TumorMetastatic adrenocorticalPediatric adrenocortical carcinomaPrognosis of adrenocorticalManagement of adrenocorticalPoor prognosisIncidenceAdenomasCancerMalignancyNeoplasmsBenignTumoursCancersTumors in childrenPrognostic valueBilateralMitotaneRareMicroenvironmentHammer GDClinicalEpidemiologyPatientsChemotherapyBiomarkersHormonesProposalDiagnosisTreatmentCortisolDiagnosticSyndromesAdultsPrimary
Tumor12
- Adrenocortical carcinoma is a rare tumor, with incidence of one to two per million population annually. (wikipedia.org)
- The widely used angiotensin-II-responsive steroid-producing cell line H295R was originally isolated from a tumor diagnosed as adrenocortical carcinoma. (wikipedia.org)
- citation needed] Radiological studies of the abdomen, such as CT scans and magnetic resonance imaging are useful for identifying the site of the tumor, differentiating it from other diseases, such as adrenocortical adenoma, and determining the extent of invasion of the tumor into surrounding organs and tissues. (wikipedia.org)
- Adrenocortical carcinoma (ACC) is a rare tumor with an annual incidence of 2 cases per 1 million population. (cancer.gov)
- Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade. (cancer.gov)
- Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
- The reticulin algorithm for adrenocortical tumor diagnosis: a multicentric validation study on 245 unpublished cases. (diagnosticpathology.eu)
- Adrenocortical carcinoma (ACC) is a rare malignant tumor with an incidence rate of approximately 0.7/million to 2.0/million in the population [ 1 ]. (aging-us.com)
- Adrenocortical carcinoma (ACC), a rare tumor has the propensity to produce and secrete steroids with the most frequent condition is a cortisol-secreting ACC causing Cushingoid phenotype. (jofem.org)
- Introduction: Adrenocortical Carcinoma (ACC) is a rare and aggressive tumor with poor prognosis. (endocrine-abstracts.org)
- Background: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous prognosis. (endocrine-abstracts.org)
- In a review of 551 cases of adrenocortical carcinoma, mitotane induced a tumor response in 35% of patients. (medscape.com)
Metastatic adrenocortical2
- Context: We investigated the role of Gallium 68 dodecanetetraacetic acid Tyr3-octreotide ( 68 Ga-DOTATOC) positron emission tomography/computed tomography (PET/CT) in detecting somatostatin receptors (SSTRs) in 19 patients with metastatic adrenocortical carcinoma (ACC) and explored the activity of yttrium-90/lutetium-177 ( 90 Y/ 177 Lu-DOTATOC) peptide receptor radionuclide therapy (PRRT). (uni-luebeck.de)
- A Phase II Study to Evaluate the Effects of Cabozantinib in Patients with Unresectable/Metastatic Adrenocortical Carcinoma. (mdanderson.org)
Pediatric adrenocortical carcinoma1
- Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Prognosis of adrenocortical2
- Xu F , Guan Y , Ma Y , Xue L , Zhang P , Yang X , Chong T , . Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. (aging-us.com)
- Background: Molecular classification is important for diagnosis and prognosis of adrenocortical tumors (ACT). (endocrine-abstracts.org)
Management of adrenocortical2
- Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
- European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors. (lysodren.com)
Poor prognosis4
- Adrenocortical carcinoma (ACC) (also known as adrenal cortical carcinoma) is a rare malignancy with a poor prognosis, affecting 1-2 people per million per year year. (medscape.com)
- Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional treatment. (oncotarget.com)
- Survival analysis revealed that a low NRP1 expression in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. (hindawi.com)
- A high NRP2 expression in bladder urothelial carcinoma (BLCA), kidney renal papillary cell carcinoma (KIRP), and mesothelioma (MESO) was associated with poor prognosis. (hindawi.com)
Incidence7
- The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
- Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
- In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
- Bond lab researchers study the genetic factors associated with the age-dependent incidence of adrenocortical carcinoma. (ox.ac.uk)
- Adrenocortical carcinoma (ACC) is a rare cancer that has two peaks in incidence: between birth and 4 years, and after the 5th decade of life. (ox.ac.uk)
- A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence. (ox.ac.uk)
