DifferentiationRegenerativeRegenerationAmputationProliferationHomeostasisOsteogenicGeneticTransformationAcuteEmbryonicTranscriptionMaturationStem cellBiolMesenchymalKidneyCellularNeuronsInjectionSkeletalFindingsFormationTissueBrainHumansDevelopmentLargelyUnderstoodMuscleMiceTypesDiagnosticTargetImportantSingleDeath
Differentiation6
- It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types. (wikipedia.org)
- In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
- In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
- Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
- Neural control of growth and size in the axolotl limb regenerate [2] "Upon the completion of the developmental stages of regeneration, when the regenerative organ known as the blastema completes patterning and differentiation, the limb regenerate is proportionally small in size. (edu.au)
- HIF-1α drives the transcription of NOG to inhibit osteogenic differentiation of periodontal ligament stem cells in response to hypoxia. (stembook.org)
Regenerative6
- Interestingly, the neoblast mitotic response was increased around the amputation area but the regenerative blastema failed to form. (biomedcentral.com)
- This organism is well known for its stem cell-based regenerative capability. (biomedcentral.com)
- therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. (biomedcentral.com)
- Consequently, because of the increased rate of RF in terminal stage and few alternative treatments, new investigations focused on regenerative medicine have been developed, including the use of stem cells (SCs) [ 7 ]. (biomedcentral.com)
- How adult muscle stem cells contribute to this decrease in regenerative capacity is incompletely understood. (bvsalud.org)
- Members of the free-living genus Planaria are widely interrogated in the realm of stem cell biology due to their remarkable regenerative abilities [ 8 ]. (biomedcentral.com)
Regeneration13
- Planarians are flatworms with large populations of stem cells capable of dividing to support adult tissue renewal and regeneration. (biomedcentral.com)
- Our results also reveal novel roles for Akt signaling during regeneration, specifically for the timely localization of cell death near the injury site. (biomedcentral.com)
- This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)
- Histological studies focusing on the early cephalic tentacle regeneration in P. canaliculata, have demonstrated that wound closure and blastema formation took place within 24 h post amputation (hpa). (unimore.it)
- This wellknown fact has prompted several basic studies on organisms capable of adult regeneration, such as amphibians, bony fish, and invertebrates. (unimore.it)
- Callus is a reprogrammed cell mass involved in plant regeneration and gene transformation in crop engineering. (bvsalud.org)
- Pluripotent callus cells develop into fertile shoots through shoot regeneration. (bvsalud.org)
- Notably, chlorenchyma cells, enriched in photosynthesis-related processes, play a crucial role in promoting shoot primordia formation and subsequent shoot regeneration. (bvsalud.org)
- Light is shown to promote shoot regeneration by inducing chlorenchyma cell development and coordinating sugar signaling. (bvsalud.org)
- Skeletal muscle regeneration relies on the reciprocal interaction between many types of cells. (bvsalud.org)
- To conclude, our study revealed that miR-378 deletion influences the abundance of mSCs and the adipogenic potential of FAPs, but does not affect overall regeneration upon acute, glycerol-induced muscle injury. (bvsalud.org)
- Muscle regeneration was induced using intramuscular cardiotoxin injection or treadmill exercise and analysed using single cell and bulk RNA sequencing, qRT-PCR and immunofluorescence. (bvsalud.org)
- Importantly, in aged skeletal muscle where miR-501 was significantly downregulated and its target Esrrg significantly upregulated, the number of myog+/CD74+ cells during regeneration was upregulated to similar levels as observed in 501 knockout mice. (bvsalud.org)
Amputation3
- Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
- However, in response to amputation, levels of cell death were decreased and failed to localize near the injury site. (biomedcentral.com)
- After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail Pomacea canaliculata. (unimore.it)
Proliferation4
- In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)
- Functional disruption of Smed-Akt alters the balance between cell proliferation and cell death leading to systemic impairment of adult tissue renewal. (biomedcentral.com)
- The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)
- This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)
Homeostasis2
- BMP-7 is also important in homeostasis of the adult kidney by inhibiting ephithelial-mesenchymal transition (EMT). (wikipedia.org)
- One of these conserved effector-receptor systems is retinoic acid (RA) signaling that plays critical roles not only during development, but also in the regulation of adult homeostasis. (mdpi.com)
Osteogenic1
- BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes. (wikipedia.org)
Genetic1
- Many conditions do not appear to be induced entirely by environmental factors and so genetic profiles have been studied to determine why some individuals are more susceptible to particular diseases. (biomedcentral.com)
Transformation2
- Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. (wikipedia.org)
- In the case of schistosomes, it is necessary to maintain active populations of freshwater snails as intermediate hosts, manage periodic shedding of the infective cercariae, induce transformation to schistosomula or allow for penetrance into a definitive host (usually mice). (biomedcentral.com)
Acute1
- Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. (stembook.org)
Embryonic2
- Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
- According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)
Transcription2
- These genes, acquired at conception or mutated during life, make the affected person prone to most cancers by altering or impairing several processes: & Production of nuclear transcription factors that control cell growth. (ehd.org)
- Animal development is characterized by the deployment of highly conserved sets of morphogens and transcription factors that contribute to the patterning and formation of a startling variety of adult morphologies. (mdpi.com)
Maturation2
- Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
- However, not forgotten is the axolotl's equally amazing ability to thwart aspects of tissue maturation and retain juvenile morphology into the adult phase of life. (edu.au)
