• The nerve supply is cholinergic and alpha-adrenergic. (medscape.com)
  • Alpha-adrenergic fibers innervate the smooth muscle fibers in the trigone and urethra, resulting in contraction of these muscle fibers to form a functional internal urethral sphincter. (dvm360.com)
  • The normal storage phase is created by sympathetic autonomic domination, which results in detrusor muscle relaxation and urethral sphincter contraction created by alpha-adrenergic stimulation. (dvm360.com)
  • The pain can be caused by damage to afferent nerve fibers and sensitization of afferent terminal due to the release of neuropeptides, or an increase in the number of sodium and calcium channels in the site of damage and changes in neurotransmitter and receptors, especially the increase in alpha-adrenergic receptors [ 4 , 5 ]. (siftdesk.org)
  • We further demonstrated in this artery that nicotine acted on nicotinic acetylcholine receptors (nAChRs) on presynaptic sympathetic nerve terminals to release norepinephrine (NE), which then acted on β 2 -adrenoceptors located on the neighboring NOergic nerve terminals to release NO, resulting in vasodilation. (aspetjournals.org)
  • Norepinephrine gets released by postganglionic neurons of the sympathetic nervous system, which binds to and activates adrenergic receptors. (clambaronline.com)
  • Furthermore, adrenergic receptors are expressed in different knee joint tissues. (uni-frankfurt.de)
  • What is mediated by adrenergic receptors? (assignguru.com)
  • During the phase of storage or continence the urinary bladder remains relaxed and slowly adapts to the filling due to the activation of the β-adrenergic receptors generated by autonomous sympathetic route by the hypogastric nerve towards the β-activated receptors in the bladder and simultaneously generating the excitation of the β-adrenergic receptors in the smooth muscle of the urethra. (vin.com)
  • As the volume and the vesical pressure increase, the expansion receptors are activated and recounted sensors as information towards the efferent nerves via pelvic nerve towards the brain. (vin.com)
  • The resistance of the exit of a normal animal is mediated for the α-adrenergic receptors. (vin.com)
  • As the bladder fills and intramural tension exceeds the threshold, stretch receptors in the bladder send impulses via the sensory portion of the pelvic nerve through spinal cord pathways to the thalamus and cerebral cortex. (dvm360.com)
  • NPY fibers richly innervate arteries, arterioles and veins. (cdc.gov)
  • Innervate" means to supply an organ or tissue with nerves. (ashp.org)
  • What is secreted by preganglionic sympathetic fibers? (clambaronline.com)
  • Some sympathetic preganglionic fibers stimulate the adrenal medulla to release norepinephrine and epinephrine into the blood, producing a "surge of adrenaline. (clambaronline.com)
  • Sympathetic innervation to the bladder via the hypogastric nerve is composed of preganglionic fibers exiting the lumbar spinal cord from the L1-4 spinal cord segments and synapsing in the caudal mesenteric ganglion. (dvm360.com)
  • Adrenal medulla): receive preganglionic fibers from Sympathetic. (easynotecards.com)
  • These data indicate that olfactory receptor (OR) proteins are indeed present in the axonal processes and nerve terminals of olfactory sensory neurons, thus supporting the notion that ORs may participate in the molecular processes underlying the fasciculation and targeting of olfactory axons. (jneurosci.org)
  • In the periphery, CGRP is mainly detected in sensory afferents projecting to the spinal cord, in motor neurons at the neuromuscular junctions and in nerve fibers associated with the vasculature. (bachem.com)
  • In the peripheral nervous system, cholinergic and adrenergic transmission were known to arise from different groups of nerve fibers. (wikipedia.org)
  • He wrote: It is to be noted, further, that in the cases for which direct evidence is already available, the phenomena of regeneration appear to indicate that the nature of the chemical function, whether cholinergic or adrenergic, is characteristic for each particular neurone, and unchangeable. (wikipedia.org)
  • Consists of cholinergic and adrenergic fibers. (drbeen.com)
  • Pupil size is governed by the tone of the pupillary sphincter (parasympathetic) and the pupillary dilator muscles (sympathetic) in response to ambient light, adrenergic tone, and local pharmacologic or pathophysiologic conditions. (allnurses.com)
  • Approximately 50% of the fibers of the optic nerve decussate in the optic chiasm, and the input to each of the parasympathetic nuclei in the brain stem remains equal. (allnurses.com)
