Adult mice inbred c57bl. Medical search. Frequent questions

One of the first INBRED MOUSE STRAINS to be sequenced. (uchicago.edu)
Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains. (sciencedaily.com)
Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains," said project leader Helene Benveniste, who is a researcher in Brookhaven's medical department and a professor of anesthesiology at Stony Brook University. (sciencedaily.com)
Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. (wikipedia.org)
Treatment of both strains with exogenous IFN before and during viral infection led to an increase in survival time in C57BL/6 mice, but all animals of both strains ultimately succumb to SeV caused disease. (wikipedia.org)
Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)
There are over 400 documented inbred strains of mice. (uwm.edu)
Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. (musc.edu)
Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. (musc.edu)
Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. (musc.edu)
Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
characterise several novel Rag1 −/− mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. (biologists.com)

In humans, CX3CR1int CD8+ T cells were strongly induced following adenovirus-vectored vaccination for hepatitis C virus (HCV) (ChAd3-NSmut) and during natural CMV infection and were associated with a memory phenotype similar to that in mice. (ox.ac.uk)
These data indicate that CX3CR1int cells form an important component of the memory pool in response to persistent viruses and vaccines in both mice and humans. (ox.ac.uk)

Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)

Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice. (musc.edu)
No differences in the rate of synapse elimination were detected in unoperated Wlds compared with CBA, C3H/HE and BALB/c mice. (elsevierpure.com)

We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. (nih.gov)
We explored which genes are actively transcribed in the regions of controversial ancestry in a representative bird (chicken) and mammal (mouse) at adult stages. (ox.ac.uk)
Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)

This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
One naturally occurring genetic defect in mice results in an animal with no hair that is called a nude. (uwm.edu)
Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. (musc.edu)
Chaum E, Winborn CS, Bhattacharya S 2015 Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. (genenetwork.org)
Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)
We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. (researchsquare.com)
Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. (biomedcentral.com)
background genetic variation in this mouse population (i.e., mixed C57BL/6 and DBA/2J strain). (studyres.com)

Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)

The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, and contains data on 20 segmented structures, including variability of brain structures across the strain, and downloadable visualization tools. (sciencedaily.com)
Degeneration of motor terminals after nerve section occurs much more slowly than normal in young adult mice of the C57Bl/Wlds strain. (elsevierpure.com)
The similarity strain-typing panels of wild-type mice with brain material from between BSE and vCJD was shown by experimental human vCJD case-patients from France, the Netherlands, transmission of the 2 diseases into standard panels of Italy, and the United States. (cdc.gov)
The strain properties of vCJD and BSE have been occurred from each sample tested, and data were similar extensively characterized in these sets of mice by using between non-UK and UK cases, with the exception of the a combination of the order in which each strain of mouse ranking of mean clinical incubation times of mouse lines. (cdc.gov)
Variant Creutzfeldt-Jakob disease (vCJD) is an acquired strain in the RIII, C57BL, and VM mice, whereas in the transmissible spongiform encephalopathy (TSE), FVB mice, both diseases exhibit the same pattern of PrPSc or prion disease, that results in a fatal neurodegenerative deposition ( 3-5 ). (cdc.gov)

Expression of LRH-1 mRNA in juvenile (30 days old) and adult (60 days old) mouse brain was examined using non-radioactive in situ hybridization with digoxigenin labeled cRNA probes and with RT PCR using specific primers. (nel.edu)

Enduring influences of peripubertal/adolescent stressors on behavioral response to estradiol and progesterone in adult female mice. (umassmed.edu)
Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. (musc.edu)
In all three cases, the Court drew on scientific studies of the adolescent brain in concluding that adolescents, by virtue of their inherent psychological and neurobiological immaturity, are not as responsible for their behavior as adults. (harvard.edu)
And yet, to adults, the adolescent mind is a mystery-a Brigadoon-like place that's at once vivid and inaccessible. (harvard.edu)

We produced a 75.2-Mb high-quality draft genome assembly from a clinically isolated adult male T. trichiura using Illumina technology. (nature.com)
Young male C57BL/6Js who were alone drank roughly the same amount as adult males. (harvard.edu)

Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice. (oregonstate.edu)

The development of a pyramidotomy lesion model in mice, together with behavioural tests which can reliably measure functional impairments, will provide a valuable tool for assessing therapeutic strategies to promote regeneration and plasticity. (nih.gov)
Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. (ox.ac.uk)

