Adult stem cell stem cell lineages. Medical search. Frequent questions

Current Research and Scholarly Interests The thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. (stanford.edu)
We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)
To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)
In recent years, induced pluripotent stem (iPS) cells have generated a great deal of interest as a potentially unlimited source of various cell types for transplantation. (eurekalert.org)
Moreover, there is no standardized approach applicable to all cell types, and the development of personalized therapies based on patient-derived pluripotent cells remains very expensive and time consuming. (eurekalert.org)
The researchers started to genetically reprogram adult Club cells isolated from mice, transiently expressing the four iPS reprogramming factors, but interrupted the process early, prior to reaching the pluripotent state, to generate progenitor-like cells, which are more committed to a specific lineage and show more controlled proliferation than pluripotent cells. (eurekalert.org)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
It uses CombiCult, its proprietary bead-based combinatorial screening platform, to differentiate induced pluripotent stem cells, embryonic and adult stem cells into a variety of somatic lineages for use by biotechnology and pharmaceutical companies. (technologynetworks.com)
Adult stem cells are classified as pluripotent and are undifferentiated cells that remain quiescent in tissues until stimulated, when they can create cell types that are compatible with the tissue in which they reside. (bvsalud.org)
Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. (bvsalud.org)
Owing to their manifold roles in health and disease, there have been intense efforts to synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs). (bvsalud.org)
Here, we generate >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days. (bvsalud.org)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
Here we apply human induced pluripotent stem cell (hiPSC)-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2. (cdc.gov)

All eligible vaccines compared with no vaccination against COVID-19- adults aged 18 years§ should receive a booster dose, which associated hospitalization among immunocompetent adults currently consists of a bivalent mRNA vaccine, to maximize aged 18 years during December 26, 2021-August 31, 2022. (cdc.gov)

MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
The French flag model represents how embryonic cells receive and respond to genetic information and subsequently differentiate into patterns. (asu.edu)
Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. (cipsm.de)
The key to these cells' utility is their ability to differentiate into many different cell types depending on the stimulus received and they have been used in treatments for diseases such as cancer and neural degeneration, in rehabilitation of tetraplegic and paraplegic patients and even in dentistry 1 . (bvsalud.org)
Hematopoietic stem cells are cells isolated from blood and bone marrow that can differentiate into a variety of different specialized cells and suffer apoptosis 1 . (bvsalud.org)
The have been applied to both the plant and ani- stem cells possess pluripotential charac- mal kingdoms without even stirring a ripple teristics, and can differentiate into various of concern in international conscience [ 2 ]. (who.int)

Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)
These growth factors are mitogens for cells of mesenchymal origin. (thermofisher.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)

Therefore, finding out molecular mechanisms by which reactive astrocytes can be coaxed into neurons will be of utmost importance for regenerative therapies as these astrocytes are the imminent cell types around the lesion site. (frontiersin.org)
Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
We're a partnership of more than 400 stem cell and regenerative medicine labs across Europe, connected via research centres, consortia, networks and hubs. (eurostemcell.org)
Paolo De Coppi is a Consultant Paediatric Surgeon at Great Ormond Street Hospital (GOSH), and Reader and Head of Stem Cells and Regenerative Medicine at the UCL Institute of Child Health in London. (eurostemcell.org)
A major block in the critical path of regenerative medicine is the lack of suitable cells to restore function or repair damage," says co-senior author Tom Waddell, a thoracic surgeon at the University of Toronto. (eurekalert.org)
According to the authors, the approach could be used for a variety of regenerative medicine practices, including cell replacement therapy, disease modelling, and drug screening for human diseases. (eurekalert.org)
Given their plasticity and regenerative abilities, stem cells provide opportunities for treating human diseases such as diabetes. (cshlpress.com)
This volume is therefore an indispensable reference for molecular, cell, and developmental biologists, as well as anyone wishing to explore the possibilities of stem cells in regenerative medicine and tissue engineering. (cshlpress.com)
Cell therapy and regenerative medicine is a focus of SBC's open innovation activities, and these two new tenants are expected to play a major role in the incubator's growing network in this area. (technologynetworks.com)
Dennis Saw, CEO of Plasticell Ltd, added: 'The attraction of co-locating Plasticell and Progenitor at SBC has been to group complementary stem cell technologies in a creative environment, obtaining access to expertise from GSK and SBC's other stakeholders, allowing us to deploy capital more efficiently towards discovering regenerative medicines. (technologynetworks.com)