  • Parasympathetic innervation to the bladder is provided by the pelvic nerve, which arises from the sacral spinal cord segments S1-3. (dvm360.com)
  • Parasympathetic activity via the motor portion of the pelvic nerve causes the detrusor muscle to contract and there is simultaneous inhibition of the sympathetic stimulation that closes the internal urethral sphincter. (dvm360.com)
  • The question whether OR proteins are indeed present in the axons and nerve terminals of OSNs is thus of fundamental importance toward an understanding of the functional wiring in the olfactory system. (jneurosci.org)
  • The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. (wakehealth.edu)
  • These results suggest the presence of functional α 7 -nAChRs on postganglionic sympathetic adrenergic nerve terminals of SCG origin, which mediate nicotine-induced neurogenic NOergic vasodilation. (aspetjournals.org)
  • autonomic ganglia, which likely increases peripheral vasoconstriction sympathetic nerve fiber transmission. (medscape.com)
  • Utilizing a FRMD6-aimed antiserum, we detected particular immunoreactivity in varicose nerve fibers in the rat peripheral and central nervous program. (bioinf.org)
  • In contrast, over time after a variety of injuries to the peripheral nerve, the animal and human will often reflect the appearance of a constellation of pain events. (asra.com)
  • Frequent components of this evolving syndrome are i) ongoing incidences of sharp-shooting sensations referred to the peripheral distribution of the injured nerve and ii) abnormal painful sensations in response to light tactile stimulation of the peripheral body surface. (asra.com)
  • This ability of light touch evoking this anomalous pain state is de facto evidence that the peripheral nerve injury has led to a reorganization of central processing, i.e. it is not a simple case of a peripheral sensitization of otherwise high threshold afferents. (asra.com)
  • This review addresses the principal changes that occur in connectivity and processing after peripheral nerve injury. (asra.com)
  • Following peripheral nerve ligation or section, several events occur signaling long-term changes in peripheral and central processing. (asra.com)
  • Following peripheral nerve injury there is a very significant upregulation in the expression of a wide variety of proteins in the dorsal root ganglion and thus the axon and terminals of the injured primary afferent. (asra.com)
  • This increased pressure can cause glaucoma, which defines a group of eye disorders that affect the optic nerve, causing damage to the optic nerve fibers leading out of the back of the eye to the brain and may lead to gradual loss of sight, starting with a peripheral vision and eventually to total blindness in that eye. (onlinepharmacydropshipper.in)
  • Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
  • The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
  • Results from double-labeling immunohistochemical studies in whole-mount porcine basilar and middle cerebral arteries and in cultured porcine superior cervical ganglia (SCG) indicated that α 7 -nAChR- and tyrosine hydroxylase immunoreactivities were colocalized in same nerve fibers. (aspetjournals.org)
  • Nerve fibers from these ganglia connect with internal organs. (msdmanuals.com)
  • originates from the right and left stellate ganglia, which provide the sympathetic nerves to form the cardiac plexus of the heart. (slideshare.net)
  • Corbuterol (beta adrenergic receptor agonist) What are the causes of ligament disorders? (hirefornursingexam.com)
  • With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system, and/or the beta-adrenergic receptor stimulating action of epinephrine when present. (nih.gov)
  • The sensory fibers of the vagus nerve also seem to play an important but poorly understood role in modulating several CNS functions as evidenced by the development of chronic intermittent stimulation of the vagus as a therapy for refractory seizure disorders. (mhmedical.com)
  • Loss of sensory fibers leads to loss of feeling. (cdc.gov)
  • The epithelium is supported by a loose lamina propria consisting of collagen fibrils and elastic fibers, arranged both circumferentially and longitudinally. (medscape.com)
  • The 2 suspensory ligaments, composed of primarily elastic fibers, support the penis at its base. (medscape.com)
  • The paired corpora cavernosa contain erectile tissue and are each surrounded by the tunica albuginea, a dense fibrous sheath of connective tissue with relatively few elastic fibers. (medscape.com)
  • The smooth muscle of the urethra is arranged longitudinally and obliquely with only a few circular fibers. (medscape.com)
  • Fibers have been observed to be deficient along the posterior aspect of the urethra. (medscape.com)
