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  • patient's
  • Scientists have long hoped to find a way to reprogram a patient's cells to produce new ones. (redorbit.com)
  • Henry Ford Cancer Institute has treated its first patient with CAR T-cell therapy, an approach that uses engineered cells from a patient's immune system to destroy cancer. (medicalxpress.com)
  • To create specialized cell types for use in cell therapy requires only that we insert the genes (or use non-transgenic approaches) and then test the drug dose and timing required for each cell type and each patient, so it should be relatively scalable at low cost compared to other approaches using each patient's own cells," Waddell says. (eurekalert.org)
  • If human cells can be exploited for therapeutic treatments, Miller says, "complications seen in donor transplantations are avoided as the patient's own cells are being transplanted. (scientificamerican.com)
  • Harvard Stem Cell Institute
  • Although this is a huge scientific step, Douglas Melton, co-director of the Harvard Stem Cell Institute and a researcher with the Howard Hughes Medical Institute, wrote in the journal Nature that the approach is not ready for people. (redorbit.com)
  • The Melton [ Harvard Stem Cell Institute (HSCI) co-director Doug Melton ] team reports in today's online edition of the journal Nature that, using a technique it is calling 'direct reprogramming,' the team is able to turn mouse exocrine cells, which make up about 95 percent of the pancreas, into precious and rare insulin-producing beta cells. (medgadget.com)
  • intestinal
  • The Vatican will help fund a research study into the potential use of adult stem cells to treat intestinal and possibly other diseases, officials announced April 23. (thenewamerican.com)
  • He said that intestinal stem cells have certain features that make them appealing for this kind of research. (thenewamerican.com)
  • The two most well-studied examples of adult stem cells are the hematopoietic stem cells, which give rise to blood cells, and the intestinal crypt stem cells, which give rise to the intestinal epithelium. (conservapedia.com)
  • As far back as 1962 Gurdon became the first scientist to clone an animal, making a healthy tadpole from the egg of a frog with DNA from another tadpole's intestinal cell. (reuters.com)
  • organs
  • This technology can theoretically be applied to almost any cell type that can be isolated and purified, and isolation of highly purified populations of adult cells from most organs is already possible with existing techniques. (eurekalert.org)
  • Cancer risk is not linked to different rates of adult stem-cell division in organs, a study suggests. (bionews.org.uk)
  • tumors
  • Despite significant progress, these protocols remain limited by low yield and purity of the desired mature cell types, as well as the potential of immature cells to form tumors. (eurekalert.org)
  • One problem with using iPS cells therapeutically is that the reprogramming process creates cells prone to forming tumors . (scientificamerican.com)
  • Among concerns is the fear that implanted cells could grow out of control and develop into tumors. (reuters.com)
  • pancreas
  • Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. (springer.com)
  • These beta cells, which comrpise [ sic ] about one percent of the pancreas, are the cells that die off in Type I diabetes. (medgadget.com)
  • Eventually we learned that of the 1,100, only about 200 are actually expressed in cells that are involved in forming the pancreas. (medgadget.com)
  • Next,' Melton continued, 'we decided that of the 200, we only cared about the ones that are expressed in the key part of the pancreas where the beta cells are - and that got us down to about 28. (medgadget.com)
  • leukaemia
  • People with blood cancers like leukaemia have to undergo chemotherapy to eradicate the blood cells that are causing their cancer. (newscientist.com)
  • But doctors thought this came at a price - if the immune cells in the cord blood are less aggressive to the recipient, then presumably they are also less aggressive to any residual leukaemia cells. (newscientist.com)
  • Reprogramming
  • The work is "a major leap" in reprogramming cells from one kind to another, said one expert not involved in the research, John Gearhart of the University of Pennsylvania. (redorbit.com)
  • The work brings "more excitement to the idea of using reprogramming as a way to treat diabetes," said researcher Mark Kay of Stanford University, who is studying the approach with liver cells. (redorbit.com)
  • A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, potentially safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. (eurekalert.org)
  • In investigating Jmjd3 and its role in iPSC reprogramming, Wang's team found Jmjd3 has two previously unknown functions - it helps regulate cell growth and cellular aging and Jmjd3 deactivates another nuclear protein, PHF20. (healthcanal.com)
  • genes
  • These cells were modified by a standard lab technique employing retroviruses customized to insert genes into the cell's DNA. (scienceblog.com)
  • The inserted genes were Oct4, Sox2, Lif4 and c-Myc, known to act together as master regulators to keep cells in an embryonic-stem-cell-like state. (scienceblog.com)
  • Potential alternatives include other forms of viruses, synthesized versions of the proteins created by the four master regulator genes that are modified to enter the cell nucleus, and small molecules, Hanna says. (scienceblog.com)