It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Bone marrow appears to contain three stem cell populations: hematopoietic stem cells, stromal stem cells and endothelial precursor cells. (bvsalud.org)
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)

The important functions of skin stem cell populations in tissue development, homeostasis, and repair are described, as are the roles of resident and recruited cells in inflammatory responses. (cshlpress.com)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
As demonstrated November 30 in the journal Stem Cell Reports , researchers in Canada converted adult mouse respiratory tract cells called Club cells into large, pure populations of induced progenitor-like (iPL) cells, which retained a residual memory of their parental cell lineage and therefore specifically generated mature Club cells. (eurekalert.org)
This technology can theoretically be applied to almost any cell type that can be isolated and purified, and isolation of highly purified populations of adult cells from most organs is already possible with existing techniques. (eurekalert.org)
We are currently investigating the function of chromatin modifiers during embryonic development, in adult stem cell populations and in cancer, and modelling chromatin-based intellectual disability to discover ameliorating treatments. (edu.au)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)

Three key components are necessary for this database to be effective: cell type-specific gene expression profiles, anatomical and developmental relationships between cells and tissues and signals important for development and differentiation of stem cells to mature cell types. (wikipedia.org)
Adult stem cell lineages underlie most of the tissues in our body. (genetics-gsa.org)
During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (wisc.edu)
In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
Abstract: Lineage tracing studies based on inducible genetic labeling have emphasized a central role for stochasticity in the maintenance and regeneration of cycling adult tissues, with frequent stem cell loss through differentiation compensated by the duplication of neighbors, leading to the consolidation of clonal diversity. (ucl.ac.uk)
They play critical roles during embryonic development and in the maintenance and repair of adult tissues. (cshlpress.com)
The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). (cshlpress.com)
Its sister company Progenitor Labs uses CombiCult to produce 'synthetic' adult progenitor cells for drug screening, for discovery of small molecules that regenerate specific tissues, potentially restoring organ function in disease and ageing. (technologynetworks.com)
Many studies have shown the utility of embryonic or adult stem cells for forming teeth and for regeneration of bone and soft tissues. (bvsalud.org)
Additionally, they can form specialized cell types from other tissues if they are transplanted 6 . (bvsalud.org)
Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)

In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
SSCs are adult-tissue stem cells in the mammalian testis that balance self renewing and differentiating fate decisions to give rise to and sustain the entire spermatogenic lineage. (utsa.edu)
With a focus on mammalian spermatogenesis and intestinal maintenance, we review the role of "dynamical heterogeneity" in the regulation of adult stem cell self-renewal. (ucl.ac.uk)
This work also highlights the physiological role of cell competition in regulating mammalian organ size. (phys.org)

The lung is a complex organ composed of many types of epithelial cells, immune cells, endothelial cells and stromal cells. (stemcell.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
How can we specifically generate either arterial or venous endothelial cells (ECs) from hPSCs in vitro? (bvsalud.org)

Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
Stem cells are nonspecific cells with powerful self-regeneration properties and they are capable of organizing other cell types in the body. (bvsalud.org)

Correct regulation of self-renewal, proliferation, and differentiation into the proper downstream cell fate(s) is critical for tissue maintenance and repair, with defects contributing to tissue dismorphogenesis, aging, and cancer. (genetics-gsa.org)
Stem cells have two fundamental properties: self-renewal and multipotency. (wisc.edu)
Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. (stanford.edu)
Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
A stem cell is an undifferentiated unit with powerful self-renewal properties that is capable of organizing other cell types in the body. (bvsalud.org)
Stem cells are defined as undifferentiated cells that have precursor properties, are capable of forming many different cell types and have the property of unlimited self-renewal 5 . (bvsalud.org)
By definition, adult stem cells are capable of differentiation into at least two lineages and have the property of self-renewal. (bvsalud.org)