Using single-cell qRT-PCR and clonal analyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium all sharing stem cell antigen-1 (Sca1), based on side population (SP) phenotype, PECAM-1 (CD31) and platelet-derived growth factor receptor-α (PDGFRα) expression. (ox.ac.uk)
In mice, both CMV and vaccine-induced inflationary T cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools, in early memory. (ox.ac.uk)
Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF1 KO mice. (researchsquare.com)

Using a diet-induced obesity model, we show that TLR3-deficient mice had enhanced glycemic control, facilitated by elevated insulin secretion. (ox.ac.uk)
Active and inactive (or total) incretin plasma concentrations, plasma DPP-4 activity, and preproglucagon (GCG) gene expression were determined after administration of each agent alone or in combination to mice with diet-induced obesity (DIO) and to healthy human subjects. (ku.dk)
Inbred for the purposes of experimentation, they exhibit a number of infelicitous traits, including a susceptibility to obesity, a taste for morphine, and a tendency to nibble off their cage mates' hair. (harvard.edu)

In addition, recombinant inbred lines can provide both replicates from genetically identical individuals and samples from different segregants. (biomedcentral.com)
It was shown that resistance to the lethal effects of Sendai virus in mice is genetically controlled and expressed through control of viral replication within the first 72 hours of infection. (wikipedia.org)
Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. (musc.edu)

To overcome these limitations, novel tools are arising, fostering a new avenue in the study of the mouse naturalistic behavior. (eneuro.org)
We combined novel technical advancements of system neuroscience with a traditional ethology-based behavioral observation to design a simple computational tool for behavior detection in freely moving mice. (eneuro.org)
As with any behaving animal, naturalistic mouse behavior incorporates innate strategies to balance explorative and aversive responses to the surrounding environment. (eneuro.org)
Neuroscientists often exploit this dichotomy to design behavioral tests assessing mouse emotional behavior. (eneuro.org)

Age- and sex-related differences in alcohol and nicotine effects in C57BL/6J mice. (musc.edu)

In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)

In contrast, FXGs are found in rats throughout life in both hippocampal and olfactory bulb circuits while recapitulating the developmental downregulation in other forebrain regions seen in mice. (biorxiv.org)
Further, the absence of USF1 did not lead to alterations of adult hippocampal neural progenitor cell proliferation, differentiation, or survival. (researchsquare.com)

The work was done in parallel with an international collaboration, the Mouse Phenome Database (MPD) project, which was created to establish a collection of baseline phenotypic data from commonly used inbred mice. (sciencedaily.com)
The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)
It commonly presents itself in the distal limbs (fingers, hands, forearms, or feet) of young adults as a small, soft mass or a series of bumps. (studyres.com)
They typically stain positive for CA125.Epithelioid sarcoma most commonly strikes young adults, yet no age group is immune. (studyres.com)

FXGs were previously identified in mouse, rat, and human brains in a conserved subset of neuronal circuits but with species-dependent developmental profiles. (biorxiv.org)

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. (ox.ac.uk)
Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. (ox.ac.uk)
We have previously shown that murine postmitotic rod photoreceptor precursor cells, identified by expression of the rod-specific transcription factor Nrl, are able to migrate into and integrate within the adult murine neural retina. (ox.ac.uk)
Half of the test mice were four weeks old, which, in murine terms, qualifies them as adolescents. (harvard.edu)

Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)

Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)

Mice quickly habituate to tunnel handling and can subsequently be restrained by the scruff or tail base for procedures or health and welfare assessments without negating the positive impacts of the non-aversive capture. (uwm.edu)
Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice. (musc.edu)

Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice. (musc.edu)
For adults, but not adolescents, recruitment of the basal ganglia during presentation of a filtering cue was associated with neural and behavioral indices of successful filtering, suggesting that WM filtering and related basal ganglia function may still be maturing throughout adolescence and into adulthood. (harvard.edu)
Every adult has gone through adolescence, and studies have shown that if you ask people to look back on their lives they will disproportionately recall experiences they had between the ages of ten and twenty-five. (harvard.edu)

LRH-1 is strongly expressed throughout the mouse brain suggesting important roles for this transcription factor, although its precise roles in the CNS remain to be elucidated. (nel.edu)

At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)

In mice, FXGs are found in the olfactory bulb throughout life but in other forebrain regions are only found in juvenile animals during periods of robust experiencedependent circuit refinement. (biorxiv.org)

Autophagy, a process known to prevent aging, is critical for the maintenance of immune memory in mice. (ox.ac.uk)