  • The discovery led to one even more intriguing - that the memory is fully retrievable: under certain conditions, cells can play the story of their development in reverse to switch on genes that were active in the fetal state. (newswise.com)
  • It also holds promise for cancer research, particularly on the ability of cancer cells to activate long-unused genes to help them spread throughout the body. (newswise.com)
  • PRC2 is one of the major proteins used by cells to turn off specific genes. (newswise.com)
  • Undifferentiated stem-like cells and differentiated cells from one person have the exact same genes. (healthcanal.com)
  • fetal
  • The results are a surprise because fetal immune cells haven't had the lifelong "training" that adult immune cells have had, yet they still seem to recognise and destroy abnormal cells. (newscientist.com)
  • Increasingly, donated umbilical cord blood - which contains fetal stem cells - is being used instead of bone marrow transplants because the risk of rejection is lower with the immature cells. (newscientist.com)
  • About 99 percent of cells found in amniotic fluid are terminally differentiated cells mostly from fetal skin, which are shed into the amniotic fluid as a fetus develops. (scienceblog.com)
  • Biology
  • Biology textbooks say that once a cell matures to serve a specific role, like, say a red blood cell, it can never go back into a less mature state. (tvnewslies.org)
  • A recent paradigm-shift in cancer biology was the discovery that cancer is a disease resulting from dysregulation of adult stem cells. (conservapedia.com)
  • Critical and cutting edge, Protocols for Adult Stem Cells is an essential guide which provides groundbreaking and novel techniques certain to redefine the field of stem cell biology. (worldcat.org)
  • clinical
  • Tsang is optimistic that the research presented by MacLaren's group 'will pave the way for clinical use of stem cell derived photoreceptors. (freerepublic.com)
  • Ludovic Vallier , one of the paper's corresponding authors, said in a prepared statement: 'Our work represents an important step towards delivering the clinical promises of stem cells. (scientificamerican.com)
  • diseases
  • Amniotic fluid skin cells can be safely obtained from pregnant women undergoing amniocentesis at about 15 weeks of pregnancy as part of a diagnostic workup for chromosome aberrations and other genetic diseases. (scienceblog.com)
  • Developing cell lines from individual amniotic fluid samples can accelerate the development of existing targets for different diseases. (scienceblog.com)
  • We have pursued cell therapy for lung diseases for many years," Waddell says. (eurekalert.org)
  • Cultures representing two other hereditary liver diseases, alpha 1-antitrypsin deficiency (a protein-folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder-specific abnormalities. (scientificamerican.com)
  • The implications of this discovery for how we think about cells' capabilities, and for the future treatment of degenerative and other diseases, are potentially profound. (newswise.com)
  • In two different attempts to treat degenerative eye diseases with stem cells, three patients have been blinded, while disease progression has been stopped in a separate patient. (bionews.org.uk)
  • A few of these questions include: Which patients with cardiovascular diseases should be considered for stem cell therapy? (ahajournals.org)
  • Because they are responsible for the body's natural ability to fight diseases, heal and recover, or fail and succumb to various maladies, it has become increasingly important to adapt or devise new methods to identify and obtain these cells in quantity and purity for further study. (worldcat.org)
  • types
  • Amniotic fluid cells work much better than any other cell types when turning back their 'internal clock. (scienceblog.com)
  • This may account for the heterogeneous mixture of models, methods, types, quantity, and nature of the cells employed and the timing of experiments. (ahajournals.org)
  • immune
  • The transplant has an extra benefit: the new immune cells in the blood can help finish off any residual cancer cells that survived the chemotherapy. (newscientist.com)
  • Certain kinds of these cells may be rejected by the immune system, which would thus doom them as an option for transplant, according to a study published online by the British science journal Nature. (medindia.net)
  • The responders were T cells -- the heavy artillery of the immune system, which are designed to destroy invading microbes. (medindia.net)
  • donors
  • When the team compared three of the disease-specific cultures with the cells generated from the healthy controls, they discovered that the diseased cells had many of the key molecular defects characteristic of the original donors' liver disorder. (scientificamerican.com)
  • study's lead author
  • There remains today a need in stem cell research for an easily reprogrammable cell type," said the study's lead author, Dr. Katalin Polgar, Assistant Professor of Medicine, Cardiology and Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine. (scienceblog.com)
  • One problem in liver research is that no one is able to grow liver cells in the lab,' says the study's lead author, Sheikh Tamir Rashid. (scientificamerican.com)