AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth Care
Wakefulness-Promoting AgentsReceptors, Adrenergic, alpha-2FenofibratePPAR alphaBezafibrateReceptors, Cytoplasmic and NuclearHypolipidemic AgentsPeroxisome ProliferatorsPropionatesPyrimidinesTranscription FactorsLiverRNA, MessengerCells, CulturedDopamine Agonistsalpha 1-AntitrypsinReceptors, Adrenergic, alphaGABA AgonistsHypoxia-Inducible Factor 1, alpha SubunitNicotinic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-AgonistsDose-Response Relationship, DrugPurinergic P1 Receptor AgonistsMuscarinic AgonistsGlaucoma, Open-AngleNational Eye Institute (U.S.)Intraocular PressureOcular HypertensionOphthalmologyEye DiseasesExfoliation Syndrome
ReceptorsReceptorSympathomimeticsSympathomimetic agentsBrimonidineAntagonistsPotentReducing cardiacMeSHTherapeuticMethoxamineMedicationsAdrenoreceptorActivatesChemicalsEffectsAgentsWithdrawalActivityBetaTreatmentTreatStudyClonidineEpinephrineAntagonistAlpha2-adrenergicSelectiveBlockersAdrenoceptor agonistGuanfacineBrimonidineTicsHypotensionXylazineClassSedationNorepinephrineRatsPropranololVeterinaryBlood pressureInjectionActs
Receptors15
  • Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. (wikipedia.org)
  • Alpha 2 receptors are associated with sympatholytic properties. (wikipedia.org)
  • Nonspecific agonists act as agonists at both alpha-1 and alpha-2 receptors. (wikipedia.org)
  • ergotamine etilefrine indanidine mephentermine metaraminol methoxamine mivazerol naphazoline norfenefrine octopamine phenylpropanolamine propylhexedrine rilmenidine romifidine synephrine talipexole Alpha-adrenergic agonists, more specifically the auto receptors of alpha 2 neurons, are used in the treatment of glaucoma by decreasing the production of aqueous fluid by the ciliary bodies of the eye and also by increasing uveoscleral outflow. (wikipedia.org)
  • In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
  • In this study we examined the role of alpha 1-adrenergic receptors. (nih.gov)
  • Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
  • Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. (pharmacycode.com)
  • Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (ebi.ac.uk)
  • An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)
  • Cirazoline is a full agonist at the α 1A adrenergic receptor , a partial agonist at both the α 1B and α 1D adrenergic receptors, [1] and a nonselective antagonist to the α 2 adrenergic receptor . (wikipedia.org)
  • Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. (rndsystems.com)
  • The NBOMe compounds are highly potent 5HT2A receptor agonists and are also agonists at alpha-adrenergic receptors, which likely account for their serotonergic and sympathomimetic symptoms. (erowid.org)
  • Agmatine acts as an agonist at imidazoline and alpha-2-adrenergic receptors, also modulating NMDA receptor activity. (psicothema.com)
  • There is strong evidence that obesity leads to increased sympathetic modulation and a decreased vagal tone leading to a lack of autonomic control (characterized by reduction of heart rate variability) that can bring about changes in the renin-angiotensin-aldosterone system in alpha agonists and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)
Receptor18
  • The alpha-adrenergic receptor has two subclasses α1 and α2. (wikipedia.org)
  • amitraz Detomidine[citation needed] Lofexidine, an α2A adrenergic receptor agonist. (wikipedia.org)
  • Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)
  • Background The α1-adrenergic receptor (α1AR) agonist phenylephrine (PE), acts via ERK1/2 to phosphorylate (i.e. activate) p90 ribosomal S6 kinases (RSKs). (bmj.com)
  • Epinephrine belongs to a class of drugs called alpha-adrenergic and beta-adrenergic receptor agonists. (medicalnewstoday.com)
  • Guanfacine extended-release tablets are a central alpha 2A -adrenergic receptor agonist indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications (1, 14). (nih.gov)
  • Receptor subtype involved in α 1A -adrenergic receptor-mediated Ca 2+ signaling in cardiomyocytes. (rndsystems.com)
