• Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology. (ox.ac.uk)
  • For the first time, researchers have described the possible regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes. (ox.ac.uk)
  • details] The relationship between temperature and calcium in acute cell damage after exposure to radiofrequency or thermal energy in isolated neonatal and adult rabbit cardiac myocytes [med. (emf-portal.org)
  • It is expected that 30% of the time will be dedicated to scientific services which support experimental research including aseptic tissue collection, tissue and cell culture and isolation of primary neonatal and adult cardiac myocytes from both mice and rats. (vascular-proteomics.com)
  • Building upon doctoral and postdoctoral experience working with protein kinases, Dr Allen initiated studies on the role mitogen activated protein kinase (MAPK) activities in the cardiac hypertrophy. (icm-mhi.org)
  • Microscopically, all hamartomas were involved by myocyte hypertrophy and disarray, without inflammation or calcification. (elsevierpure.com)
  • The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy. (foo-lab.sg)
  • Increases in cardiac afterload caused by disease conditions results in remodeling of heart structure by hypertrophy and alterations in the molecular regulation of contractile performance. (temple.edu)
  • Previous reports indicate that STIM1 may play a role in regulation of cardiac hypertrophy. (temple.edu)
  • We induced cardiac hypertrophy by slow progressive pressure overload in adult cats. (temple.edu)
  • Cardiac hypertrophy and failure are characterized by transcriptional reprogramming of gene expression. (ca.gov)
  • Cardiac stress triggers adult hearts to undergo hypertrophy and a shift from alpha-MHC to fetal beta-MHC expression. (ca.gov)
  • The aim of the present study was to investigate the effect of grape seed extract consumption with moderate intensity aerobic exercise on some markers of cardiac myocyte apoptosis in male Wistar rats with type 1 diabetic. (magiran.com)
  • During extended myocardial ischemia combinations of hypoxia and acidosis drive cardiac cell loss by apoptosis and necrosis that contribute importantly to myocardial infarction (MI). (biomedres.us)
  • Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
  • Cardiac myocyte cell death by apoptosis accompanies heart disease of both ischemic and nonischemic origin [1-3]. (biomedres.us)
  • Our group reported that severe chronic hypoxia alone does not cause apoptosis of cardiac myocytes in culture. (biomedres.us)
  • Inhibition of Na+/H+ exchange is protective against ischemic injury, while inhibition of the vacuolar ATPase promotes apoptosis, in part by shifting the proton load toward the Na+/H+ transporter and thus increasing Ca2+ uptake, and in part by reducing the myocyte capacity to control [pH]i. (biomedres.us)
  • This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
  • AcceGen Human Cardiac Myocytes are produced at AcceGen's cell culture fa-cility from normal human ventricle tissue of the adult heart. (bjbiocreative.com)
  • Shortly after isolation, all AcceGen Human Cardiac Myocytes are cryo-preserved at assage 2 (P2) using AcceGen's proprietary serum-free freezing medium, Cryo-SFM. (bjbiocreative.com)
  • Cholesterol uptake was tested by Filipin staining in neonatal cardiac myocytes. (nih.gov)
  • ß-Adrenergic stimulation regulates cardiac contractility through a cyclic adenosine monophosphate (cAMP)- and protein kinase A (PKA)- dependent signaling pathway. (fu-berlin.de)
  • Ventricular myocyte contractility assay Cardiac myocytes had been isolated from adult feminine mice as referred to by O'Connell evaluation. (woofahs.com)
  • Ccna2 mediated cardiac repair showed both a decrease in fibrosis in the peri-infarct tissue and a greater number of cardiomyocytes at the sites of injection. (wikipedia.org)
  • Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodelling and susceptibility to arrhythmias. (elsevierpure.com)
  • It is postulated that the lack of cardiac regeneration in the postnatal heart confounds the myocyte dysfunction, cell death and tissue fibrosis that is associated with decompensated heart failure. (ucdavis.edu)
  • Endomyocardial fibrosis (EMF) is an idiopathic disorder of the tropical and subtropical regions of the world that is characterized by the development of restrictive cardiomyopathy and fibrotic changes in the endocardium, usually limited to the cardiac apex. (medscape.com)
  • [ 6 ] Fibrosis has also been suggested as facilitating focal activity by fibroblast-myocyte coupling as well. (medscape.com)
  • Cardiac myocytes isolated from neonatal or adult rat hearts were cultured in control or in three different hypercholesterolemic media with increasing cholesterol content (hiChol) or hiChol + hyperglycemic medium, respectively. (nih.gov)