  • a neuron carrying nerve impulses to the central nervous system (brain and spinal cord) from the periphery (other parts of the body). (ashp.org)
  • a neuron carrying nerve impulses toward an effector organ. (ashp.org)
  • Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. (bvsalud.org)
  • Numerous studies from our laboratory and others have demonstrated that noradrenergic (NA) and peptidergic nerve fibers are present in various compartments of primary (bone marrow, thymus) and secondary (spleen, lymph nodes) lymphoid organs and that these nerve fibers can modulate immune functions [5-10]. (brainimmune.com)
  • What identifies depolarization of the atria, ventricles and perkinje fibers? (assignguru.com)
  • stimulation of the pelvic nerve results in depolarization of pacemaker fibers throughout the detrusor muscle. (dvm360.com)
  • [ 9 , 10 ] Anti-AChR antibodies reduce the number of available AChR sites with which acetylcholine can interact to induce local depolarization and subsequent muscle fiber contraction. (medscape.com)
  • a mass of neuron bodies (nerves). (ashp.org)
  • These findings are consistent with our hypothesis that nicotine acts on nAChRs on presynaptic sympathetic nerve terminals to release NE, which then acts on presynaptic β 2 -adrenoceptors located on the neighboring NOergic nerve terminals, resulting in release of NO and dilation of porcine basilar arteries. (aspetjournals.org)
  • The erectile tissue within the corpora contains arteries, nerves, muscle fibers, and venous sinuses lined with flat endothelial cells, and it fills the space of the corpora cavernosa. (medscape.com)
  • On the dorsal aspect of the corpora cavernosa, the deep dorsal vein and paired dorsal arteries and branches of the dorsal nerves are contained within the deep penile (Buck) fascia. (medscape.com)
  • The voluntary urethral sphincter actually is a group of circular muscle fibers and muscular loops within the pelvic floor. (medscape.com)
  • The fibers that help to correct these conditions are the fibers responsible for transmitting special info to the nerves that produce the muscular tension that runs through muscles. (hirefornursingexam.com)
  • The sacral spinal cord segments S1-3 are also the source of the somatic innervation to the external urethral sphincter via the pudendal nerve. (dvm360.com)
  • Is composed of motor nerves for the innervation of cardiac muscle, smooth muscle, and glands. (drbeen.com)
  • Stimulation of the pudendal nerve causes contraction of the striated skeletal muscle of the external urethral sphincter. (dvm360.com)
  • originates from the medulla and passes through the right and left vagal nerves, which further divide into the superior and inferior cardiac nerves. (slideshare.net)
  • There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)
  • The additional nervous completions in the bladder submucous that project the sensation via hypogastric nerve and sympathetic tracts. (vin.com)
  • The autoimmune responses that inhibit acetylcholine interaction on the postsynaptic membrane at neuromuscular junctions (NMJs), resulting in the inability of muscle fibers to contract, are often initiated and maintained by the thymus. (medscape.com)
  • The penile shaft is composed of 3 erectile columns, the 2 corpora cavernosa and the corpus spongiosum, as well as the columns' enveloping fascial layers, nerves, lymphatics, and blood vessels, all covered by skin (see the following images). (medscape.com)
  • Types of Diabetes Complications People with diabetes mellitus have many serious long-term complications that affect many areas of the body, particularly the blood vessels, nerves, eyes, and kidneys. (merckmanuals.com)
  • The subsequent spread of excitation to adjoining muscle fibers through tight junctions of smooth muscle cells leads to contraction of the detrusor muscle. (dvm360.com)
  • An autonomic nerve pathway involves two nerve cells. (msdmanuals.com)
  • Brain stem The brain's functions are both mysterious and remarkable, relying on billions of nerve cells and the internal communication between them. (msdmanuals.com)
  • It is connected by nerve fibers to the other cell, which is located in a cluster of nerve cells (called an autonomic ganglion). (msdmanuals.com)
  • The present study of hammer vibration was conducted to validate that complete cross sections of the tail could be cut and stained for nerve subtypes and mast cells. (cdc.gov)
  • After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)
  • Discussion: PGP9.5, NPY and CGRP staining of nerve fibers and avidin-positive mast cells is feasible in rat tail sections. (cdc.gov)
