• Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
  • These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
  • The proliferation and differentiation of adult stem cells must be tightly balanced to avoid excessive proliferation or premature differentiation. (sdbonline.org)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
  • The superfamily includes large families of growth and differentiation factors. (wikipedia.org)
  • Continuous growth and differentiation of organoids depend on both Wnt and Notch paracrine signalling. (nature.com)
  • Clearly, establishing the right conditions is critical to encouraging growth and differentiation," said Gage. (salk.edu)
  • Cells recovered from healthy individuals could provide a model for understanding how to stimulate and guide the normal processes of brain cell growth and differentiation," he said, "lending insight to how growth might be stimulated in people suffering from neurodegenerative diseases such as Alzheimer's or Parkinson's. (salk.edu)
  • Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
  • Fu T, Towers M & Placzek M (2017) Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation. . (sheffield.ac.uk)
  • Moreover, it has been shown that in the SVZ BMP4 has a prodifferentiative effect, since it rescues a defect of terminal differentiation in SVZ neurospheres where the gene Tis21/BTG2 - required for terminal differentiation - has been deleted. (wikipedia.org)
  • However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
  • PPARγ is highly expressed in adipose tissue and is a key transcription factor involved in the terminal differentiation of white and brown adipose tissue. (sigmaaldrich.com)
  • Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
  • These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
  • HUB Organoids™ are experimental models derived from the adult stem cells present in epithelial tissues. (stemcell.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
  • It is a monomorphic blue spindle cell soft tissue cancer with variable degree of epithelial differentiation characterized by the specific SS18-SSX/1/2/4 fusion gene but is often biphasic with both spindle cell and glandular-like components. (msdmanuals.com)
  • however, the molecular mechanisms of renewal and differentiation remain obscure in many cases, including the fallopian tube, a central organ of human reproduction. (nature.com)
  • These architecturally diverse microenvironments serve to balance stem cell self-renewal and differentiation. (ca.gov)
  • PPARδ is abundant in many tissues during development especially in the adult rat digestive tract where a high rate of cell renewal and differentiation is required. (sigmaaldrich.com)
  • WNT pathway is important because it is one of the primary signaling transduction that regulates the renewal and differentiation of adult stem cells. (hairsite.com)
  • Endocrine lineage markers were detected upon in vitro differentiation. (prinsesmaximacentrum.nl)
  • The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
  • A much higher percentage of alternatively spliced transcripts are found during differentiation of human myocytes in vitro. (jci.org)
  • Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
  • Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
  • To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
  • The ability to use autologous dental progenitor cells (DPCs) to form organized periodontal tissues on titanium implants would be a significant improvement over current implant therapies. (nih.gov)
  • Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the generation of a cell subpopulation with progenitor characteristics. (prinsesmaximacentrum.nl)
  • We conclude that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential. (prinsesmaximacentrum.nl)
  • Previous attempts to recover progenitor cells from adult tissue had failed, but the Gage laboratory applied growth factors to extracted tissue that appear to have made a crucial difference. (salk.edu)
  • Testing in whole animals is the only way to know if adult tissue can be a source of stem or progenitor cells for transplant purposes to treat neurodegenerative disease," said Gage. (salk.edu)
  • During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (wisc.edu)
  • In recent years, the lab has identified stem and progenitor cells in articular cartilage, muscle and synovial tissues. (ucdavis.edu)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
  • Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)
  • This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
  • Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. (hindawi.com)
  • In contrast to adipogenic differentiation, high glucose suppressed osteogenic differentiation and downregulated the expression levels of osteogenic gene runt-related transcription factor 2 ( RUNX2 ), collagen type I ( COL1A1 ), osteonectin ( ON ), and osteocalcin ( OCN ) of mouse BM-MSCs and MG63 cells [ 7 , 9 ]. (hindawi.com)
  • The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
  • On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
  • AT-MSC submitted to osteogenic differentiation showed higher MTT conversion in formazan than BM-MSC, under the same conditions on days 7 and 21. (scielo.br)
  • It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
  • However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
  • We found that high glucose reduced proliferation but enhanced adipogenic differentiation of all MSCs examined. (hindawi.com)
