Adult human homeobox genes. Medical search. Frequent questions

This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (wikipedia.org)
We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. (ntnu.edu.tw)
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. (abnova.com)
The product of the Drosophila gene decapentaplegic ( dpp) encodes a TGFβ homolog that plays multiple roles during embryogenesis and the development of imaginal discs. (biologists.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
Echinocandin-resistant clinical isolates of Candida albicans have been reported, and key-hot spot mutations in the FKS1 gene, which encodes a major glucan synthase subunit, have been identified in these (caspofungin-resistant [CAS-R]) strains. (who.int)

Recent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer. (elsevierpure.com)
Utilizing quantitative TaqMan RT-PCR, we compared expression profiles of the 39 HOX genes in human familial MEN1 (fMEN1) parathyroid tumors and sporadic parathyroid adenomas with normal samples. (elsevierpure.com)
These findings provide the first evidence that loss of the MEN1 tumor suppressor gene is associated with deregulation of specific HOX gene expression in the development of familial human parathyroid tumors. (elsevierpure.com)
Our results strongly reinforce the idea that abnormal expression of developmental HOX genes can be critical in human cancer progression. (elsevierpure.com)
In C2C12 muscle cell line, Duxbl expression pattern is similar to differentiated marker gene, Myogenin, increased in expression from 2 days onward in differentiating medium. (ntnu.edu.tw)
Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. (abnova.com)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
The phenotype of iPS-HSCs, including gene and protein expression profiles and vitamin A storage, resembled that of hepatic stellate cells. (ca.gov)
Additionally, we also examined the effect of atRA treatment on the expression of homeobox genes in the CAOV3 cells and SKOV3 cells model system. (temple.edu)
In human tumors, an association between the deregulation of the expression of homeobox genes and oncogenic transformation has been reported. (temple.edu)
In these studies we examined the expression of 13 homeobox genes in CAOV3 cells and SKOV3 cells following ethanol or atRA treatment. (temple.edu)
The 13 homeobox genes were analyzed because previous studies done by our laboratory observed differences in expression of these homeobox genes when comparing atRA sensitive oral squamous carcinoma cells (SCC) to atRA resistant oral squamous cell carcinoma cells. (temple.edu)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
For example, targeted disruptions of these Hox genes result in abnormal development of the mouse radius, while over-expression of HoxA10 stimulates mouse megakaryocyte (MK) development in vitro. (uky.edu)
To examine the expression of Hox genes in human MK cells, we utilized reverse transcription polymerase chain reaction with degenerate oligo-nucleotides to study megakaryocytic cell lines (MEG-01, DAMI), and primary human MK purified from adult and cord blood. (uky.edu)
Although these studies cannot completely exclude the possibility that the TAR syndrome results from non-coding mutations that affect the level of Hox gene expression in megakaryocytes, mutations in the coding sequence of the Hox genes known to affect radial development are not a common cause of TAR syndrome. (uky.edu)
Cerebellar and hippocampal tissue samples from three En2 -/- and wild type (WT) littermate mice were assessed for differential gene expression using microarray hybridization followed by RankProd analysis. (biomedcentral.com)
Several studies have analyzed genome-wide expression profiles of ASD patients using lymphoblastoid cell lines and blood samples, supporting upregulation of immune genes and downregulation of neurodevelopmental genes as key players in the pathogenesis of ASD (see [ 8 ] for a review). (biomedcentral.com)
The tkv receptor is therefore involved in delimiting the expression domains of homeotic genes in the visceral mesoderm. (biologists.com)
We are analyzing the normal developmental function of early transcription factors that regulate digit patterning (Gli3, 5'Hoxd), with the long-term aim of linking regulatory cascades and patterned gene expression to the morphogenesis of specific structures. (nih.gov)
Thus, understanding how normal transcription programs are regulated during development may also help to decipher abnormal gene expression patterns in tumors and devise new strategies to intercept cellular targets driving tumor cell behavior. (nih.gov)
To directly test this model of Shh function, we have restored cell survival in Shh mutant embryos after transient Shh expression by concomitant removal of the pro-apoptotic genes Bak/Bax to intercept cell death, in order to rescue the proposed late Shh role. (nih.gov)
Adult β 2 AR -/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor (PPAR)γ, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. (elsevierpure.com)
In addition, such studies could facilitate targeted expression of potentially therapeutic genes to the vestibular system epithelium. (nih.gov)
Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. (cusabio.com)
KEGG pathway overrepresentation analysis of digital gene expression in order yasmin online Escherichia coli. (eviematilda.art)
Expression of order yasmin online irradiation responsive genes independently (Table 2). (eviematilda.art)
To study the genetic regulation of growth control and pattern formation during fin development and regeneration, we have analysed the expression of four homeobox genes, msxA, msxB, msxC and msxD in zebrafish fins. (zfin.org)
Expression of the msx genes in the fin fold and fin buds is transient and, by 3 days after fertilization, msx expression in the median fin fold falls below levels detectable by in situ hybridization. (zfin.org)
Although the fins of adult zebrafish normally have levels of msx transcripts undetectable by in situ hybridization, expression of all four genes is strongly reinduced during regeneration of both paired and unpaired fins. (zfin.org)
Induction of msx gene expression in regenerating caudal fins occurs as early as 30 hours postamputation. (zfin.org)
Our results suggest distinct roles for each of the four msx genes during fin development and regeneration and differential regulation of their expression. (zfin.org)
The dorsal hippocampus, which connects and shares similar gene expression with the neocortex ( Fanselow and Dong, 2010 ), serves the 'cold' cognitive function associated with declarative memory and spatial navigation. (elifesciences.org)
Furthermore, external acid environment triggered expression of the GFP reporter gene fused downstream of the cdx 2 intestinal homeogene regulatory sequences in P3E6 transfected cells. (silverchair.com)
A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). (uky.edu)
These proteins all contain two zinc fingers and four homeodomains, suggesting that they function as regulators of gene expression. (uky.edu)
Mouse strain-specific differences in adult liver Elovl3 mRNA levels and transgenic mouse data indicate that Zhx2 activates Elovl3 expression in the female adult liver. (uky.edu)
The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)
Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
The genetic structure includes 4 zinc-finger regions, which suggest that WT1 may be important in controlling the expression of other genes. (medscape.com)

Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
Homeobox (HOX) genes encode evolutionarily conserved transcription factors that are essential for embryonic morphogenesis and differentiation [5]. (cancerhugs.com)

Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia. (wikipedia.org)
There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)
Visual acuity (VA) in children with LCA varies significantly among patients with differing gene mutations and can be as low as no light perception (NLP). (aao.org)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome caused by mutations in the MEN1 tumor suppressor gene. (elsevierpure.com)
Despite considerable ongoing effort toward the identification of chromosome regions affected in autism and the characterization of many potential gene candidates, only a few genes have been reproducibly shown to display specific mutations that segregate with autism, likely because of the complex polygenic nature of this syndrome. (neurotransmitter.net)

AFP is highly expressed in the fetal liver, silenced at birth, and remains at very low levels in the adult liver. (uky.edu)

By contrast, targeted deletion of genes such as Math1 (a mouse homolog of Drosophila proneural gene atonal ) or sequences encoding BRN 3.1 and BDNF produces congenital sensorineural anomalies of the inner ear. (nih.gov)

Loss of the functional second copy of the MEN1 gene causes individuals to develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and pancreas. (elsevierpure.com)
We identified a large set of 23 HOX genes whose deregulation is specific for fMEN1 parathyroid tumors, and only 5 HOX genes whose misexpression are specific for sporadic parathyroid tumor development. (elsevierpure.com)
We proven that three HOXA genes previously, HOXA4, HOXA7 and HOXA10, had been overexpressed in serous ovarian adenocarcinomas in comparison with harmless serous tumors or tumors with low malignant potential. (cancerhugs.com)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. (cusabio.com)

