• Khabibrakhmanov I.I. Effect Of α1A-Adrenergic Receptors Stimulation To The Isolated Rat Hearts Chronotropy/ I.I. Khabibrakhmanov, N.I. Ziyatdinova, A.M. Kuptsova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences. (kpfu.ru)
  • However, the chronotropic effects of selective stimulation of α1A-adrenergic receptors directly on the isolated heart in ex vivo experiments have not been revealed. (kpfu.ru)
  • The results obtained may indicate that this subtype of α1-adrenergic receptors is not involved in the regulation of heart rate. (kpfu.ru)
  • Since beta 1 receptors are densely located in the heart, beta 1 blockers can effectively control heart rate by chronotropic effect and contractility by inotropic effect. (wikipedia.org)
  • In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
  • In this study we examined the role of alpha 1-adrenergic receptors. (nih.gov)
  • This is a first-generation antihistamine with anticholinergic effects that binds to H1 receptors in the CNS and the body. (medscape.com)
  • Here we show that in adipocytes, chronically high insulin levels inhibit β-adrenergic receptors (but not other cAMP-elevating stimuli) from activating PKA. (nature.com)
  • Chronically high insulin levels may disrupt the close apposition of β-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways. (nature.com)
  • Since norepinephrine axons are anatomically intact following these lesions of the serotonin system, this model may prove useful in testing and understanding the effects of antidepressant treatments on the regulation of increased numbers of beta-adrenergic receptors in brain. (grantome.com)
  • Selectively blocks beta1-adrenergic receptors with little or no effect on beta2-receptors. (medscape.com)
  • To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
  • The effects of vasodilator hormones acting through receptors linked to adenylyl cyclase are impaired in the hypertensive state. (aspetjournals.org)
  • Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability . (bvsalud.org)
  • Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. (bvsalud.org)
  • beta-Adrenergic receptors showed little or no change in any region. (duke.edu)
  • During embryo development, Beta adrenergic receptors are involved in fetal growth, tissue differentiation and axonal outgrowth. (proteopedia.org)
  • In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on beta 2 -adrenergic receptors compared with isoproterenol. (theodora.com)
  • While it is recognized that beta 2 -adrenergic receptors are the predominant receptors on bronchial smooth muscle, recent data indicate that there is a population of beta 2 -receptors in the human heart which comprise between 10% and 50% of cardiac beta-adrenergic receptors. (theodora.com)
  • Activation of beta 2 -adrenergic receptors on airway smooth muscle leads to the activation of adenylyl cyclase and to an increase in the intracellular concentration of cyclic-3',5'-adenosine monophosphate (cyclic AMP). (theodora.com)
  • Phenylephrine and methoxamine are examples of drugs that selectively activate α 1 -adrenergic receptors (adrenomimetic). (pharmacology2000.com)
  • Whereas the above two example drugs show α-adrenergic receptor selectivity (α 1 vs. α 2 ), oxymetazoline activates both α 1 and α 2 adrenergic receptors. (pharmacology2000.com)
  • Dobutamine is an example of a drug that selectively stimulates the heart via β 1 receptors, although dobutamine also has activity at α adrenergic receptors as well. (pharmacology2000.com)
  • Isoproterenol (Isuprel, Isoprenaline) is a classical nonselective β-adrenergic agonist, with prominent actions at β 1 and β 2 receptors. (pharmacology2000.com)
  • that is, of the 182 amino acids defining the TM domains of the human α 2A -adrenergic receptors, about 40% are identical with the human β 2 -adrenergic receptors. (pharmacology2000.com)
  • Regardless of how and where it is released, norepinephrine acts on target cells by binding to and activating adrenergic receptors located on the cell surface. (wikipedia.org)
  • Beta blockers , which counter some of the effects of noradrenaline by blocking their receptors, are frequently used to treat glaucoma , migraine , and a range of cardiovascular problems. (wikipedia.org)
  • Blocks beta 1- and beta 2-receptors and has mild intrinsic sympathomimetic effects. (medscape.com)
  • Selectively blocks beta 1-adrenergic receptors with little or no effect on beta 2-receptors. (medscape.com)