  • The knowledge gained from this study will increase our understanding about the effect of high glucose on adipogenic differentiation of MSCs and might lead to an improvement in the diabetic treatment in the future. (hindawi.com)
  • An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)
  • After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells. (wikipedia.org)
  • They can also play a role in adult processes such as embryo implantation, hematopoiesis, and endothelial differentiation. (intechopen.com)
  • Since endothelial cell differentiation is one of the main steps to initiate vasculogenesis and angiogenesis, we analyzed the role of several Hox genes in the regulation of these two processes. (intechopen.com)
  • In this chapter, we summarized the evidence to support the function of Hox genes in adult tissues, specifically in endothelial cell differentiation, by studying their mechanism of action and how their target genes regulate vasculogenesis and angiogenesis. (intechopen.com)
  • In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
  • Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
  • The Church also supports research and therapies using adult stem cells, which are cells that come from any person who has been born - including umbilical cord blood, bone marrow, skin and other organs. (archstl.org)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • These pathways play a critical role in tissue health including repair to regeneration of various tissues and cells. (hairsite.com)
  • This is thought that inducing osteoblastic commitment and differentiation of stem cells such as mesenchymal stem cells. (wikipedia.org)
  • In the SVZ , BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis. (wikipedia.org)
  • BMP4, in conjunction with FGF2, promote differentiation of stem cells to mesodermal lineages. (wikipedia.org)
  • Interestingly, gene expression profiling revealed that ALDH hi cells are closer to human fetal pancreatic tissue compared with adult pancreatic tissue. (prinsesmaximacentrum.nl)
  • Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)
  • The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
  • This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). (medlineplus.gov)
  • The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
  • In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)
  • Promotes also differentiation and proliferation of hematopoietic cells. (joplink.net)
  • Their findings indicate that postmortem tissue may be a potential source of multipotent stem cells, with a variety of uses and applications. (salk.edu)
  • Tissue from older individuals yielded fewer proliferating cells. (salk.edu)
  • This study employed a pool of cells from extracted tissue," said Gage. (salk.edu)
  • The cells derived from these tissues constitute a model system for studying the brain cell biology of these disorders, according to Gage. (salk.edu)
  • In addition to isolating single cells in order to determine if true stem cells are present in adult brain tissue, Gage also plans to transplant recovered cells into animals to test if the cells can survive and differentiate in vivo. (salk.edu)
  • An adult source of stem cells would circumvent the need to derive such cells from fetal tissue, currently an issue of ethical debate. (salk.edu)
  • The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
  • The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
  • Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
  • During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
  • Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
  • These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
  • Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
  • The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • After division, cells need to respond to external cues from the surrounding tissue and decide whether to continue dividing or to halt the cell cycle to become specialised in a task required for the proper function of the tissue/organ where they reside. (europa.eu)
  • The right balance between these two fates of cells is essential not only for forming proper shapes of organs and tissues but also for maintaining their functions throughout the life of the organisms. (europa.eu)
  • Alternatively, all the cells may become specialised and stop producing new cells, which accelerates the degeneration of tissues or the ageing process. (europa.eu)
  • We found that when the function of the APC/C is compromised, the cells that normally become photoreceptors fail to acquire their fate and unspecialised masses of cells are formed in the middle of the adult fly eyes. (europa.eu)
  • The De Falco lab is interested in uncovering the mechanisms underlying the differentiation of the fetal gonad, focusing on how myeloid cells (such as macrophages) and vasculature promote tissue remodeling during organogenesis. (cincinnatichildrens.org)
  • Additionally, we are investigating the roles of myeloid cells in regulating spermatogonial stem cell differentiation in the adult testis. (cincinnatichildrens.org)
  • In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
  • TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM. (tocris.com)
  • This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
  • The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
  • Adult tissue homeostasis is maintained by residential stem cells. (sdbonline.org)
  • Stem cells exist both in embryos and adult cells. (articlecity.com)
  • Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
  • Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