- Adrenocortical carcinoma (ACC) is rare with an incidence of 0.7 - 2.0 per million per year. (jofem.org)
Adenomas5
- Also, a loss occurs of activity of the p57kip2 gene product in virilizing adenomas and adrenal cortical carcinomas. (wikipedia.org)
- Seventy-nine adrenal cortical tumours were divided into adenomas (n = 17), non-metastatic carcinomas (n = 24) and carcinomas with metastatic disease and/or local recurrence during follow-up (n = 19) or at time of presentation (n = 19). (surgeonsoftomorrow.com)
- 0.005) between adenomas and carcinomas. (surgeonsoftomorrow.com)
- Some elegant clinical observations of dysregulated cortisol-secretion in cases of ACTH-independent macronodular hyperplasia (AIMAH) and more rarely adrenocortical adenomas (ACA) have led to the concept of aberrant or illegitimate membrane receptors (AR) in adrenal Cushing syndrome. (endocrine-abstracts.org)
- The major role for surgery in this patient population occurs with primary adrenal hypercorticalism either due to adenomas or to adrenal carcinomas. (medscape.com)
Cancer9
- Adrenocortical carcinoma (ACC) is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland. (wikipedia.org)
- Adrenocortical carcinoma (ACC) is a rare aggressive form of cancer that grows in the outer part of the adrenal glands. (lysodren.com)
- Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification. (lysodren.com)
- LYSODREN is a prescription medication used to treat the symptoms of adrenal cortical carcinoma (cancer of the outer layer of the adrenal gland). (lysodren.com)
- There is no official awareness ribbon color for adrenocortical carcinoma(ACC), definitely not one that would be recognizable since it is such a rare cancer. (livinglfs.org)
- Adrenocortical carcinoma is cancer that starts in the adrenal cortex. (epnet.com)
- Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. (ox.ac.uk)
- 21 cases of adrenal mass biopsy specimens collected at Sun Yat-sen University Cancer Center from November 2008 to July 2021 which included 19 cases of adrenal cortical carcinoma (ACC) and 2 cases of normal adrenal cortical were evaluated for their histologic,immunohistochemical(IHC)and reticulin stain features, and relevant literature was reviewed. (diagnosticpathology.eu)
- However, three additional histologies (thyroid carcinoma, melanoma, and testicular cancer) with incidences of more than 2 cases per 1 million people were also included in the very rare group because there is a lack of knowledge and expertise in the management of these tumors. (cancer.gov)
Malignancy4
- Despite recent advances in elucidating molecular pathways underlying adrenocortical carcinoma (ACC), this orphan malignancy is associated with poor survival. (providence.org)
- Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. (londonmet.ac.uk)
- Adrenocortical carcinoma (ACC) is a rare and highly metastatic malignancy. (usz.ch)
- Adrenocortical carcinoma (ACC) is a rare malignancy without good treatment options. (biomedcentral.com)
Neoplasms1
- Berstein L, Gurney JG: Carcinomas and other malignant epithelial neoplasms. (oncolink.org)
Benign4
- Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
- IGFII and MIB1 immunohistochemistry is helpful for the differentiation of benign from malignant adrenocortical tumours. (diagnosticpathology.eu)
- Transcriptome profiles separate benign ACT ( C2 cluster) from carcinomas (ACC) and identify two groups of ACC, C1A ( steroid and proliferation signatures) and C1B ( immune signature), of poor and better prognosis respectively. (endocrine-abstracts.org)
- Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) are benign adrenocortical disease responsible for benign tumors and cortisol autonomous secretion. (endocrine-abstracts.org)
Tumours3
- The majority of bilateral tumours can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenocortical disease, which can be sporadic or part of Carney complex, and primary bilateral macro nodular adrenal hyperplasia. (wikipedia.org)
- Ribeiro RC, Figueiredo B: Childhood adrenocortical tumours. (oncolink.org)
- Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation. (oncolink.org)
Cancers1
- Rarely, pheochromocytoma-like hypersecretion of catecholamines has been reported in adrenocortical cancers. (wikipedia.org)
Tumors in children2
- Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
- Rodriguez-Galindo C: Adrenocortical tumors in children. (oncolink.org)
Prognostic value1