  • Isoflurane anesthesia does not add to the bronchodilating effect of a beta 2-adrenergic agonist after tracheal intubation. (druglib.com)
  • This double-blind study investigates whether isoflurane/N2O anesthesia adds to the bronchodilating effect of the beta 2-adrenergic agonist, fenoterol, after an endotracheal tube (ETT)-induced increase in airway resistance. (druglib.com)
  • The α2-adrenergic agonist apraclonidine is better tolerated systemically in children, but the risk of follicular conjunctivitis increases with long-term use. (aao.org)
  • BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)
  • Tables describing a pro-thrombotic anti-fibrinolytic state induced after ß- adrenergic receptor agonist stimulation and the opposite after α1-, ß- adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis -related variables to their baseline. (bvsalud.org)
  • Tizanidine is a central alpha-2-adrenergic agonist indicated for the management of spasticity. (nih.gov)
  • AAT is sensitive to both opioid and adrenergic agonist modulation. (okstate.edu)
  • Patients with acetylcholine receptor deficiency can also benefit from the addition of a β2-adrenergic receptor agonist to their medication. (ox.ac.uk)
  • Coincidently we used a disease model to mirror the treatment of acetylcholine receptor deficiency, and demonstrate improved muscle fatigue, improved neuromuscular transmission and improved synaptic structure resulting from the addition of the β2-adrenergic agonist salbutamol to the anticholinesterase medication pyridostigmine. (ox.ac.uk)
  • Oxymetazoline is an example of a non-selective α-adrenergic receptor agonist. (pharmacology2000.com)
  • A relatively selective alpha-adrenergic agonist that does not have significant local anesthetic activity. (medscape.com)
  • Advair Diskus and Advair HFA (fluticasone propionate and salmeterol oral inhaler) is a combination of a corticosteroid and a beta2-adrenergic bronchodilator used to treat asthma or chronic obstructive pulmonary disease ( COPD ) associated with chronic bronchitis . (medicinenet.com)
  • Combivent (ipratropium bromide and albuterol sulfate ) is an inhaler that is a combination of an anticholinergic bronchodilator and a selective beta2-adrenergic bronchodilator used to treat and prevent symptoms ( wheezing and shortness of breath) caused by ongoing lung disease ( chronic obstructive pulmonary disease - COPD which includes bronchitis and emphysema ). (rxlist.com)
  • Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
  • Not only is this specific context devoid of adrenergic stimulation, but also it provides the patient with the benefits of preemptive analgesia, avoiding the postoperative pain Dr. Durieux says "may play a very important role in metastasis after cancer surgery. (apsf.org)
  • Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review. (bvsalud.org)
  • By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or ß- adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review . (bvsalud.org)
  • β-adrenergic sensitivity was measured with the isoproterenol test after a hyperinsulinemic euglycemic clamp and after a hyperinsulinemic hypoglycemic clamp. (diabetesjournals.org)
  • β-adrenergic sensitivity was expressed as the dose of intravenous isoproterenol that increased the heart rate by 25 beats/min (IC25). (diabetesjournals.org)
  • Isoproterenol with limited activity at alpha recetors has little effect. (pharmacology2000.com)
  • In microarray studies, the effect of isoproterenol to regulate transcription was significantly impaired in SHR (as was the effect of forskolin). (aspetjournals.org)
  • In this model, Beta2-Adrenergic Receptor (B2AR) - T4 Lysozyme fusion was developed to allow for structure solution. (proteopedia.org)
  • Scholars@Duke publication: Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding. (duke.edu)
  • Albuterol sulfate, chemically known as (1,3-benzenedimethanol, α'-[[(1,1dimethylethyl) amino] methyl]-4-hydroxy, sulfate (2:1)(salt), (±)- is a relatively selective beta 2 -adrenergic bronchodilator. (rxlist.com)
  • Albuterol (Ventolin, Proventil), terbutaline (Brethine, Brethaire) and metaproterenol (Metaprel, Alupent) are classified as β 2 -selective adrenergic agonists and as such reduce smooth muscle tone. (pharmacology2000.com)
  • Yohimbine is classified as a selective α 2 -adrenergic receptor antagonist. (pharmacology2000.com)
  • This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor -targeting drugs on scale variables related to hemostasis . (bvsalud.org)
