• Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampus dentate gyrus (DG) subgranular zone. (monash.edu)
  • For example, in mice, pregnancy and lactation promote proliferation of neuroblasts in the subventricular zone and adult neurogenesis in the olfactory bulb. (researchgate.net)
  • Introduction: The adult mammalian brain retains neural stem cells (NSCs) that continually generate new neurons within two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus (HC). (uni-marburg.de)
  • DESCRIPTION (provided by applicant): In the mammalian adult brain, there are two regions where stem cells continuously give rise to new neurons, a process termed neurogenesis: the subventricular zone and the subgranular zone of the dentate gyrus. (neurotree.org)
  • In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
  • It is widely accepted that new neurons are generated throughout life, which is called adult neurogenesis, in limited regions of the adult mammalian brain, such as the hippocampal dentate gyrus and subventricular zone. (jneurology.com)
  • There are many reports that adult neurogenesis occurs in the subventricular zone (SVZ) and hippocampal dentate gyrus (HDG) of mammalian brains since the 1960s 1,2 . (jneurology.com)
  • This study proposes such a mathematical model that describes adult mammalian neurogenesis occurring in the subventricular zone and the subsequent migration of cells through the rostral migratory stream to the olfactory bulb (OB). (ox.ac.uk)
  • Adult neurogenesis in songbirds is observed in brain circuits that underlie complex specialized behavior, including the song control system and the hippocampus. (wikipedia.org)
  • Adult neurogenesis in the avian brain occurs in many different pallial regions, including the song nuclei, the hippocampus, and the olfactory regions. (wikipedia.org)
  • Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). (jneurosci.org)
  • In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were specifically localized to intermediate-stage progenitor cells (IPCs), a type of transit amplifying cells. (jneurosci.org)
  • Adult-born granule cells (abGCs) project to the CA2 region of the hippocampus, but no previous studies have assigned a behavioral function to this circuit. (researchgate.net)
  • X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis. (jci.org)
  • But in the early part of the decade Elizabeth Gould, then at the Rockefeller University demonstrated that new cells arise in the adult brain -- particularly in a region called the hippocampus, which is involved in learning and memory. (delanceyplace.com)
  • Building on our previous discoveries that have uncovered distinct populations of quiescent stem/precursor cells in the adult hippocampus, I will present data unravelling their molecular signature and identifying pharmacological agents that can selectively activate these subpopulations and enhance neuronal production with the goal of utilising these to examine functional improvement in a mouse model of depression. (edu.au)
  • Taken together, our data suggest that C9ORF72 is required for synaptic plasticity and adult neurogenesis in the hippocampus and Klotho deregulations may be part of C9ORF72-mediated toxicity. (biomedcentral.com)
  • Major depressive disorder was linked with decreased neurogenesis in the hippocampus. (rug.nl)
  • Adult hippocampal neurogenesis, the process of formation of new neurons, occurs throughout life in the hippocampus. (biomedcentral.com)
  • In the adult mammalian brain few neurogenic niches that include the main and accessory olfactory bulb and the hippocampus, are maintained. (unito.it)
  • Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. (johnshopkins.edu)
  • This is nowhere more true than in the dentate gyrus, where competing forces such as neurodegeneration and neurogenesis dynamically modify neuronal connectivity, and can occur simultaneously. (frontiersin.org)
  • Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. (frontiersin.org)
  • Adult hippocampal neurogenesis is a constitutive but highly regulated process that occurs in a neurogenic niche, the subgranular zone (SGZ) of the dentate gyrus (DG). (jneurosci.org)
  • The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. (jci.org)
  • Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. (jci.org)
  • Effects of HU210 treatment on cell proliferation in the dentate gyrus in adult rats ( n = 5-7 rats in each group). (jci.org)
  • Specifically, we will use mice where the Bax pro-apoptotic gene has been deleted specifically from adult-born granule cells, as well as pharmacological strategies to increase neurogenesis in the dentate gyrus of aged mice and test whether such manipulations improve both cognitive discrimination and pattern separation. (neurotree.org)
  • Sanchez-Pascual I., O'Laoi R., El M'Ghari I., Kocher-Braissant J., Ellisman MH, Toni N . "Fine processes of Nestin-GFP positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature. (chuv.ch)
  • Study design: Adult neurogenesis in the SGZ, SVZ and rostral migratory stream (RMS), where the cells migrate from the SVZ to the olfactory bulb (OB), was studied by immunohistology. (uni-marburg.de)
