Adult stem cells led scientists. Medical search. Frequent questions

Flies have the potential to provide many insights into how to promote the regeneration of sensory hearing cells," said Bonaguidi, who is an assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine of USC. (eurekalert.org)
Lizards have been around for more than 250 million years, and in all that time no lizard has ever regrown a tail with dorsoventral patterning, until now," said study lead author Thomas Lozito, an assistant professor of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine at USC. (earth.com)
Chris Mason, professor of Regenerative Medicine Bioprocessing at University College London, said: "For the next decade, the role of iPS cells in therapy is more likely to be in the fight against cancer than for permanent implantation to regenerate tissues and organs. (scotsman.com)
For this work, scientists have combined adult stem cells with a repurposed drug that improves healing to create a novel bioengineered scaffold that could someday lead to a new treatment for chronic diabetic ulcers," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (ipscell.com)
Experts in the field of regenerative medicine believe one of the first areas of success when using stem cell-derived therapies will be the treatment of macular degeneration, which causes progressive loss of sight, and other retinal diseases. (cnn.com)
Our study is the first to detail the presence of newborn neurons and an immature version of a related cell type, known as astroglia, in patients with epilepsy," said Michael Bonaguidi, an assistant professor of stem cell biology and regenerative medicine, gerontology, and biomedical engineering at USC. (sflorg.com)
Established in 2011, CRI is creating interdisciplinary groups of exceptional scientists and physicians to pursue research at the interface of regenerative medicine, cancer biology and metabolism, which together hold unusual potential for discoveries that can yield groundbreaking advances in science and medicine. (utsw.edu)
PALO ALTO, Calif.-Physician-scientist Tanja Gruber, MD, PhD , has been appointed Division Chief of Hematology, Oncology , and Stem Cell Transplantation and Regenerative Medicine in the Division of Pediatrics at the Stanford University School of Medicine , Associate Director for Childhood Cancer in the Stanford Cancer Institute , and Director of the Bass Center for Childhood Cancer and Blood Diseases at Stanford Children's Health . (stanfordchildrens.org)
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2023. (bvsalud.org)

The additional funding committed to research into adult and induced pluripotent stem cells produced amazing medical breakthroughs. (christianheadlines.com)
The team from the RIKEN Research Centre for Allergy and Immunology said they had created cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS) - those which have been artificially extracted from adult cells. (scotsman.com)
NEI just received FDA approval to begin the first-ever trial using tissue derived from patient-derived human induced pluripotent stem cells (hIPSCs), reprogrammed adult cells that can be converted into other cell types. (nih.gov)
Wu's group created his blastoids from human embryonic stem cells and from "induced pluripotent stem cells," which are made from adult cells. (kmuw.org)
We now need to work quickly to unlock the recipe for converting pluripotent stem cells into HHyPs so that we could transplant those cells into patients at will. (kcl.ac.uk)
Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics. (prnewswire.com)
Induced pluripotent stem cells represent one of the most promising research advances within the past decade, making this a valuable report for both executives and investors to use to optimally position themselves to sell iPSC products. (prnewswire.com)
A distinctive feature of this report is an end-user survey of 273 researchers (131 U.S. / 143 International) that identify as having induced pluripotent stem cells as a research focus. (prnewswire.com)
I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)
In this review we summarize the data on the main advantages, drawbacks and research applications of CM cell lines published to date including primary cells, immortalized cell lines, lymphoblastoid cell lines, embryonic stem cells, and induced pluripotent stem cells. (bvsalud.org)
Our most recent initiative is having established a platform for induced pluripotent stem cells (iPSC). (lu.se)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

President Bush, saying he wanted to "proceed with great care," announced in a national address on August 9 that he would allow federal funding of an existing 60 stem-cell lines but would not permit tax dollars to pay for the destruction of any additional human embryos. (christianitytoday.com)
The rule circumvented a 1995 congressional ban on using federal money for biomedical research on embryos outside the womb by allowing researchers to use stem cells extracted by a third party. (christianitytoday.com)
The groups argue that rather than waste embryos that will be destroyed along with their stem cells, researchers should use them to help save those whose lives are being cut short by disease. (christianitytoday.com)
Indeed, some observers believe the demand for stem cells is dangerously close to spawning a huge commercial industry around the sale of and experimentation on human embryos. (christianitytoday.com)
Already, news that Advanced Cell Technology-a Massachusetts-based, privately held biotech company-and Virginia Medical School's Jones Institute had created or planned to create human embryos for the sole purpose of extracting their stem cells has troubled those on both sides of the debate. (christianitytoday.com)
Bush strongly opposed the creation of any new stem cell lines that required the destruction of human life, including embryos. (christianheadlines.com)
Chinese scientists have successfully created chimeric embryos containing a combination of human and pig cells. (bioedge.org)
Researchers in Wisconsin and Japan have turned ordinary human skin cells into what are effectively embryonic stem cells without using embryos or women's eggs - the two hitherto essential ingredients that have embroiled the medically promising field in a long political and ethical debate. (washingtonmonthly.com)
In 2000, the National Institutes of Health issued guidelines for the use of embryonic stem cells in research, specifying that scientists receiving federal funds could use only extra embryos that would otherwise be discarded. (cnn.com)
Jun Wu's team at the University of Texas Southwestern Medical Center in Dallas have created hollow balls of cells that closely resemble embryos at the stage when they usually implant in the womb - known as blastocysts. (kmuw.org)
So in recent years, scientists started creating structures that resemble human embryos in the lab by using chemical signals to coax cells into forming themselves into entities that look like very primitive human embryos. (kmuw.org)
Federal financing would still be restricted to stem cell lines derived from embryos that were slated to be discarded by in vitro fertilization clinics. (consumerwatchdog.org)
But creating the stem cells now involves the destruction of human embryos, which some people, including Mr. Bush, say is immoral. (consumerwatchdog.org)
Even under the new legislation, scientists said, they could still not use federal money to create new cell lines if it involved the destruction of embryos. (consumerwatchdog.org)
The cost seems to be small, experimentation with stem cells derived from "spare" embryos that are no longer needed or wanted for in vitro fertilization. (jcrelations.net)
Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