Genetical genomics is further enhanced by using recombinant inbred lines as a mapping population. (biomedcentral.com)

Forced swim stress increases ethanol consumption in C57BL/6J mice with a history of chronic intermittent ethanol exposure. (musc.edu)

Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)

The virus is responsible for a highly transmissible respiratory tract infection in mice, hamsters, guinea pigs, rats, and occasionally marmosets, with infection passing through both air and direct contact routes. (wikipedia.org)

Researchers at the US Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse. (sciencedaily.com)
Researchers at the U.S. Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse (see http://www.bnl.gov/CTN/mouse/ ). (sciencedaily.com)
Oct. 15, 2021 Researchers have created an atlas of metabolites in the mouse brain. (sciencedaily.com)
High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
CONCLUSIONS: Dietary n-3 PUFA-deficiency in early life exhibits more aggravated MPTP-induced neurotoxicity in old age, than DHA/EPA-PLs supplementation recovers brain DHA levels and exerts neuroprotective effects in old age in long-term n-3 PUFA-deficient mice, which might provide a potential dietary guidance. (bvsalud.org)
Chronic intermittent ethanol exposure and withdrawal alters (3a,5a)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice. (musc.edu)
Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (musc.edu)
Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain. (researchsquare.com)
Widespread expression of liver receptor homolog 1 in mouse brain. (nel.edu)
The distribution of Liver receptor homolog 1 (LRH-1) mRNA was studied in mice brain with the aim to establish whether this nuclear hormone receptor is expressed also in the brain in addition to liver and classical steroidogenic tissues. (nel.edu)
Grgurevic N, Tobet S, Majdic G. Widespread expression of liver receptor homolog 1 in mouse brain. (nel.edu)
However, differences in incubation times require further (PrPSc) in the brain, and glycosylation pattern of PrPSc as subpassage in mice to establish any true differences in assessed by Western blot analysis. (cdc.gov)

Epizootic infections of mice are usually associated with a high mortality rate, while enzootic disease patterns suggest that the virus is latent and can be cleared over the course of a year. (wikipedia.org)
Only 10% mortality rate was observed in C57BL/6 mice after the administration of very high virulent dose of 1*105 TCID50. (wikipedia.org)

Here, we report that mouse haESCs can differentiate in vitro into haploid epiblast stem cells (haEpiSCs), which maintain an intact haploid genome, unlimited self-renewal potential, and durable pluripotency to differentiate into various tissues in vitro and in vivo. (refine.bio)

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris . (nature.com)
Here we present high-quality genome sequences for T. trichiura and T. muris , the first duo of a major human STH and its mouse counterpart. (nature.com)
In parallel, multiple technologies and manual finishing were used to produce an 85-Mb reference genome assembly from the more readily available mouse parasite species T. muris (Online Methods and Supplementary Note ). (nature.com)

Using a cued WM filtering task ( McNab & Klingberg, 2008 ), we investigated neural activity during WM filtering in a sample of 64 adults and adolescents. (harvard.edu)

To study this aspect in freely behaving mice, neuroscientists have relied on the observation of ethologically relevant bodily cues to infer the affective content of the subject, both in neutral conditions or in response to a stimulus. (eneuro.org)
In this work we developed a computational tool [stimulus-evoked behavioral tracking in 3D for rodents (SEB3R)] to automate and standardize an ethologically driven observation of freely moving mice. (eneuro.org)

Evidence is mounting to suggest that multiple decision processes are tuned differently in adolescents and adults including reward reactivity, uncertainty-tolerance, delay discounting, and experiential assessments of value and risk. (harvard.edu)

Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. (musc.edu)

The mean number of terminals per triangularis sterni muscle fibre 7 days after birth was 1.55 +/- 0.07 in Wlds and 1.56 +/- 0.09 in wild-type mice. (elsevierpure.com)

Using RNA sequencing data from whipworm-infected mice, we describe the regulated T helper 1 (T H 1)-like immune response of the chronically infected cecum in unprecedented detail. (nature.com)
Gene expression data from mice with low-dose whipworm infection provide a detailed description of a regulated T H 1-like immune response to the infected cecum that is not limited to the immediate site of infection. (nature.com)
These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)

Using a tunnel or cupped hand to pick up mice causes less anxiety than traditional tail handling. (uwm.edu)

Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)
We argue that new technologies will enable insights into how specific models align with human disease states and that this knowledge can be used to develop a diverse ecosystem of complementary mouse models of cancer. (biologists.com)
Thus, careful characterisation and judicious use of an array of mouse models provides an opportunity to address some of the issues surrounding both the reproducibility and translatability crises often referenced in pre-clinical cancer research. (biologists.com)
To unravel complexity, we rely on models recapitulating key features of disease under investigation, and mice have long provided a reliable model to investigate cancer. (biologists.com)

Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. (musc.edu)
However, differences in plasma and tissue exposures, and pharmacologic activity were observed compared to the adult data. (uantwerpen.be)

We have developed a pyramidotomy model in mice to lesion the corticospinal tract at the level of the brainstem pyramidal tract, and evaluated the resultant impairments in motor function in a series of behavioural tests. (nih.gov)
We studied the effects of this lesion on forepaw function using five behavioural paradigms, some of which have been widely used in rat studies but have not been fully explored in mice. (nih.gov)

The virus can be detected in mouse colonies worldwide, generally in suckling to young adult mice. (wikipedia.org)
Young mice ( pups) should be grasped by the cupping the hands around the whole body or by grasping the skin across the shoulder blades with a forceps. (uwm.edu)

With this tool we aim to automate, accelerate and standardize data collection across research laboratories, improving the quality and reproducibility of behavioral studies in mice. (eneuro.org)
The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)

In older adults, however vaccines are generally less efficacious and the molecular mechanisms that underpin this remain largely unknown. (ox.ac.uk)

Bacillary cells and stichocytes are distinctive cell types found only in clade I nematodes 5 and are located in the slender anterior part of the adult whipworm that is burrowed within the intestinal epithelium. (nature.com)
The bulbous posterior end of the whipworm lies free in the intestinal lumen and harbors the reproductive organs, giving adult Trichuris parasites their characteristic whip-like morphology. (nature.com)
The functional effects of APC (adenomatous polyposis coli gene) germ-line mutations on crypt fission and cell proliferation were investigated in the normal intestine of human familial adenomatous polyposis (FAP) and multiple intestinal neoplasia (MIN) mice. (ox.ac.uk)

These FXG properties are conserved in both mice and rats, suggesting these granules may support conserved cellular functions. (biorxiv.org)

Our data on direct platelet activation and aggregation by ASOs in adult minipig samples are remarkably comparable to human data. (uantwerpen.be)
abstract=In the field of organ transplantation, the state of thymic function has not been a major concern but data from bone marrow transplantation studies have unravel the persistence of some thymopoiesis in the adult and, more importantly, the possibility of reinducing it. (transhumanist.ru)

METHODS AND RESULTS: The PD mice induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in n-3 PUFA-adequate (N) and -deficient (DEF) group are supplemented with a DHA/EPA-PLs diet for 2 weeks (N+DPL, DEF+DPL). (bvsalud.org)
METHODS: The study included 85 nonhospitalized, symptomatic adults, who were enrolled from September 2020 to November 2021. (cdc.gov)

Accordingly, the model ASO that had been previously characterized in adult Göttingen Minipigs and NHPs showed comparable clinical chemistry and toxicity profiles in the juvenile minipigs. (uantwerpen.be)

T. muris is an established laboratory mouse model for human trichuriasis and shares with T. trichiura many aspects of its biology, including the specialized niche within the host. (nature.com)

The deployment of these new tools is already changing some paradigms and has now established that re-enactment of thymic activity in the course of bone marrow transplantation or in patients with human immunodeficiency virus on highly active anti-retroviral therapy is beneficial and that can be achieved in the adult. (transhumanist.ru)

Anatomy5

Organisms8

Chemicals and Drugs3

Phenomena and Processes6

Strains14

Humans2

Recombinant Inbred Mice2

BALB2

Genes3

Genetic8

Transgenic1

Strain5

Situ Hybridization1

Adolescent4

Male2

Metabolism1

Regeneration2

Phenotype3

Obesity3

Genetically3

Behavior4

Nicotine1

Genetics1

Hippocampal2

Commonly4

Developmental1

Murine4

Lung1

Progenitor1

Aversive2

Adolescence3

Transcription Factor1

Homeostasis1

Animals1

Aging1

Genomics1

Consumption1

MeSH1

Transmissible1

Brain12

Mortality2

Stem cells1

Genome4

Neural1

Observation2

Tolerance1

Female mice1

Wild-type mice1

Immune3

Anxiety1

Models4

Exposures2

Behavioural2

Young2

Behavioral2

Vaccines1

Intestinal3

Rats1

Data2

Methods2

Clinical1

Laboratory mouse1

Activity1