Adult neural precursors. Medical search. Frequent questions

In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were specifically localized to intermediate-stage progenitor cells (IPCs), a type of transit amplifying cells. (jneurosci.org)
suggesting that progenitor cells in the embryonic and adult brain may share similar molecular phenotypes. (jneurosci.org)
Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
Neural progenitor cells: methods and protocols. (edu.au)
Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
Precursor/progenitor cells from the organ of therapeutic concern typically lack only one critical attribute--the capacity for sustained self-renewal. (nih.gov)
Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is necessary for proper neuronal differentiation and migration. (stanford.edu)
Braun S., Moss J., Toni N. , Jessberger S. "Programming hippocampal neural stem/progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury" Cell Reports , 2015 Jun 23;11(11):1679-85. (chuv.ch)

The neural plate is the source of the majority of neurons and glial cells of the CNS. (wikipedia.org)
Synaptic communication between neurons leads to the establishment of functional neural circuits that mediate sensory and motor processing, and underlie behavior. (wikipedia.org)
In the brain of adult mammals neural stem cells ensure that new nerve cells, i.e. neurons, are constantly formed. (uni-heidelberg.de)
This new type of stem cell, and not the one previously known, is primarily involved in the production of new neurons in the olfactory bulb of adult mice. (uni-heidelberg.de)
They were once believed to form the precursor cells that then differentiate in the olfactory bulb of mice into interneurons, nerve cells that modulate stimuli transmission between interconnecting neurons. (uni-heidelberg.de)
Introduction: The adult mammalian brain retains neural stem cells (NSCs) that continually generate new neurons within two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus (HC). (uni-marburg.de)
Cell proliferation ceased, and differentiation into electrophysiologically active neurons and other CNS cell types in vivo ensued upon transplantation into rats, both during development and after adult injury--with functional improvement and without neoplasia, overgrowth, deformation, emergence of non-neural cell types, phenotypic or genomic instability, or need for immunosuppression. (nih.gov)
The major niche for generation of new neurons in adult brain surrounds the lateral ventricles. (fapesp.br)
Toni N ., Song H., Ming GL "Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain", PNAS 2015 July 13. (chuv.ch)
D: Coronal view showing the adult mouse subgranular zone (SGZ) and the newborn neurons (red) being integrated in the granular cell layer (gr). (wjgnet.com)
Neural precursor cells (NPCs) transplanted into the adult neocortex generate neurons that synaptically integrate with host neurons, supporting the possibility of achieving functional tissue repair. (academic-accelerator.com)
In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)

Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). (jneurosci.org)
These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex. (jneurosci.org)
Adult hippocampal neurogenesis is a constitutive but highly regulated process that occurs in a neurogenic niche, the subgranular zone (SGZ) of the dentate gyrus (DG). (jneurosci.org)
The functional significance of adult neurogenesis is currently not well understood. (jneurosci.org)
Madrid LI, Bandhavkar S, Hafey K, Jimenez-Martin J, Milne M, Coulson EJ, Jhaveri DJ (2022) Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis. (atsbio.com)
Summary: This work reveals stage-specific roles of cholinergic signaling in regulating functionally relevant adult hippocampal neurogenesis. (atsbio.com)
This process, known as adult neurogenesis, helps mice maintain their sense of smell. (uni-heidelberg.de)
Adult neurogenesis in the orex. (uni-marburg.de)
This process is called adult neurogenesis. (uni-marburg.de)
However, our knowledge is still insufficient to exploit adult neurogenesis for controlled brain repair or for stimulation of its physiological function. (uni-marburg.de)
Aim: We aimed to study the possible role of the protein orexin in the regulation of adult neurogenesis in the orexin/ataxin-3 mouse. (uni-marburg.de)
Study design: Adult neurogenesis in the SGZ, SVZ and rostral migratory stream (RMS), where the cells migrate from the SVZ to the olfactory bulb (OB), was studied by immunohistology. (uni-marburg.de)
We show that Ankrd11 is expressed in the embryonic cortex, and that when it was knocked-down in murine cortical precursors this caused decreased proliferation, reduced neurogenesis, and aberrant neuronal positioning in developing cortex. (springeropen.com)
After the description of the chemistry and pharmacokinetics of HTyr and OLE, we summarize studies reporting their effects in in vivo and in vitro models of neurodegenerative diseases of the central/peripheral nervous system, adult neurogenesis and depression, senescence and lifespan, and age-related skeletal muscle disorders, as well as their impact on the composition of the gut microbiota. (bvsalud.org)