Bush promised in January to review a Clinton administration rule that allowed federal funding for researchers experimenting on embryo cells from fertility clinics. (christianitytoday.com)
Researchers value the cells for their ability to replicate quickly and turn into any kind of human tissue. (christianitytoday.com)
The prolife lobby also received help from Do No Harm, a coalition of researchers, bioethicists, and doctors who spearheaded a nationwide petition urging Bush to oppose destructive human embryonic stem-cell research. (christianitytoday.com)
The hope of most researchers in the field is that one day it will be possible to use stem cells - which possess the ability to develop into many other distinct cell types, such as nerve, heart, or lung cells - to repair damaged tissue from any number of diseases, from Type 1 diabetes to Parkinson's disease, as well as from injuries. (x-journals.com)
In the paper, the researchers demonstrated that they could use purified proteins to transform adult cells all the way back to the most primitive embryonic-like cells, avoiding the problems associated with inserting genes. (x-journals.com)
The researchers identified the most active compounds, then looked at their effects on stem cell creation when used singly and in combination. (x-journals.com)
The researchers found two chemicals - ALK5 inhibitor SB43142 and MEK inhibitor PD0325901 - used in combination were highly effective in promoting the transformation of fibroblasts into stem cells. (x-journals.com)
The researchers discovered that as normal, healthy adult cells approach cell-death, they produce a burst of telomerase that prevents malignancies and softens the final steps in the aging process. (sciencedaily.com)
What's more, the researchers found that as skin cells from non-telomerase-deficient mice approached critical telomere length, they naturally produced a burst of telomerase, which slowed the process of telomere shortening and reduced the amount of DNA damage that could lead to cancer. (sciencedaily.com)
The researchers also found that reactivating the gene for expressing telomerase in the telomerase-deficient cells rescued them, prolonging their ability to divide and reducing DNA damage. (sciencedaily.com)
The researchers found that human cells also expressed telomerase as they approached critical telomere length. (sciencedaily.com)
Cao said that the next step for researchers is to find out how telomerase expression is turned on as cells approach critical telomere length and to explore the underlying mechanisms by which telomerase acts as a buffer against the stresses of shortening telomeres. (sciencedaily.com)
Researchers now say around 18% of healthy adults above the age of 50 face accelerated aging in at least one of their organs. (medicaldaily.com)
Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
But none of the promises of embryonic stem cell therapies ever materialized, even after his Oval Office successor reversed Bush's policies , rebuilt the Council around only scientists and medical researchers, and released enormous funding for embryo-destructive research. (christianheadlines.com)
THE prospect of a major breakthrough in cancer treatment was announced by researchers yesterday who said they had created stem cells capable of killing diseased cancer cells for the first time. (scotsman.com)
The researchers, whose work is reported in the journal Cell Stem Cell , said previous research had shown that producing such cells in a laboratory using conventional methods had been inefficient in killing cancer cells, mainly because of their short lifespan. (scotsman.com)
And as the researchers haven't shown that these reprogrammed T cells can actually kill cancer cells in animals or humans, more research is needed to find out whether this approach will be safe and effective for treating -patients. (scotsman.com)
Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB). (scitechdaily.com)
In the study, published online on July 31, 2018, in Cell Research, researchers zeroed in on a protein that affects multiple targets and pathways involved in hematopoietic stem cell self-renewal, a broader approach than other studies that focus on a single target or pathway in the process. (scitechdaily.com)
A Boston-based scientific collaborative, led by Harvard Stem Cell Institute (HSCI) researchers, has discovered a way to collect the best cell type for regenerating a damaged cornea -the clear membrane that covers the pupil and directs light into the back of the eye. (drcremers.com)
The biological marker the researchers found is the ABCB5 protein, which is located on the surface of limbal stem cells. (drcremers.com)
The researchers transplanted purified limbal stem cells from adult humans into mice with corneal blindness and checked to see if the corneas had regrown 5 weeks later, as well as 13 months later. (drcremers.com)
Editas Medicine, a biotech company building on work by NEI researchers is conducting the first-in-human CRISPR trial to help patients with vision loss caused by a mutation in CEP290, another crucial gene in the eye, which was also discovered by NEI scientists. (nih.gov)
Especially gratifying to stem cell researchers was that some of their biggest critics seemed mollified. (washingtonmonthly.com)
In a 2013 study , the researchers found that CBC stimulates neurogenesis, or the growth of brain cells. (cannabis.net)
In January 2014, researchers announced they had developed a new method of making stem cells: by placing skin cells in an acidic environment. (cnn.com)
Although researchers find money elsewhere-scientists in Kotton's lab have secured funds from the Massachusetts Life Sciences Center , the American Lung Association , and the Alpha-1 Foundation , among others-the NIH is the big enchilada, distributing about $30 billion in FY 2014. (bu.edu)
The researchers believe this technique has possibility for use in cell-based therapy for cardiovascular diseases. (livescience.com)
Heart cells created this way could be used to test treatments for heart disease and, if created from a particular patient, used to personalize treatment, according to the researchers. (livescience.com)
In experiments reported online in the April issue of the Journal of Molecular and Cellular Medicine , Yale researchers led by Hugh Taylor, M.D., professor of obstetrics, gynecology, and reproductive sciences, explored the therapeutic potential of cells from the lining of the uterus, or endometrium. (yale.edu)
18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
6 Jun, 2007 07:00 pm Researchers have reprogrammed skin cells into embryonic stem cells. (scitizen.com)
A bill approved by the Senate yesterday to spur stem cell research would go a long way toward removing restrictions that have slowed progress, burdened laboratories with red tape, reduced American competitiveness and discouraged young researchers from entering the field, several leading stem cell scientists said. (consumerwatchdog.org)
Some researchers hope the legislation would lead eventually to more financing, though the federal research budget has been tight. (consumerwatchdog.org)
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. (kcl.ac.uk)
Researchers have developed a technique that employs 'dancing molecules' to create more mature neurons from stem cells than standard methods have achieved. (nyscf.org)
By focusing on the HA stem, the researchers believe the new vaccine candidate could provide wider and longer-lasting immunity. (medscape.com)
To create the vaccine candidate, researchers used the stem of an H1N1 influenza virus. (medscape.com)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
By triggering certain genes, researchers may be able to cause the stem cells to specialize and become the cells that need to be replaced. (msdmanuals.com)
But researchers think that these stem cells have the most potential for producing different kinds of cells and for surviving after transplantation. (msdmanuals.com)

These findings represent a major advance in the field and have significant potential to improve the outcomes of thousands of children and adults who undergo umbilical cord blood transplantation every year. (scitechdaily.com)
Jan. 25, 2012 - Scientists with the new Children's Research Institute at UT Southwestern Medical Center have identified the environment in which blood-forming stem cells survive and thrive within the body, an important step toward increasing the safety and effectiveness of bone-marrow transplantation. (utsw.edu)
Doing so will make it possible to expand blood-forming stem cells prior to transplantation into patients, thereby increasing the safety and effectiveness of this widely used clinical procedure. (utsw.edu)
It is the policy of Washington state that research involving the derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation , is permitted upon full consideration of the ethical and medical implications of this research. (cbc-network.org)
On the heels of opening our new inpatient cancer center in 2019, Dr. Gruber's leadership as a remarkably accomplished and collaborative physician-scientist will further enhance Stanford Children's Health's ability to offer preeminent, innovative treatment for pediatric cancer and blood diseases, and stem cell transplantation. (stanfordchildrens.org)
We could integrate our coating into large-scale manufacturing of patient-derived neurons for cell transplantation therapies without immune rejection," remarked Dr. Stupp. (nyscf.org)
About 650 publications in the fields of neuroanatomy, neuronal regeneration, cell transplantation and repair in the central nervous system. (lu.se)
Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
These stem cells are most often used for transplantation. (msdmanuals.com)
Therefore, a central goal of diabetes research is to regenerate pancreatic beta cells or produce large numbers of functional beta cells for transplantation into diabetic patients. (lu.se)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
Although longitudinal natural history data are limited, published guidelines are available to assist with decisions related to the pursuit of transplantation and whether to use bone marrow or umbilical cord blood-derived cells. (medscape.com)
Some evidence indicates that at least in certain disorders, combination ERT and hematopoietic stem cell transplantation together might be superior to hematopoietic stem cell transplantation alone in patients who are appropriate candidates. (medscape.com)
The availability of both ERT and hematopoietic stem cell transplantation has prompted ongoing consideration of newborn screening efforts to diagnose lysosomal storage diseases. (medscape.com)

Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. (x-journals.com)
The creation of iPS cells from adult cells sidesteps ethical concerns associated with the use of embryonic stem cells, and allows the generation of stem cells matched to a patient's own immune system, avoiding the problem of tissue rejection. (x-journals.com)
He decided he would focus his efforts on manipulating a naturally occurring process in cells, in particular in a type of adult cell called fibroblasts, which give rise to connective tissue. (x-journals.com)
Telomerase's only known role in normal tissue was to protect certain cells that divide regularly, such as embryonic cells, sperm cells, adult stem cells and immune cells. (sciencedaily.com)
Adult Stem Cells Taken from Human Fat Tissue Used to Treat Heart Failure Sweden Company Wants To Start First Stem Cell Research Factory Leading Scientist Charges Colleagues With "Misleading" Public British Stem Cell Researcher: Benefits of. (physiciansforlife.org)
Even if this ventralizing signal is absent, adult NSCs are still incapable of generating nerve tissue for the upper or dorsal side of the tail. (earth.com)
The research, to be published in the June 5 issue of Cell Stem Cell , shows for the first time that a protein called Wnt7a increases the number of stem cells in muscle tissue, leading to accelerated growth and repair of skeletal muscle. (disabled-world.com)
This discovery shows us that by targeting stem cells to boost their numbers, we can improve the body's ability to repair muscle tissue," said senior author Dr. Michael Rudnicki. (disabled-world.com)
Stem cells give rise to every tissue and organ in the body. (disabled-world.com)
Satellite stem cells are specialized muscle stem cells that live in adult skeletal muscle tissue and have the ability to both replicate and differentiate into various types of muscle cells. (disabled-world.com)
Dr. Rudnicki's team found that the Wnt7a protein, when introduced into mouse muscle tissue, significantly increased the population of these satellite stem cells and fueled the regeneration process, creating bigger and stronger muscles. (disabled-world.com)
Scientists at Columbia University have created part of a human jaw joint by growing human adult stem cells on a tissue scaffold. (bioedge.org)
In February 2012, early research published by scientists at Cedars-Sinai Medical Center and Johns Hopkins University showed that a patient's own stem cells can be used to regenerate heart tissue and help undo damage caused by a heart attack. (cnn.com)
Scientists have created the first lab-dish models of the cellular clock, where each 'tick' stimulates the formation of the vertebra, which uses stem cells derived from adult human tissue. (biotechnology.report)
In general, heart-muscle cells may help repair an injured heart by replacing lost tissue, making them intriguing to scientists who study how lost or damaged tissue or organs could be regenerated . (livescience.com)
Regularly regenerated after menstruation, this tissue is a rich source of stem-like cells in adults. (yale.edu)
In a mouse model of Parkinson's, transplanted endometrial cells migrated to damaged brain tissue and differentiated into dopamine-producing neurons, significantly raising dopamine levels. (yale.edu)
Endometrial tissue is probably the safest, most easily attainable source of stem cells currently available," says Taylor. (yale.edu)
8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
The potential of these cell is to heal the damaged tissue with no pain to the individual. (medgadget.com)
The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more. (prnewswire.com)
Although such standards have been previously proposed for repositories and distribution centers, no widely accepted best practices exist for laboratory research with human pluripotent and tissue stem cells. (bvsalud.org)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)

While most panelists felt that clinical use of pancreatic stem cells as a cure for diabetes was 15-20 years away, they also believed that application of stem cell therapies would likely include spinal cord injuries, Parkinson's disease and dementia. (news-medical.net)
If this differentiation of adult stem cells can be controlled in the laboratory, these cells may become the basis of therapies for many serious common diseases. (news-medical.net)
Biotechnology companies specializing in stem-cell research stand to reap huge financial windfalls from successful therapies developed via this science," said the CPI report. (christianitytoday.com)
AGI has launched three key research consortia, to image individual cells in the eye as they respond to light, to identify factors that control cell regeneration in the visual system, and to develop animal models to test regenerative therapies. (nih.gov)
From Gizmodo Shady Stem Cell Therapies Can Cause Tumors, Infections, and Death, Doctors Report and here's the original article " Complications from "Stem Cell Tourism in Neurology . (ipscell.com)
This is a tremendous scientific milestone, the biological equivalent to the Wright Brothers' first airplane," said Robert Lanza, chief scientific officer of Advanced Cell Technology in Worcester, Mass., a developer of stem cell therapies. (washingtonmonthly.com)
How did your research impact therapies for sickle cell disease? (medlineplus.gov)

These findings have led scientists to ask whether adult stem cells could be used for transplants. (news-medical.net)
Adult blood forming stem cells from bone marrow have been used in transplants for 30 years. (news-medical.net)
Life-saving bone marrow transplants have been the common practice for decades, but this doesn't work for everybody," says Stowers Institute Investigator Linheng Li, Ph.D., study lead who is also co-leader of the cancer biology program at the University of Kansas Cancer Center and an affiliate professor of pathology and laboratory medicine at the University of Kansas School of Medicine. (scitechdaily.com)
This may also be complementary to the approach of haploidentical adult stem cell transplants, which involve donors from a close but still mismatched family member. (scitechdaily.com)
Limbal stem cell transplants from an uninjured eye or deceased organ donor have had promising results, but outcomes have been inconsistent. (drcremers.com)
Previously published work on limbal epithelial cell grafts showed that when more than three percent of transplanted cells were stem cells, transplants were successful-less than three percent and the transplants were not, "said HSCI Affiliated Faculty member Natasha Frank. (drcremers.com)
The team then developed an antibody that could tag limbal stem cells in a general sample of human limbal cells, making it possible to purify only the cells responsible for successful limbal cell transplants. (drcremers.com)
From 2004 to 2013, our team, led by Dr. John Tisdale and Dr. Matt Hsieh] developed ways to use bone marrow stem cell transplants to expand the possibility of curing the disease. (medlineplus.gov)

This naturally occurring process - called MET (mesenchymal to ephithelial cell transition) - pushes fibroblasts closer to a stem-cell-like state. (x-journals.com)
Co-culture of human bone marrow mesenchymal stem cells (HBMSCs) and macrophages showed immunomodulatory effects via regulation of cytokine regulation. (drcremers.com)
The mesenchymal stem cells market is anticipated to grow at a CAGR of 7.0% from 2018 to 2026. (medgadget.com)
Mesenchymal stem cells are adult stem cells, which are traditionally found in the bone marrow. (medgadget.com)
The global mesenchymal stem cells market growth is primarily driven by the increasing demand for these stem cells as an effective treatment alternative for knee replacement in the recent past. (medgadget.com)
However, some of the political point of views, and higher cost of treatment by using mesenchymal stem cells might restraint the growth during the forecast period. (medgadget.com)
Increasing demand for better healthcare facilities, rising geriatric population across the globe, and continuous research and development activities in this area by the key players is expected to have a positive impact on the growth of Mesenchymal Stem Cells market. (medgadget.com)