  • Forced expression of these factors in dividing non-cardiomyocytes in mice reprograms these cells into functional cardiac-like myocytes, improves cardiac function and reduces adverse ventricular remodelling following myocardial infarction. (elsevierpure.com)
  • Pulmonary exposure of rats to UFTiO2 increased the phosphorylation levels of p38 mitogen-activated protein kinase and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. (cdc.gov)
  • First, we examine the experimental research data that provide insights into the mechanisms and origins of the replicating cardiac myocytes, including cell populations referred to as cardiac progenitor cells ( i.e ., c-kit+ cells). (wjgnet.com)
  • A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart. (foo-lab.sg)
  • Here, we outline a convenient, alternative approach to isolation and culture of viable myocytes and non-myocytes from the adult mouse heart, developed in our lab. (foo-lab.sg)
  • With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. (foo-lab.sg)
  • However, the detailed epigenetic processes involved in maturation from fetal to adult CMs and in cardiac disease leading to terminal heart failure have not been fully uncovered, yet. (nature.com)
  • It preserves fetal cardiac differentiation by interacting with histone deacetylase (HDAC) and poly (ADP ribose) polymerase (PARP) to repress alpha-MHC and activate beta-MHC. (ca.gov)
  • Javier E. Lopez is interested in studying how soluble factors may regulate the transition of cardiac myocytes from regeneration during fetal growth to hypertrophic growth postnatally. (ucdavis.edu)
  • Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells: role in regulation of inducible nitric oxide synthase (NOS2). (ksw.ch)
  • Regulation of cytokine-inducible nitric oxide synthase (NOS2) in cardiac myocytes and microvascular endothelial cells: role of ERK1/ERK2 (p44/p42) mitogen activated protein kinases and STAT1a. (ksw.ch)
  • Regulation of bFGF expression and ANG II secretion in cardiac myocytes and microvascular endothelial cells. (ksw.ch)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • abstract = "Only 8 cases of hamartomas of mature cardiac myocytes have been reported. (elsevierpure.com)
  • Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
  • Here we show that Brg1, a chromatin-remodelling protein, has a critical role in regulating cardiac growth, differentiation and gene expression. (ca.gov)
  • There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)
  • Delivery of Ccna2 into cardiac tissue invokes a regenerative response and markedly enhances cardiac function. (wikipedia.org)
  • Myocyte vacuolization and venular dilatation occurred only in the pediatric cases, and interstitial adipose tissue only affected 1 adult. (elsevierpure.com)
  • Localization of AKAP18δ in cardiac tissue 49 3.1.2. (fu-berlin.de)
  • AKAP18δ is expressed in adult rat heart tissue 77 4.1.2. (fu-berlin.de)
  • Myocardial strain imaging uses speckle-tracking echocardiography to measure tissue deformation through the cardiac cycle. (medscape.com)
  • Because ECV defines the proportion of a volume of tissue that consists of extracellular matrix or space between myocytes, it is a marker of myocardial tissue remodeling. (medscape.com)
  • Cardiac myosin binding protein-C (cMyBP-C) is one of the proteins that make up the contractile apparatus of cardiomyocytes. (scirp.org)
  • Adult cardiomyocytes in mice primarily express alpha-myosin heavy chain (alpha-MHC, also known as Myh6), whereas embryonic cardiomyocytes express beta-MHC (also known as Myh7). (ca.gov)
  • In adults, Brg1 (also known as Smarca4) is turned off in cardiomyocytes. (ca.gov)
  • In an ex vivo coronary perfusion model of intact adult rabbit hearts, we previously reported gene transfer to 96% of cardiac myocytes after a 60 min exposure to 1.6 x 10(9) p.f.u./ml Ad beta gal, a recombinant adenovirus encoding beta-galactosidase. (nih.gov)
  • CORVERT Injection prolongs action potential duration in isolated adult cardiac myocytes and increases both atrial and ventricular refractoriness in vivo , ie, class III electrophysiologic effects. (pfizermedicalinformation.com)
  • recently demonstrated that the developmental VEGFA-MEF2 pathway, which was thought to be involved, is in fact impaired in adult ischaemic hearts. (elifesciences.org)
  • We hypothesized that the inflammatory state of heart failure would cause translocation of HSP60 to the plasma membrane and that this would provide a pathway for cardiac injury. (houstonmethodist.org)
  • Dr. Allen is now studying the role of nuclear GPCRs in regulating cardiac growth and function. (icm-mhi.org)