Rockenstein E, Torrance M, Adame A, Mante M et al (2007) Neuroprotective effects of regulators of the glycogen synthase kinase-3 beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. (springer.com)
The APP gene provides instructions for making a protein called amyloid precursor protein. (medlineplus.gov)
Little is known about the function of amyloid precursor protein. (medlineplus.gov)
Amyloid precursor protein is cut by enzymes to create smaller fragments (peptides), some of which are released outside the cell. (medlineplus.gov)
Two of these fragments are called soluble amyloid precursor protein (sAPP) and amyloid beta (β) peptide. (medlineplus.gov)
The most common APP gene variant changes one of the protein building blocks (amino acids) in the amyloid precursor protein. (medlineplus.gov)
These variants change single amino acids in the amyloid precursor protein. (medlineplus.gov)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

Adult NPCs are particularly enriched in the subventricular zone, in the dentate gyrus, and potentially also in the hypothalamus. (sanbio.nl)
In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)
These neural stem cells are located in the subventricular zone near the lateral cerebral ventricle. (uni-heidelberg.de)
Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone. (stanford.edu)
Here, we show that ependyma-derived matricellular protein CCN1 (cellular communication network factor 1) negatively regulates niche capacity and NSC number in the adult ventricular-subventricular zone (V-SVZ). (stanford.edu)
During development, neural stem cells (NSCs) undergo transitions from neuroepithelial cells to radial glial cells (RGCs), and later, a subpopulation of slowly dividing RGCs gives rise to the quiescent adult NSCs that populate the ventricular-subventricular zone (V-SVZ). (stanford.edu)
A: Sagittal view showing the adult mouse subventricular zone (SVZ) and the migrating neuroblasts (red) reaching the olfactory bulb (OB) through the rostral migratory stream (rms). (wjgnet.com)

Recent studies have reported that taurine causes increased proliferation of neural stem/progenitor neural cells (neural precursor cells, NPCs) obtained from embryonic and adult rodent brain. (nih.gov)
Results: We found a significantly higher proliferation of stem/precursor cells in the orexin/ataxin-3 mice in both neurogenic regions, the SGZ and the SVZ. (uni-marburg.de)
Conclusion: In the absence of orexin in the adult mouse brain, the proliferation of adult neural stem/precursor cells was increased, the survival rate was significantly increased in the granular zone of the OB and a consistent not significant trend was seen in the HC. (uni-marburg.de)
Adult ependyma-specific deletion of Ccn1 transiently enhanced NSC proliferation and reduced neuronal differentiation in mice, increasing the numbers of NSCs and NSC units. (stanford.edu)
Decreased proliferation of embryonic and adult neural precursors and neuronal mispositioning were also observed in Yoda mice carrying a point mutation in the histone deacetylase (HDAC)-binding domain of Ankrd11. (springeropen.com)
Finally, the Ankrd11 knockdown-mediated decrease in precursor proliferation was rescued by inhibiting histone acetyltransferase activity or expressing HDAC3. (springeropen.com)
CA1 precursors displayed a greater proliferation capacity than dentate gyrus precursors. (hal.science)

What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
NSCs and neural progenitors are often regarded as neural precursors (NPCs). (sanbio.nl)

Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
Symmetric division of NSCs maintains the population of undifferentiated NSCs, while asymmetric division gives rise to neural progenitors. (sanbio.nl)
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
Adult neural stem cells (NSCs) reside in specialized niches, which hold a balanced number of NSCs, their progeny, and other cells. (stanford.edu)
Here we show that VCAM1, a transmembrane protein previously found in quiescent adult NSCs, is expressed by a subpopulation of embryonic RGCs, in a temporal and region-specific manner. (stanford.edu)
This in turn diminished the embryonic origin of postnatal NSCs, resulting in loss of adult NSCs and defective V-SVZ regeneration. (stanford.edu)
A: Schematic of DNA methylation and histone modifications in neural stem cells (NSCs). (wjgnet.com)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)

Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. (nature.com)
Upon demyelination, new oligodendrocyte precursor cells (OPCs) and OLs can be generated and partial myelin repair can take place ( Franklin & Ffrench-Constant, 2017 ). (biorxiv.org)

As the embryo develops, the anterior part of the neural tube expands and forms three primary brain vesicles, which become the forebrain (prosencephalon), midbrain (mesencephalon), and hindbrain (rhombencephalon). (wikipedia.org)
Knockdown of Ankrd11 in human forebrain neural precursors phenocopied Ankrd11 knockdown in murine neural precursors. (springeropen.com)
2009) Prolonged voluntary exercise promotes neural precursor activity in the hippocampal and forebrain stem cell niches of adult CD1 mice. (umontreal.ca)

Our preliminary data suggests that grafting interneuron precursors into the postnatal rodent brain allows for up to a 35% increase in the number of cortical interneurons. (ca.gov)

Figure 1 The neurogenic niches in the adult murine mammalian brain. (wjgnet.com)

Experiments were also conducted to assess the responses of Tbr2+ cells to neurogenic stimuli, with the goal of understanding how Tbr2+ IPCs contribute to neuron production in the adult DG. (jneurosci.org)
Towards the therapeutic development of inhibitory neuron precursor transplantation for human neurological disorders, we have made significant progress in the differentiation of these cells from human ESCs and will complete optimization of this protocol. (ca.gov)
Our discovery that another stem cell type exists in the mouse brain of adult animals throws new light on the processes of neuron formation," emphasises Dr Ciccolini. (uni-heidelberg.de)

F: Confocal images showing immunostaining in the DG for the astrocyte marker GFAP in green, for the progenitor precursor marker T-box brain protein 2 (TBR2) in red and for the neuronal precursor marker Doublecortin (DCX) in red. (wjgnet.com)

The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. (wikipedia.org)
The spinal cord constitutes an excellent model system for studying development and regeneration of a functional nervous system, from specification of its precursors to circuit formation. (biologists.com)
These adult brain cells, neural precursor cells, can only evolve into cells of the nervous system. (sci-info-pages.com)
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. (peprotech.com)
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. (edu.au)

Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
we conditionally induced self-renewal efficiently within neural progenitors solely by introducing v-myc tightly regulated by a tetracycline (Tet)-on gene expression system. (nih.gov)

Thus, Ankrd11 is a crucial epigenetic regulator of neural development that regulates histone acetylation and gene expression, thereby providing a likely explanation for its association with cognitive dysfunction and ASD. (springeropen.com)

Neural stem cells have long lives, much of which they spend in a quiescent state. (elifesciences.org)

Sandström J., Eggermann E., Charvet I., Roux A., Toni N ., Greggio C., Broyer A., Monnet-Tschudi F., Stoppini L. "Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing. (chuv.ch)

Early postnatal cerebellar granule cell precursors (GCPs) of this model show, in consequence of the deletion of Tis21, a defect of the Cxcl3-dependent migration. (bvsalud.org)

it influences the behavior of neural precursors. (wikipedia.org)
We have also compared the behavior of primary fetal cells to these human interneuron precursor-like cells both in vivo and in vitro. (ca.gov)
As we continue to optimize our ES cell differentiation protocol, these primary interneuron precursors will enable initial human cell dose response and behavior experiments and, along with rodent-derived cells, will provide important baseline measures. (ca.gov)
Krieger JP, Asker M, Van der Velden P, Börchers S, Richard JE, Maric I, Longo F, Singh A, De Larigue G, Skibicka KP (2022) Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior. (atsbio.com)

