The expression of the PNUTL1 protein was also evaluated by immunohistochemistry on normal pancreas, additional 26 PETs, eight pancreatic adenocarcinomas, one mixed endocrine-exocrine pancreatic neoplasm, a specimen of solid papillary pseudomucinous tumor, an adult islet cell hyperplasia and a case of neonatal nesidioblastosis. (core.ac.uk)
Hyperplasia1
citation needed] In recent years, the term has been revived to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery. (wikipedia.org)
Pancreatic5
Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive insulin production by pancreatic beta cells that have an abnormal microscopic appearance. (wikipedia.org)
By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1980s it was used as a synonym for what is now referred to as congenital hyperinsulinism. (wikipedia.org)
Most congenital hyperinsulinism is now known to be caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern, and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features of nesidioblastosis were sometimes seen in pancreatic tissue from normal infants and even from adults, and are therefore not consistently associated with hyperinsulinemic hypoglycemia. (wikipedia.org)
Once the diagnosis of nesidioblastosis was established, a sub-total pancreatectomy was performed, and the patient was discharged and placed on acarbose, a competitive reversible inhibitor of pancreatic α-amylase and intestinal brush border α-glucosidases which slows carbohydrate absorption. (bioscientifica.com)
It is rare, but the true frequency is not known, and pathology specimens show nesidioblastosis (hypertrophy of pancreatic beta cells). (msdmanuals.com)
is a hyperinsulinemic hypoglycemia that develops sometimes years after bariatric (especially roux-en-Y gastric bypass) surgery. (msdmanuals.com)
Congenital hyperinsulinism (H.I.), also referred to as persistent hyperinsulinemic hypoglycemia of infancy (PHHI), or less commonly as nesidioblastosis, is a rare autosomal recessive genetic defect occurring in the Ashkenazic Jewish population, among others. (forward.com)
Diffuse1
The key diagnostic clue to identifying nesidioblastosis is a positive selective arterial calcium stimulation test, showing a diffuse pattern of increased basal hepatic venous insulin concentration, whereas insulinomas would show focal increases. (bioscientifica.com)
The incidence is 0.1-0.3% of all post Roux-en-Y gastric bypass patients. (bioscientifica.com)
With the prevalence of obesity increasing and more patients turning to Roux-en-Y gastric bypass, more patients may be at risk of this potential surgical complication. (bioscientifica.com)
There is limited information about Off-Label Guideline-Supported Use of Diazoxide in adult patients. (wikidoc.org)
Children2
A non-profit dedicated to improving the lives of children, adults, and families living with congenital hyperinsulinism. (jscreen.org)
Our Kaiser wrongful death specialists brought a Kaiser Permanente Arbitration claim on behalf of the surviving husband and two adult children of a 58-year-old Permanente member who died from an untreated pulmonary embolism. (walkuplawoffice.com)
Years2
Adult-onset nesidioblastosis is a rare complication of Roux-en-Y gastric bypass surgery and may occur months to years after the initial surgical procedure. (bioscientifica.com)
Most birds with APP were adult (age range of 1.5 months to 15.75 years old). (vin.com)
Hyperinsulinemic Hypoglycemia6
Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive insulin production by pancreatic beta cells that have an abnormal microscopic appearance. (wikipedia.org)
Most congenital hyperinsulinism is now known to be caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern, and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features of nesidioblastosis were sometimes seen in pancreatic tissue from normal infants and even from adults, and are therefore not consistently associated with hyperinsulinemic hypoglycemia. (wikipedia.org)
Nesidioblastosis, or the more recent and accurate terms congenital hyperinsulinism or persistent hyperinsulinemic hypoglycemia of infancy, presents shortly after birth with symptoms of hypoglycemia (eg, hunger, jitteriness, lethargy, apnea, seizures). (medscape.com)
Post-bariatric surgery hypoglycemia is a hyperinsulinemic hypoglycemia that develops sometimes years after bariatric (especially roux-en-Y gastric bypass) surgery. (msdmanuals.com)
Hyperinsulinism4
By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1980s it was used as a synonym for what is now referred to as congenital hyperinsulinism. (wikipedia.org)
citation needed] In recent years, the term has been revived to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery. (wikipedia.org)
Postprandial hypoglycaemia can be an indicator of either endogenous hyperinsulinism linked to non-insulinoma pancreatogenic hypoglycaemia syndrome (NIPHS, unknown incidence in adults) or very rarely, inherited fructose intolerance. (nih.gov)
We experienced a female infant of 3 months old who has suffered from persistent hypoglysemia due to hyperinsulinism and was suspected nesidioblastosis for ' its cause clinically. (koreamed.org)
Hypoglycaemia3
13. Nesidioblastosis--a rare cause of hypoglycaemia in adults. (nih.gov)
In non-diabetic adult patients, hypoglycaemia may be related to drugs, critical illness, cortisol or glucagon insufficiency, non-islet cell tumour, insulinoma, or it may be surreptitious. (nih.gov)
In both adults and children, hypoglycaemia can be clinically classified according to its timing. (nih.gov)
Surgical2
The early surgical management is satisfactory to this goal in nesidioblastosis and maintains normal blood sugar level without administration of drugs or supplement of sugar postperatively in many cases. (koreamed.org)