To identify functional categories overrepresented in the differentially expressed genes, we used integrated gene-network analysis, gene ontology enrichment and mouse phenotype ontology analysis. (biomedcentral.com)
Furthermore, we performed direct enrichment analysis of ASD-associated genes from the SFARI repository in our differentially expressed genes. (biomedcentral.com)
Given the limited number of animals used in the study, we used permissive criteria and identified 842 differentially expressed genes in En2 -/- cerebellum and 862 in the En2 -/- hippocampus. (biomedcentral.com)
Furthermore, when directly compared to the repository of the SFARI database, our differentially expressed genes in the hippocampus showed enrichment of ASD-associated genes significantly higher than previously reported. (biomedcentral.com)
The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)

Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene. (wikipedia.org)
Recombinant human growth hormone is a protein that is manufactured to be nearly identical to the main form of the naturally occurring human growth hormone. (fda.gov)
The amino acid sequences of Duxbl homeodomains are most similar to those of human DUX4 protein, associated with facioscapulohumeral muscular dystrophy. (ntnu.edu.tw)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
in the absence of functional tkv gene product, visceral mesoderm parasegment 7 cells fail to express Ultra-bithorax , but instead accumulate Antennapedia protein. (biologists.com)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP015841HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NKX2-1. (cusabio.com)
Death by protein damage in their first, third, and last order yasmin online mating for the S regime and the generalizability of these phenomena in humans. (eviematilda.art)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

During gonad development, Duxbl is expressed from embryonic to adult stages and specifically expressed in oocytes and spermatogonia. (ntnu.edu.tw)
It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. (abnova.com)
Homeobox genes comprise a family of transcription factors which function during embryonic development to control pattern formation, differentiation and proliferation. (temple.edu)
Dr. Porter came to the NIH in 1993 as a Senior Staff Fellow, to investigate homeobox genes -genes which determine when groups of other genes are expressed during embryonic development. (nih.gov)
My lab previously identified several transcription factors (homeobox genes and T-box genes) involved in formation and patterning of both the primary embryonic axis and the limb axis in vertebrates. (nih.gov)

In the United States, recombinant human growth hormone is used in the pediatric population to treat short stature due to growth hormone deficiency (including idiopathic [of unknown cause] growth hormone deficiency), Turner syndrome, Noonan syndrome, Prader-Willi syndrome, short stature homeobox-containing gene (SHOX) deficiency, chronic renal insufficiency, idiopathic short stature and children small for gestational age. (fda.gov)
2 Other relatively rare conditions that also affect growth in children are Turner syndrome (TS), small for gestational age (SGA) (with failure to attain the lower portion of the normal growth curve by age 2), Prader-Willi syndrome (PWS), chronic renal insufficiency (CRI), Noonan syndrome, and short stature due to short stature homeobox (SHOX) gene haploinsufficiency ( Table 1 ). (ajmc.com)
Children with short stature homeobox-containing gene (SHOX) deficiency. (backpharma.com)
Bodybuilders can boost their efforts with Turner syndrome Idiopathic Short Stature (ISS) Short stature or growth failure in short stature homeobox-containing gene (SHOX) deficiency Small for Gestational Age (SGA) and have not caught up in growth by age 2-4 years old. (queobathrooms.co.uk)

