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  • Autologous
  • With post-natal stem cells taken from the recipient and then reintroduced in an autologous manner, rejection would not be an issue. (scienceblog.com)
  • Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G and Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. (wikipedia.org)
  • This company has established treatments for osteoarthritis using autologous adult stem cells. (wikipedia.org)
  • In a study that is currently underway (February 2012), however, more positive results were being reported: In the SCIPIO trial, patients treated with autologous cardiac stem cells post MI have been reported to be showing statistically significant increases in LVEF and reduction in infarct size over the control group at four months after implant. (wikipedia.org)
  • regenerate
  • These post-natal cells were able to undergo population doublings while maintaining their ability to regenerate muscle in an animal model, a key finding indicating that they could maintain their treatment potential. (scienceblog.com)
  • To battle aging, the human body holds a reservoir of nonspecialized cells that can regenerate organs. (eurekalert.org)
  • Reports of the heart's ability to repair itself have started to appear in peer reviewed journals and a paper has been published that has shown the potential of bone marrow cells to regenerate myocardium (myogenesis). (wikipedia.org)
  • Neural cells, for example, express growth-associated proteins, such as GAP-43, tubulin, actin, an array of novel neuropeptides, and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • vitro
  • These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. (wikipedia.org)
  • It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
  • The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment. (wikipedia.org)
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • regulate
  • TGFβ The TGFβ family of cytokines regulate the stemness of both normal and cancer stem cells. (wikipedia.org)
  • Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. (wikipedia.org)
  • Several factors are important to regulate stem-cell characteristics within the niche: cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, interactions between stem cells and adhesion molecules, extracellular matrix components, the oxygen tension, growth factors, cytokines, and the physicochemical nature of the environment including the pH, ionic strength (e.g. (wikipedia.org)
  • Progerin activates genes that regulate stem cell differentiation via the Notch signaling pathway. (wikipedia.org)
  • Political leaders are debating how to regulate and fund research studies that involve the techniques used to remove the embryo cells. (wikipedia.org)
  • Her current research is focused on the mechanisms that regulate hematopoietic stem cells (HSC), and how those regulatory mechanisms go awry in hematologic malignancies. (wikipedia.org)
  • cardiac
  • In addition to searching for a cure for DMD, Dr. Huard's laboratory also is researching the use of stem cells to repair injured muscle following sports-related injuries, as well as to treat cardiac, joint and bone injuries. (scienceblog.com)
  • Neocardiogenesis replaces dead cardiac muscle cells with living cells so that both the structure and function of the heart are maintained. (wikipedia.org)
  • Cardiomyocytes (muscle cells of the heart) were thought to be terminally differentiated cells that were irreplaceable and thus required to maintain cardiac function throughout life. (wikipedia.org)
  • The activation of cardiac progenitor cells (a special type of stem cell with long telomeres located in the storage areas of the heart) and circulating stem cells induce cardiomyocytes to proliferate. (wikipedia.org)
  • Quaini F, Cigola E, Lagrasta C, Saccani G, Quaini E, Rossi C, Olivetti G and Anversa P. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. (wikipedia.org)
  • He has studied cardiac mutant axolotls, transgenic mice, and induced pluripotent adult stem cells. (wikipedia.org)
  • He is known for discovering unique and specific ribonucleic acids (RNAs) that have the capacity to promote cardiac myofibrillogenesis in non-muscle cells. (wikipedia.org)
  • However, it has been suggested that this drug has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes. (wikipedia.org)
  • 2002
  • Catherine Verfaillie and colleagues at the University of Minnesota first described these novel stem cells in 2002, but other teams have had difficulty in replicating the work. (bionews.org.uk)
  • human
  • Debate continues over human embryonic stem cell research, but medical breakthroughs have been made using adult stem cells and other body cells. (washingtontimes.com)
  • These cells also have shown promise in treating human heart patients. (washingtontimes.com)
  • Some say these advancements show that adult stem cells and other types of body cells hold more promise for medical treatments then do human embryonic stem cells. (washingtontimes.com)
  • Embryonic stem cell research has shown positive results in animals but hasn't produced successful human studies. (washingtontimes.com)