  • Adrenergic neurone blockers, commonly known as adrenergic antagonists, are a group of drugs that inhibit the sympathetic nervous system by blocking the activity of adrenergic neurones. (wikipedia.org)
  • Clinicians should consider the adverse effects, tolerability, method of administration, safety, efficacy, and cost of the drugs in addition to patient preferences when selecting an appropriate therapy. (drugs.com)
  • Many important psychiatric drugs exert strong effects on noradrenaline systems in the brain, resulting in side-effects that may be helpful or harmful. (wikipedia.org)
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
  • Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract. (janusinfo.se)
  • indicates that the article is not about the liver in general, but about the effect of drugs on the liver. (who.int)
  • Clinical consideration for BPH should include the elements of male sexual function, patients' age, and the characteristics and comprehensive effects of each group of drugs. (medscape.com)
  • Adverse sexual side effects can occur as a result of the drug group itself or specific drugs within the group. (medscape.com)
  • Thus, enhanced alpha-adrenergic responsiveness occurs during myocardial ischemia and appears to be primary mediator of the electrophysiological derangements and resulting malignant dysrhythmias induced by catecholamines during myocardial ischemia and reperfusion. (jci.org)
  • Furthermore, the enhanced adrenergic receptor sensitivity suggests an augmented sympathetic responsiveness. (cdc.gov)
  • We hypothesized that variations in the amino acid at position 16 of the β 2 -adrenergic receptor would result in different lipolytic responses to intravenous epinephrine and exercise. (elsevierpure.com)
  • The polymorphisms resulting in Arg/Arg and Gly/Gly at position 16 of the β 2 -adrenergic receptor do not result in clinically meaningful differences in lipolysis responses to epinephrine or submaximal exercise. (elsevierpure.com)
  • Distribution of adrenergic receptor subtypes and adrenergic receptor number are important factors in organ or cellular responses to adrenergic input. (pharmacology2000.com)
  • However, animal models have been used in relatively few studies on the myocardial alpha(1)-adrenergic responses. (bezmialem.edu.tr)
  • Hence, this report describes the effect of alloxan-induced diabetes and insulin-treatment on the alpha(1)-adrenergic responses of this isolated rat atria. (bezmialem.edu.tr)
  • Furthermore, this study supports the hypothesis that the blunting of β-adrenergic responses relating to increased G protein-coupled receptor kinase 2 expression reflects a "generalized uncoupling" of β-adrenergic-mediated responses and do not support the concept of "enhanced coupling" of "alternate" pathways of β-adrenergic growth regulatory pathways in the hypertensive state. (aspetjournals.org)
  • The effect of a single episode of hypoglycemia on β-adrenergic sensitivity was studied in 10 type 1 diabetic patients with apparently normal awareness of hypoglycemia (age 29 ± 5 years, diabetes duration 13 ± 8 years, HbA 1c 7.3 ± 0.9%) and 10 age-matched healthy control subjects. (diabetesjournals.org)
  • In control subjects, the IC25 was lower after hypoglycemia than after euglycemia (0.83 ± 0.22 vs. 1.13 ± 0.21 μg, P = 0.02) indicating an increase in β-adrenergic sensitivity. (diabetesjournals.org)
  • In diabetic subjects, on the other hand, the IC25 was greater after hypoglycemia than after euglycemia (1.00 ± 0.26 vs. 0.65 ± 0.14 μ, P = 0.04), indicating a decrease in β-adrenergic sensitivity. (diabetesjournals.org)
  • In normal subjects, a single episode of hypoglycemia increases β-adrenergic sensitivity. (diabetesjournals.org)
  • In diabetic subjects, in contrast, hypoglycemia reduces β-adrenergic sensitivity. (diabetesjournals.org)
  • A unifying hypothesis is presented for the pathogenesis of hypoglycemia unawareness in type 1 diabetic patients incorporating the concepts of both a reduced catecholamine response and reduced adrenergic sensitivity. (diabetesjournals.org)
  • MOR produced dose-related elevations of response thresholds in all three sensory tests, whereas DEX produced elevations in the thermal and AAT assays but had no effect on sensitivity to non-noxious mechanical stimuli. (okstate.edu)
  • The pharmacological mechanism of the facilitatory effect of TFP is thought to be the result from its specific inhibition of CaM, without any involvement of the Ca2+ channel blocking effect. (chinaphar.com)