  • Early developmental events involving the olfactory and limbic system start and conclude possibly slightly early in primates than rodents, and we find a comparable early conclusion of primate hippocampal neurogenesis (as assessed by the relative number of Ki67 cells) suggesting a plateau to low levels at approximately 2 years of age in humans. (figshare.com)
  • Summary: Researchers observe how adult neurons form and evolve in the olfactory bulb of mice. (neurosciencenews.com)
  • Scientists from the Institut Pasteur and the CNRS were able to make real-time observations over a period of several months that reveal how new adult-born neurons are formed and evolve in the olfactory bulb of mice. (neurosciencenews.com)
  • We are also interested in unravel the potential role of adult-born neurons in olfactory sensory processing with particular attention to olfactory experiences that are behaviourally relevant. (unito.it)
  • We previously observed persistent expression of UBE3A in the suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian regulatory region in the mammalian brain, of AS model mice 15 , thus identifying a novel site for relaxation of maternal expression bias of Ube3a in the adult brain. (nature.com)
  • Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the effects of ELA on adult female mice across the estrous cycle. (researchgate.net)
  • It is now well-established that the hippocampal CA2 region plays an important role in social recognition memory in adult mice. (researchgate.net)
  • It is fortunate that the differences are not observed in rodents," he adds, "because the majority of neurogenesis studies are performed using rats and mice. (vetscite.org)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • lt;p>There is still evidence, i.e. from mice, that neurogenesis of useful neurons does happen in some mammals. (scienceblogs.com)
  • Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. (mcgill.ca)
  • Furthermore, adult hippocampal neurogenesis was reduced in C9orf72 knockout mice. (biomedcentral.com)
  • suggesting that progenitor cells in the embryonic and adult brain may share similar molecular phenotypes. (jneurosci.org)
  • We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. (jci.org)
  • The role of p60 katanin in the mammalian brain with respect to embryonic and adult neurogenesis is poorly understood. (monash.edu)
  • New neurons are generated throughout life in distinct areas of the mammalian brain. (uzh.ch)
  • This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. (uzh.ch)
  • On 18.11.2019, Dr. Instructor The presentation on 'Regulation of adult neurogenesis in the mammalian brain', where our member Pınar Öz was a speaker, was held at Nermin Tarhan Hall between 09:00-12:01. (uskudar.edu.tr)
  • Adult neurogenesis is the process in which new neurons are born and subsequently integrate into functional brain circuits after birth and into adulthood. (wikipedia.org)
  • Neurogenesis observed in the song system brain areas is shown to be associated with the learning of new songs. (wikipedia.org)
  • The adult brain is in a continuous state of remodeling. (frontiersin.org)
  • This plasticity of the adult nervous system is particularly important in the context of traumatic brain injury or deafferentation. (frontiersin.org)
  • Early studies revealed that in response to deafferentation, axons of remaining fiber systems and dendrites of mature granule cells undergo lamina-specific changes, providing one of the first examples of structural plasticity in the adult brain. (frontiersin.org)
  • The ability of the mammalian brain to change with experience is perhaps its most important feature. (frontiersin.org)
  • The cellular and molecular landscape can impose limits on plasticity and regenerative capacity of the adult brain. (frontiersin.org)
  • This classic lesion provided some of the first evidence for structural plasticity following injury in the CNS, and also provides an opportunity to examine the injury response of some of the most highly plastic neurons in the brain, adult-generated newborn granule cells. (frontiersin.org)
  • To study the role of transcription factors (TFs), we focused on Tbr2 (T-box brain gene 2), which has been implicated previously in developmental glutamatergic neurogenesis. (jneurosci.org)
  • Chemical marker that is commonly used to identify newly generated cells in the brain may be distorting the results of studies of neurogenesis, according to research published today in The Journal of Neuroscience. (vetscite.org)
  • The technique has been used routinely for decades to identify replicating cells, and particularly to investigate neurogenesis, the generation of neurons in the developing brain. (vetscite.org)
  • It is also widely used in studies of neurogenesis in the adult mammalian brain. (vetscite.org)
  • They could, however, distort the data in studies using BrdU to quantify cell proliferation in postnatal and adult brain tissue. (vetscite.org)
  • Microglia, the resident immune cells in the CNS, have been studied extensively with regard to their roles in inflammation and disease, but less is known about their functions in the developing and adult brain ( Casano and Peri, 2015 ). (biologists.com)
  • In the mammalian brain, neurogenesis continues only in few regions of the forebrain. (cipsm.de)
  • Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
  • However, our knowledge is still insufficient to exploit adult neurogenesis for controlled brain repair or for stimulation of its physiological function. (uni-marburg.de)
  • Conclusion: In the absence of orexin in the adult mouse brain, the proliferation of adult neural stem/precursor cells was increased, the survival rate was significantly increased in the granular zone of the OB and a consistent not significant trend was seen in the HC. (uni-marburg.de)
  • Dr. Joseph Altman, who discovered neurogenesis in the adult mammalian brain, received the International Prize for Biology from His Majesty the Emperor of Japan. (swissneuroscience.ch)
  • Abstract The ventricularCsubventricular area (V\SVZ) from the mammalian human brain is a niche site of adult neurogenesis. (holyexperiment.org)
  • Adult neurogenesis, limited to particular locations in the mammalian human brain, represents perhaps one of the most interesting types of plasticity in the mature anxious system. (techuniq.com)
  • This structural plasticity reveals a unique dynamic mechanism that is vital for the regeneration and integration of new neurons within the adult brain circuit," concluded the scientists. (neurosciencenews.com)
  • We found that neurons in the brain and cells of the vascular network both express multiple genes for voltage gated Na+ and Ca2+ ion channels homologous (based on sequence) to mammalian ion channel genes. (stanford.edu)
  • Recent work, albeit mostly in rats, indicates that learning enhances the survival of new neurons in the adult brain. (delanceyplace.com)
  • In the 1990s scientists rocked the field of neurobiology with the startling news that the mature mammalian brain is capable of sprouting new neurons. (delanceyplace.com)
  • Abstract: Neurogenesis has emerged as an important cellular mechanism underpinning plasticity in the adult mammalian brain. (edu.au)
  • I will also present our recent findings that have established the basolateral amygdala as a neurogenic region in the adult brain, harbouring precursors which generate new, functional interneurons. (edu.au)
  • Toni N ., Song H., Ming GL "Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain", PNAS 2015 July 13. (chuv.ch)
  • Braun S., Moss J., Toni N. , Jessberger S. "Programming hippocampal neural stem/progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury" Cell Reports , 2015 Jun 23;11(11):1679-85. (chuv.ch)
  • This review focuses on the effects of regulating factors on cortical adult neurogenesis, such as brain damages, aging and certain drugs, and we discuss implications of cortical adult neurogenesis for brain diseases and damages. (jneurology.com)
  • U.S.A. Neurogenesis of the adult mammalian brain. (idival.org)
  • Covalent modifications of DNA at the 5-carbon position of cytosine, such as 5-methylcytosine (5mC), play significant epigenetic roles in the mammalian brain. (biomedcentral.com)
  • For a long time, the generation of new neurons in the adult mammalian brain was disputed. (rug.nl)
  • There are two major brain areas where neural stem cells are located and neurogenesis occurs. (rug.nl)
  • Our research interest is focused on the study of these neurogenic niches by tackling different aspects of the process that govern the generation and integration of new neurons into pre-existing neuronal circuits in the adult brain. (unito.it)
  • Our studies contributed to the definition of the morphological, molecular and functional features of postnatal/adult neurogenic zones, including neural stem cell niches and parenchymal progenitors, in brain homeostasis and in animal models of lesion/neurodegeneration. (unito.it)
  • Remarkably, the same TF cascade was found to be linked to stages of neuronal lineage progression in adult SGZ. (jneurosci.org)
  • Our data identify a critical role for the microtubule-severing protein katanin p60 in regulating neuronal progenitor proliferation in vivo during embryonic development and adult neurogenesis. (monash.edu)
  • In an article published in the journal Neuron , scientists from a unit at the Institut Pasteur directed by CNRS scientist Pierre-Marie Lledo provide further evidence of the highly dynamic nature of the changes observed at the neuronal level in adult brains. (neurosciencenews.com)
  • Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a life history in which controlled neurodegeneration happens simultaneously in the brains of adult zooids during a cyclical phase named takeover. (stanford.edu)
  • Using an ultrastructural and transcriptomic approach, we described neuronal death forms in adult zooids before and during the takeover phase while comparing adult zooids in takeover with their buds where brains are refining their structure. (stanford.edu)
  • During early development, neural networks are formed by a process involving neurogenesis (the generation of new neurons), and synaptogenesis (the generation of interconnections between neurons, later refined by neuronal death and pruning of neural connections). (ibe-unesco.org)
  • Some years ago, after a long period of suspicion, it was seemingly demonstrated that neurogenesis (the formation of new neurons) happened in the human nose. (scienceblogs.com)