  • They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
  • Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
  • The three key elements of regenerative medicine and tissue engineering are morphogenetic signals, stem cells, and scaffolds of extracellular matrix. (ucdavis.edu)
  • Building upon this work we are exploring the differentiation of embryonic and adult stem cells for articular cartilage and bone repair. (ucdavis.edu)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
  • Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
  • The non-embryonic stem cells like adult stem cells are in clinical use for many years and embryonic stem cells are now emerging as an alternative source for the same purpose with huge potentials in drug discovery and toxicological studies. (benthamscience.com)
  • Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)
  • Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. (scielo.br)
  • Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • The adipose tissue is an important reservoir of adult stem cells which have capacity of differentiating in osteoblasts with potential implication in reaching bone regeneration. (bvsalud.org)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
  • BMP4 also plays important roles in adipose tissue: it is essential for white adipogenesis, and promotes adipocyte differentiation. (wikipedia.org)
  • e) Antagonist but partial agonist in transactivation assays but inhibitor of adipocyte differentiation. (sigmaaldrich.com)
  • The tumors were screened for neural differentiation with an antibody panel consisting of neuron-specific enolase, S100 protein, Leu-7, chromogranin, synaptophysin, and neurofilament. (nih.gov)
  • Hence, five of 11 SRCT of bone or soft tissue with the t(11;22) showed morphologic and/or immunohistochemical evidence of neural differentiation. (nih.gov)
  • The clinical significance of additional cytogenetic abnormalities and of morphologic or immunohistochemical evidence of neural differentiation in this group of tumors needs to be further studied. (nih.gov)
  • citation needed] BMP4 also limits the extent to which neural differentiation in Xenopus embryos occurs by inducing epidermis formation rather than neural tissue. (wikipedia.org)
  • In some cases, "master" genes have been described which control differentiation versus self-renewal. (justia.com)
  • With a focus on mammalian spermatogenesis and intestinal maintenance, we review the role of "dynamical heterogeneity" in the regulation of adult stem cell self-renewal. (ucl.ac.uk)
  • Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
  • The UC Davis Center for Tissue Regeneration and Repair focuses on regeneration for the musculoskeletal system to restore function to tissue diseased or damaged from cancer, trauma, and arthritis. (ucdavis.edu)
  • Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
  • These genes play a central role during embryonic development by controlling body organization, organogenesis, and stem cell differentiation. (intechopen.com)
  • Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
  • Within the adult organism, stem cell reside in defined anatomical microenvironnments called niches. (ca.gov)
  • The related concept of Longevity Determination , however, is the result of a species-specific genomic expression during early development that positions the somatic tissues of an organism to survive long after its reproductive period has been completed. (agemed.org)
  • The evaluation of the osteoblastic differentiation can be verified through immunohistochemical markers such as bone morphogenetic protein- 2 (BMP-2). (bvsalud.org)
  • Alternative splicing eliminates exon 2 in 0.6-2% of AMPD1 mRNA transcripts in adult skeletal muscle. (jci.org)
  • RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
  • Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
  • PPARδ is ubiquitously expressed in tissues and has been implicated in energy metabolism in both adipose and skeletal muscle. (sigmaaldrich.com)
  • Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
  • Clinical, cytogenetic, histopathologic, and immunohistochemical data were obtained in a series of 11 small round cell tumors (SRCT) of bone and soft tissue with the translocation t(11;22) (q24;q12). (nih.gov)
  • Synovial tumors are extremely rare in both children and adults. (msdmanuals.com)
  • Synovial sarcoma is a malignant soft tissue tumor that arises in different types of soft tissue but is not of synovial origin and seldom occurs inside of a joint. (msdmanuals.com)
  • Abstract: Lineage tracing studies based on inducible genetic labeling have emphasized a central role for stochasticity in the maintenance and regeneration of cycling adult tissues, with frequent stem cell loss through differentiation compensated by the duplication of neighbors, leading to the consolidation of clonal diversity. (ucl.ac.uk)
  • The SULF1 and SULF2 transcripts were widely distributed in various tissues. (scielo.br)
  • The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. (tocris.com)
  • In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)
  • The maintenance of their "stemness" state and commitment to differentiation are tightly controlled by both intrinsic genetic and epigenetic programs and extrinsic stimuli. (wisc.edu)
  • Our results support the hypothesis that SRCT of bone of soft tissue with the t(11;22) form a single biologic entity displaying varying degrees of neuroectodermal differentiation. (nih.gov)