  • The subunit dissociates from the receptor when activated, subsequently activating adenylyl cyclase to convert adenosine triphosphate (ATP) to cAMP, which is a secondary messenger mediating the pharmacological effects. (wikipedia.org)
  • Pharmacological effects include an increase in blood pressure and a cholinergic-system (parasympathetic) mediated reduction in heart rate. (pharmacology2000.com)
  • In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. (duke.edu)
  • Our Combivent Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Here, we report the long-term follow-up for the addition of β2-adrenergic agonists for a cohort of patients with acetylcholine receptor deficiency on anticholinesterase medication that demonstrates a sustained quantitative improvement. (ox.ac.uk)
  • The current study was designed to determine the impact of an important anti-spasticity medication, tizanidine, by quantifying the effect of single dose tizanidine on reflex and intrinsic components of muscle response to stretch in individuals with spinal cord injury. (biomedcentral.com)
  • E-Pilo-2 is a brand name medication included in a group of medications called Adrenergic and dopaminergic agents . (rxwiki.com)
  • To determine the relationship between calmodulin (CaM) and transmitter release, the effects of trifluoperazine (TFP) on adrenergic transmission in rat portal vein preparations prelabelled with [3H]norepinephrine ([3H]NE) were studied. (chinaphar.com)
  • They inhibit the release of circulating adrenergic neurotransmitters like norepinephrine, which contributes to the contraction of smooth muscles. (wikipedia.org)
  • However, beta-receptor blockade was without effect. (jci.org)
  • Prostaglandin analogues have minimal systemic side effects and are dosed once daily. (aao.org)
  • See Table 22-4 in BCSC Section 6, Pediatric Ophthalmology and Strabismus, for a comparison of systemic and ocular adverse effects of glaucoma medications in children. (aao.org)
  • The risk of adverse effects can also be diminished with occlusion of the nasolacrimal drainage system for 2 to 5 minutes after administration and use of the lowest effective dose (eg, timolol 0.25% or levobunolol 0.25% as opposed to 0.5%), particularly for young children. (aao.org)
  • Topical use of dorzolamide or brinzolamide has a minimal risk of systemic adverse effects and is an excellent first-line therapy. (aao.org)
  • Systemic CAIs (acetazolamide and methazolamide) provide slightly more IOP lowering than the topical preparations but are associated with numerous systemic adverse effects, including anorexia, diarrhea, weight loss, paresthesia, hypokalemia, risk of sickle cell crisis in patients with sickle cell anemia, and metabolic acidosis, which can affect bone growth. (aao.org)
  • Children using other diuretics are particularly at risk for these adverse effects. (aao.org)
  • Because of the risk of these adverse effects and of rare but life-threatening reactions such as Stevens-Johnson syndrome and aplastic anemia, systemic CAIs are reserved for patients at great risk of vision loss due to highly elevated IOP. (aao.org)
  • β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure. (ox.ac.uk)
  • Potential adverse effects of these medications are similar to latanoprost (eg, eyelash growth, increased iris pigmentation). (medscape.com)
  • These agents are considered by some glaucoma specialists as first-line agents for glaucoma, mainly because of the lack of systemic adverse effects. (medscape.com)
  • A review of the current literature identified several adverse sexual side effects, including erectile dysfunction (ED), decreased libido, orgasmic disorders, and ejaculatory disorders. (medscape.com)
  • The chief adverse effect is ejaculatory disorders, including the absence of ejaculation. (medscape.com)
  • However, clinical studies in the 1990s reported that despite the amelioration of LUTS, adverse effects of BPH drug therapy began to surface. (medscape.com)
  • Nonetheless, ABs do vary in uroselectivity and the production of adverse effects. (medscape.com)
  • Skeletal muscle hypertrophy has been studied in cattle fed β-adrenergic agonists (β-AA), which are receptor-mediated enhancers of protein synthesis and inhibitors of protein degradation. (tdl.org)
  • Treatment with β-AA increased mRNA concentration of the β2 or β1-adrenergic receptor and myosin heavy chain IIX in bovine skeletal muscle tissue. (tdl.org)
  • This review will examine the effects of skeletal muscle and adipose development with β-AA, and will interpret how the use of β-AA affects performance, body composition, and growth in beef cattle. (tdl.org)