Scientists view stem cells as a possible gateway to curing many medical conditions, from Parkinson's disease to diabetes. (cnn.com)
Parkinson's disease, which degenerates motor function and speech, results from a loss of dopamine-producing brain cells. (yale.edu)
Scientists hope one day to produce tissues to repair the damage caused by Parkinson's disease, diabetes and other diseases. (consumerwatchdog.org)
Turning patient stem cells into the different cell types of the brain offers immense promise for studying and treating neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis. (nyscf.org)
Cell replacement therapy can be very challenging for a disease like ALS, as transplanted motor neurons in the spinal cord will need to project their long axons to the appropriate muscle sites in the periphery but could be more straightforward for Parkinson's disease," said Dr. Kiskinis. (nyscf.org)
Conditions such as Huntington's disease, Parkinson's disease, and spinal cord injuries are examples of clinical applications in which stem cells could offer benefits in halting or even reversing damage. (prnewswire.com)

Telomerase plays a critical role during embryonic development and stem cell differentiation, when cells divide profusely. (sciencedaily.com)
Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use. (prnewswire.com)
To use this knowledge to improve beta cell differentiation protocols. (lu.se)

Egg harvesting and Embryonic Stem-cell Research Pose Serious Threat to Women's Health A congressional hearing last Thursday raised awareness on the risks to women's health and fertility by in vitro fertilization (IVF), human cloning, embryonic stem-cell. (physiciansforlife.org)
Thus, the aim of this study was to investigate the effect of the interaction of these cells on in vitro DES model. (drcremers.com)
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. (bvsalud.org)
Early stages of such research often include in vitro experiments which require standardized and well-characterized CM cell cultures derived from different tissues. (bvsalud.org)
The successful generation of beta cells in vitro and regeneration of pancreatic beta cells in vivo will require a thorough understanding of the pathways that direct the normal development and function of these cells. (lu.se)

Lead researcher Dr Gordana Vunjak-Novakovic told the BBC: 'The availability of personalised bone grafts engineered from the patient's own stem cells would revolutionise the way we currently treat these defects. (bioedge.org)
In CAR T-cell therapy, some of the patient's T cells are collected from the patient's blood. (ohsu.edu)
The cells are returned to the patient's bloodstream in an IV drip to find and destroy cancer. (ohsu.edu)
A patient's NK (natural killer) cells - like T cells - can be modified to develop chimeric antigen receptors (CARs) that target cancer cells. (ohsu.edu)

This is the first time we have been able to trigger advanced functional maturation of human induced pluripotent stem cell (iPSC)-derived neurons by plating them on a synthetic matrix," said Dr. Kiskinis. (nyscf.org)
Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
That's what led me by the nose to genetics-because if you're going to focus on something, the best lens to use initially is human genetics, and from human genetics to IPSC and the genome editing tools that we use today in the lab. (medscape.com)
We procure skin biopsies from patients, reprogram fibroblasts from these into stem cells, i.e., iPSC, which are then differentiated into insulin-producing beta-like cells. (lu.se)

Fuchs will speak on "Skin Stem Cells: Their Biology and Clinical Promise" at 9:15 a.m., and Chin will present a lecture titled "The Life of a Judge: From Megan's Law to Bernie Madoff" at 10:30 a.m. (princeton.edu)
NEI is also leveraging a major AMD clinical trial to create a valuable scientific resource: a repository of stem cell lines generated from consenting AMD trial participants. (nih.gov)
In November 2010, William Caldwell, CEO of Advanced Cell Technology, said the FDA had granted approval for his company to start a clinical trial using cells grown from human embryonic stem cells. (cnn.com)
The cancer research network based at OHSU is leading the first federally funded clinical trial of immunotherapy for rare cancers. (ohsu.edu)
We designed and are leading the clinical trial for this therapy. (ohsu.edu)
While at St. Jude, she became a nationally and internationally recognized leader and physician-scientist who ran a research laboratory in addition to national clinical trials. (stanfordchildrens.org)
Her expertise as both a laboratory scientist and clinical trialist will bring added strength to our cancer drug discovery efforts, and her background in immunology will enable us to explore new synergies between our adult and pediatric efforts. (stanfordchildrens.org)
Grace Chen, MD, of the NIAID's Vaccine Research Center (VRC) Clinical Trials Program, is leading the study at the NIH Clinical Center in Bethesda, Maryland. (medscape.com)
This phase 1 clinical trial is the culmination of years of research and development made possible by the unique collaborative setting that the VRC offers by bringing together top scientists, manufacturing expertise, and an outstanding clinical team," VRC Director John Mascola, MD, said in the news release. (medscape.com)
This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)

The Stem Cell Network, established in 2001, brings together more than 80 leading scientists, clinicians, engineers, and ethicists from universities and hospitals across Canada with a mandate to investigate the immense therapeutic potential of stem cells for the treatment of diseases currently incurable by conventional approaches. (disabled-world.com)
The results of this study might lead to the identification of new therapeutic targets for DES. (drcremers.com)
Only days after the world's leading embryonic stem cell researcher began receiving thousands of applications from sick patients who want him to make therapeutic clones. (bioedge.org)
Nor could federal money be used for therapeutic cloning, in which stem cells are created from a body cell of a person. (consumerwatchdog.org)
Such therapeutic cloning might be used to create stem cells from people with specific diseases. (consumerwatchdog.org)
No end believed to be good, such as the use of [embryonic] stem cells for the preparation of other differentiated cells to be used in what look to be promising therapeutic procedures, can justify [the destruction of embryonic life]. (jcrelations.net)
These receptors allow leukemia cells to interact with their microenvironment and are accessible through antibody-mediated targeting, making them a promising therapeutic target. (lu.se)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

To achieve this, the scientists have initially investigated how lizard tails form during adult regeneration in comparison to embryonic development. (earth.com)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)

We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)

In a new study published in the journal Development , USC Stem Cell scientists describe how adult flies can regenerate sensory hearing cells in their antennae, and how studying flies can provide a new way to understand and develop treatments for the hundreds of millions of patients worldwide who live with hearing and balance disorders. (eurekalert.org)

In May 2011, stem cell therapy in sports medicine was spotlighted after New York Yankees pitcher Bartolo Colon was revealed to have had fat and bone marrow stem cells injected into his injured elbow and shoulder while in the Dominican Republic. (cnn.com)