  • The revised AJCC Cancer Staging Manual, Eighth edition classifies soft tissue sarcoma based on tumor-node-metastasis (TNM) and tumor grade (G). (medscape.com)
  • Soft tissue sarcoma of the head and neck is a new classification and anatomic staging and prognostic groups have not yet been defined due to a lack of data. (medscape.com)
  • Tenosynovial giant cell tumor Tumors rarely affect joints, unless by direct extension of an adjacent bone or soft tissue tumor. (msdmanuals.com)
  • An increased number of skin and soft-tissue abscesses caused by community-acquired methicillin-resistant S aureus (MRSA) have occurred in children. (medscape.com)
  • Primary Malignant Bone Tumors Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)
  • In adults, especially those over age 40, metastatic tumors are about 100 times more common than primary malignant tumors. (msdmanuals.com)
  • Multiple myeloma Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)
  • These accessory tissues have been reported to undergo malignant transformation and should be removed. (medscape.com)
  • Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
  • Adipocytes in the accumulated fat tissues, especially around waist area and visceral organs, release several cytokines which reduce the sensitivity of several cell types to insulin leading to insulin resistant and type 2 diabetes [ 4 , 5 ]. (hindawi.com)
  • In this system, hormones are responsible for transmitting information between the organs, in addition to being essential in functions such as reproduction, being involved in the normal development of organisms, and in brain function and differentiation. (ivis.org)
  • BMP4 antagonizes organizer tissue and is expressed in early development in ectoderm and mesoderm tissue. (wikipedia.org)
  • VANCOUVER, BRITISH COLUMBIA, August 18, 2021 - STEMCELL Technologies and Hubrecht Organoid Technology (HUB) have announced that they have signed an agreement for the use of tissue-derived organoids-including lung, intestinal, and liver organoids-for use in preclinical toxicology screening and non-cancer drug development services to be offered by the Contract Assay Services division of STEMCELL. (stemcell.com)
  • Founded in 2008, Samumed is a California based pioneer in medical research and development for tissue regeneration applications. (hairsite.com)
  • Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
  • Neuroscience focusing on human development and disease has long been hampered due to ethical rea¬sons, low tissue availability, and low translatability from animal models. (lu.se)
  • Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)
  • These rare tumors arise from connective tissue, which provides strength and flexibility to structures such as bones, ligaments, and muscles. (medlineplus.gov)
  • Soon after birth, the nipples are raised from the shallow mammary pits by proliferation of the surrounding connective tissue. (medscape.com)
  • Among the chromatin accessibility methods, complex methods DeepAccess and diffTF have higher correlation with the ranked significance of transcription factor candidates within reprogramming protocols for differentiation. (nature.com)
  • Tumor grade is based on cellular differentiation, mitotic rate, and extent of necrosis, as outlined in Table 1. (medscape.com)
  • In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)
  • not only can gene expression be manipulated and lineages traced at single-cell and whole-tissue levels, but complete population counts of all cell types are possible. (stanford.edu)
  • In adults, participates in wound healing as well as organ regeneration and tissue remodeling. (joplink.net)
  • One type of organ adaptation occurs through tissue growth and shrinkage, tuning an organ's functional capacity to meet variable levels of physiologic demand. (stanford.edu)
  • Unlike embryonic growth, adult organ remodeling is reversible and repeatable, suggesting that it occurs through different mechanisms. (stanford.edu)
  • In adult flies, the midgut is a stem cell-based organ analogous to the vertebrate small intestine. (stanford.edu)
  • In adult, BMP4 is important for the neurogenesis (i.e., the generation of new neurons) that occurs throughout life in two neurogenic niches of the brain, the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles. (wikipedia.org)
  • Div-Seq: single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons. (nature.com)
  • Secondly, we have developed an all-in-one vector-based strategy to convert adult human dermal fibroblasts directly from Huntington's disease (HD) patients and control individuals into induced neurons (iNs). (lu.se)
  • The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
  • Interestingly, aux depletion causes a dramatic increase in EGFR signaling, with a strong accumulation of EGFR at the plasma membrane and an increased expression of EGFR ligands in response to tissue stress. (sdbonline.org)
  • Each receptor shows a differential pattern of tissue expression and is activated by structurally diverse compounds including endogenous long-chain fatty acids. (sigmaaldrich.com)
  • The tissue specific expression of these cofactors may be responsible for the differential transcriptional regulation and responses observed in different cell types in vivo . (sigmaaldrich.com)
  • The dynamics of RACK1 levels in isolated adult SC of mice, i.e., progressively high during differentiation and low compared to proliferating conditions, and RACK1 silencing indicated that RACK1 promotes both the formation of myotubes and the accretion of nascent myotubes. (sdbonline.org)