The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
Plasticell, a leading UK biotech company in the stem cell field, specializes in the differentiation of stem cells to obtain cell types for a range of biomedical applications. (technologynetworks.com)

The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
When the Club-iPL cells were administered to CFTR-deficient mice, the cells incorporated into tissue lining the respiratory tract and partially restored levels of CFTR in the lungs without inducing tumor formation. (eurekalert.org)
not only can gene expression be manipulated and lineages traced at single-cell and whole-tissue levels, but complete population counts of all cell types are possible. (stanford.edu)
Similarly, in multicellular organisms, competitive interactions also occur between cells, creating a cell selection mechanism that eliminates less fit cells within the local tissue environment. (phys.org)
These cells are classified as totipotent and they can form any of the tissue types found in the adult body, in addition to having unlimited proliferation potential 6 . (bvsalud.org)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)

Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)

Also, another feature of the database is that it includes information based on in vivo and in vitro lineages. (wikipedia.org)
One could go in and compare certain lineage factors between in vivo and in vitro, as well as look at what factors influence the stem cells down specific pathways. (wikipedia.org)
Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)
Through the combination of long-term genetic lineage tracing assays with short-term in vivo live-imaging, the cellular basis for stochastic stem cell loss and replacement has begun to be resolved. (ucl.ac.uk)

The researchers showed that the resulting Club-iPL cells could give rise to not only Club cells, but also to other respiratory tract cells such as mucus-secreting goblet cells and ciliated epithelial cells that produce the CFTR protein, which is mutated in patients with cystic fibrosis. (eurekalert.org)
The alveolar epithelium is lined with type I and II alveolar epithelial cells (AECs). (stemcell.com)

Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
A major advantage of this approach is the ability to generate patient-specific iPS cells for transplantation, thereby minimizing the risk of harmful immune reactions. (eurekalert.org)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
Transplantation experiments further verified the cell-autonomous nature of this phenotype. (cipsm.de)
Due to serious organ shortage for pancreas transplantation, cell-based therapy represents the most promising option and different potential sources for new β cells are currently being explored, including embryonic stem cells and other cell types. (europa.eu)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)

The identification of endogenous cell competition among NPCs provides a fundamental basis for comprehending the developmental origin of neuronal vulnerability as well as improving brain health. (phys.org)

p class=\'abstract\'>Barrier epithelial organs face the constant challenge of sealing the interior body from the external environment while simultaneously replacing the cells that contact this environment. (stanford.edu)

The Hsieh laboratory is a neural stem cell biology laboratory that focuses on 4 major areas: (1) epilepsy-in-a-dish, (2) 3D cerebral organoids, (3) patient recruitment, and (4) mechanisms of adult neurogenesis. (utsa.edu)
Recent advances in isolating epithelial progenitor cells and stromal cells, as well as defining niche factors important for lung development, have led to the establishment of an in vitro 3D lung culture system: pulmonary (lung) organoids. (stemcell.com)
Recent progress isolating lung epithelial progenitor and stromal cells, as well as defining stem cell niche factors that are important for lung development, has led to the establishment of an in vitro three-dimensional (3D) culture system: lung organoids 2 , also known as airway organoids or pulmonary organoids. (stemcell.com)
Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights. (cshlpress.com)

This creates uncertainty about whether it is at all possible to create new eggs with the help of stem cells," says Kui Liu, a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg. (sciencedaily.com)
Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. (biologists.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. (cshlpress.com)
In a study published in Developmental Cell , a group led by Prof. Wu Qingfeng from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences demonstrated the presence of cell competition between neural progenitor cells (NPCs) during neurodevelopment. (phys.org)

We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
Towards a Mechanistic Model of Tau-Mediated Pathology in Tauopathies: What Can We Learn from Cell-Based In Vitro Assays? (ibecbarcelona.eu)

Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
With the recent discovery that adult olfactory bulb neurogenesis in the human brain likely ceases after 18 months of age, there is increased interest in studying the NPs of the neonate [ 1 ]. (karger.com)
Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. (cipsm.de)
Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis. (cipsm.de)