In addition to its significant practical advantages, the development of the technique deepens the understanding of the biology behind the transformation of adult human cells into stem cells. (x-journals.com)
If he could manipulate such a fundamental process to encourage MET and the formation of stem cells, Ding reasoned, such a method would be both safer and more direct than hijacking other aspects of biology, for example those directly involved in cancer. (x-journals.com)
Fuchs, who is the Rebecca C. Lancefield Professor in Molecular Genetics and Cell Biology at Rockefeller University, has been lauded for her groundbreaking discoveries in the field of skin biology. (princeton.edu)
Her many honors include the National Medal of Science, which was presented to Fuchs in 2009 by Obama in recognition of "her pioneering use of cell biology and molecular genetics in mice to understand the basis of inherited diseases in humans and her outstanding contributions to our understanding of the biology of skin and its disorders, including her notable investigations of adult skin stem cells, cancers and genetic syndromes. (princeton.edu)
We asked experts in gerontology, neuroscience, genetics, cell biology, development, and health and fitness science to devise a human that would stand the test of time. (the-scientist.com)
This study reshapes the current understanding of telomerase's function in normal cells,"said Kan Cao, senior author of the study and an associate professor of cell biology and molecular genetics at UMD. (sciencedaily.com)
Under Dr. Morrison's leadership, the institute is focusing on research at the interface of stem cell biology, cancer, and metabolism that has the potential to reveal new strategies for treating disease. (utsw.edu)
Dr. Morrison's lab focuses on adult stem cell biology and cancers of the blood, nervous system and skin. (utsw.edu)
In my thesis, we covered four different projects that led us to explore different fields of biology, with a general focus on exploring cell surface receptors in leukemia cells. (lu.se)

The primary cloning technique is called "somatic cell nuclear transfer" (SCNT). (cbc-network.org)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)

Adult stem cells from umbilical cords are more likely to be a match for more people because there are fewer compatibility requirements than for a bone marrow transplant. (scitechdaily.com)
Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)

Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
Cao and her colleagues suspected telomerase may have a function in adult cells when they observed dramatic differences in the laboratory among sibling mice with shortened telomeres. (sciencedaily.com)
To see if what they observed in mice held true for humans, the team conducted laboratory studies on human skin cells. (sciencedaily.com)
Dr. Yue Wang's laboratory investigates the molecular mechanisms that control the growth transition, particularly how cells establish and maintain the highly polarized hyphal morphogenesis. (a-star.edu.sg)
This work represents a path forward by demonstrating the ability to reliably expand adult stem cells from umbilical cord blood in the laboratory without terminally differentiating the cells into more mature and relatively short-lived blood cells," says Joseph McGuirk, MD, professor of medicine and medical director of blood and marrow transplant at the University of Kansas Health System, who was not directly involved with the study. (scitechdaily.com)
A closeup of a microscope slide taken in 2000 at the Reproductive Genetics Institute's Chicago laboratory shows transplanted stem cells taken from the umbilical cord blood of a baby named Adam Nash. (cnn.com)
Above, a human stem cell colony, which is no more than 1 millimeter wide and comprises thousands of individual stem cells, grows on mouse embryonic fibroblast in a research laboratory in September 2001. (cnn.com)
Above, dozens of packages containing frozen embryonic stem cells remain in liquid nitrogen in a laboratory at the University of Sao Paulo's human genome research center in Sao Paulo, Brazil, in March 2008. (cnn.com)
In the first breakthrough from the Children's Research Institute, Dr. Morrison's laboratory addressed this issue by systematically determining which cells are the sources of stem cell factor, a protein required for the maintenance of blood-forming stem cells. (utsw.edu)
If scientists can identify the remaining signals by which perivascular cells promote the expansion of blood-forming stem cells, then they may be able to replicate these signals in the laboratory. (utsw.edu)
Scientists from the University of Michigan and Cold Spring Harbor Laboratory also contributed to the study, which was supported by the HHMI and the National Heart, Lung and Blood Institute. (utsw.edu)
They are behaving bizarrely," Dr. George Q. Daley, associate professor at Harvard and Children's Hospital Boston, said of one of the cell lines his laboratory had been nurturing for five years. (consumerwatchdog.org)
Despite the long history of laboratory work with CMs and high translational potential of such studies, the number of available standardized, well-defined, stable, and validated CM cell lines is still small. (bvsalud.org)
METHODS: Using a test-negative design among eight VISION Network sites, VE against laboratory-confirmed COVID-19-associated emergency department (ED) or urgent care (UC) events and hospitalizations from 26 August-25 December 2021 was estimated separately among IC and non-IC adults and among specific IC condition subgroups. (cdc.gov)

Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
The scientists studies the impact of CBC on adult mouse neural stem progenitor cells outside the body. (cannabis.net)
In a paper published today in Nature Communications , the scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that forms during our early development in the womb. (kcl.ac.uk)

Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
Particularly troublesome are two kinds of cells in the body that generally stop replicating past the stage of growth and development - neurons and muscle fibers. (the-scientist.com)
image: In the fly, the sensory hearing cells are neurons located in a segment of their antennae known as the Johnston's Organ, or JO. (eurekalert.org)
The scientists were able to label, trace and view newborn JO neurons in live flies under microscopes. (eurekalert.org)
Instead, they observed JO neurons proliferate and produce more of themselves--although this doesn't rule out the potential for other types of cells to also produce JO neurons. (eurekalert.org)
In flies given the chemotherapy drug cisplatin, which is known to kill sensory hearing cells, JO neurons compensated for the damage by proliferating even more. (eurekalert.org)
The scientists also observed the JO neurons developing hair-like extensions known as cilia, and extending long nerve fibers called axons into hearing- and balance-related circuits in the brain. (eurekalert.org)
For decades, scientists thought that neurons in the brain were born only during the early development period and could not be replenished. (nih.gov)
More recently, however, they discovered cells with the ability to divide and turn into new neurons in specific brain regions. (nih.gov)
Using two types of specially engineered mice, they were able to specifically target and eliminate the stem cells that give rise to these new neurons in adults, while leaving other olfactory bulb cells intact. (nih.gov)
To further explore this idea, his team also eliminated the formation of adult-born neurons in mice that did not experience sensory deprivation. (nih.gov)
According to Dr. Belluscio, it is generally assumed that the circuits of the adult brain are quite stable and that introducing new neurons alters the existing circuitry, causing it to re-organize. (nih.gov)
Similar structures are found in many cell types in diverse organisms, such as dendritic protrusions of neurons, root hairs and pollen tubes. (a-star.edu.sg)
These mature cells provide a more accurate window into neurodegenerative diseases, and the 'dancing molecules' technique could one day be leveraged to treat patients by replacing damaged neurons with healthy ones. (nyscf.org)
Most stem cell-based labs use mouse or rat neurons co-cultured with human stem cell-derived neurons. (nyscf.org)
But that does not allow scientists to investigate what happens in human neurons because you end up working with a mixture of mouse and human cells. (nyscf.org)
The team decided to employ a technique Dr. Stupp developed last year to create mature neurons from stem cells. (nyscf.org)
First, the team turned the stem cells into two types of neurons - motor and cortical neurons - then stationed them on synthetic nanofibers containing the 'dancing molecules. (nyscf.org)
Excitingly, the neurons showed features of mature cells, including enhanced abilities to branch out and form connections. (nyscf.org)
The cells also managed not to clump together: a common issue with stem cell-derived neurons that can make them challenging to maintain. (nyscf.org)
The scientists then tested the method on stem cell-derived motor neurons - the cells impacted by ALS - created from an ALS patient. (nyscf.org)
The cells matured in the dancing molecules, and the team found that they still exhibited hallmarks of ALS, including protein aggregation in the neurons that normally occurs in adulthood. (nyscf.org)
For the first time, we have been able to see adult-onset neurological protein aggregation in the stem cell-derived ALS patient motor neurons. (nyscf.org)

