Daily oral beta-adrenoreceptor antagonist has been shown to be effective in preventing migraine headaches. (ku.edu)
Hence, the purpose of this trial is to determine the anxiolytic and fear memory reconsolidation inhibiting effects of the beta-adrenoreceptor antagonist propranolol on patients with high levels of fear in anticipation of a dental extraction. (eur.nl)
Tamsulosin2
Non-selective α-adrenergic receptor antagonists include: Phenoxybenzamine Phentolamine Tolazoline Trazodone Selective α1-adrenergic receptor antagonists include: Alfuzosin DoxazosinPrazosin (inverse agonist) Tamsulosin Terazosin Silodosin Selective α2-adrenergic receptor antagonists include: Atipamezole Idazoxan Mirtazapine Yohimbine Finally, the agents carvedilol and labetalol are both α and β-blockers. (wikipedia.org)
Selective antagonist of alpha 1A/1B adrenoreceptor sub-type contains Tamsulosin, available in capsule. (globalpharmaceuticalspk.com)
Prazosin2
Using α1 selective antagonists, such as prazosin, has been efficacious in treating mild to moderate hypertension. (wikipedia.org)
Prazosin is a selective α- 1 -adrenergic receptor antagonist used to treat hypertension. (pharmfair.com)
Selective antagonist3
Silodosin is a selective antagonist of alpha-1 adrenoreceptors. (mdtodate.com)
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. (mdtodate.com)
The positive inotropic effect and the hydrolysis of phosphoinositide induced by endothelin-3 in rabbit ventricular myocardium: inhibition by a selective antagonist of ET(A) receptors, FR139317. (aspetjournals.org)
Agonist2
1 ) showed that systemic treatment with β 2 -adrenoreceptor agonist improved glucose tolerance in diabetic rats and obese mice. (diabetesjournals.org)
In reality, there is a continuum between estrogen receptor agonist and estrogen receptor antagonist activity and some compounds behave as estrogen receptor agonists in some tissues but estrogen receptor antagonists in others. (justia.com)
Receptor antagonist3
Silodosin, an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). (nih.gov)
Animal studies suggest that some of the metabolites may also have 5-HT 3 receptor antagonist activity. (nih.gov)
LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190. (aspetjournals.org)
Adrenoceptor antagonist2
SR 59230A hydrochloride is a potent and selective β 3 adrenoceptor antagonist (IC 50 values are 40, 408 and 648 nM for β 3 , β 1 and β 2 receptors respectively). (bio-techne.com)
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity. (bvsalud.org)
Female rats treated by beta(2)-adrenergic stimulating ligands exhibit an increased, male type SDN-POA volume while male rats treated by beta1-adrenergic antagonists show a decreased, female type of SDN-POA volume. (nel.edu)
Adrenergic3
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). (wikipedia.org)
Silodosin 4 mg Capsules - Silodosin belongs to the group of medicines called selective alpha-1 adrenergic receptor antagonists. (medibyte.in)
In the present study we document that short postnatal treatment with beta-adrenergic agonists or antagonists may permanently reverse the morphological sex of the brain, as judged by the volume of sexually dimorphic nucleus of the preoptic area (SDN-POA). (nel.edu)
Blockers1
Current guidelines recommend α1-adrenoreceptor blockers (A1Bs) for treating lower urinary tract symptoms suggestive of benign prostatic hyperplasia, but their adverse effects can be problematic. (nih.gov)
Compounds2
The invention generally relates to the field of neurokinin antagonists, and more particularly to new substituted aminopyrimidine compounds which are neurokinin antagonists and use of these compounds and their use in treatment and prevention of neurokinin conditions. (justia.com)
However, to date, a detailed understanding of the physiological role of these compounds has been severely hampered by a lack of selective, high affinity, metabolically stable neurokinin receptor antagonists that possess both good bioavailability and CNS penetration. (justia.com)
Hepatic2
