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  • MSCs
  • This study demonstrates the safety of adult allogenic human BM-MSCs transplanted into the SVZ of the brain and its efficacy in early-stage PD patients. (hindawi.com)
  • Study
  • The Bone Marrow Transplant Survivor Study, a collaborative effort between the City of Hope Cancer Center and the University of Minnesota, examines the long-term outcomes of individuals who have survived 2 or more years after undergoing HCT and compares them with nearest-age siblings. (aacrjournals.org)
  • The Human Subjects committee at the participating institutions approved the Bone Marrow Transplant Survivor Study protocol. (aacrjournals.org)
  • HSCs
  • These findings place B-2, MZ, and B-1b in a single adult developmental lineage and place B-1a in a separate lineage derived from HSCs that are rare or missing in adults. (pnas.org)
  • These differences in B-cell reconstitution capabilities of adult versus neonatal BM underlie the idea that B-1 and B-2 belong to distinct developmental lineages derived from distinct HSCs ( 13 ). (pnas.org)
  • In studies here, we close this gap by definitively demonstrating that individual HSCs sorted from adult BM fully reconstitute B-2, MZ, and some B-1b but do not reconstitute B-1a. (pnas.org)
  • populations
  • By sorting and transferring highly enriched HSC populations from adult BM and neonatal sources, these investigators demonstrate that the HSC population sorted from adult BM principally reconstitutes B-2 and B-1b and only poorly reconstitutes B-1a ( 5 ). (pnas.org)
  • primary
  • Primary care physicians provide health care for an increasing number of adult long-term survivors of HCT, emphasizing the need for increased awareness of the long-term follow-up needs of the HCT survivors by the health care providers. (aacrjournals.org)