2020, Cell Research . (ipscell.com)
Her influence in the field of stem cell research led her to become the president of International Society for Stem Cell Research in 2020, and she has won numerous awards, including the Hans Bloemendal Medal 2014 for innovative interdisciplinary research, with Gordon Keller, the prestigious Lefoulon-Delalande Prize 2021 and the International Society for Stem Cell Research (ISSCR) Public Service Award 2023. (bvsalud.org)

Recent research on adult stem cells has found adult stem cells in many more tissues than once thought possible. (news-medical.net)
27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
These stem cells mainly function for the replacement of damaged cell and tissues. (medgadget.com)
Scientists already have determined how to make large quantities of stem cells and how to change these cells into those of the nervous system, skin and other tissues. (utsw.edu)

Conditional deletion of the Bmi-1 polycomb protein depleted pre-GEPCOT and GEPCOT cells, though pre-GEPCOT cells were more dependent upon Bmi-1 for Cdkn2a ( p16 Ink4a ) repression. (elifesciences.org)
Hgc1 is a G1 cyclin-related protein and directly interacts with the master cell-cycle regulatory kinase Cdc28. (a-star.edu.sg)
The protein, called Ythdf2, recognizes a particular type of modification on a group of mRNAs encoding key transcription factors for hematopoietic stem cell self-renewal and promotes the decay of these mRNAs within cells. (scitechdaily.com)
Since the Ythdf2 protein is present in different kinds of adult stem cells, targeting it and how it affects hematopoietic stem cells seemed a safer approach and, if it worked, broadly applicable. (scitechdaily.com)
A lab then genetically modifies the T cells so they develop a special type of protein that binds to and kill cancer cells. (ohsu.edu)
They stick to specific targets, such as protein on the outside of a cancer cell. (ohsu.edu)
It has the protein distribution (shown in green and red) indicative of a young heart-muscle cell. (livescience.com)
His team swapped out the mouse gene responsible for stem cell factor with a gene from jellyfish that encodes green fluorescent protein. (utsw.edu)
Ferritin is a natural protein that can be found in cells from all living species. (medscape.com)

Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
The sperm fertilizes the egg and the resulting cell divides, forming an embryo. (msdmanuals.com)

Certain kinds of adult stem cells seem to have the ability to differentiate into a number of different cell types, given the right conditions. (news-medical.net)

A research team led by the University of Southern California (USC) has recently managed to significantly improve the regeneration of lizard tails through stem-cell therapy. (earth.com)
This process led to the regeneration of perfect tails with dorsoventral patterning. (earth.com)
Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa have discovered a powerful new way to stimulate muscle regeneration, paving the way for new treatments for debilitating conditions such as muscular dystrophy . (disabled-world.com)
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. (ipscell.com)

While the work was a major breakthrough, it left two major challenges for the field to solve before iPS cell therapy could be considered of any potential practical use. (x-journals.com)
Dr Hiroshi Kawamoto, who led the research, said of the results: "This strategy may solve the problem which the current immunotherapy strategies are facing, and thus would make a major breakthrough in cancer therapy. (scotsman.com)
Stem Cell Breakthrough? (washingtonmonthly.com)
27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)

A coordinated network of molecular processes providing cells with nearly flawless surveillance, maintenance, and repair capabilities exemplifies the "perfection" of the human body. (the-scientist.com)
However, adult NSCs produce a molecular system blocking skeletal and nerve formation and encouraging cartilage growth, thus "ventralizing" both sides of the tail. (earth.com)
But not a lot with humans," says Jun Wu , a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, who led one of the two research teams publishing the results of the new experiments. (kmuw.org)
I contacted the head of the sickle cell disease branch in the Extramural Research Program at the National Heart, Lung, and Blood Institute, and they referred me to Dr. Alan Schechter [Chief of the Molecular Medicine Branch at NIDDK]. (medlineplus.gov)
To understand the molecular and cellular mechanisms that control beta cell maturation and function in the embryonic and adult pancreas. (lu.se)

The panel was responding to recently published research where pancreatic insulin-producing islet cells were discovered in mice. (news-medical.net)
D ) Immunostaining for ZBTB16 (red), FOXC2 (green), and DAPI (blue) in testicular paraffin sections from wild-type adult C57 mice. (elifesciences.org)
F ) Immunostainings for MKI67 (red), FOXC2 (green), and DAPI (blue) in adult mice testis and the proportion of MKI67 + cells in FOXC2 + population (n=10). (elifesciences.org)
Validation and characterization of the magnetic-activated cell sorting (MACS)-sorted THY1 + undifferentiated spermatogonia (uSPG) from wild-type adult C57 mice. (elifesciences.org)
B ) Immunostainings for LIN28A (red), DAPI (blue), and newly found markers (green) in testicular paraffin sections from adult mice. (elifesciences.org)
To understand what was going on, Cao and her colleagues compared the skin cells of the sibling mice and found that while both cell lines had comparably short telomeres, cells from telomerase-deficient mice stopped dividing sooner and had more malignant transformations than cells from siblings that produced telomerase. (sciencedaily.com)
The investigators report in the journal Nature that purified human stem cells can be used to improve long-term vision in mice. (drcremers.com)
The team examined HHyPs and found that they resemble mouse stem cells which have been found to rapidly repair mice liver following major injury, such as occurs in cirrhosis. (kcl.ac.uk)

Thoroughness by institutional review boards can frustrate scientists so much that they will ignore guidelines, break rules and become deceitful, a social science researcher has. (bioedge.org)
What's new about this approach for heart-cell generation is that we directly converted one cell type to another using RNA, without an intermediate step," said James Eberwine, a professor of pharmacology at the University of Pennsylvania and a study researcher. (livescience.com)
NIDDK Director Dr. Griffin P. Rodgers is a prominent researcher in the treatment of sickle cell disease. (medlineplus.gov)

Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
Neural stem cells have long lives, much of which they spend in a quiescent state. (elifesciences.org)
However, the exact relationship between neural stem cells and neurosphere-forming cells has been uncertain. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)
The neural stem cells, which Mich, Signer et al. (elifesciences.org)
In both cases, neural stem cells (NSCs) play a crucial role. (earth.com)

Brain and skin cells have now been reprogrammed into heart cells using RNA, a molecule related to DNA that is crucial to the creation of proteins within a cell. (livescience.com)
This mRNA contains the instructions, derived from DNA, to create proteins, the building blocks of cells. (livescience.com)
These cells then contained much more heart mRNA than skin or brain mRNA, causing the cell to build heart-cell proteins. (livescience.com)
The presence of the heart-cell proteins influenced the expression of genes and encouraged the production of more heart-cell proteins. (livescience.com)
Cytokines are small signaling proteins secreted by cells that can activate host immune responses, play a crucial role in biological processes like wound healing, and can also contribute to the development of diseases like cancer. (lu.se)