Reporting in the January issue of Developmental Dynamics, Northwestern researchers Hans-Georg Simon and Stuart Stock showed that bone formation in a regenerated forelimb combines elements of embryonic development and of adult wound healing. (scienceblog.com)

These results suggest that CA1 precursors are more stem-cell-like than granule cell precursors, which may represent a more restricted precursor cell. (hal.science)
About 30% of medulloblastomas (MBs), a tumor of the cerebellum, arise from cerebellar granule cell precursors (GCPs) undergoing transformation following activation of the Sonic hedgehog (Shh) pathway. (bvsalud.org)

Transplantation of interneuron precursors therefore holds therapeutic potential for treatment of human neurological diseases involving an imbalance in circuit inhibition/excitation. (ca.gov)
During this first year, we have made considerable headway in the optimization of the human interneuron precursor differentiation protocol, verified functional engraftment of these cells in mice, and begun to collect dose, safety and efficacy data for rodent-derived interneuron transplantation. (ca.gov)

Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

In the present article we investigated the properties of CA1 and dentate gyrus cell precursors in adult rodents both in vivo and in vitro. (hal.science)
Thus, we compared the renewal- expansion and multipotency of dentate gyrus and CA1 precursors isolated in vitro. (hal.science)

C: SVZ neural stem cell (NSC) cultures in self-renewal (neurosphere formation) and differentiation. (wjgnet.com)

These dosing and safety data will then serve as the baseline for comparison with human interneuron precursors and inform design of preclinical studies of these cells in immunosuppressed mice. (ca.gov)
Scientists at Toronto University and the Toronto Western Research Institute of Canada managed to reduce some of the paralysis of rats with spinal cord injury with cells transplanted from adult mice brain cells. (sci-info-pages.com)
Brain cells from adult mice were implanted into the spinal cords of the rats at two and eight weeks after injury. (sci-info-pages.com)
These adult mice brain cells, when implanted into the spinal cord, create a sheath (kind of insulation) around the nerve fibers - very much like the plastic insulation you find around electric cables in your home. (sci-info-pages.com)
We used Long-Evans rats and C57Bl6 and GFAP:GFP mice, adults. (fapesp.br)

2014 ) A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats. (neurotree.org)

The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals. (wikipedia.org)

Gebara E., Bonaguidi M., Beckervordersandforth R., Sultan S., Udry F., Gijs P., Lie C., Ming G., Song H., Toni N . "Morpho-functional characterization of adult neural hippocampal stem cells reveals two morphotypes of radial glia-like cells. (chuv.ch)
DarkASDNet: Classification of ASD on Functional MRI Using Deep Neural Network. (cdc.gov)

Integrating Patient Data Into Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review. (cdc.gov)

The majority of BrdU-labeled cells in CA1 expressed Nestin and Mash-1, two markers of neural precursors. (hal.science)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders including limb paresis and paralysis, balance and vision disorders, and seizures, and in humans other disorders such as Rett syndrome, Down syndrome and intellectual disability. (wikipedia.org)
The Alvarez-Buylla lab at UCSF is part of a collaboration that is pioneering the investigation of therapeutic interneuron replacement for the correction of neurological disorders arising from defects in neural excitation/inhibition. (ca.gov)
Infants born to overweight and obese women are at increased risk for neural tube defects (12), large for gestational age (13), childhood obesity (14), and type 2 diabetes in adulthood (15). (cdc.gov)

it is not surprising that key objectives of Healthy People 2020 target improving physical activity levels in both children and adults. (diabetesjournals.org)
Dugan EA, Jergova S, Sagen J. ( 2020 ) Mutually beneficial effects of intensive exercise and GABAergic neural progenitor cell transplants in reducing neuropathic pain and spinal pathology in rats with spinal cord injury. (neurotree.org)

Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. (peprotech.com)

