• Muscle satellite cells make up a stem cell populace that is capable of differentiating into myocytes and contributing to muscle mass regeneration upon injury. (healthyguide.info)
  • In recent research, scientists unlocked ways to boost muscle regeneration in the experimental animal by activating the precursors of muscle cells. (sciencetrend.ca)
  • In recent research, scientists managed to activate the precursors of muscle cells, which contributes to aiding muscular regeneration and rebuilding damaged tissue. (sciencetrend.ca)
  • Salk Institute researchers are finding methods to speed up methods to accelerate the regeneration of muscle tissue, utilizing a combination of molecular compounds that are generally utilized in the stem-cell analysis. (sciencetrend.ca)
  • 2021), the investigators confirmed that utilizing these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, known as myogenic progenitors. (sciencetrend.ca)
  • The analysis offers perception into the underlying mechanisms associated with muscle regeneration and growth and will help athletes and aging adults regenerate tissue more effectively. (sciencetrend.ca)
  • Within the myofiber-specific model, they discovered that adding the Yamanaka factors accelerated muscle regeneration in mice by decreasing the levels of a protein referred to as Wnt4 in the area of interest, which activated the satellite cells. (sciencetrend.ca)
  • In contrast, Yamanaka factors didn't activate satellite cells within the satellite-cell-specific model and didn't enhance muscle regeneration, suggesting that Wnt4 performs an essential role in muscle regeneration. (sciencetrend.ca)
  • An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. (sciencetrend.ca)
  • In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. (sciencetrend.ca)
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
  • These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
  • Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
  • Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
  • Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
  • The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • 1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
  • 6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
  • The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
  • The meeting, organized by Elisa Martí (IBMB-CSIC, Barcelona, Spain), Jonas Muhr (Karolinska Institutet, Stockholm, Sweden) and Kate Storey (University of Dundee, UK), brought together international researchers interested in spinal cord development and those who are developing strategies to restore the function of the spinal cord in pathological situations using regeneration of the damaged tissue, including controlled cell replacement. (biologists.com)
  • Epimorphic regeneration can be thought of as occurring in two phases: wound healing and cell proliferation. (biomedcentral.com)
  • Satellite cells (SCs), which are precursors of skeletal muscles, such as the TA muscle, play a key role in muscle homeostasis and regeneration. (biomedcentral.com)
  • SCs are normally in a quiescent state in adult muscles, and start proliferating during muscle regeneration in response to denervation. (biomedcentral.com)
  • Finally we found that in an mouse model of fracture healing where muscle mass progenitor cells were lineage-traced Nkx3.2 and Sox9 are significantly upregulated while Pax3 is significantly downregulated in the muscle mass progenitor cells that give rise to chondrocytes during fracture restoration. (healthyguide.info)
  • Therefore our and analyses suggest that the balance of Pax3 Nkx3.2 and Sox9 may act as a molecular Talniflumate switch during the chondrogenic differentiation of muscle mass progenitor cells which may be important for fracture healing. (healthyguide.info)
  • Collectively our data suggest that the balance of Nkx3.2 Sox9 and Pax3 can act as a molecular switch during the chondrogenic differentiation of satellite cells which may play an important part in the healing process experiments were normalized to GAPDH. (healthyguide.info)
  • Aberrant PAX3 and PAX7 expression. (wikipedia.org)
  • 30] The additional approach used a transgenic reporter mouse for Pax3 a paralog of Pax7 which allowed for the immediate isolation of Pax3+ (GFP+) muscle satellite television cells by movement cytometry. (biotech-angels.com)
  • We demonstrate that mdPCR can give exact molecule counts per cell for mRNA isoforms encoding the myogenic transcription factor Pax3. (biomed.news)