The cells carry the potential to cure neurological diseases, diabetes, and many other illnesses. (christianitytoday.com)
Leonard Hayflick, who demonstrated the finitude of repeated cell divisions so elegantly in the 1960s (see Foundations ) offers perhaps the most fantastic if most unattainable fix: Perfect or near perfect synthesis, maintenance, and repair of every biomolecule in the human body, he says, would make the risk for most age-related diseases and disorders simply vanish. (the-scientist.com)
Infectious diseases are the leading cause of human death worldwide. (a-star.edu.sg)
This development could make these cells available to more people, and be more readily accepted in those who undergo adult stem cell treatments for conditions such as leukemia, blood disorders, immune system diseases, and other types of cancers, but who do not have an appropriate available bone marrow match. (scitechdaily.com)
For decades, science has been trying to unlock the mysteries of how a single cell becomes a fully formed human being and what goes wrong to cause genetic diseases, miscarriages and infertility. (kmuw.org)
Scientists are majorly focusing on developing new and innovative treatment options for the various chronic diseases like cancer. (medgadget.com)
While stem-cell research holds enormous potential for treating or even curing some diseases, the cloning of a human being is morally and ethically unacceptable…Any attempt to clone a human being is in direct conflict with the public policies of this state. (cbc-network.org)
The only treatment for severe liver diseases at present is a liver transplant which can lead to a lifetime of complications and for which the need for donor organs greatly outweighs the increasing demands. (kcl.ac.uk)
The passion for providing excellent patient care rooted in cutting-edge science is clear, and the opportunity to lead a group that is so committed to advancing the field of pediatric cancer and blood diseases is very exciting. (stanfordchildrens.org)
Telomere shortening and chronic diseases could be caused by the same cell-damaging processes, such as oxidative stress and inflammation. (cdc.gov)

OHSU's Dr. Richard Maziarz leads research on CAR T-cell therapy, a type of immunotherapy that's bringing powerful new options to children and adults with blood cancer. (ohsu.edu)
The bone marrow and blood of children and adults contain stem cells. (msdmanuals.com)

Although scientists have searched for decades to identify the stem cell home, this is the first study to reveal the cells that are functionally responsible for the maintenance of blood-forming stem cells in the body," said Dr. Morrison, director of the new institute and senior author of the study available Jan. 26 in Nature . (utsw.edu)
But they have been stymied by similar efforts to make blood-forming stem cells. (utsw.edu)
A key obstacle has been the lack of understanding about the microenvironment, or niche, in which blood-forming stem cells reside in the body. (utsw.edu)
The cells that glowed green were endothelial and perivascular cells, revealing them as the creators of the niche that nurtures healthy blood-forming stem cells. (utsw.edu)
Additional lab work showed that blood-forming stem cells become depleted if stem cell factor is eliminated from either endothelial or perivascular cells. (utsw.edu)

A report from a medical panel of academic and community-based endocrinologists and transplant surgeons acknowledged that a recent study supports the use of stem cells as a future cure for type I diabetes. (news-medical.net)
Molly received a stem cell transplant from stem cells from Adam's umbilical cord. (cnn.com)
Learn more about our nationally recognized doctors, on our Bone Marrow and Stem Cell Transplant page. (ohsu.edu)

All the Catholic scientists and ethicists at the conference…had no moral problem with it at all," he said. (washingtonmonthly.com)
Medical ethicists from my Roman Catholic religious tradition face a dilemma when investigating the morality of human embryonic stem cell research. (jcrelations.net)

When the team knocked out Ythdf2 function in a mouse model or knocked down Ythdf2 function in hUCB cells, they observed increased expression of these transcription factors and expansion of hematopoietic stem cells, which are the major type of adult stem cells in hUCB. (scitechdaily.com)

We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
In a process known as neurogenesis, adult-born neuroprogenitor cells are generated in the subventricular zone deep in the brain and migrate to the olfactory bulb where they assume their final positions. (nih.gov)

His action overturned an order approved by President George W. Bush in August 2001 that barred the National Institutes of Health from funding research on embryonic stem cells beyond using 60 cell lines that existed at that time. (cnn.com)

T cells are immune cells that circulate in the body to fight infection. (ohsu.edu)

If they do, these cells might be directly injected into patients for therapy. (scotsman.com)
Cancer charities and experts gave the research a cautious welcome, but said a similar treatment method - adoptive T cell therapy - was further advanced. (scotsman.com)
OHSU was the first hospital in the Northwest to offer the CAR-T cell therapy Kymriah. (ohsu.edu)
Learn more about CAR T-cell therapy and our team's role in developing the first CAR T therapy approved by the FDA. (ohsu.edu)
Those older cell lines, because they were grown using animal cells or serum, might not be suitable for use as medical therapy. (consumerwatchdog.org)
Traditionally, scientists have worked with both embryonic and adult stem cells for research tools, as well as for cellular therapy. (prnewswire.com)
This was the first effective, FDA-approved therapy for sickle cell anemia in adults. (medlineplus.gov)
Beta cell replacement therapy is the only available cure for type 1 diabetes. (lu.se)
Understanding the mechanisms underlying embryonic beta cell development will be a prerequisite for the development of a universally available cell replacement therapy in diabetes. (lu.se)

The identification of undifferentiated pre-GEPCOT and GEPCOT cells will make it possible to directly study the properties of these cells inside the mouse brain, and to isolate live cells to test how they function. (elifesciences.org)
Both in terms of speed and efficiency, we achieved major improvements over conventional conditions," said Scripps Research Associate Professor Sheng Ding, Ph.D., who led the study. (x-journals.com)
We can quickly and inexpensively perform sophisticated experiments on large swarms of flies, and we already possess a detailed map of their genomes and neural circuitry," said postdoctoral fellow Ismael Fernández-Hernández, who led the study, along with co-author Evan Marsh and corresponding author Michael Bonaguidi . (eurekalert.org)
This is a surprising new role for brain stem cells and changes the way we view them," said Leonardo Belluscio, Ph.D., a scientist at NIH's National Institute of Neurological Disorders and Stroke (NINDS) and lead author of the study. (nih.gov)
The new study found that telomerase reactivates in normal adult cells at a critical point in the aging process. (sciencedaily.com)
In 1993 he was promoted to senior scientist to lead a group in the study and utilization of equatorial microbial diversity for the discovery of novel bioactive compounds. (a-star.edu.sg)
The latest study used human adult stem cells taken from bone marrow. (bioedge.org)
The study, led by co-senior investigators Natasha Frank , MD, and Markus Frank , MD, was a highly collaborative effort, with work done at Massachusetts Eye and Ear/Schepens Eye Research Institute , Boston Children's Hospital , Brigham and Women's Hospital , and the US Department of Veterans Affairs Boston Healthcare System . (drcremers.com)
But until this study there was no specific marker that could isolate these cells," added Frank, who is a physician of the VA Boston Healthcare System and Brigham and Women's Hospital, and a Harvard Medical School assistant professor of medicine in the Division of Genetics at Brigham and Women's Hospital. (drcremers.com)
In 1998, President Bill Clinton requested a National Bioethics Advisory Commission to study the question of stem cell research. (cnn.com)
A study led by scientists from USC Stem Cell and the USC Neurorestoration Center presents evidence that adults can replenish at least some of what they've lost by generating new brain cells, and that this process is dramatically altered in patients with long-term epilepsy. (sflorg.com)
A leading US medical school is to create children to study the social and personal impact of sex selection. (bioedge.org)