May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
Xue-Lian Sun et al, Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development, Developmental Cell (2023). (phys.org)
Cell Reports, Available online 14 November 2023. (lu.se)

A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, potentially safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. (eurekalert.org)
This method involves genetically reprogramming skin cells taken from adult donors to an embryonic stem-cell-like state, growing these immature cells to large numbers, and then converting them into specialized cell types found in different parts of the body. (eurekalert.org)
In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. (cshlpress.com)
A particularly attractive therapeutic strategy is to convert liver adult cells of diabetic patients into functional pancreatic β cells through lineage reprogramming. (europa.eu)
Olariu V, Manesso E, commitment and Peterson C. 2017 A deterministic method for estimating free energy genetic network reprogramming paths landscapes with applications to cell commitment and reprogramming paths. (lu.se)
those of cell reprogramming, thereby avoiding exhaustive trial- energy landscape, deterministic models, and-error simulations with rate equations for different stem cell commitment, reprogramming parameter sets. (lu.se)
We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)

A main focus of my lab research is to understand the epigenetic basis of cell fate specification and neurodevelopment. (wisc.edu)
By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
Student projects in my lab will revolve around cell-fate decisions in Spermatogonial Stem Cells (SSC). (utsa.edu)
This approach enabled the researchers to induce genetic mosaicism in NPCs, allowing NPCs to carry different fluorescent proteins, and to track cell fate during the developmental continuum. (phys.org)
To determine whether cell competition naturally occurs in the developing brain , the researchers collected more than 1,000 mouse brains with clonal labeling of NPCs and studied their fate using short- and long-term lineage tracing. (phys.org)

This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
One focus of my group lies on a better understanding of the physiological process ofneurogenesis in the adult mouse brain with emphasis on the lineage progression from adult neural stem cells to their neuronal and glial progeny as well as the functional integration of adult-generated neurons into the pre-existing circuit. (unimedizin-mainz.de)
Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Astrocytes are abundant cell types in the vertebrate central nervous system and can act as neural stem cells in specialized niches where they constitutively generate new neurons. (frontiersin.org)
in contrast, abnormal tau deposition in neurons and glial cells occurs only exceptionally in children. (ibecbarcelona.eu)
In contrast, large numbers of tau-positive cells, including neurons and oligodendrocytes, were found in the thalamus of mice inoculated at three months and killed at the ages of six months and nine months. (ibecbarcelona.eu)
Their findings showed that this manipulation caused a significant enlargement of brain size and a remarkable rise in the number of neurons, indicating the survival of otherwise unfit stem cells during development. (phys.org)

6. Patients with a concurrent active malignancy or a prior malignancy, except lobular breast carcinoma in situ, fully resected basal cell or squamous cell carcinoma of the skin or treated cervical carcinoma in situ, an incidental histologic finding of prostate cancer (T1a or T1b using the tumour, node, metastasis (TNM) clinical staging system), previous MDS, CMML, MPN resulting in secondary AML. (who.int)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
Stem cells are the progenitors of specialized cell types in the body and have the ability to self-renew. (cshlpress.com)

The database allows user to update information found from the organic developmental stages and it also allows users to discuss experimental practices that altered the stem cells. (wikipedia.org)
This volume is therefore a vital reference for dermatologists, cancer biologists, cell and developmental biologists, immunologists, and all who seek to understand the numerous functions and diseases of this major organ. (cshlpress.com)
Developmental regulation of cell cycle progression during male meiosis. (stanford.edu)
Notably, stem cells that were eliminated at an early developmental stage had no chance of contributing any cells to adult organs. (phys.org)
Welfare in Europe and Japan, for immuno- ods for developmental neurotoxicity and System toxicity testing in adult rodents. (cdc.gov)

Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)

Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)

I will be discussing how primordial germ cells are set aside from other cells in the body to fulfill their unique function in reproduction and how we have started to probe the quality control mechanisms that regulate the faithful transmission of cytoplasmic structures including mitochondria from the egg to the embryo. (genetics-gsa.org)
The research in our laboratory focuses on understanding the molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the treatment of neurological disorders and injuries. (wisc.edu)
Using neural stem cells as model systems, we are investigating the molecular mechanisms that regulate neuronal development during postnatal period and their implications in human neurodevelopmental disorders such as Rett Syndrome, Autism, and Fragile X syndrome. (wisc.edu)
They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. (cshlpress.com)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)