At this time, FDA recommends that patients continue their recombinant human growth hormone treatment as prescribed by their healthcare provider. (fda.gov)
1-3 It was designed to assess the long-term mortality of patients treated with recombinant human growth hormone during childhood. (fda.gov)
The study population was based on a mandatory registry of patients in France who received recombinant human growth hormone treatment during childhood between 1985 and 1996 and whose vital status and cause of death was determined through September 2009. (fda.gov)
Do not stop taking recombinant human growth hormone without talking to your healthcare professional. (fda.gov)
Discuss any questions or concerns about recombinant human growth hormone with your healthcare professional. (fda.gov)
If you prescribe recombinant human growth hormone, follow the recommended indications and doses in the product labels. (fda.gov)
FDA is aware of the results of a long-term epidemiological study called SAGhE (Santé Adulte GH Enfant), which was designed to assess the long-term mortality of patients treated with recombinant human growth hormone during childhood. (fda.gov)
The investigators report a 30% increased risk of death with recombinant human growth hormone therapy compared to the general population, with 93 observed deaths in the treated group versus 70 expected deaths in the general population in France. (fda.gov)
The treatment of growth hormone deficiency (GHD) in children and adults has been impacted greatly by the availability of recombinant human growth hormone (rhGH). (ajmc.com)
The commercial introduction of recombinant human growth hormone (rhGH) in 1985 dramatically changed the field of therapy for growth hormone (GH). (medscape.com)

The division's clinical research program currently includes more than 100 research protocols focusing on adult, pediatric, and reproductive endocrinology, human genetics, growth and development, national and international health, and women's health. (nih.gov)

FDA indications in children include GH deficiency (GHD), Turner syndrome, idiopathic short stature, small for gestational age with failure to attain normal growth percentiles, Prader-Willi syndrome (PWS), chronic renal insufficiency, Noonan syndrome, and short stature due to short stature homeobox gene haploinsufficiency. (ajmc.com)
Replacement of endogenous GH in adults with GH deficiency. (backpharma.com)
My translational interests and contributions have spanned blood/lymphatic vascular endothelial cell biology and pathobiology in vitro and in vivo, hepatosplanchnic lymphatic/microcirculatory physiology, small animal models, in vivo lymphatic imaging, thoracic duct lymph drainage, lymphogenous cancer spread, and genomics/proteomics of lymphedema-angiodysplasia syndromes in man and experimental models, including defects, deficiency, and overexpression of human and murine lymphangio- gene-sis genes and their syndromic/phenotypic manifestations. (arizona.edu)

The role of HOX genes in adult cell differentiation is still obscure, but growing evidence suggests that they may play important roles in the development of cancer. (elsevierpure.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
HOX genes exert pleiotropic functions in many cell types and may control cell proliferation, differentiation, adhesion, and migration [7]. (cancerhugs.com)
Latest research claim that HOX genes might play essential jobs in ovarian cancer differentiation [9-11]. (cancerhugs.com)
Recently, we have focused on the role of Shh/Gli3 and 5'Hoxd genes in regulating several aspects of limb development, including early digit patterning, as well as condensation and differentiation of cartilage precursors during final morphogenesis of the limb skeleton. (nih.gov)
These findings demonstrate that chronic exposure of esophageal keratinocytes to acid pH induces transcription of cdx 2, an intestinal specific homeobox gene known to play a critical role in the differentiation and maintenance of intestinal epithelial functions. (silverchair.com)

Recent studies have suggested the HoxA10, HoxA11 and HoxD11 homeobox genes as candidate loci for the thrombocytopenia with absent radius (TAR) syndrome. (uky.edu)

For example, the identification of regulatory sequences of genes expressed specifically in the vestibular system will allow the targeted introduction of foreign genes into the vestibular system of transgenic mice. (nih.gov)

More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. (nature.com)

The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)

Treatment of adult GHD primarily targets improvements in body composition, quality of life, and surrogate markers for cardiovascular disease. (ajmc.com)
Four mitochondrial genes and 22 nuclear microsatellite markers were used to assess relatedness of worms associated with the outbreak in comparison with other worms from elsewhere in Chad. (cdc.gov)

Among those, several candidate genes have been shown to control the early patterning and/or the late synaptic maturation of specific neuronal subpopulations controlling the balance between excitation and inhibition in the developing cortex and cerebellum. (neurotransmitter.net)
Finally, we review the classes of genes that have been linked to autism in recent genetic studies and discuss several candidate genes in the context of this neurodevelopmental hypothesis. (neurotransmitter.net)
Although association can be found in some candidate genes the field of research regarding genetic association with the onset of IS still requires more information. (biomedcentral.com)