Stem cell5
- However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
- Our findings abrogating Smed-Akt with RNA-interference in the planarian Schmidtea mediterranea led to a gradual decrease in stem cell (neoblasts) numbers. (biomedcentral.com)
- Stem Cell Res Ther. (stembook.org)
- CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties. (stembook.org)
- Leptin and NAP2 promote mesenchymal stem cell senescence through activation of PI3K/Akt pathway in patients with systemic lupus erythematosus. (stembook.org)
Biol1
- Cell Mol Biol (Noisy-le-grand). (stembook.org)
Mesenchymal1
- Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells. (stembook.org)
Kidney5
- The role of BMP7 in mammalian kidney development is through induction of MET of the metanephrogenic blastema. (wikipedia.org)
- Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant BMP-7 (rhBMP-7) could be a viable treatment of chronic kidney disease. (wikipedia.org)
- ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
- The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)
- In a normal human adult, each kidney is about 10 cm long, 5.5 cm in width and about 3 cm thick, weighing 150 grams. (wikidoc.org)
Cellular4
- mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)
- The planarian ortholog Smed-Akt is molecularly conserved providing unique opportunities to analyze the function of Akt during cellular turnover and repair of adult tissues. (biomedcentral.com)
- Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
- The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)
Neurons1
- One concentrate inside the mechanism of neuronal death in AD would be the aberrant expression of cell cycle related proteins, this kind of as cdc2, cdk4, cyclin B1, and cyclin D, which med iate cell cycle progression, in vulnerable neurons from the AD brain, these molecules perform important roles in neuronal death related with several paradigms of neuronal death. (fgfrinhibitors.com)
Injection1
- After the injection of clodronate liposomes, a specific computer-assisted image analysis protocol still evidenced the presence of granular hemocytes in the tentacle blastema. (unimore.it)
Skeletal1
- Skeletal muscle stem cells confer maturing macrophages anti-inflammatory properties through insulin-like growth factor-2. (stembook.org)
Findings2
- The findings reveal the presence of highly heterogeneous cell populations within the callus, including epidermis, vascular tissue, shoot primordia, inner callus, and outgrowth shoots. (bvsalud.org)
- These findings suggest that blood and brain neuronal cells could possess a frequent regulatory mecha nism for gene expression. (fgfrinhibitors.com)
Formation1
- By characterizing the spatially resolved molecular features of shoot primordia and surrounding cells, specific factors essential for shoot primordia formation are identified. (bvsalud.org)
Tissue2
- Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)
- We investigated mechanisms of age-related changes in myogenic progenitor cells using the tissue-specific microRNA 501. (bvsalud.org)
Brain3
- On top of that to cell cycle progres sion molecules, quite a few cell cycle inhibitors, such as p16 and p27, and tumor suppressor proteins such as p53 and BRCA1 are also increased in levels during the AD brain. (fgfrinhibitors.com)
- Also to your human AD brain, the improved expression levels of cell cycle relevant proteins were also found in transgenic mouse models of AD. (fgfrinhibitors.com)
- Although it selleckchem is unclear why cell cycle connected proteins show enhanced in ranges within the AD brain and AD mouse models, 1 chance is that DNA harm induced by Ab may possibly improve the levels of or activate these molecules. (fgfrinhibitors.com)
Humans1
- In vitro analysis was performed in primary muscle cells obtained from mice and humans. (bvsalud.org)
Development1
- This quantitative study explores the acceptability of Online Learning Action Cell (LAC) practice as a school-based professional development strategy for Tagumpay National High School (TNHS) teachers. (philarchive.org)
Largely1
- The reduced neoblast numbers largely affected the maintenance of adult tissues including the nervous and excretory systems and ciliated structures in the ventral epithelia, which impaired planarian locomotion. (biomedcentral.com)
Understood1
- Nevertheless, the mechanisms by which neuronal degeneration and death happen in AD and no matter whether they may be induced by Ab will not be wholly understood. (fgfrinhibitors.com)
Muscle4
- We subjected 6-week-old wild-type (WT) and miR-378 knockout (miR-378-/-) animals to the glycerol-induced muscle injury and performed analyses in various time-points. (bvsalud.org)
- In miR-378-/- animals, an elevated abundance of muscle satellite cells (mSCs) on day 3 was found. (bvsalud.org)
- RESULTS: Single cell sequencing revealed myogenic progenitor cells in miR-501 knockout mice at day 6 after muscle injury that are characterized by high levels of myogenin and CD74. (bvsalud.org)
- In control mice these cells were less in number and already downregulated after day 3 of muscle injury. (bvsalud.org)
Mice2
- Eventually this restores the healthy epithelial cell population, and normal function of the kidneys in mice. (wikipedia.org)
- It was discovered that mice injected with BMP7 increased their production of "good" brown fat cells, while keeping their levels of the normal white fat cells constant. (wikipedia.org)
Types3
- An improved ontological representation of dendritic cells as a paradigm for all cell types. (philarchive.org)
- The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. (philarchive.org)
- Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)
Diagnostic1
- The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. (tractorgallery.net)
Target1
- Within a target cell, RA signaling is activated by the binding of all- trans RA, the biologically active metabolite of vitamin A, to heterodimers of two nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). (mdpi.com)
Important1
- 13. Which class of antibody is most important for activating antibody dependent cell cytotoxicity (ADCC) with NK cells? (mockdocs.org)
Single2
- Recently, we described that the genome of S. mediterranea contains a single Akt ortholog termed Smed-Akt , which affects cell division and impairs planarian locomotion [ 22 ]. (biomedcentral.com)
- The orthotopic ureterocele usually arises from a single renal unit with one collecting system and is more commonly diagnosed in adults. (medscape.com)
Death1
- Downregulation of Smed-Akt function also resulted in an increase of cell death throughout the animal. (biomedcentral.com)