- To compare two different multiparameter histopathological scoring indices and determine their prognostic value in patients presenting with adrenocortical carcinoma (ACC). (surgeonsoftomorrow.com)
Bilateral2
- Bilateral adrenocortical tumors are less common than unilateral. (wikipedia.org)
- Adrenal carcinomas arise from the adrenal cortex and are bilateral in up to 10% of patients. (medscape.com)
Mitotane1
- The goal of this clinical research study is to learn if mitotane alone or in combination with cisplatin and etoposide can help to control adrenocortical carcinoma (ACC) in patients who are at a high risk of having the disease return after surgery. (mdanderson.org)
Rare3
- Adrenocortical carcinoma in children in the general population is even more rare- less than 1 case per million people. (livinglfs.org)
- Adrenal cortical carcinoma (ACC) is a rare disease. (sooperarticles.com)
- Background: Adrenocortical carcinoma (ACC) is a rare neoplasm with a high propensity for locoregional recurrences and distant metastases for which there are no effective systemic therapies. (johnshopkins.edu)
Microenvironment1
- Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and tumour microenvironment, particularly in bladder urothelial carcinoma (BLCA). (hindawi.com)
Hammer GD1
- 5. Williams AR, Hammer GD, Else T. Transcutaneous biopsy of adrenocortical carcinoma is rarely helpful in diagnosis, potentially harmful, but does not affect patient outcome. (diagnosticpathology.eu)
Clinical4
- Adrenocortical Carcinoma: Basic Science and Clinical Concepts. (cancer.gov)
- Allolio B, Fassnacht M: Clinical review: Adrenocortical carcinoma: clinical update. (cancer.gov)
- Adrenocortical carcinoma (ACC) can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment. (cancer.gov)
- The goal of this clinical research study is to learn if cabozantinib can help to control unresectable (cannot be removed with surgery) or metastatic (has spread) adrenocortical carcinomas. (mdanderson.org)
Epidemiology1
- Fassnacht M, Allolio B: Epidemiology of adrenocortical carcinoma. (cancer.gov)
Patients2
- Adrenocortical carcinoma is remarkable for the many hormonal syndromes that can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization, and feminization. (wikipedia.org)
- Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. (nih.gov)
Chemotherapy1
- Chemotherapy largely has been unsuccessful in treating adrenocortical carcinoma. (medscape.com)
Biomarkers2
- 2. Mizdrak M, TiÄ inović Kurir T, Božić J. The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives. (diagnosticpathology.eu)
- 4. Cheng Y, Kou W, Zhu D, Yu X, Zhu Y. Future Directions in Diagnosis, Prognosis and Disease Monitoring of Adrenocortical Carcinoma: Novel Non-Invasive Biomarkers. (diagnosticpathology.eu)
Hormones1
- A detailed hormonal workup is also recommended to identify potential autonomous excess of glucocorticoids, sex hormones, mineralocorticoids, and adrenocortical steroid hormone precursors. (medscape.com)
Proposal1
- Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification. (diagnosticpathology.eu)
Diagnosis2
- Libé R. Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment. (lysodren.com)
- Reticulin stain was an effective method for accurate diagnosis of adrenal cortical carcinoma. (diagnosticpathology.eu)
Treatment3
- Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. (cancer.gov)
- Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
- 3. De Filpo G, Mannelli M, Canu L. Adrenocortical carcinoma: current treatment options. (diagnosticpathology.eu)
Cortisol1
- Expression of the h19 gene is markedly reduced in both nonfunctioning and functioning adrenal cortical carcinomas, especially in tumors producing cortisol and aldosterone. (wikipedia.org)
Diagnostic2
- To investigate the diagnostic significance of reticulin stain in biopsy of adrenocortical carcinoma. (diagnosticpathology.eu)
- 6. Wanis KN, Kanthan R. Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature. (diagnosticpathology.eu)
Syndromes1
- Adrenocortical carcinoma can be seen in familial syndromes such as multiple endocrine neoplasia type 1 (MEN-1), Li-Fraumeni syndrome , Beckwith-Wiedemann syndrome , and Carney complex . (medscape.com)
Adults1
- Adrenocortical carcinoma may present differently in children and adults. (wikipedia.org)
Primary1
- A 68-year-old woman with a large right upper quadrant primary adrenocortical carcinoma with curvilinear calcification. (medscape.com)