  • Even aside from the serious moral issues, embryonic stem cells are very far away from helping any human patient," said Richard Doerflinger, deputy director of the Secretariat for Pro-Life Activities at the U.S. Conference of Catholic Bishops. (washingtontimes.com)
  • The assumption that cells derived from iPSCs are totally immune-tolerant has to be re-evaluated before considering human trials," warned lead investigator Yang Xu, a professor of biology at the University of California at San Diego. (medindia.net)
  • Among the dozens of speakers invited to help translate the new developments into layman's terms were Nobel Prize winner John B. Gurdon -- a pioneer of adult stem-cell research -- and Tommy G. Thompson -- former U.S. secretary of Health and Human Services and former governor of Wisconsin. (ncronline.org)
  • Speculation regarding the scientific promise of human embryonic stem cells leads some to dismiss the ethical questions raised by the embryo's destruction. (freerepublic.com)
  • However, embryonic stem cells (human or animal) have not cured or treated a single human patient. (freerepublic.com)
  • Fortunately, there are alternative sources of stem cells for research that do not require the destruction of human life. (freerepublic.com)
  • NASA is hopeful the Human adult stem cell experiments will lead to the reversal of the rapid aging process that zero gravity has on astronauts. (prweb.com)
  • They can transform into about 250 types of specialised cells that make up a human being. (newsweekly.com.au)
  • Totipotent cells have the capacity to develop into a complete human being. (newsweekly.com.au)
  • They also mocked those who opposed embryonic stem cell experimentation and defended human life at its most vulnerable stage. (lifeissues.org)
  • Human embryonic stem cells are often grown in fibroblastic growth factor-2 containing, fetal bovine serum supplemented media. (wikipedia.org)
  • Human ES cells measure approximately 14 μm while mouse ES cells are closer to 8 μm. (wikipedia.org)
  • The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical trials. (wikipedia.org)
  • Presently, the success of adult stem cells in regenerating human myocardium is just a fraction of what it could be. (wikipedia.org)
  • Pluristem Therapeutics is an Israeli company engaged in the development of human placental adherent stromal cells for commercial use in disease treatment. (wikipedia.org)
  • Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. (wikipedia.org)
  • Most cells in the human body have 23 pairs of chromosomes, or a total of 46 chromosomes. (wikipedia.org)
  • In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. (wikipedia.org)
  • Many of the debates surrounding human embryonic stem cells concern issues such as what restrictions should be made on studies using these types of cells. (wikipedia.org)
  • Much of the criticism has been a result of religious beliefs, and in the most high-profile case, US President George W Bush signed an executive order banning the use of federal funding for any cell lines other than those already in existence, stating at the time, "My position on these issues is shaped by deeply held beliefs," and "I also believe human life is a sacred gift from our creator. (wikipedia.org)
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
  • Goodell has been on the faculty of Baylor College of Medicine since 1997 as a member of the Center for Cell and Gene Therapy, and the Departments of Pediatrics, Molecular and Human Genetic, and Immunology. (wikipedia.org)
  • Although the funds could be used to finance all kinds of stem cell research, it gives priority to human embryonic stem cell research. (wikipedia.org)
  • genes
  • These cells are activated by a mixture of transcriptional factors, genes, growth factors, receptors, the extracellular matrix and signalling pathways. (wikipedia.org)
  • Cells in the primordia of zebrafish fins, for example, express four genes from the homeobox msx family during development and regeneration. (wikipedia.org)
  • Cells in Wharton's jelly express several stem cell genes, including telomerase. (wikipedia.org)
  • patient's
  • This type of cloning is not intended to produce an offspring, but instead to produce an embryo that has stem cells are made specifically for treating a specific patient's disease. (medindia.net)
  • In most cases, doctors are able to isolate the patient's own stem cells and reinfuse them into the body to treat disease or injury. (lifeissues.org)
  • By reconstructing the structures of the face with one's own adult stemcells, FAMI rejuvenates the patient's face with restored volume to the facial muscles and bones. (wikipedia.org)
  • clinical
  • Two men were the first subjects of a groundbreaking clinical research trial to establish the efficacy of treating patients with stem cells from their own bone marrow hours after a heart attack. (bionews.org.uk)
  • Two new studies have cast further doubt on the ability of blood stem cells to turn into heart cells, even though several clinical trials based on this promising new treatment are currently underway. (bionews.org.uk)