  • European Blot analysis For European Blot analysis total protein lysates were obtained following a standard protocol from confluent 6 cm cells culture plates comprising roughly 3×106 cells [25]. (healthyguide.info)
  • Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene. (wikipedia.org)
  • The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)
  • The basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family and is a key protein in regenerative medicine. (biomedcentral.com)
  • Cell therapy with young bone marrow from green fluorescent protein (GFP) transgenic mice exhibited GFP+ myofibres in aged muscle tissues. (nagoya-u.ac.jp)
  • Interestingly recent data indicated that although MyoD is not indicated in quiescent satellite cells in the adult it is transiently indicated in satellite cell progenitors in the embryo suggesting that satellite cells are derived from committed embryonic precursors of myogenic lineage [4] [5]. (healthyguide.info)
  • Furthermore these authors demonstrated that Pax7(+)luciferase(+) mononuclear cells could possibly be readily re-isolated offering proof for the self-renewal of the cell human population. (biotech-angels.com)
  • Human PBMC Genomic DNA was prepared from purified healthy human peripheral blood mononuclear cells (PBMCs). (3hbiomedical.com)
  • Ex vivo cultures of myofiber explants demonstrate that ablation of IRE1α reduces the proliferative capacity of myofiber-associated satellite cells. (elifesciences.org)
  • Myofiber-specific ablation of IRE1α dampens Notch signaling and canonical NF-κB pathway in skeletal muscle of adult mice. (elifesciences.org)
  • These cells are located beneath the basal lamina of myofiber in a dormant state. (elifesciences.org)
  • Understanding the effects of strabismus surgery on muscle cell biological reactions and myofiber remodeling may suggest new approaches for improving surgical outcomes. (arvojournals.org)
  • There are a number of factors that initiate myofiber remodeling in adult skeletal muscles. (arvojournals.org)
  • 1 Adult Stem Cells 1.1 Satellite Cells Studies in the last decade have clearly proven that the regenerative ability of adult skeletal muscle is due to the satellite cell a quiescent stem cell population of muscle precursors located between the basal lamina and sarcolemma of each myofiber. (biotech-angels.com)
  • 30-32] The satellite cell was first described by Mauro in 1961 using electron microscopy[33] and later by Bishoff in 1986 utilizing phase-contrast microscopy on solitary myofiber explants. (biotech-angels.com)
  • 30 31 One group took the approach of transplanting sole muscle fibers which demonstrated that every myofiber including 7 or fewer satellite television cells could create over 100 new myofibers in engrafted muscles. (biotech-angels.com)
  • Upon activation satellite cells rapidly initiate MyoD expression which leads to the activation of myogenin and terminally differentiated structural muscle mass genes such as myosin heavy chain (MHC) [1] [3]. (healthyguide.info)
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
  • In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)
  • Their fate is regulated by the expression of various transcription factors, including paired box 7 (Pax7) and myogenic differentiation (MyoD) [ 6 ]. (biomedcentral.com)
  • 31] Cells isolated from mature skeletal muscles displayed homogenous expression of Pax7 and contributed to both dietary fiber repair also to the muscle satellite television cell URMC-099 compartment subsequent their transplantation into dystrophic mice. (biotech-angels.com)
  • Satellite cells from your trunk and the limb are derived from an embryonic populace of progenitor cells in the somites transient mesodermal constructions that develop on either part of the neural tube [1]. (healthyguide.info)
  • Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. (wikipedia.org)
  • We were able to demonstrate, that mouse and human neural stem cells which express SOX2, KLF4 and cMYC, can be reprogrammed to iPS cells by retroviral expression of OCT4 (Kim, Zaehres et al. (ruhr-uni-bochum.de)
  • Afterwards, we have comparatively evaluated the hematopoietic and erythroid as well as neural differentiation potential of human cord blood and neural stem cell derived iPS cells (Hargus et al. (ruhr-uni-bochum.de)
  • We are currently focusing to model neural (Frontotemporal Dementia) and skeletal muscle (Duchenne, LGMD) diseases with human iPS cells and CRISPR/Cas9 genome editing. (ruhr-uni-bochum.de)
  • Loss of FKBP8 causes ectopic and ligand-independent activation of the Shh pathway, leading to expansion of ventral cell fates in the posterior neural tube and suppression of eye development. (silverchair.com)
  • Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development. (silverchair.com)
  • The cells at the ventral pole of the neural tube instead acquire dorsal or lateral identities that are normally repressed by SHH signaling. (silverchair.com)
  • Using the NM-ALM we discovered that non-neural extrinsic factors from differently sized host animals do not play a prominent role in determining the size of the regenerating limb. (edu.au)
  • We determined the developmental and functional status of both skeletal muscle progenitor cells as well as adult human satellite cells. (ca.gov)
  • A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. (ca.gov)
  • We are developing a target product profile for human satellite cells derived from human pluripotent stem cells which will be used to use muscle stem cells in personalized medicine for patients with devastating muscle wasting or degenerative diseases. (ca.gov)
  • Patient-derived induced pluripotent stem cells and their differentiation derivatives hold great promise as novel in vitro model systems to study human pathogenesis. (ruhr-uni-bochum.de)
  • These cells have the ability to self-renew and to differentiate into specialized cell types and can be primarily classified as adult and pluripotent stem cells which differ significantly in regard to their differentiation potential and expansion capability. (biotech-angels.com)
  • Adult stem cells are tissue specific and have limited capacity to be expanded while pluripotent stem cells have the ability to differentiate into any cell type of the body while possessing unlimited self-renewal. (biotech-angels.com)
  • We will perform single cell RNA sequencing (scRNA-seq) of embryonic, fetal, juvenile and adult muscle stem cells (MuSCs) and identify unique gene signatures and cell states across human myogenesis. (ca.gov)
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • By contrast, transforming growth factor (TGF)-β1 was demonstrated to markedly downregulate HGF gene expression ( 10 , 11 ). (spandidos-publications.com)
  • Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. (fsrmm.ch)
  • One such alternative cell fate is the adipogenic fate as Pax7(+) satellite cells isolated from solitary myofibers used adipogenic fate in addition ARHGAP1 to muscle mass fate significance of these factors we used a mouse fracture healing model inside a genetically altered reporter mouse where muscle mass progenitors were lineage-traced. (healthyguide.info)
  • We will molecularly and functionally define muscle stem cells in human muscle in development, juvenile and adult and develop strategies to generate the most regenerative muscle stem cells from hPSCs. (ca.gov)
  • Rapidly expanding technological innovations have led to a resurgence of interest in defining the factors that enable regenerative healing, and in coupling these factors to human therapeutic interventions. (frontiersin.org)
  • Skeletal muscle, the most abundant tissue of the body, has remarkable regenerative capacity mainly due to its resident muscle stem cells, also known as satellite cells. (elifesciences.org)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • Below we review the literature on some of the most studied stem cell populations that have been ascribed with muscle regenerative potential pointing out their advantages as well as caveats. (biotech-angels.com)
  • 45 47 48 It took about fifty years using their initial identification in the first 1960s for genuine preparations of mouse satellite television cells to become isolated and tested for his or her URMC-099 regenerative potential. (biotech-angels.com)
  • Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. (biomedcentral.com)
  • Furthermore, we demonstrate that the asymmetric cell-fate determinant Numb segregates selectively to one daughter cell during mitosis and before differentiation, suggesting that Numb is associated with self-renewal. (nih.gov)
  • Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. (nih.gov)
  • We are further developing our iSTEM (Molecular and Developmental Stem Cell Biology) master program since its inception in 2010 by incorporating state-of-the-art topics of stem cell research in the teaching modules. (ruhr-uni-bochum.de)
  • In vitro-generated human muscle reserve cells are heterogeneous for Pax7 with distinct molecular states and metabolic profiles. (fsrmm.ch)
  • Dual luciferase assay and Western-blot results demonstrated that SFRP1 was a target of miR-1/206 in porcine iliac endothelial cells. (biomedcentral.com)
