• Matthew M. Hsieh, M.D., of the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md., and colleagues explored a nonmyeloablative approach in a pilot group of 10 adults with severe sickle cell disease, using a simplified HSCT regimen (with stem cell donation from a immunologically matched sibling), that had few toxic effects, yet all patients continued taking immunosuppression medication. (eurekalert.org)
  • While common among children with sickle cell disease, the risk of complications makes the procedure rare for adults. (kucancercenter.org)
  • Although bone marrow lesions (BML) have been implicated in the pathogenesis of osteoarthritis, their natural history in a healthy population is unknown. (bmj.com)
  • Withdrawing life support from mechanically ventilated recipients of bone marrow transplants: a case for evidence-based guidelines. (semanticscholar.org)
  • These findings place B-2, MZ, and B-1b in a single adult developmental lineage and place B-1a in a separate lineage derived from HSCs that are rare or missing in adults. (pnas.org)
  • These differences in B-cell reconstitution capabilities of adult versus neonatal BM underlie the idea that B-1 and B-2 belong to distinct developmental lineages derived from distinct HSCs ( 13 ). (pnas.org)
  • Interestingly, nestin expression is reinduced in the adult during pathological situations, such as the formation of the glial scar after CNS injury and during regeneration of injured muscle tissue. (wikipedia.org)
  • By sorting and transferring highly enriched HSC populations from adult BM and neonatal sources, these investigators demonstrate that the HSC population sorted from adult BM principally reconstitutes B-2 and B-1b and only poorly reconstitutes B-1a ( 5 ). (pnas.org)
  • Many adults have treatment-resistant chronic ITP evident after 3-6 months of treatment, and an alternative diagnosis may be pursued vigorously at that time. (medscape.com)
  • Borst F, Keuning JJ, van Hulsteijn H, Sinnige H, Vreugdenhil G. High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults. (medscape.com)
  • 1 Conversely, the probability of success of a bone marrow- or peripheral blood-matched unrelated donor search is related to ethnicity, and is limited by stringent matching criteria. (nature.com)
  • When is bone marrow exam indicated in adults with suspected immune thrombocytopenic purpura (ITP)? (medscape.com)
  • Jubelirer SJ, Harpold R. The role of the bone marrow examination in the diagnosis of immune thrombocytopenic purpura: case series and literature review. (medscape.com)
  • Acute renal failure after intravenous anti-D immune globulin in an adult with immune thrombocytopenic purpura. (medscape.com)
  • In studies here, we close this gap by definitively demonstrating that individual HSCs sorted from adult BM fully reconstitute B-2, MZ, and some B-1b but do not reconstitute B-1a. (pnas.org)