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  • neurons
  • When cultured, the cellstermed SKPs, for skin-derived precursorsgenerated a variety of different cell types, including neurons, muscle cells and fat cells. (scientificamerican.com)
  • Motor neurons carry signals from the central nervous system to other parts of the body, including the muscles, skin, and glands, but damage to them also underlies many destructive neurodegenerative diseases , like amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease) and muscular atrophy. (mcgilldaily.com)
  • Recent research by Abernathy and his colleagues aimed to characterize this repackaging process in order to better understand how skin cells are first transformed into generic neurons, then are further differentiated into neuron subtypes, such as motor neurons. (mcgilldaily.com)
  • They found that exposure to two transcription factors, ISL1 and LHX3 , could turn skin cells into fully differentiated spinal cord motor neurons in approximately thirty days. (mcgilldaily.com)
  • The combination of miRNAs and transcription factors instructs the cell to close the genetic instructions for becoming skin and open the instructions for making motor neurons. (mcgilldaily.com)
  • Unlike those originating from stem cells, motor neurons resulting from the transformation of skin cells retain the age of the original sample and, therefore, the age of the patient. (mcgilldaily.com)
  • Overall, the converted motor neurons appeared similar to normal mouse motor neurons based on activated and inactivated genes and how the cells function. (mcgilldaily.com)
  • Biology
  • The aim of this grant is to explore the basic biology of skin and hair self- renewal. (grantome.com)
  • In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin. (vetscite.org)
  • Lynne Quarmby's love of the natural world inspires her to explore beyond her cell biology lab through art. (the-scientist.com)
  • epithelial
  • This proposal aims to investigate the role of the Planar Cell Polarity pathway in regulating epithelial homeostasis and cancer progression. (grantome.com)
  • organs
  • He says it should be possible to develop replacement cells or even grow organs from the newly created stem cells. (voanews.com)
  • I think about people who suffer from failing hearts, kidneys, or livers and imagine a future where we can grow replacement organs from stem cells. (futurepundit.com)
  • molecular
  • Adult stem cells orchestrate this cycle of self renew via a complex set of molecular signals. (grantome.com)
  • Understanding the molecular switch from a normal to a cancer cell, the mechanisms that allow metastasis, and the precise causes of death by these aberrant cells are essential to finding a cure. (grantome.com)
  • human skin cells
  • Here, we discovered that BAY 11-7082 (BAY11), at least partially through an NF-κB-inhibition based mechanism, could significantly increase the expression of OCT4 following transfection of synthetic mRNA (synRNA) into adult human skin cells. (biomedcentral.com)
  • lineage
  • Alternatively, cells from a given lineage might dedifferentiate into a more naive state that allows the cell to redifferentiate along new lineages. (rupress.org)
  • Expression
  • This small molecule-based inhibition of innate immune responses and subsequent robust expression of transfected synthetic mRNAs may have multiple applications for future cell-based research and therapeutics. (biomedcentral.com)
  • Thus, the delivery and stable expression of synthetic OCT4 mRNA and other synthetic mRNAs (synRNAs) may have multiple applications for future cell-based research and therapeutics. (biomedcentral.com)
  • The effect on the cells will be explored, from changes in the differentiation state of the stem cells to altered expression or localization patterns of adhesion molecules. (grantome.com)
  • transcription
  • Activity of four transcription factors distinguishes a small proportion of glioblastoma stem cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. (medindia.net)