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  • degeneration
  • The focus of our study was to investigate the unexplored Ca 2+ homeostasis in cerebellar granule neurons (CGNs) and in cardiomyocytes of FRDA cellular models to understand the pathogenesis of degeneration. (frontiersin.org)
  • Findings
  • Our findings demonstrate that in both neurons and cardiomyocytes the decreased Ca 2+ level within the stores has a comparable detrimental impact in their physiology. (frontiersin.org)
  • direct
  • Important cardiac fibroblast-cardiomyocyte interactions have been demonstrated in appositional cocultures involving direct membrane contact and/or cell fusion as well as through the use of noncontact cell culture paradigms to assess the role of soluble factors ( 12 , 13 , 17 , 42 ). (physiology.org)
  • By characterizing the stress of cantilevers in response to cardiomyocyte contraction, a more direct representation of how cardiotoxicity affects the functionality of cardiac tissue is realized. (washington.edu)
  • found
  • In cardiomyocytes, we found that ryanodine receptors (RyRs) may be leaking and expel more Ca 2+ out from the SR. At the same time mitochondrial uptake was altered and we found that Vitamin E can restore this defect. (frontiersin.org)