  • Separately, the incubation of cardiac myocytes isolated from naïve adult rat hearts in vitro with UFTiO2 did not alter the phosphorylation status of the same cardiac proteins. (cdc.gov)
  • Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. (elsevierpure.com)
  • Thus, GLP-1 and insulin may regulate skeletal and cardiac muscle endothelial surface area and nutrient delivery under physiological conditions. (medscape.com)
  • Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia. (cdc.gov)
  • By growing cardiac myocytes from neonatal rats in media with different pH, the team were able to identify genes which are pH-sensitive. (ox.ac.uk)
  • These nuclear pH differences are important in heart pathology, and are significantly dysregulated in myocytes from cryo-infarcted adult rats or sheep with heart failure. (ox.ac.uk)
  • Forty adult male Wistar rats with an initial weight range of 160-220 g were divided into 5 groups of including diabetic / training + extract, diabetic / training, diabetic / extract, diabetic / control and healthy / control (8 heads per group). (magiran.com)
  • By combining the antioxidant and anti-inflammatory effects of moderate-intensity aerobic exercise along with the consumption of grape seed extract, more anti-apoptotic effects may be induced in the myocytes of type 1 diabetic rats. (magiran.com)
  • Using an inducible, cardiac-specific PGC-1a transgene, she showed that overexpression of PGC-1a induces mitochondrial biogenesis in neonatal mice, but causes cardiomyopathy in adult mice (Circ. (slu.edu)
  • Man mice 2C10 a few months of age had been useful for all tests except for tests using isolated ventricular myocytes, that have been isolated from feminine mice. (woofahs.com)
  • The adult mammalian heart possesses little regenerative potential following injury. (elsevierpure.com)
  • Considering the complex nature of the adult heart, it is no wonder that innate regenerative processes, while maintaining adequate cardiac function, fall short in myocardial jeopardy. (wjgnet.com)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
  • The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
  • This is the first demonstration that the combination of the current hypercholesterolemic medium and SI/R in cardiac myocytes mimics the cardiac pathology of the comorbid heart with I/R and hypercholesterolemia. (nih.gov)
  • Our anatomical pathology database was searched for all cases of cardiac hamartoma, of which 7 represented mature myocyte type. (elsevierpure.com)
  • Changes in intracellular pH also often accompany cardiac development or heart pathology. (ox.ac.uk)
  • In doing so, they explain how it is relevant in the context of heart physiology and cardiac development, and in pathology, namely cardiac ischaemia and heart failure. (ox.ac.uk)
  • The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
  • Important roles of inflammatory mediators in cardiac cell death by ischemia with or without reperfusion are well established [12-14]. (biomedres.us)
  • Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury. (foo-lab.sg)
  • Hypoxic cardiac myocytes generate excess H+ through increased anaerobic glycolysis, net hydrolysis of ATP, and CO2 retention. (biomedres.us)
  • We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis -regulatory and genic regions to shape the cardiac myocyte transcriptome. (nature.com)
  • Here we describe the human CM epigenome during prenatal development and postnatal maturation of the heart from infant to adult age and in terminal failure. (nature.com)
  • Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
  • Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5) P 3 ester provoked the occurrence of spontaneous diastolic Ca 2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (biologists.com)
  • Most of these pH-sensitive genes are related to cardiac muscle contraction. (ox.ac.uk)
  • Researchers discovered that the expression of genes important for cardiac contraction is dependent on the transcriptional co-factor p300/CBP. (ox.ac.uk)
  • Be-cause they are responsible for the myo-genic contraction of the whole cardiac muscle, Cardiac Myocytes are the most physically energetic cells in the body. (bjbiocreative.com)
  • Both the RYR2 and CASQ2 proteins are involved in the movement of calcium within myocytes, which is critical for the regular contraction of these cells. (medlineplus.gov)
  • Mutations in either the RYR2 or CASQ2 gene disrupt the handling of calcium within myocytes, which interferes with the coordination of contraction and relaxation of the heart, particularly during exercise or emotional stress. (medlineplus.gov)
