution, clearance, elimination and DDI potential as rapidly and cost effectively as possible. (europeanpharmaceuticalreview.com)
Rapid feedback to medicinal chemistry led design teams providing estimates of human PK and predicted therapeutic dose are pivotal to the efficient optimisation of lead compounds into candidate drugs. (europeanpharmaceuticalreview.com)

Drive hypothesis generation to improve clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes. (novartis.com)
Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. (hindawi.com)
This India I EMBO Lecture Course will bring together eminent researchers and experts across the disciplines of cancer and molecular biology, structural biology, bioinformatics, medicinal chemistry and drug discovery, to share the recent advances, challenges, and opportunities in the field of tumour metabolism and drug discovery. (embo.org)
Teaching is primarily delivered at our South Kensington campus, with regular opportunities to advance your skills at our state-of-the-art Molecular Sciences Research Hub in White City. (imperial.ac.uk)
A new approach to drug discovery is to understand how the diseases and infections are controlled at the molecular and physiological level and to target speciﬁc entities based on this knowledge. (pharmacy180.com)
Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd. (wikipedia.org)
Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)
With the help of various forms of mass spectrometry, synchrotron radiation, protein production & labelling, and bioinformatics, our facilities provide the opportunity to study protein structure and dynamics, molecular probes and drug design. (lu.se)

The applications of the deuterium isotope effect has increased over time, and it is now applied extensively in mechanistic studies of the metabolism of drugs as well as other studies focused on pharmacokinetics (PK), efficacy, tolerability, bioavailability, and safety. (wikipedia.org)

Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. (hindawi.com)
The system integrates scaled 'wet-lab' biology and chemistry data with computational tools, using advanced machine learning technologies to industrialize drug discovery by validating and advancing therapeutic programs efficiently and with minimal bias. (worldpharmanews.com)

However, there has been a de-emphasis on natural product-based drug discovery programs over the last 20 years by the pharmaceutical industry, in part because of a perceived promise of high-throughput screening and combinatorial chemistry which never came to fully meet heightened expectations. (selectbiosciences.com)

BALTIMORE , June 30, 2017 /PRNewswire/ -- AgeneBio , a pharmaceutical company developing innovative therapeutics for unserved patients battling neurodegeneration, today announced that the Company has received an additional $750,000 grant from the Alzheimer's Drug Discovery Foundation (ADDF). (prnewswire.com)
Running alongside the Drug Discovery India 2017 conference will be an Exhibition covering the latest technological advances within these fields. (selectbiosciences.com)
We look forward to welcoming you at the Drug Discovery India 2017 Conference and Exhibition and hope that the two days will be both informative and enjoyable. (selectbiosciences.com)

The global lab automation market for drug discovery is expected to grow by a CAGR of 5% between 2021 - 2026, according to a report by Mordor Intelligence. (ddw-online.com)

The Design Make Test Analyse (DMTA) cycle is the multi-disciplinary engine of lead optimisation and drug discovery screening cascades. (europeanpharmaceuticalreview.com)

It will begin with a general overview, followed by focused subsections that flow from early target identification, hit discovery, lead optimization, pre-clinical considerations, up to clinical trials. (concordia.ca)
His current research focus in Alzheimer's Disease has led to the identification of a molecule that has advanced into Phase 1b/2a clinical trials. (uclahealth.org)
The pandemic might have affected the number of clinical trials taking place for cell and gene therapies, with activity decreasing by around 15% compared to 2020, but major therapies such as Novartis' gene therapy drug for spinal muscular atrophy (SMA) Zolgensma still made it to market. (ddw-online.com)

Frontiers in Medicinal Chemistry 2015 will be jointly organised by EFMC, ACS and the local Dutch and Belgian organisers: the Medicinal and Bioorganic Chemistry Division of the Royal Flemish Chemical Society (KVCV, Belgium), the Société Royale de Chimie (SRC, Belgium), and the Section Medicinal Chemistry of the Royal Netherlands Chemical Society (KNCV, The Netherlands). (ldorganisation.com)
In connection with the FMC Meeting, EFMC will organise the second edition of the EFMC Young Medicinal Chemist Symposium ( EFMC-YMCS 2015 ), which will take place on September 17 in the same location. (ldorganisation.com)
Due to the connection between the EFMC Young Medicinal Chemist Symposium and FMC Meeting, the participants who are registered to FMC 2015 can benefit from a special rate and a free registration for students. (ldorganisation.com)