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. (ca.gov)
In this study, we developed a model system for improving interactions between human iPS-derived hepatic progenitor cells (iPS-HPCs) and human iPS-derived hepatic stellate cell-like cells (iPS-HSCs). (ca.gov)
Hepatocytic maturation in iPS-HPCs was significantly increased in direct co-culture with iPS-HSCs overexpressing LHX2, but not in co-culture with a human hepatic stellate cell line (LX-2) overexpressing LHX2. (ca.gov)
The Zhx2 gene was originally characterized in our lab based on its ability to control the developmental repression of several hepatic genes, including AFP (PNAS, 102:401). (uky.edu)

Limb development is a particularly attractive model for unraveling the function and interaction of such regulatory components, because it is very accessible to study and is extremely well conserved between genetic (mouse) and embryologic (chick) model organisms and humans. (nih.gov)
Using the limb as a model for vertebrate organogenesis, we deleted Shh at different developmental times in genetically engineered mice with a conditional, floxed-Shh gene and inducible Cre to determine the temporal requirements for Shh during limb development. (nih.gov)

Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
The strength of evidence is compelling , using rigorous state-of-the-art methods to demonstrate functional redundancy of these genes in regulating the Lhx2/Lhx5 axis. (elifesciences.org)
Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. (nature.com)

Epithelial tissue from both the rat BE model and human BE patients strongly expressed KLF5, CDX2, MUC2, and villin. (jcancer.org)

The identification of the gene responsible for Wilms tumor did not occur until 1990, when 3 groups independently identified the WT1 gene on band 11p13. (medscape.com)

In general, mRNA levels of ECM and collagen genes have been found to be downregulated in both the adult mouse sclera [ 6 ] and cornea [ 7 ] when compared with samples from an earlier developmental stage. (molvis.org)

Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepatocytes. (ca.gov)

Growth hormone (GH) therapy has evolved rapidly since the introduction of recombinant human GH (rhGH). (ajmc.com)

This gene is involved in the regulation of uterine development and is required for female fertility. (wikipedia.org)
Therefore, we hypothesized that specific HOX genes were regulated by menin in parathyroid tumor development. (elsevierpure.com)
these pathways are also shown to donate to the irregular development of various kinds human being malignancies [20]. (cancerhugs.com)
Forbes D. Porter, M.D., Ph.D., has been appointed Clinical Director of the Division of Intramural Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). (nih.gov)
The face is the anatomical feature which is truly unique to each human, though the basis of its general development is identical for all humans and similar to that seem for other species. (edu.au)
The scientific presentations emphasized developmental processes, encompassing such areas as: 1) the role of homeobox genes and growth factors in inner ear development and plasticity, 2) effects of altered gravitational loading on the development of the inner ear gravity receptor, 3) effects of altered gravitational loading on developing and mature neuromuscular systems and 4) molecular mechanisms that determine muscle fiber diversity and hypertrophic responses. (nih.gov)
The growth and development of bones from fetus to adult. (lookformedical.com)
The median fin fold, which gives rise to the unpaired fins, expresses these four msx genes during development. (zfin.org)
This study systematically reviews the available literature to identify the most significant genes or variants related to the development and onset of IS. (biomedcentral.com)
This is an important study demonstrating distinct roles for the nuclear receptor genes COUP-TFI and COUP-TFII in hippocampal development. (elifesciences.org)
Note the nifty schematic of eye development in cephalopods vs. vertebrates, emphasizing the aspect of convergence in a process induced by a homologous gene (I think). (tonmo.com)
Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)
In addition, we propose that Ppargc1a might play a role in regulating postnatal scleral development by interacting with a different set of genes at different scleral growth stages. (molvis.org)
The constitutional loss of one allele of the Wilms tumor gene ( WT1 ) results in GU anomalies and forms the first of 2 genetic events in the development of a Wilms tumor. (medscape.com)
Both the GU abnormalities and the development of a Wilms tumor in patients with WAGR syndrome are related to the loss of WT1 gene function. (medscape.com)
A neighboring gene, PAX6 , is responsible for the development of the iris. (medscape.com)
Deletion of the PAX6 gene, which plays a role in myelinization of the cerebral hemispheres during CNS development, may also be responsible for the mental retardation seen in the WAGR association. (medscape.com)