He has been leader of a research group at the Max-Delbrück-Center for Molecular Medicine in Berlin until 2011 focusing his research on signal transduction mechanisms in human and murine embryonic stem cells. (eurostemcell.org)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
Wu and his team systematically investigated the potential regulators, spatial properties, molecular features, mechanism and physiological role of cell competition between NPCs. (phys.org)
To gain deeper insight, the researchers generated phenotype-, genotype- and transcriptotype-dependent datasets through single-cell and bulk RNA sequencing, developed a loser signature scoring system and identified the molecular characteristic of loser cells. (phys.org)
This work elucidates the drivers, properties, molecular features and physiological function of cell competition in the context of neural stem/progenitor cells during early neurodevelopment. (phys.org)
My ERC-funded project (ERC Starting Grant "HEPATOPANCREATIC") is focused on the molecular mechanisms underlying cellular plasticity between liver and pancreatic cells. (europa.eu)

One of the major factors that separates SCLD from other stem cell databases is that it allows users to edit information pertaining to cell types, markers, and lineages. (wikipedia.org)
term pre-GEPCOT cells (based on an acronym of the markers used to isolate the cells), were long-lived and quiescent, but they lacked the ability to form colonies in culture. (elifesciences.org)
With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
Merkel cells were thought to be of neural crest origin because they are excitable cells that secrete neuropeptides and stain positively for neuroendocrine markers. (medscape.com)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

The neurosphere-forming cells, named GEPCOT cells, were short-lived and highly proliferative in the brain. (elifesciences.org)

We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)

The paths open vs. closed to evolutionary exploitation are dictated by the population-genetic environment, which varies substantially among phylogenetic lineages. (genetics-gsa.org)
His group specialises in the study of the genetic and epigenetic regulation of female germ cell development. (sciencedaily.com)
Azacitidine is an analogue of cytidine, which means that it is incorporated into the genetic material of cells (RNA and DNA). (europa.eu)
To investigate cell competition between NPCs, the researchers first developed a novel strategy for genetic mosaic induction and clonal tracking based on a dual-color labeling system. (phys.org)
Created by Lewis Wolpert in the late 1960s, the model uses the French tricolor flag as visual representation to explain how embryonic cells can interpret genetic code to create the same pattern even when certain pieces of the embryo are removed. (asu.edu)

The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)

This laboratory pursues several lines of investigation to understand how T cells contribute to autoimmune diseases and protection from infection, and how to modulate T cell immunity for therapeutic purposes in humans. (utsa.edu)

The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

The Stem Cell Lineage Database could help compare stem cell information around the world and eliminate taking a global gene expression profiling approach, which although sufficient, is not as effective as it could be. (wikipedia.org)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
The diverse cell types are genetically identical, but differ in their form and function due to differences in gene expression. (edu.au)

Currently, the database only includes human and mouse stem cell lineages, but the database hopes to expand into more species. (wikipedia.org)
Currently, the SCLD has stem cell information for only human stem cells and mice stem cells. (wikipedia.org)
Human MC were initially divided into three subsets based on the cell surface expression of CD14 and CD16, and recently classified based on CD40 expression ( 2 - 5 ). (frontiersin.org)
For their own part, the researchers plan to test this approach with other cell types, including human cells. (eurekalert.org)
The brains of three adult murine genotypes expressing different forms of tau-WT (murine 4Rtau), hTau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3Rtau and 4Rtau proteins), and mtWT (homozygous transgenic mice knock-out for murine tau protein)-were analyzed following unilateral hippocampal inoculation of sarkosyl-insoluble tau fractions from the same AD and control cases. (ibecbarcelona.eu)
These cells modeled viral infection of human vasculature by Nipah and Hendra viruses, which are extraordinarily deadly (â ¼57%-59% fatality rate) and require biosafety-level-4 containment. (bvsalud.org)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. (biologists.com)
Here, we discuss some of the advances in the field of zebrafish models of adult disease, and where we see opportunities and challenges ahead. (biologists.com)
Adult zebrafish. (biologists.com)