  • Both α and β adrenergic receptor are present in skeletal muscle vascular beds. (pharmacology2000.com)
  • Salbutamol enhances neuromuscular junction synaptic structure by counteracting the detrimental effects of long-term acetylcholinesterase inhibitors on the postsynaptic neuromuscular junction. (ox.ac.uk)
  • These effects of clonidine are reduced or blocked by the α 2 ‐receptor antagonist, yohimbine (0.5 μM), but not the α 1 ‐blocker, prazosin. (bgu.ac.il)
  • A clonidine‐like synaptic effect on type B cells, therefore, could amplify conditioning‐specific changes of membrane currents by increasing type B depolarization and possibly, as well, by elevating intracellular second messengers. (bgu.ac.il)
  • Clonidine activates another type of adrenergic receptor, designated α 2 . (pharmacology2000.com)
  • Issues for future research include the effects of the newer long-acting beta-agonists, large versus small airway effects, and combination effects with other inhaled therapeutic agents (eg, steroids and ion-channel blockers). (nih.gov)
  • There are various labeled uses of adrenergic neurone blockers that are approved by the Food and Drug Administration (FDA), alongside some off-label uses. (wikipedia.org)
  • Beta 1 blockers Beta 1 blockers bind to the beta 1 receptor without activating it, inhibiting the receptor-mediated effects. (wikipedia.org)
  • Beta-blockers marketed under the names Inderal, Lopressor, Corgard, Blocadren, and Tenormin have fewer side effects, but many people who take them still complain of sexual dysfunction. (healthyplace.com)
  • Alpha blockers , which counter a different set of noradrenaline effects, are used to treat several cardiovascular and psychiatric conditions. (wikipedia.org)
  • Today, α1-adrenoceptor blockers and 5α-reductase inhibitors are often combined to give a synergistic effect. (medscape.com)
  • Either increases effects of the other by pharmacodynamic synergism. (medscape.com)
  • ozanimod increases toxicity of fenoldopam by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (medscape.com)
  • aldesleukin increases effects of fenoldopam by pharmacodynamic synergism. (medscape.com)
  • Moran CN, Vassilopoulos C, Tsiokanos A, Jamurtas AZ, Wilson RH & Pitsiladis YP (2005) Physical Activity-dependent Effects Of Beta-adrenergic Receptor Polymorphisms On Obesity-related Phenotypes In Children. (stir.ac.uk)
  • Polymorphisms that result in amino acid substitutions in the β 2 -adrenergic receptor have been reported to alter lipolysis. (elsevierpure.com)
  • Beta-2 Adrenergic Receptor s (B2ARs) are a type of G Protein-Coupled Receptor (GPCR) . (proteopedia.org)
  • Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the beta 2 -adrenergic bronchodilator, albuterol sulfate. (theodora.com)
  • The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology. (duke.edu)
  • Because of the short duration of therapeutic effect, treatment with tizanidine should be reserved for those daily activities and times when relief of spasticity is most important. (nih.gov)
  • Since spasticity is manifested as a mechanical abnormality, to evaluate the therapeutic effects of treatments, there is a need to quantify these effects on neuromuscular mechanics. (biomedcentral.com)
  • Potential exacerbation of symptoms (eg, parkinsonian symptoms) or decreased therapeutic effects of metoclopramide. (medscape.com)
  • Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats. (jci.org)
  • and complete inhibition was observed at 80 ymol/L, a concentration needs by [3H]NE release facijitatory effect. (chinaphar.com)
  • In addition, β-adrenergic-mediated inhibition of PI3 kinase activity was attenuated in SHR (whereas the effect of forskolin remained intact). (aspetjournals.org)
  • however, adrenergic receptor inhibition revealed a more robust effect. (cdc.gov)
  • The bronchodilation following inhalation of ipratropium bromide is primarily a local, site-specific effect, not a systemic one. (theodora.com)
  • however, the biological effects of nanoparticle inhalation are poorly understood. (cdc.gov)
  • Disruption of PKA scaffolding mimics the interference of insulin with β-adrenergic receptor signalling. (nature.com)
  • Effect of insulin pretreatment on PKA activity. (nature.com)
  • The insulin-induced delay in PKA activity is specific for a β-adrenergic-coupled pool of PKA. (nature.com)