  • We therefore examined the role of Nogo-A and NgR1 in the regulation of neurogenesis. (jneurosci.org)
  • However, the regulation of neurogenesis was complex and more research is needed to understand this completely. (rug.nl)
  • The expression of Wnt ligands and Wnt signalling components in the mature mammalian CNS suggests that this pathway might also play a part in synaptic maintenance and function. (nih.gov)
  • In addition, Wnts participate in adult neurogenesis and protect excitatory synaptic terminals from amyloid-beta oligomer toxicity. (nih.gov)
  • Thus, adult neurogenesis represents another means, apart from molecular, synaptic, or morphological changes of an individual cell, to alter the functional circuitry depending on the demand. (biomedcentral.com)
  • Recently, adult neurogenesis in the cerebral cortex is becoming clear gradually, and cortical NSCs and NPCs are identified in a few mammals. (jneurology.com)
  • In the last decade, cortical adult neurogenesis and its neural stem cells (NSCs), which are self-renewing and can generate neurons, astrocytes and oligodendrocytes, and neural progenitor cells (NPCs), which have a tendency to differentiate into certain types of neurons, have been found in the cerebral cortex of adult mammals 3 . (jneurology.com)
  • 2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
  • Neurogenesis generates various functional neural cell types from multipotent neural stem cells (NSCs) in the mammalian CNS, which participate in specific neural activities and responses [ 3 ]. (biomedcentral.com)
  • The formation of neural circuits involves the generation of neurons through a process called neurogenesis, and the subsequent formation of interconnections (synapses) between them. (ibe-unesco.org)
  • Controlled stimulation of endogenous neurogenesis might be an elegant way to treat neurodegenerative diseases. (uni-marburg.de)
  • Here, the latest insights into the function of Wnt signalling in the adult nervous system and therapeutic opportunities for neurodegenerative diseases such as Alzheimer's and Parkinson's disease are discussed. (nih.gov)
  • Neurogenesis occurs throughout the ventricular zone, but proliferation is especially high in specific locations in the lateral wall of the ventricle. (wikipedia.org)
  • If it turns out that neurogenesis occurs in the adult human nose but that those nascent neurons never enervate, well, that is what we might expect evolution, which is not intelligent but, rather, pragmatic, to come up with. (scienceblogs.com)
  • On the other hand, it remains controversial whether adult neurogenesis occurs in other regions of the central nervous system (CNS). (jneurology.com)
  • The degree of postnatal and adult neurogenesis in songbirds varies between species, shows sexual dimorphism, fluctuates seasonally, and depends on hormone levels, cell death rates, and social environment. (wikipedia.org)
  • Although the recruitment of new neurons is widespread in the avian telencephalon, songbirds exhibit particularly robust postnatal and adult neurogenesis in their song control system nuclei. (wikipedia.org)
  • Recent studies with adult-generated granule cells indicate that these cells are highly dynamic following denervation, surprisingly developing dendritic spines in the denervated zone in the absence of functional input. (frontiersin.org)
  • The functional significance of adult neurogenesis is currently not well understood. (jneurosci.org)
  • Gebara E., Bonaguidi M., Beckervordersandforth R., Sultan S., Udry F., Gijs P., Lie C., Ming G., Song H., Toni N . "Morpho-functional characterization of adult neural hippocampal stem cells reveals two morphotypes of radial glia-like cells. (chuv.ch)
  • In male rats, TRAP significantly increased hippocampal neurogenesis, while in females, TRAP increased granule cell layer width. (nature.com)
  • Even though adult neurogenesis is widespread across the telencephalon, all the regions where it is especially high are associated with the learning of new information, suggesting a possible function of adult neurogenesis to be offering an additional avenue of plasticity required during learning. (wikipedia.org)
  • Glia account for more than half of the cells in the mammalian nervous system, and the past few decades have witnessed a flood of studies that detail novel functions for glia in nervous system development, plasticity and disease. (biologists.com)
  • This did not compromise DG plasticity or spatial and contextual learning and memory tasks employed in our study, consistent with the interpretation that adult neurogenesis may be associated with selective forms of hippocampal-dependent cognitive processes. (monash.edu)
  • In mammalian species, motherhood is a critical period of neural plasticity, allowing the dam to adapt its behaviour to the demanding task of taking care of the pups. (researchgate.net)
  • While much is known about the molecular basis of hypothalamic control in mammalian energy homeostasis, neural circuit plasticity including changes in neural cell numbers has only recently been implicated in body weight regulation. (mcgill.ca)
  • Robins SC, Villemain A, Liu X, Djogo T, Kryzskaya D, Storch K-F, & Kokoeva MV "Extensive regenerative plasticity among adult NG2-glia populations is exclusively based on self-renewal" Glia, 10:1735-47. (mcgill.ca)