The panelists were unanimous in their enthusiasm that this research, conducted jointly at the Universities of Alberta and Toronto, adds more hope to the goal of getting human stem cells to produce insulin, and thus finding a cure for diabetes. (news-medical.net)
A major undertaking for us was to understand how expression of IAPP is regulated in these cell systems and in diabetes. (lu.se)
We showed how insulin deficiency in Friedreich's ataxia is likely to evolve, and that a mouse model for Huntington's disease develops diabetes due to loss of beta-cells. (lu.se)
Diabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. (lu.se)

In addition, their "unspecialized" nature allows them to differentiate into a wide variety of specialized cell types. (prnewswire.com)
While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use. (prnewswire.com)
The have been applied to both the plant and ani- stem cells possess pluripotential charac- mal kingdoms without even stirring a ripple teristics, and can differentiate into various of concern in international conscience [ 2 ]. (who.int)

Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. (prnewswire.com)

Dr. Rudnicki is the Scientific Director of Canada's Stem Cell Network and a Senior Scientist at OHRI and Director of OHRI's Sprott Center for Stem Cell Research, as well as a Professor of Medicine at the University of Ottawa. (disabled-world.com)

The main reason for this is that the true potential of stem cells only a handful of people really could foresee (the dreamers). (news-medical.net)

Institute investigators led by Dr. Sean Morrison asked which cells are responsible for the microenvironment that nurtures haematopoietic stem cells, which produce billions of new blood cells every day. (utsw.edu)

In this way, we hope our lizard research will lead to medical breakthroughs for treating hard-to-heal injuries. (earth.com)

This project was funded by the Canadian Institutes of Health Research, the Muscular Dystrophy Association, the National Institutes of Health, the Howard Hughes Medical Institute, Canada's Stem Cell Network and the Canada Research Chairs Program. (disabled-world.com)

Professor Lozito and his team used gene-editing tools to make embryonic NSCs unresponsive to the ventralizing signal and they implanted them into adult tail stumps. (earth.com)
Professor Sir John Burn, of the Institute of Genetic Medicine at Newcastle University, said: "This is a very appealing concept and the research team are to be congratulated on demonstrating the feasibility of expanding these killer cells using iPS techniques. (scotsman.com)
The research team includes scientists from a number of universities and academic institutions. (sflorg.com)
Over the past months, a team of scientists had reviewed Wilson's proposal for the NIH and scored its scientific merit and likelihood of success. (bu.edu)
The team, led by Tae Kyung Kim of the Perelman School of Medicine at the University of Pennsylvania, extracted messenger RNA from a heart cell, and then flooded brain and skin cells with it. (livescience.com)
Now, Wu's team and an international team of scientists have gone further than ever before. (kmuw.org)
A team of VRC scientists developed the universal influenza vaccine prototype. (medscape.com)

Bush's announcement grieved patients' groups and many in the scientific and medical communities who believe embryonic stem-cell research could provide a cure for millions. (christianitytoday.com)
Japanese scientists said they had made cancer-specific killer "T" cells, which could pave the way for them being injected into cancer patients to treat the -disease. (scotsman.com)
This involves cells taken from patients being "souped up" and re-injected. (scotsman.com)
But adult patients need two cords' worth of blood per treatment, and there aren't enough cord units available for everyone who needs the treatment. (scitechdaily.com)
Linheng Li believes that this approach could potentially be applied to other types of adult stem cells, which may lead to increasing the number of adult stem cells available for treating patients. (scitechdaily.com)
Thus far our 4 patients have felt improvement with autologous, adipose-derived stem cells, but it is likely not a cure as these cells can become damaged again over time and exposure to environmental risk factors. (drcremers.com)
I think that academic neurologists are the last line of defense against "stem cell tourism', since the majority of patients ask for guidance and have questions regarding stem cells. (ipscell.com)
The FDA would never allow us to use these virally modified cells in patients," Lanza told NewScientist, but understanding how the viruses do their work may help us understand how the transformation into stem cells proceeds in the first place, thus leading to other, safer techniques. (washingtonmonthly.com)
Altered cells create an electrical "fire" in patients with epilepsy. (sflorg.com)
NK cells can also be collected from donor blood or umbilical cord blood and given, unchanged, to patients. (ohsu.edu)
Embryonic stem cells (ESCs) have shown promise as a means of regenerating the lost cells, but scientists have been on the lookout for alternatives to ESCs that can be easily obtained from adult patients. (yale.edu)
Stanford is an incredibly inspiring place, and I look forward to working with all the physicians and scientists here to develop new treatment approaches and bring them to patients," Gruber said. (stanfordchildrens.org)
Patients [with sickle cell disease] typically have periodic bouts of extreme bone and joint pain. (medlineplus.gov)
Blood transfusion was also sometimes given to patients [for sickle cell anemia]. (medlineplus.gov)
Our approach was to focus on eradicating leukemia stem cells, which are known to persist after chemotherapy and can lead to relapse in patients. (lu.se)
The insulin-producing cells that we can make from these patients can then be used to understand the mechanisms by which these risk genes cause dysfunction of beta-cells. (lu.se)

H ) t-SNE plot of germ cells in adult human testis (GSE112013), colored by germ cell type. (elifesciences.org)
I ) The developmental trajectory of the human germ cells, colored by germ cell type, FOXC2 expression cells (red), or MKI67 expression cells (red). (elifesciences.org)
Reproductive cloning versus germ cell (egg, ovum). (who.int)

Anatomy56

Organisms10

Diseases7

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations11

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture2

Humanities8

Information Science2

Named Groups3

Health Care6

Regenerative Medicine9

Pluripotent Stem12

Embryos19

Researchers42

Transplantation15

Tissue24

Therapies7

Transplants8

Mesenchymal7

Parkinson's6

Differentiation3

Vitro5

Patient's4

IPSC4

Clinical10

Therapeutic9

Embryonic development2

Harvard Stem Cell Institute1

Regenerate1

Bone marrow stem1

Biology9

Somatic cell nuc3

Umbilical cords2

Laboratory14

Progenitor5

Neurons23

20202

Tissues4

Protein9

Sperm2

Kinds of adult stem1

Regeneration4

Breakthrough4

Molecular5

Mice8

Researcher3

Neural stem6

Proteins5

Diseases10

Children and adults2

Blood forming st5

Transplant3

Ethicists2

Hematopoietic1

Subventricular zone3

Research on embryon1

Immune cells1

Therapy9

Study12

Diabetes4

Differentiate3

Experimentation1

Senior scientist1

Potential of stem cells1

Investigators1

Medical breakthroughs1

Howard Hughes Me1

Team7

Patients16

Germ cell3