For the last five years, AgeneBio has partnered with Hager Biosciences , a leading preclinical-stage drug discovery organization with innovative medicinal chemistry capabilities, to advance the chemistry of its GABA A discovery program. (prnewswire.com)
The Clermont Group saw the opportunity to act as lead investor in PostEra's Series A investment round to raise capital for advancing its capabilities. (mwe.com)

The oncology-focused collaboration will leverage Bayer's small molecule compound library and expertise in biology and medicinal chemistry as well as Recursion's purpose-built artificial intelligence-guided drug discovery platform. (worldpharmanews.com)

BioFocus' offering includes target discovery in human primary cells, focused as well as diverse compound libraries, in vitro and cell-based screening, structural biology, medicinal chemistry and ADME/PK services, supported by unique chemogenomic and informatics tools. (labbulletin.com)

Because of the kinetic isotope effect, deuterium-containing drugs may have significantly lower rates of metabolism, and hence a longer half-life. (wikipedia.org)

In addition to taking lecture-based courses, students gain hands-on experience in lab courses tailored to industrial needs by working alongside our distinguished chemistry faculty to conduct innovative research into the areas of medicinal and pharmaceutical chemistry, including cancer drug discovery, computational drug design and modeling, and microscopic characterization of biomaterials for regenerative medicine. (iit.edu)

Within integrated modules, you'll learn about the major diseases and the science behind the drugs used to treat them. (uea.ac.uk)
It is an exciting and important time when it comes to new treatments for diseases where today's drugs and treatments are insufficient or missing altogether," says Kristina Åkesson, professor and dean at the Faculty of Medicine. (lu.se)

The group is supported by more than 100 software developers and engineers as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. (biospace.com)
The collaboration will now support medicinal chemistry optimization for the S07 leads it has identified, with the aim of progressing at least one optimized lead to deliver a pre-clinical candidate compound for visceral leishmaniasis. (dndi.org)

With this funding, Dr. Rosenzweig-Lipson and the team from Hager will continue to advance this discovery program to target hippocampal overactivity, which prior research suggests is a major contributor to neurodegeneration and cognitive decline in patients with MCI due to AD. (prnewswire.com)
Dr. Carroll is prominently known for his achievements and advancements in drug research and discovery. (auburn.edu)
Not only did his competitive edge keep him going in his research but realizing that he could help others through medicine pushed him into drug research and discovery. (auburn.edu)
Furthermore, Carroll also held the title of director of Center for Organic Chemistry and Medicinal Chemistry (1975-2001) where his research in drug discovery would prosper. (auburn.edu)
With advancements in medicinal research in cancer, malaria, and Parkinson's disease, Dr. Carroll has made strides to better understand these afflictions. (auburn.edu)
Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
The Empire Discovery Institute (EDI) is designed to help overcome key challenges typically faced by life science researchers in academia - lack of external funding to continue research efforts and lack of pharmaceutical industry expertise to advance these programs to fruition. (rochester.edu)
The course will also chart the evolution of powerful techniques from structural research (NMR, X-ray crystallography, and computational modeling) as fully integrated medicinal chemistry tools for modern drug-discovery using examples from the current literature to highlight key advances. (concordia.ca)
Bayer and US-based Recursion Pharmaceuticals, Inc., a clinical stage TechBio company decoding biology to industrialize drug discovery, announced that they have updated the focus of their research collaboration to precision oncology. (worldpharmanews.com)
'These four new investments are a further testament to the critical, long-term support provided by the GHIT Fund, which enables DNDi and our Japanese partners from the pharmaceutical industry, research institutes, and academic institutions to discover and develop innovative new treatments for neglected patients,' said Charles Mowbray, DND i Discovery Director. (dndi.org)
To facilitate the transition from discovery in the research laboratory to new treatment therapies for patients, the manufacturing process needs to be translated from research routines to clean room routines so that the medical product corresponds to so-called Good Manufacturing Practice (GMP). (lu.se)