We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)

In some cases, myelodysplastic syndromes can lead to acute myeloid leukaemia (AML, a cancer affecting white blood cells called myeloid cells). (europa.eu)

It often has multiple types of cells mirroring their counterpart in the body along with constituents of native extracellular matrix (ECM) and is typically miniature or micro-scale in size. (stemcell.com)
culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)

I will be discussing our work on the regulation of proliferation and differentiation in the Drosophila male germ line adult stem cell lineage and the surprising contributions of cell type specific alternative mRNA processing to cell state changes. (genetics-gsa.org)

Thus, somatic cells (primitive streak) and PGCLCs are related-yet distinct-lineages segregated by temporally-dynamic signaling. (bvsalud.org)

Moreover, these cells showed potential as a cell replacement therapy in mice with cystic fibrosis. (eurekalert.org)
We have pursued cell therapy for lung diseases for many years," Waddell says. (eurekalert.org)
To create specialized cell types for use in cell therapy requires only that we insert the genes (or use non-transgenic approaches) and then test the drug dose and timing required for each cell type and each patient, so it should be relatively scalable at low cost compared to other approaches using each patient's own cells," Waddell says. (eurekalert.org)
However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
Dr Martino Picardo, CEO of Stevenage Bioscience Catalyst, said 'SBC recognizes the patient benefits inherent in cell therapy, and is working to develop a network to catalyze innovation in this area. (technologynetworks.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

Outside the stem cell niches, however, these glial cells are not neurogenic. (frontiersin.org)
Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. (cipsm.de)

myelodysplastic syndromes, a group of conditions where too few blood cells are produced by the bone marrow. (europa.eu)
AML, when the bone marrow has more than 30% abnormal cells. (europa.eu)
These actions are expected to correct problems with the maturation and growth of blood cells in the bone marrow that cause myelodysplastic disorders, and to kill cancerous cells in leukaemia. (europa.eu)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Stem cells can be found in bone marrow and blood. (bvsalud.org)

This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)

Here, we investigate how new progeny acquire barrier structures as they integrate into the intestinal epithelium of adult Drosophila. (stanford.edu)
Cell competition was first described in Drosophila by Prof. Ginés Morata in 1975 and has been extensively studied in this model organism for the past five decades. (phys.org)

The thymus plays a central role in the development of the body's immune system as it is the main site in which T cells are generated. (eurostemcell.org)
During embryonic development, the unique cellular phenotypes of the adult are established. (edu.au)
Therefore, gene activity is an important mechanism in embryonic development and adult stem cell differentiation. (edu.au)
We have shown that MOZ/MYST3 is essential for the development of haematopoietic stem cells and that QKF/MYST4 has a critical role in neural stem cells and in brain development. (edu.au)
Both Lillie and Just used Echinarachnius parma for their studies of egg cell membranes and embryo development at the Marine Biological Laboratory (MBL) at Woods Hole, Massachusetts, in the early 1900s. (asu.edu)

Anatomy71

Organisms16

Diseases9

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes59

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Pluripotent16

20221

Differentiate12

Mesenchymal10

Regenerative11

Hematopoietic Stem3

Populations6

Tissues13

Mammalian4

Endothelial4

REGENERATION8

Self-renewal8

Differentiation of stem cells3

Tissue10

Epidermal Stem Cells2

Vivo4

Epithelial cells2

Transplantation7

Endogenous1

Abstract1

Organoids4

Biology5

Vitro3

Neurogenesis4

20233

Reprogramming7

Fate5

Neurons7

Squamous2

Progenitors4

Developmental5

Give rise1

NSCs4

Progenitor cell8

Regulate5

Molecular6

Markers6

Proliferative1

Subventricular zone4

Genetic5

Process of differentiation1

Modulate1

Therapeutic3

Gene expression3

Human9

Zebrafish3

Multipotency1

Acute myeloid l1

Extracellular2

Proliferation and differentiation1

Somatic cells1

Therapy7

Neurogenic2

Bone5

Tumor1

Drosophila2

Development5