  • Short-acting beta-adrenergic agonists have been shown to enhance mucociliary clearance rates to varying degrees in patients with various lung diseases (eg, asthma, chronic bronchitis, and cystic fibrosis), although the enhancement is generally less than that seen in the normal lung. (nih.gov)
  • The results indicate that alpha as well as beta adrenergic systems participate in the control of erythropoiesis following hemorrhage, whereas parasympathetic system does not take part. (eurekamag.com)
  • Alpha compared to beta adrenergic contributions to dysrhythmias induced by left anterior descending coronary occlusion and by reperfusion were assessed in chloralose-anesthetized cats (n = 96). (jci.org)
  • Serotonin axons appear to regulate beta-adrenergic receptor number and function in brain. (grantome.com)
  • The objective of this study is to test the hypothesis that serotonin neurons influence noradrenergic neurotransmission in brain by affecting beta-adrenergic receptor number and function, and to determine the nature of the underlying mechanisms that lead to these receptor changes. (grantome.com)
  • Nonselective beta-adrenergic blocking agent that lowers IOP by reducing aqueous humor production and possibly increasing outflow of aqueous humor. (medscape.com)
  • Although its influence on rest heart function has appeared minimal, recent animal studies suggest that sildenafil can have potent effects on hearts stimulated by beta-adrenergic or pressure overloads. (erowid.org)
  • beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. (duke.edu)
  • While a global rational for allosteric effects in ternary complexes would be of great help in designing ligands with specific effects, the paucity of structural data for ternary complexes with [small beta]-arrestin, together with the intrinsic difficulty of characterizing the dynamics involved in the allosteric coupling, have hindered the efforts to devise such a model. (ucl.ac.uk)
  • Here we have used enhanced-sampling atomistic molecular-dynamics simulations to investigate the dynamics and complex formation mechanisms of both [small beta]-arrestin- and Gs-complexes with the [small beta]2-adrenergic receptor (ADRB2) in its apo-form and in the presence of four small ligands that exert different allosteric effects. (ucl.ac.uk)
  • The tachycardic effects of beta-adrenergic agents may be enhanced by Buscopan. (janusinfo.se)
  • Beta-adrenergic blocker that has little or no intrinsic sympathomimetic effects and membrane-stabilizing activity. (medscape.com)
  • The β 2 -adrenergic system is an important regulator of human adipose tissue lipolysis. (elsevierpure.com)
  • This study was designed to help us understand the mechanisms of action of tizanidine on spasticity in spinal cord injured subjects with incomplete injury, by quantifying the effects of a single dose of tizanidine on ankle muscle intrinsic and reflex components. (biomedcentral.com)
  • Experiments were carried out in albino rats to find out the effect of propranolol, priscol and atropine on post-hemorrhagic erythropoiesis. (eurekamag.com)
  • Therefore, we assessed the effects of β-adrenergic activation on 1) regulation of phosphatidylinositol 3-kinase (PI3 kinase) and extracellular signal-regulated kinase (ERK) activation-two tyrosine kinase-dependent enzymes linked to cell growth-and 2) microarray analysis in vascular smooth muscle cells from spontaneously hypertensive rats (SHR). (aspetjournals.org)
  • Other medications in the same class as fluticasone propionate are secreted into breast milk, but it is not known whether the small amounts that may appear in the milk have effects on nursing infants. (medicinenet.com)
  • One hundred and twenty-four (124) dentists from private clinics in São Luís (Maranhão, Brazil) answered a questionnaire regarding the choice of solutions, selection criteria for local anesthetics and vasoconstrictors, and side effects associated with these substances. (bvsalud.org)
  • This effect may decrease aqueous humor secretion, reducing IOP. (medscape.com)
  • Apart from being used as antidotes to reverse the overdose effects of alpha 2 agonists, they only have a limited number of indications. (wikipedia.org)
  • We previously demonstrated that alpha-1 adrenergic receptor (α1-AR) antagonists can prevent cytokine storm syndrome in mice. (stanford.edu)
  • Alpha-2 agonists often have a sedating effect and are commonly used as anesthesia enhancers in surgery, as well as in treatment of drug or alcohol dependence . (wikipedia.org)
  • Many of the ergot alkaloids act as alpha-adrenergic antagonists. (bvsalud.org)