  • The present study shows CGRP in some mast cells, but it is unknown whether this represents associated nerve fibers and/ or uptake with re-release during vasoregulation. (cdc.gov)
  • The brains of people with the condition contain distinctive plaques between nerve cells, as well as clumps of fibers known as neurofibrillary tangles inside the cells. (medicalnewstoday.com)
  • They point to previous research , which found that in the absence of the tau neurofibrillary tangles, beta-amyloid does not seem to harm nerve cells. (medicalnewstoday.com)
  • In healthy brain cells, tau proteins help stabilize the internal network of microscopic tubes, or "microtubules," that transports nutrients and other molecules around nerve cells. (medicalnewstoday.com)
  • These nAChR antagonists did not affect relaxation elicited by transmural nerve stimulation (8 Hz) or that by sodium nitroprusside and NE. (aspetjournals.org)
  • The stimulating effect of NE on the TRH secretion was abolished by icv antagonist of adrenergic alpha2-receptor, yohimbine (40 nmol/L). (nel.edu)
  • Most in vitro studies indicate a potential role of the β2-adrenergic receptor, which has been not investigated during OA pathogenesis in vivo. (uni-frankfurt.de)
  • The specific focus was on the β2-adrenergic receptor effects on OA pathogenesis, which were analyzed in β2-adrenergic receptor-deficient mice. (uni-frankfurt.de)
  • Central adrenergic system may play a stimulating role through alpha2-receptor in the acute hypoxia-modulating TRH release from rat hypothalamus. (nel.edu)
  • To scrutinize the hypothesis that olfactory receptor proteins may also be present in the axonal processes and the nerve terminals, serial sections through the olfactory bulb were probed with the antibodies. (jneurosci.org)
  • Vibration white finger is likely driven by somatosympathetic reflex activation, increased á2c adrenergic receptor expression and endothelin-1 release. (cdc.gov)
  • Based on my experience-I worked personally on the experimental models of this agent-RTX blocks the TRPV1 receptor, and this in turn blocks action potentials in afferent C-fibers. (urologytimes.com)
  • Examples of the materials go right here in the literature to combat Paget's disease include collagen fibers, hydroxyapatite bone-implant material, and staphylococcal enteric bone-implant material. (hirefornursingexam.com)
  • Because they are composed primarily of slow-twitch muscle fibers, these muscles serve ideally to maintain resting urethral closure. (medscape.com)
  • the ability of sympathetic nerve terminals to take up catecholamine is a more sensitive index of nerve function and viability than the catecholamine content. (slideshare.net)
  • [4] Substance P is released from the terminals of specific sensory nerves . (wikidoc.org)
  • Vasoconstriction fiber (NPY) regeneration is expected to be higher than (CGRP) vasorelaxant fibers. (cdc.gov)
  • At the brain level, the formation of anatomical changes and the establishment of connections between the nerve fiber types C and A beta, the reduction in the activity of the inhibitory pathways of pain sense and the excessive release of neurotransmitters, such as glutamate in the spinal dorsal horn, contribute to neuropathic pain [ 6 ]. (siftdesk.org)
  • Activity in sensory afferents originates after an interval of days to weeks from the lesioned site (neuroma) and from the dorsal root ganglion (DRG) of the injured nerve. (asra.com)
  • the system of nerves that controls automatic bodily actions, such as the functions of glandular tissues, the heart and smooth muscle, and involuntary movements and body functions (including secretions, pulse, and blood pressure). (ashp.org)
  • In 2004, you studied 12 patients with BPH and associated storage lower urinary tract symptoms with results that suggested that intravesical desensitization of bladder C-fibers with RTX administered intravesically might be useful in the treatment of this condition. (urologytimes.com)
  • Markers specific for nerve subtypes are required to relate changes to functional alterations. (cdc.gov)
  • PGP9.5 binds an ubiquitin pathway protein present in all types of nerve fibers, but PGP9.5 levels may change with injury and alter identification consistency. (cdc.gov)
  • Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). (wakehealth.edu)
  • Electrophysiological studies include electroencephalography (EEG), a measure of electrical activity in the brain, as well as electromyography (EMG) and nerve conduction studies (NCS). (utswmed.org)
  • Alongside EMG, nerve conduction studies test how well and how quickly a motor and sensory nerve can send an electrical impulse. (utswmed.org)
  • Nerve Fibers, Myelinated" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)