  • 31] Down the road Sacco and colleagues proven that intra-muscular transplantation of an individual luciferase-expressing muscle stem cell isolated from Myf5 reporter mice led to intensive proliferation and contribution to muscle materials. (biotech-angels.com)
  • Evaluate myogenic ability and functional differences of embryonic, fetal, juvenile and adult MuSCs in fusion, proliferation, engraftment and repopulation assays in mouse models of muscle disease. (ca.gov)
  • Results: It was highly expressed in adult goat latissimus dorsi and leg muscles, goat fetal skeletal muscle, and at the differentiation stage of muscle satellite cells. (koreascience.kr)
  • 10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)
  • We have developed a comprehensive profile of human myogenesis using single cell sequencing. (ca.gov)
  • a reverse function mutant Talniflumate of Nkx3.2 blocks the ability of Sox9 to both inhibit myogenesis and induce chondrogenesis suggesting that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells. (healthyguide.info)
  • Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. (wikipedia.org)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • 2011). Satellite cells are located in a distinct segment between a layer of connective tissue (basal lamina) and muscle fibers (myofibers). (sciencetrend.ca)
  • For example, muscle stem cells (MuSCs), located beneath the basal lamina, exist in the quiescent state but can transition to an activated, proliferative state upon injury. (biomed.news)
  • Conclusion: These results suggest that miR-188-5p inhibits the proliferation and promotes the differentiation of goat muscle satellite cells by targeting CAMK2B. (koreascience.kr)
  • Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
  • In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • 34] Upon damage satellite television cells become activated providing rise to proliferating myoblasts which in turn fuse to existing muscle tissue fibers or even to additional myoblasts to URMC-099 create new myofibers to correct muscle tissue harm. (biotech-angels.com)
  • Limitations in the usage of AAV in murine models include cell types that are refractory to transduction and difficulties achieving tissue-specificity. (nature.com)
  • The compromised tissue repair program is attributable to the gradual depletion of stem cells and to altered regulatory signals. (biomed.news)
  • Adult stem cells play key roles in homeostasis and tissue repair. (biomed.news)
  • However, not forgotten is the axolotl's equally amazing ability to thwart aspects of tissue maturation and retain juvenile morphology into the adult phase of life. (edu.au)
  • However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. (wikipedia.org)
  • Additionally, mice lacking PAX7 had delayed recovery of spermatogenesis following exposure to busulfan when compared to control mice. (wikipedia.org)
  • Somatic cells can be reprogrammed to a pluripotent embryonic stem cell-like state (induced pluripotent stem (iPS) cells) by combinations of the transcription factors OCT4, SOX2, NANOG, LIN28, KLF4 and cMYC (Takahashi et al. (ruhr-uni-bochum.de)
  • Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)
  • WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • 3 20 21 Major factors underlining this poor outcome included low ability of myoblasts to migrate beyond the injection site[22 23 and poor survival of injected cells. (biotech-angels.com)
  • 26-29] As an alternative to poorly-engrafting myoblasts much recent interest has developed around the idea of therapy with stem cells. (biotech-angels.com)
  • Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. (biologists.com)
  • We will identify unique cell surface markers on in vivo derived MuSCs that distinguish PAX7-positive cells from other muscle cells and across cell states. (ca.gov)
  • Develop transcription factor over-expression in combination with improved directed differentiation strategies to generate MuSCs from hPSCs with genetic and functional signatures of the in vivo MuSCs. (ca.gov)
  • Strikingly, some of these cells display selective template-DNA strand segregation during mitosis in the muscle fibre in vivo, as well as in culture independent of their niche, indicating that genomic DNA strands are nonequivalent. (nih.gov)
  • Here we generate a robust system for in vivo transgene delivery by combining the versatility of AAV-mediated transgene delivery with the specificity of cell-type-specific Cre-mediated recombination. (nature.com)
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