  • Cardiac fibroblasts account for a majority of cells in the heart and represent a potential cellular source for restoration of cardiac function following injury through phenotypic reprogramming to a myocardial cell fate. (elsevierpure.com)
  • Our results suggest a strategy for cardiac repair through reprogramming fibroblasts resident in the heart with cardiogenic transcription factors or other molecules. (elsevierpure.com)
  • trx_column_item] [trx_column_item align="center"][trx_image url="http://www.foo-lab.com/wp-content/uploads/2019/06/image-4.jpeg" title="Co-culture of cardiac myocytes (green) and fibroblasts (red) isolated from a single heart. (foo-lab.sg)
  • Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. (nature.com)
  • Because of this gene silencing, adult heart muscle cells cannot divide readily to repair and regenerate after a heart attack. (wikipedia.org)
  • The enlarged cardiac silhouette on this image is due to congestive heart failure due to the effects of chronic high blood pressure on the left ventricle. (medscape.com)
  • Cardiac myocyte membrane wounding in the abruptly pressure overloaded rat heart under high wall stress. (ksw.ch)
  • Thus abnormal trafficking of HSP60 to the cell surface may be an early trigger for myocyte loss and the progression of heart failure. (houstonmethodist.org)
  • Cardiac muscle, a unique type of striated muscle in the human heart, is composed of single Cardiac Myocytes (HCM). (bjbiocreative.com)
  • trx_image url="http://www.foo-lab.com/wp-content/uploads/2019/06/Image-2-1024×374.png" title="Freshly isolated myocytes from an adult mouse heart. (foo-lab.sg)
  • The role of STIM1 in heart is not well understood, given the robust Ca2+ regulatory machinery present within cardiac myocytes. (temple.edu)
  • Glycemic Control and Heart Failure Among Adult Patients With Diabetes. (ter-arkhiv.ru)
  • This article describes how different classes of epigenetic regulators (BAF, HDAC, PARP) work together to control heart muscle development in embryos and heart function in the adult. (ca.gov)
  • Our global hypothesis is that by manipulating the cardiac gene program of the failing heart with soluble factors (drugs), we may augment endogenous and/or transplanted cardiac myocyte regeneration to ameliorate the progression of left and/or right ventricular failure. (ucdavis.edu)
  • My laboratory focus is in studying the fundamental mechanisms of this growth transition to enhance the translational efficacy of soluble factors (drugs) and cell-based strategies (stem-cells) for cardiac regeneration in the failing heart. (ucdavis.edu)
  • For example, cases of bradyarrhythmia and heart block during a seizure might require a cardiac pacemaker. (medscape.com)
  • To maintain cardiac output, the vagal nerve tone is lowered by autonomic centers, so that the heart rate is increased and the cardiac output can remain stable. (medscape.com)
  • Digitalis strengthens the force of contractions of weakened hearts, but it is not a cardiac vitamin that can make a strong heart stronger. (medscape.com)
  • If CPVT is not recognized and treated, an episode of ventricular tachycardia may cause the heart to stop beating (cardiac arrest), leading to sudden death. (medlineplus.gov)
  • Researchers suspect that CPVT may be a significant cause of sudden death in children and young adults without recognized heart abnormalities. (medlineplus.gov)
  • For the heart to beat normally, heart muscle cells called myocytes must tense (contract) and relax in a coordinated way. (medlineplus.gov)
  • In conclusion, the inhalation of UFTiO2 enhanced the phosphorylation levels of cardiac proteins. (cdc.gov)
  • In conclusion, hamartomas of mature cardiac myocytes may be detected at any age. (elsevierpure.com)
  • Normally, Ccna2 is silenced postnatally in mammalian cardiac myocytes. (wikipedia.org)
  • Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, and Kelly DP. Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor g Coactivator-1a Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a Developmental Stage-Dependent Manner. Circulation Research 94: 525 â€" 533 (2004). (slu.edu)
  • Compartmentalization of cellular signaling in cardiac myocytes 15 1.6.1. (fu-berlin.de)
  • Intracellular pH has to be tightly regulated in all cells of our body, including cardiac myocytes, as protons (H+) can have a significant impact on protein activity and cellular function. (ox.ac.uk)
  • The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)
  • Baseline perfusion with 1.0 x 10(8) p.f.u./ml Ad beta gal in normal Krebs solution (1 mM calcium) caused infection of 22% of myocytes at 30 min and 40% at 60 and 120 min. (nih.gov)
  • More recent work has employed overexpression of PGC-1a and NRF-1 in primary cardiac myocytes cultures to delineate NRF-1-dependent pathways downstream of PGC-1a. (slu.edu)
  • Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry. (medlineplus.gov)
  • Cyclin A2 (Ccna2) is a key protein involved in the direction of mammalian cardiac myocytes to grow and divide, and has been shown to induce cardiac repair following myocardial infarction. (wikipedia.org)
  • To investigate the functional significance of this interaction, we expressed green fluorescent protein fusion constructs encoding defined fragments of titin's M-line region and MURF-1 in cardiac myocytes. (rupress.org)
  • Phosphorylation of cMyBP-C is essential for normal cardiac function, since dephosphorylation of this protein leads to its degradation and has been associated with cardiomyopathy. (scirp.org)
  • Barefield, D. and Sadayappan, S. (2010) Phosphorylation and function of cardiac myosin-binding protein c in health and disease. (scirp.org)
  • Schlossarek, S., Mearini, G. and Carrier, L. (2011) Cardiac myosin-binding protein c in hypertrophic cardiomyopathy: Mechanisms and therapeutic opportunities. (scirp.org)
  • Voulgari Ch, Papadogiannis D, Tentolouris N. Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies. (ter-arkhiv.ru)
  • Thanks to technologic advances in cardiac imaging, multimodality studies provide insight into the pathophysiology of both ischemic and nonischemic cardiomyopathy. (medscape.com)
  • Unlike freshly isolated rod-shaped myocytes, AcceGen HCM are suitable for long-term experiments, as they are prepared according to a spe-cial protocol. (bjbiocreative.com)
  • Blockade of efflux of sodium increases calcium in myocytes resulting in increased activation of contractile proteins in the cardiac muscle. (medscape.com)
  • In spite of these enchaining limitations, cardiac rejuvenation occurs as well as restricted regeneration. (wjgnet.com)
  • β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. (ucdavis.edu)
  • Other than the direct effects of the beta-adrenoreceptor blockade, toxicity may result from other mechanisms, including sodium and calcium channel blockade, centrally mediated cardiac depression, and alteration of cardiac myocyte energy metabolism. (shakuhachi.net)
  • Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • Furthermore, we observed that acute injury in adult cardiac myocytes resulted in movement of HSP60 to the plasma membrane. (houstonmethodist.org)
  • Research applications should focus on mitigation/management of adverse effects associated with anti-cancer treatments including: cytotoxic chemotherapies, targeted agents, immunomodulatory therapies and radiation (that occur during cancer treatment and/or long-term survivorship) as defined by cardiac and/or vascular specific common terminology criteria for adverse events (CTCAE). (nih.gov)
  • For insulin to exert its metabolic effects in muscle and for nutrients to be used by the myocytes, insulin and nutrients first have to be delivered to the capillaries bathing the myocytes and then transported through the vascular wall to reach muscle interstitium. (medscape.com)
  • In normoxia, viability of hiChol neonatal cardiac myocytes was not significantly changed, however, superoxide levels were increased as compared to vehicle. (nih.gov)
  • Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
  • Graphpad Prism software program (NORTH PARK, CA, USA) was useful for statistical evaluation, and 0.001) increased the contractile amplitude of myocytes from both genotypes ( 0.05) ( 0.001) weighed against basal contractile function in the lack of isoproterenol. (woofahs.com)
  • A study of hemodynamic function in patients with ejection fractions both above and below 35% showed no clinically significant effects on cardiac output, mean pulmonary arterial pressure, or pulmonary capillary wedge pressure at doses of CORVERT up to 0.03 mg/kg. (pfizermedicalinformation.com)
  • It is reactivated by cardiac stresses and forms a complex with its embryonic partners, HDAC and PARP, to induce a pathological alpha-MHC to beta-MHC shift. (ca.gov)
  • Isolated adult feline ventricular myocytes (AFMs) exhibited increased STIM1 expression and activity, which correlated with altered Ca2+ handling. (temple.edu)
  • In embryos, Brg1 promotes myocyte proliferation by maintaining Bmp10 and suppressing p57(kip2) expression. (ca.gov)
  • In addition to evoking spontaneous Ca 2+ transients, stimulation of ventricular myocytes with the Ins(1,4,5) P 3 ester caused a positive inotropic effect. (biologists.com)
  • Two adult males had only mild coronary disease angiographically. (elsevierpure.com)
  • Modulation of coronary circulation and the cardiac matrix by the renin angiotensin system. (ksw.ch)
  • The goal of this work is to understand how STIM1 can affect contractile Ca2+ regulation in normal and diseased myocytes. (temple.edu)