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  • ASCs
  • They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis. (springer.com)
  • vitro
  • This finding might help to develop new strategies to increase the safety of future transplantations of in vitro differentiated cells by exploiting a selective immune response against contaminating undifferentiated cells. (beds.ac.uk)
  • The protocol involves the microdissection of the SVZ and DG from one adult mouse brain, isolation of NSCs from specific regions and cultivation of NSCs in vitro. (nih.gov)
  • As the donor source for autologous chondrocytes is limited, cells must be amplified in monolayers in vitro before implantation to meet the requirements of repair. (hindawi.com)
  • iPSCs
  • To test whether these stem cells can be rejected by the recipients, we have analyzed whether maGSCs and iPSCs can become targets for cytotoxic T lymphocytes (CTL) or whether they are protected, as previously proposed for embryonic stem cells (ESCs). (beds.ac.uk)
  • We analyzed the susceptibility of three maGSC lines to CTL in comparison to ESCs, iPSCs, and F9 teratocarcinoma cells. (beds.ac.uk)
  • 2016). Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human iPSCs. (springer.com)
  • retain
  • We have observed that maGSCs can be maintained in prolonged culture with or without leukemia inhibitory factor and/or feeder cells and still retain the capacity to form teratomas in immunodeficient recipients. (beds.ac.uk)
  • These cells still retain some epigenetic imprinting of their original type--even with the most current techniques. (conservapedia.com)
  • Even after months and years of growth in the laboratory, embryonic stem cells still retain the ability to form any cell type in the body and offer an exciting opportunity to develop new treatment strategies. (longevityfacts.com)
  • Genetic
  • However, because they are already epigenetically programmed to favor a particular fate, they generally cannot generate cell types outside of their lineage without genetic manipulation. (conservapedia.com)
  • Whereas embryonic stem cells are omnipotent, and may be coaxed with growth factors into producing any known cell type, adult stem cells are already partially committed to a particular fate and, without genetic manipulation, will only generate a limited number of cell types. (conservapedia.com)
  • neuronal
  • After 14 days, about 10% of the stem cells in the neuronal cell line -- a type of cell not present in skin or hair -- grew dendrites, the long extensions typical of nerve cells and expressed neuronal proteins. (webwire.com)
  • A conditional knockout of SMN in neuronal cell types, giving a phenotype of functional motor defects, weight loss and reduced life expectancy partially satisfies this need (Frugier, Tiziano et al. (jove.com)
  • MAPC
  • Previous research has indicated that MAPC cell therapy might attenuate this injury by its paracrine effects on the pro-/anti-inflammatory balance. (biomedcentral.com)
  • This study aims to investigate the immunoregulatory capacities of MAPC cells in PGD when administered in the airways. (biomedcentral.com)
  • In the MAPC cell group, 150 million MAPC cells (ReGenesys/Athersys, Cleveland, OH, USA) were added to this mixture. (biomedcentral.com)
  • BAL neutrophilia was significantly reduced in the MAPC cell group. (biomedcentral.com)
  • Although no physiologic effect of MAPC cell distribution in the airways was detected during EVLP, we observed a reduction in pro-inflammatory cytokines and neutrophils in BAL in the MAPC cell group. (biomedcentral.com)
  • isolate
  • Here we describe a protocol that enables us to isolate self-renewing and multipotent NSCs from the SVZ and the DG of the same adult mouse. (nih.gov)
  • lineage
  • Herein, global and single-cell analyses revealed a hierarchical organization of transcriptional lineage programs, with downregulation of megakaryocyte-erythroid genes from HSCs to LMPPs, sustained granulocyte-monocyte priming, and upregulation of common lymphoid (but not B and T cell-specific) genes. (lu.se)
  • scientists
  • This type of adult stem cell research has been welcomed by the White House, who wish to limit scientists' use of embryos . (bionews.org.uk)
  • However, not all scientists are convinced of that the cells are as versatile as they appear to be, according to a report in the Washington. (bionews.org.uk)
  • As scientists in the field devise better ways to generate these cells (new techniques are a current area of much research--there have been at least 40 published since 2009), they may become more clinically useful. (conservapedia.com)
  • Eventually, scientists learned how to derive stem cells from human embryos, human embryonic stem cells, and how to grow these cells in the laboratory. (longevityfacts.com)
  • Scientists categorize stem cells by their stage of development. (longevityfacts.com)
  • Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. (springer.com)
  • Last year scientists were first able to non-invasively collect these stem cells from lactating breasts. (everything2.com)
  • 2002
  • Catherine Verfaillie and colleagues at the University of Minnesota first described these novel stem cells in 2002, but other teams have had difficulty in replicating the work. (bionews.org.uk)
  • liver
  • 7 The exact mechanism has not been conclusively identified, but it likely occurs through transdifferentiation, the ability of haemopoietic stem cells to change into liver cells instead of blood cells, or the fusion of mesenchymal or haemopoietic stem cells with existing liver cells. (icr.org)
  • 00:03:32.18 Or, liver stem cells which as far as we know are only capable of generating hepatocytes. (ibiology.org)
  • umbilical
  • 4 Multipotent stem cells are also found in umbilical cord blood and can be collected and stored at birth with no discomfort or threat to the life of the infant or mother. (icr.org)
  • VSELs
  • In the Issues in Development article "The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells (VSELs), and Some Nomenclature Issues," the authors present the most current descriptions and terminology for characterizing VSELs . (phys.org)
  • Verfaillie
  • In a new paper published in the journal Experimental Medicine, Verfaillie has worked with a leading sceptic of the research, Dr Irving Weissman of Stanford University, to show that the cells can be grown in the laboratory and successfully transplanted into animals. (bionews.org.uk)
  • Verfaillie however, believes that stem cell research must progress on all levels including the use of embryonic cells. (bionews.org.uk)
  • There is a huge reason why we have to continue studying embryonic stem cells ', Verfaillie said. (bionews.org.uk)
  • pancreatic
  • β-Cell replacement in diabetes using pancreatic islets or β-cell surrogates is a research area undergoing intense scrutiny. (ebscohost.com)
  • distinguish
  • Recent studies have revealed that endogenous small non-coding microRNA (miRNA) play important roles in the conversion of GS cells into maGS cells and may form a miRNA signature that may be used as a molecular tool to distinguish the GS cells from maGS cells. (springer.com)
  • epidermis
  • 00:03:07.17 These cells can generate not only hair follicles but also epidermis and sebaceous glands. (ibiology.org)
  • 00:03:24.28 An example of that would be the epidermal stem cell, 00:03:27.25 which as far as we know is only capable of generating epidermis. (ibiology.org)
  • hepatocytes
  • Our strategy aims at differentiating healthy and disease hiPSCs towards hepatocytes, which are glucose sensitive cells, challenging them with glucose uptake and analyzing how they respond. (edu.sa)
  • niches
  • Adult stem cells from these niches are currently being used to treat a number of diseases and more applications are in clinical trials. (icr.org)