The developing human: clinically oriented embryology (10th ed. (edu.au)
Larsen's human embryology (5th ed. (edu.au)

Developmental processes such as axis formation and organogenesis employ regulatory components and interactions that are often also used in normal tissue renewal/homeostasis in the adult organism, as well as contributing to the pathogenesis of disease when aberrantly reactivated. (nih.gov)
Identifying the direct target promoters of developmental gene-regulators will be critical to understand how these regulators function and to link regulatory cascades in developmental genetic programs to the basic cellular processes that drive morphogenesis of anatomic structures. (nih.gov)

Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of fish adipogenesis. (biomedcentral.com)
GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
These genetically-engineered animals could be designed to create specific animal models of human disease. (nih.gov)
As in centenarians, the causal role of the specific bacterial species, genes, and metabolites in promoting healthy aging remain unclear. (eviematilda.art)
All the considered studies stated either the affected gene and/or specific SNPs. (biomedcentral.com)
[ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)

Using this approach, 13 out of 40 clones isolated from cell lines, 10 out of 21 from cord MK, and 11 out of 21 from adult MK were identified as HoxA10, while HoxA11 and HoxD11 sequences were not detected. (uky.edu)
The normal genomic sequences for the human HoxA10, -A11, and -D11 genes were then determined and sequenced in 10 unrelated individuals with TAR syndrome. (uky.edu)

The deletion of both Nr2f genes causes almost agenesis of the hippocampus with abnormalities of trisynaptic circuit and adult neurogenesis. (elifesciences.org)
Meanwhile, the deletion of one copy of the PAX6 gene is responsible for aniridia. (medscape.com)
Subject A has a large deletion on chromosome 11 that removes one copy of the BDNF gene. (medscape.com)
Deletion of the PAX6 gene as part of the band 11p13 deletion in patients with AGR or WAGR syndrome results in aniridia. (medscape.com)

The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. (nih.gov)
Novel cross-regulation interactions between dlx genes in larval zebrafish. (nih.gov)

The major strengths of the study are the dramatic morphogenic phenotypes, and the resultant altered gene networks. (elifesciences.org)

Of the 13 homeobox genes analyzed in the ovarian carcinoma cell model system, we found HOXA1 and HOXB4 to be upregulated by atRA in CAOV3 cells but not in SKOV3 cells. (temple.edu)
Among these genes, HOXA7 was among the HOX genes most overexpressed in ovarian malignancies [12] consistently. (cancerhugs.com)
Our research about the part of HOXA7 in human being ovarian folliculogenesis demonstrated that HOXA7 manifestation was predominantly adverse in primordial follicles and positive in major and mature follicles. (cancerhugs.com)

In adult tissues, Duxbl is predominantly expressed in female reproductive organs and eyes, and slightly expressed in brain and testes. (ntnu.edu.tw)
HOX genes perform essential jobs in organogenesis and in the introduction of the human being reproductive program during embryogenesis and during organic redesigning in adults [8]. (cancerhugs.com)

Search for RefSeq genes (e.g. (vectorbuilder.kr)

Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)

qPCR was performed for representative genes to confirm relative transcript levels compared to those detected in microarrays. (biomedcentral.com)