The myelin sheath provides insulation for the nerve impulse when communicating between neural systems. (wikipedia.org)
During the reporting period, we have developed methods to enable the optimization of inhibitory nerve precursor cell, or MGE cell, derivation from human pluripotent stem cells (hPSCs). (ca.gov)
They were long considered to be the only stem cell population in the adult mouse brain as well as the main driver of nerve cell formation," explains Dr Ciccolini. (uni-heidelberg.de)

Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
In Situ Prevascularization Strategy with Three-Dimensional Porous Conduits for Neural Tissue Engineering. (academic-accelerator.com)

The goal of the research in progress here is to ultimately prepare human interneuron precursors for clinical trials. (ca.gov)
Together, these data will provide essential information for developing a plan for clinical trials using human interneuron precursors. (ca.gov)
The experiments underway will yield insights that will be critical to the development of a clinical trial using human interneuron precursors. (ca.gov)
Biologists have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson's disease. (scienceblog.com)

Several cancers produce proteins that are physiologically expressed in utero by embryonic and fetal cells but not expressed by normal adult cells. (medscape.com)

Because the neural tube gives rise to the brain and spinal cord any mutations at this stage in development can lead to fatal deformities like anencephaly or lifelong disabilities like spina bifida. (wikipedia.org)
During this time, the walls of the neural tube contain neural stem cells, which drive brain growth as they divide many times. (wikipedia.org)
Unlike previous experiments which managed to ease paralysis in laboratory animals, this research managed to do it with adult brain cells, rather than embryonic stem cells (or cells from fetuses). (sci-info-pages.com)
Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain. (thermofisher.com)
The Heidelberg scientists also found out that both stem cell types and precursor cells in the mouse brain communicate with one another via so-called notch interactions. (uni-heidelberg.de)
Thus, ependyma-derived CCN1 restricts NSC expansion in the adult brain to maintain the proper niche capacity of the V-SVZ. (stanford.edu)

Our goal is to decipher the highly diverse functions of vitamin A, its active derivatives (retinoic acids), and the corresponding nuclear receptors (RARs/RXRs), in neural development, aging, and in stem cell control. (igbmc.fr)
Our studies of specific retinoid receptors and bioactive metabolites in control of diverse biological processes should contribute to a better understanding of the mechanisms underlying development and function of specific cell types and relevant neural circuits. (igbmc.fr)
The recent EMBO workshop 'Spinal cord development and regeneration' held in Sitges, a pleasant Spanish Mediterranean town, highlighted the spinal cord as a complex and accessible model system in which to analyse neural circuit formation and repair. (biologists.com)
SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. (thermofisher.com)
National data indicate that more than one-third of American adults are obese, an alarming figure that has far-reaching implications for development of weight-related chronic conditions in an aging society. (diabetesjournals.org)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)

Sanchez-Pascual I., O'Laoi R., El M'Ghari I., Kocher-Braissant J., Ellisman MH, Toni N . "Fine processes of Nestin-GFP positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature. (chuv.ch)
Differential properties of dentate gyrus and CA1 neural precursors. (hal.science)

Also, expression and histone acetylation of Ankrd11 target genes were altered in Yoda neural precursors. (springeropen.com)

Remarkably, the same TF cascade was found to be linked to stages of neuronal lineage progression in adult SGZ. (jneurosci.org)

May 9, 2018 - In a new paper, an international team led by scientists at University of California San Diego School of Medicine describe successfully grafting induced pluripotent stem cell (iPSC)-derived neural precursor cells back into the spinal cords of genetically identical adult pigs with no immunosuppression efforts. (ucsd.edu)

A Combination Therapy Promotes Quipazine-induced Weight-supported Stepping in Spinalized Adult Rats. (neurotree.org)

Neurocase: The Neural Basis of Cognition. (ed.ac.uk)

They used genetically modified animals whose neural stem cells were dyed green using a dye active in the cell nucleus. (uni-heidelberg.de)

Pheochromocytomas occur in both children and adults. (medscape.com)

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