  • A single, early local administration of high-dose bFGF prevented atrophic changes in the thyroarytenoid muscles by activating satellite cell proliferation and reforming neuromuscular junctions. (biomedcentral.com)
  • 35-39] Meanwhile a little subset of satellite television cells will not undergo differentiation but wthhold the ability to go back to a quiescent state and therefore preserve the satellite television cell pool. (biotech-angels.com)
  • There is certainly proof for heterogeneity inside the satellite television cell compartment having a subset of satellite television cells having higher potential to engraft the satellite television cell area. (biotech-angels.com)
  • Quantifying the exact expression levels of the mRNA isoforms encoding these myogenic transcription factors is therefore key to understanding how MuSCs switch between cell states. (biomed.news)
  • Objective: The aim of this study was to reveal the role and regulatory mechanism of miR-188-5p in the proliferation and differentiation of goat muscle satellite cells. (koreascience.kr)
  • By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
  • We hypothesized that AAV transgene expression could be targeted to specific tissues or cell types by selectively overexpressing AAVR. (nature.com)
  • The control of MuSC state depends on the expression levels of myogenic transcription factors. (biomed.news)
  • First, the expression of miR-188-5p in goat muscle tissues at different developmental stages was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (koreascience.kr)
  • eph dsRNA was injected into syncytial stage embryos to perturb eph expression at the larval time points relevant to axon targeting in the adult visual system. (sdbonline.org)
  • The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
  • The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. (nature.com)
  • Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
  • It is considered postmitotic, in that the myonuclei residing within these myofibers do not divide in adult muscle. (arvojournals.org)
  • Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. (nih.gov)
  • In this research, the team used two completely different mouse models to pinpoint the muscle stem-cell-specific or niche-specific modifications following the addition of Yamanaka factors. (sciencetrend.ca)
  • We determined the true SC state needed to repopulate after reinjury- the gold standard requirement for maintaining stem cell function long term. (ca.gov)
  • We demonstrate that transgenic AAVR overexpression greatly increases the efficiency of transduction of many diverse cell types, including muscle stem cells, which are normally refractory to AAV transduction. (nature.com)
  • Originally discovered as axon guidance factors, they have been implicated in cancer progression, embryonal organogenesis, skeletal muscle innervation, and other physiological and developmental functions in different tissues. (biomed.news)
  • The investigators are also studying different methods to rejuvenate cells, including utilizing mRNA and genetic engineering. (sciencetrend.ca)
  • Unlike PAX7+ muscle satellite cells, PAX7+ spermatogonia rapidly proliferate and are not quiescent. (wikipedia.org)
  • 7 8 9 In fact, passive stretching alone can activate limb muscle satellite cells. (arvojournals.org)
  • Methods: Goat skeletal muscle satellite cells isolated in the pre-laboratory were used as the test material. (koreascience.kr)
  • In addition, miR-188-5p was transfected into goat skeletal muscle satellite cells by constructing mimics and inhibitors of miR-188-5p, respectively. (koreascience.kr)
  • Overexpression and interference of miR-188-5p showed that miR-188-5p inhibited the proliferation and promoted the differentiation of goat muscle satellite cells. (koreascience.kr)
  • Further functional studies revealed that CAMK2B promoted the proliferation and inhibited the differentiation of goat muscle satellite cells, whereas si-CAMK2B restored the function of miR-188-5p inhibitor. (koreascience.kr)
  • Here, we investigated the benefits and mechanisms of the preventive effects of YBMT on loss of muscle mass and function in a senescence-associated mouse prone 10 (SAMP10) model, with a special focus on the role of growth differentiation factor 11 (GDF-11). (nagoya-u.ac.jp)
  • At the cellular level, several processes are highly controlled, including the establishment and maintenance of apico-basal polarity, the control of the cell cycle and cell cycle exit, and the acquisition of cell subtype identities. (biologists.com)
  • 3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)