Treatment with a selective β 2 -adrenoreceptor antagonist blunted the hepatic glycogenolysis and the increase in plasma glucose levels ( 3 ). (diabetesjournals.org)
Thus, following systemic β 2 -adrenoreceptor activation, the beneficial effect from increased peripheral glucose uptake in skeletal muscle may be overridden by simultaneous increases in hepatic glycogenolysis and/or glucagon release. (diabetesjournals.org)
Silodosin2
An in vitro study examining binding affinity of silodosin to the three subtypes of the alpha-1 adrenoreceptors (alpha-1A, alpha-1B, and alpha-1D) was conducted. (mdtodate.com)
Silodosin blocks the alpha-1 adrenoreceptors present in tissues of the human prostate and bladder and relax the smooth muscle in these tissues, resulting in improvement of symptoms of BPH. (medibyte.in)
Dilation2
For example, β 2 -adrenoreceptor activation also causes arteriolar dilation and capillary recruitment in skeletal muscle and thus increases tissue perfusion and (insulin-mediated) glucose uptake ( 4 ). (diabetesjournals.org)
Importantly, antagonists of cADPR and BK(Ca) channels, respectively, inhibited beta-adrenoreceptor-induced artery dilation. (ox.ac.uk)
Tissues1
Blockade of these alpha-1 adrenoreceptors can cause smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in BPH symptoms. (mdtodate.com)
Analgesic1
An animal study in rats did find O-DSMT had analgesic effects and those were blocked by a MOR antagonist (Valle, 2000). (thedrugclassroom.com)
Affinity1
A number of high-affinity non-peptide antagonists have been reported, e.g. (justia.com)
Beneficial effect1
These studies suggest that blocking beta-adrenoreceptor-mediated signaling pathways might have beneficial effect in preventing cancer development, progression or complications. (brainimmune.com)
Responses1
Although the current study eloquently provided evidence for β 2 -adrenoreceptor-mediated glucose uptake in skeletal muscle via the cAMP-mTORC2-GLUT4 pathway at the cellular level, future studies are needed to determine the interactions between cellular and systemic glucose responses following β 2 -adrenoreceptor activation. (diabetesjournals.org)
Class1
Belongs to the class of alpha-adrenoreceptor antagonists. (azurewebsites.net)
Possess1
Although several tachykinin receptor antagonists have been described, most have been developed through modifying and/or deleting one or more of the amino acids that comprise the endogenous mammalian tachykinins such that the resulting molecules are still peptides that possess poor pharmacokinetic properties and limited in vivo activities. (justia.com)
Treatment2
Considerable pre-clinical findings suggest the use of neurokinin receptor antagonists for the treatment of a wide range of biological diseases including migraine (Goadsby, P. J. (justia.com)
However, the statement that "this signaling pathway provides new opportunities for the treatment of type 2 diabetes" ( 1 ) may be debatable because the impacts of systemic β 2 -adrenoreceptor activation on glucose control and hemodynamic changes are not considered. (diabetesjournals.org)
Rats2
In support of this, the current study demonstrated an increased peripheral glucose uptake following β 2 -adrenoreceptor activation in diabetic rats and obese mice ( 1 ). (diabetesjournals.org)
From the presented data it may be concluded that beta adrenoreceptors participate in sexual differentiation of preoptic area in rats and the modulation of their activity in postnatal period permanently influences the morphology of the sexually differentiated nucleus of the preoptic area. (nel.edu)
Alpha1
The dysrhythmogenic effects of epinephrine on the heart during halothane anesthesia involve actions mediated by alpha 1 - and beta-adrenoceptors (alpha 1 - and beta-adrenoreceptor). (silverchair.com)
Type1
Therefore, the net increase in plasma glucose following β 2 -adrenoreceptor activation could be more profound in obesity and type 2 diabetes. (diabetesjournals.org)
Levels1
We recently demonstrated that traumatic injury rapidly increased plasma glucose levels via β 2 -adrenoreceptor-dependent glycogenolysis in the liver. (diabetesjournals.org)