Amiri, Z. Recent Advances in Stetter Reaction and Related Chemistry: An update. (beilstein-journals.org)
Massi, A. Recent advances in continuous-flow organocatalysis for process intensification. (beilstein-journals.org)
This conference is especially aimed to provide a forum to critically examine these barriers and revive interest in natural products to ease drug discovery bottleneck being experienced by the pharmaceutical industry in recent years. (selectbiosciences.com)
New technologies, results, and theories are emerging in the field of microbiomics in recent years with the advances in high-throughput sequencing and multi-omics technologies. (bvsalud.org)

ILI provides students and professionals lifelong learning opportunities to innovate through collaboration, practice, and career discovery. (aiche.org)

Additionally, Axxima intends to partner its drug discovery technology in indications outside Axxima's core focus areas. (evotec.com)
Its world-class team works across a range of disease areas where drug specificity is a significant challenge, such as cancer and neurological disease. (bioindustry.org)

Many new classes of drugs that are currently available including DPP-4 inhibitors, GLP-1 agonists and SGLT-2 inhibitors have undergone cardiovascular outcome trials which had been made mandatory by the regulatory authority and thereby established their cardiovascular safety or at least neutrality. (eurekaselect.com)
Targeting KRAS Mutations: Discovery of Small Molecule Inhibitors for the Potential Treatment of Intractable Cancers. (cdc.gov)
We strive to contribute to a better understanding of these toxins and to create inhibitors also for their activities, with the aim of creating new anti-infective drugs. (lu.se)

Numerous publications have discussed the advantages and disadvantages of deuterated drugs A number of publications have discussed aspects of intellectual property of deuterated versions of drugs. (wikipedia.org)

Reducing attrition is the current focus for R&D and DMPK has a key role to play, not only in discovering and developing drugs with sufficient oral bioavailability, adequate half-lives and minimising potential for DDI liabilities, but to contribute via reducing attrition for lack of efficacy and poor safety profiles. (europeanpharmaceuticalreview.com)

Taking place at the ExCel in London from 4-5 October, ELRIG Drug Discovery 2022 is set to provide visitors with access to the latest trends, technologies and expertise driving the life sciences sector. (ddw-online.com)
As one of the exciting fields in the pharmaceutical industry, it's no surprise that Drug Discovery 2022 will feature sessions on developments in CAR-T and the technologies helping researchers in this field. (ddw-online.com)

PostEra will use the funding to further its work on drug discovery programs, begin its own internal discovery program and advance its medicinal chemistry platform. (mwe.com)
Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. (uclahealth.org)
BioFocus delivers drug discovery solutions through a comprehensive platform run by dedicated teams with a track record in gene-to-clinical candidate discovery. (labbulletin.com)

Anatomy12

Organisms31

Diseases7

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology3

Phenomena and Processes41

Disciplines and Occupations32

Anthropology, Education, Sociology and Social Phenomena14

Technology, Industry, Agriculture11

Humanities7

Information Science21

Named Groups1

Health Care11

Exploiting medicinal chemistry1

Chemists8

Small-molecule drug discovery3

European Federation for Medicinal Chemistry2

Synthetic4

Journal of Medici5

Medicines5

Anti-Infective Drug Discovery2

20233

Programme4

PHARMACOLOGY7

Plants8

Development32

Scientists7

Chem1

Candidates12

Targets12

Biological16

Synthesis5

Approaches1

Compounds3

Molecular8

PHARMACOKINETICS1

Therapeutic2

Combinatorial Chemistry1

20173

20211

Optimisation and drug1

Clinical Trials3

EFMC3

Capabilities2

Artificial1

ADME1

Metabolism1

Computational drug1

Diseases2

Optimization2

Research11

Recent4

Collaboration1

Areas2

Inhibitors3

Aspects1

DMPK1

20222

Platform3