Human induced pluripotent stem cells (iPSCs) offer a potential unlimited source of adult cell types with numerous applications in regenerative medicine. (ca.gov)
Next, we generated iPS cell lines overexpressing LIM homeobox 2 (LHX2), which suppresses myofibroblastic changes in HSCs in mice. (ca.gov)
The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
Furthermore, while much is now known about the biology of normal granulosa cells [4], the molecular changes that contribute to human granulosa cell dysfunction remain to be elucidated. (cancerhugs.com)
Furthermore, the manifestation of HOX cofactors had been temporally and spatially particular in human being granulosa cells also, which indicated the precise part of HOXA7 in regulating granulose cell function [14]. (cancerhugs.com)
Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)

It has approved indications in both the adult and pediatric populations. (fda.gov)
Achievement of final adult height consistent with a child's genetic potential remains the primary therapeutic endpoint for recombinanat human growth hormone (rhGH) therapy in the pediatric population. (medscape.com)

To unravel recurrent ASD-related neuropathological mechanisms, we took advantage of the En2 -/- mouse model and performed transcriptome profiling on cerebellar and hippocampal adult tissues. (biomedcentral.com)

Here, we show that Nr2f1 and Nr2f2 genes are distinctively expressed in the dorsal and ventral hippocampus, respectively. (elifesciences.org)
The rodent hippocampus can be divided into the dorsal and ventral domains, corresponding to the posterior and anterior hippocampus in humans, respectively. (elifesciences.org)

Besides their dominant role during embryogenesis, they are also expressed in adults. (temple.edu)
We review the link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders. (biomedcentral.com)
Blobe, G. C., Schiemann, W. P. & Lodish, H. F. Role of transforming growth factor β in human disease. (nature.com)

My second project was to study the control of Elongation of very long chain fatty acids like 3 (Elovl3) in the liver by Zinc fingers and homeoboxes 2 (Zhx2). (uky.edu)

They have important roles in the regulation of cellular functions both in the adult organism and during embryogenesis. (nature.com)

Immunohistochemistry was performed to analyze human and mouse esophageal specimens. (jcancer.org)
The resulting cDNA was fragmented, labeled with biotin, and hybridized to a Mouse Gene 1.0 ST Array. (molvis.org)

6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)

These factors operate in signaling pathways that are used extensively in a number of processes in both the embryo and adult. (nih.gov)

It is known that some homeobox genes are atRA targets due to the presence of retinoic acid response element (RARE) either in their promoter region or in their 3' region. (temple.edu)
Transgenes regulated by the wild-type AFP promoter are expressed at low levels in the adult liver. (uky.edu)

Human esophageal squamous epithelial (HET-1A) cells were treated with bile acid and used in transfection experiments. (jcancer.org)

Isidore Geoffroy Saint-Hilaire studied anatomy and congenital abnormalities in humans and other animals in nineteenth century France. (asu.edu)

In this review, we summarize the results regarding the activation of primordial oocytes in neonatal and adult ovaries of different species and propose a model in which ovaries of neonatal mammals contain a mixed population of both quiescent and activated primordial oocytes, while almost all primordial oocytes are quiescent in adult females. (go.jp)

Anatomy4

Organisms1

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes7

Disciplines and Occupations1

Information Science3

Encodes6

Expression45

Encode2

Mutations5

Fetal1

Drosophila1

Tumors4

Transcription factor1

Differentially expressed5

Proteins2

Tumor Suppr4

Protein8

Embryonic5

SHOX4

Recombinant human growth10

Genetics1

Deficiency3

Differentiation7

Thrombocytopenia1

Foreign genes1

Superfamily1

Identify the genes1

Markers2

Candidate genes3

Hepatic4

Limb2

Functional3

CDX21

19901

MRNA levels1

Phenotype1

Introduction of recombinant human1

Development17

Embryology2

Developmental2

Specific6

HOXA102

Deletion4

Apoptosis1

Zebrafish2

Phenotypes1

Ovarian3

Reproductive2

RefSeq1

Enrichment1

Transcript1

Cell6

Pediatric2

Tissues1

Hippocampus2

Role3

Zinc1

Organism1

Mouse2

Significantly1

Pathways1

Promoter2

Squamous1

Abnormalities1

Species1