  • Doug joined a clinical trial and his own adult stem cells were injected into the diseased areas of his eyes. (lifeissues.org)
  • The positive effects observed in clinical trials today are a result of the work of donated stem cells that persist in the damaged myocardium for just days to weeks after delivery. (wikipedia.org)
  • endothelial
  • A recent publication in Cancer Research (August 2010) has shown that ID1 can be used to mark Endothelial Progenitor Cells which are critical to tumour growth and angiogenesis. (wikipedia.org)
  • injections of their own stem cells
  • Heart Disease - Patients with heart failure experienced a marked improvement after being given injections of their own stem cells, thanks to research at the University of Pittsburgh. (freerepublic.com)
  • Patients with heart failure could one day be treated with injections of their own stem cells, according to new US trials that provide the 'first convincing evidence' that such an approach might work. (bionews.org.uk)
  • transplants
  • Paralysis/Spinal Cord Injury - After sustaining paralyzing spinal cord injuries, Susan Fajt, Laura Dominguez and Erica Nader of the U.S. are each regaining muscle control and walking with the aid of braces due to stem-cell transplants from their own nasal cavities conducted in Portugal. (freerepublic.com)
  • On October 27, 2014, it was reported that Case Western Reserve University will conduct a preclinical study of PLX-R18 cells in umbilical cord blood transplants for the treatment of blood cancers and genetic diseases. (wikipedia.org)
  • The girl had undergone two allogenic stem cell transplants since being admitted in August 2011, both of which failed to improve her condition. (wikipedia.org)
  • proliferation
  • The results show that some adult progenitor cells remain able to respond to signals that drive proliferation and maintain dedifferentiation in embryonic cells. (alzforum.org)
  • The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. (wikipedia.org)
  • Moreover, the minimum probability of double-hit mutant generation corresponds to purely symmetric division of SCs with a large proliferation rate of border stem cells along with a small, but non-zero, proliferation rate of central stem cells. (wikipedia.org)
  • Adult stem cells exhibit a minimal[clarification needed] commitment to engraft into the damaged myocardium, they have low survival rates and they have limited proliferation. (wikipedia.org)
  • When ID proteins are overexpressed, cell proliferation is enhanced and cells become insensitive to growth factor depletion. (wikipedia.org)
  • tumors
  • The investigators also found that the CD34+ cells had a limited lifespan and did not produce teratomas, tumors that sometimes form with the use of embryonic stem cells and adult stem cells cultivated from other methods that require some genetic manipulation. (eurekalert.org)
  • Further, it also eliminates the concern of embryonic stem cells going AWOL and developing into tumors. (lifeissues.org)
  • Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. (wikipedia.org)
  • Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. (wikipedia.org)
  • In different tumor subtypes, cells within the tumor population exhibit functional heterogeneity and tumors are formed from cells with various proliferative and differentiation capacities. (wikipedia.org)
  • The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex (Fig. 3). (wikipedia.org)
  • vivo
  • Though the concept of stem cell niche was prevailing in vertebrates, the first characterization of stem cell niche in vivo was worked out in Drosophila germinal development. (wikipedia.org)
  • July 14, 2014 https://www.youtube.com/watch?v=vLGtjimtDHA Burning Man https://www.mediawiki.org/wiki/Melly_goodell[permanent dead link] http://www.livingprimetime.com/AllCovers/Mar1998/maestro_of_business.htm Grace Goodell Goodell, M. A., Brose, K., Paradis, G., Conner, A. S., and R. C. Mulligan (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. (wikipedia.org)
  • genetic
  • He currently is working with the stem cells he discovered while searching for a cure for Duchene muscular dystrophy (DMD), a genetic disease that is estimated to affect one in every 3,500 boys. (scienceblog.com)
  • Without going into too many of the technical details, the activity of this tracer protein is controlled by genetic elements that are only turned on in the cell type of interest. (diabetesincontrol.com)
  • This study has offered a novel way for Bam to carry out the switch from self-renewal to differentiation," says Xie, whose lab uses a combination of genetic, molecular, genomic and cell biological approaches to investigate GSCs as well as somatic stem cells of fruit flies. (innovations-report.com)
  • Such a scenario could result in each daughter cell possessing a disjoint set of genetic material. (wikipedia.org)
  • Pattern formation in the morphogenesis of an animal is regulated by genetic induction factors that put cells to work after damage has occurred. (wikipedia.org)