  • Avian species including songbirds are among vertebrate species that demonstrate particularly robust adult neurogenesis throughout their telencephalon, in contrast with the more limited neurogenic potential that are observed in adult mammals after birth. (wikipedia.org)
  • Experiments were also conducted to assess the responses of Tbr2+ cells to neurogenic stimuli, with the goal of understanding how Tbr2+ IPCs contribute to neuron production in the adult DG. (jneurosci.org)
  • The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. (cipsm.de)
  • Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. (cipsm.de)
  • Here, based on the branching process theory and biological evidence, we developed a computational model that represents the early stage hippocampal neurogenic cascade and allows prediction of the overall efficiency of neurogenesis in both normal and diseased conditions. (biomedcentral.com)
  • Emerging evidence suggests that various epigenetic mechanisms play important roles in fine-tuning and coordinating gene expression during adult neurogenesis. (johnshopkins.edu)
  • Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, as well as cross-talk among these mechanisms, in regulating different aspects of adult mammalian neurogenesis. (johnshopkins.edu)
  • We are proposing to test the hypothesis that pharmacological strategies aimed at stimulating adult hippocampal neurogenesis, may have therapeutic potential for reversing impairments in pattern separation such as those seen during normal aging and in patients with Mild Cognitive Impairment. (neurotree.org)
  • These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex. (jneurosci.org)
  • After that, using the DNA synthesis marker tritiated thymidine, Altman rediscovered the addition of new neurons in the cerebral cortex of adult rats 6 . (jneurology.com)
  • Thereafter, using a combination of autoradiography and electron microscopy, Kaplan demonstrated that new cells containing tritiated thymidine are stellate cells that have an axonal hillock, initial segment, and synapses on their dendrites and cell bodies in the cerebral cortex of adult rats 7 . (jneurology.com)
  • We also have demonstrated that cells proliferate on an ongoing basis in the adult hypothalamus, even in the absence of external cues such as growth factor administration. (mcgill.ca)
  • Comparing adult timelines when lifespans stretch from 1 year to 75 years, when underlying cellular mechanisms under scrutiny do not scale similarly, presents challenges to simple detection and comparison. (figshare.com)
  • It is believed that the basal rate of neurogenesis is genetically determined [ 29 ], but the mechanisms that govern it under various physiological and pathological stimuli are poorly understood. (biomedcentral.com)
  • The question of adult hippocampal neurogenesis has generated numerous controversies regarding its simple presence or absence in humans versus rodents, whether it is best described as the tail of a distribution centered on early neural development, or is several distinct processes. (figshare.com)
  • Here, we extend and adapt a model of the cross-species transformation of early neurodevelopmental events which presently reaches up to the equivalent of the third human postnatal year for 18 mammalian species (www.translatingtime.net) to address questions relevant to hippocampal neurogenesis, which permit extending the database to adolescence or perhaps to the whole lifespan. (figshare.com)
  • When all species are so modeled, and represented in a common time frame, the envelopes of hippocampal neurogenesis are essentially superimposable. (figshare.com)
  • Historically, the discovery of adult neurogenesis in songbirds substantially contributed to establishing the presence of adult neurogenesis and to progressing a line of research tightly associated with many potential clinical applications. (wikipedia.org)
  • In addition, adult neurogenesis may have substantially changed in evolutionary time in different taxonomic groups. (figshare.com)
  • Recent developments in bioluminescent imaging (BLI) allow direct in vivo imaging of neurogenesis, and in order to interpret the experimental results, mathematical models are necessary. (ox.ac.uk)
  • Finally, we discovered a novel signaling pathway that regulates the differentiation of adult neural stem cells into neurons (Ashton). (ca.gov)
  • 2013) "A Modular Optogenetic Platform for Inducible Protein Clustering and Signaling Activation in Mammalian Cells. (ca.gov)
  • Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. (jci.org)
  • The donors in the study died at the Karolinska Institute, he notes, and some had a history of substance abuse or psychiatric illness, both of which have been shown to decrease neurogenesis. (scienceblogs.com)
  • But, when the question comes up "Do humans generate new neurons as adults" please make sure that the assumption that they do is not based on this earlier nose research, or on any studies that merely looked for new neuron proteins. (scienceblogs.com)
  • Happily, scientists have discovered that we also have a mechanism by which we can generate new neurons throughout our lives: neurogenesis. (ibe-unesco.org)