  • Synthesis and in vitro characterisation of N -[5-(4,5-dihydro-1 H -imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α 1A receptor agonist. (rndsystems.com)
  • A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)
  • An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. (rndsystems.com)
  • A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. (rndsystems.com)
  • The α-1A Adrenergic Receptor in the Rabbit Heart. (rndsystems.com)
  • p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)
  • The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries. (rndsystems.com)
  • Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. (rndsystems.com)
  • It is classified as a centrally acting alpha 2 adrenergic agonist and imidazoline receptor agonist and has been in clinical use since 1966. (uspharmacist.com)
Sympathomimetics1
  • Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
Sympathomimetic agents1
  • Epinephrine oral inhalation is in a class of medications called alpha- and beta-adrenergic agonists (sympathomimetic agents). (safemedication.com)
Brimonidine3
  • Brimonidine is in a class of drugs called alpha adrenergic agonists. (medlineplus.gov)
  • Mirvaso is a once daily topical gel formulation of brimonidine, an alpha-2 adrenergic agonist with potent vasoconstrictive activity. (centerwatch.com)
  • Mirvaso (brimonidine) is a relatively selective alpha-2 adrenergic agonist. (centerwatch.com)
Antagonists1
  • Many of the ergot alkaloids act as alpha-adrenergic antagonists. (bvsalud.org)
Potent1
  • A 61603 hydrobromide is a potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. (rndsystems.com)
Reducing cardiac1
  • The reduction of the stress response caused by alpha 2 agonists were theorised to be beneficial peri operatively by reducing cardiac complications, however this has shown not to be clinically effective as there was no reduction in cardiac events or mortality but there was an increased incidence of hypotension and bradycardia. (wikipedia.org)
MeSH1
  • Xylometazoline Oxymetazoline Apraclonidine[citation needed] Cirazoline Epinephrine The following agents are also listed as agonists by MeSH. (wikipedia.org)
Therapeutic1
  • Aim 2: Determine how agents that augment PKA, especially therapeutic beta-adrenergic agonists, dampen dust extract-induced PKC isoform activation and attenuate lung inflammation in vitro and in vivo. (cdc.gov)
Methoxamine1
  • The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
Medications1
  • Other dogs require medications called alpha-adrenergic agonists. (vetinfo.com)
Adrenoreceptor1
  • Alpha adrenoreceptor ligands mimic the action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity. (wikipedia.org)
Activates1
  • Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. (rndsystems.com)
Chemicals1
  • Alpha-adrenergic agonists work by enhancing the release of the neurotransmitter chemicals that increase the sensitivity of the sphincter. (vetinfo.com)
Effects1
  • A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. (ebi.ac.uk)
Agents1
  • We will test this hypothesis via three specific aims: Aim 1: Establish how agents that specifically target TNF-alpha, IL-6, and IL-8 modulate dust extract-induced lung inflammation in vivo. (cdc.gov)
Withdrawal1
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/435680/all/Alpha_2__adrenergic_agonists_for_the_management_of_opioid_withdrawal:_Cochrane_systematic_review. (unboundmedicine.com)
Activity1
  • α1 agonist: stimulates phospholipase C activity. (wikipedia.org)
Beta1
  • Alpha blocker Adrenergic agonist Beta-adrenergic agonist Declerck I, Himpens B, Droogmans G, Casteels R (September 1990). (wikipedia.org)
Treatment1
  • treatment may include Comprehensive Behavioral Intervention for Tics and alpha-adrenergic agonists or antipsychotics. (msdmanuals.com)
Treat1
  • Proin is the brand name for the alpha-adrenergic agonists medication that veterinarians prescribe most often to treat canine urinary incontinence. (vetinfo.com)
Study1
  • The present study focuses on tizanidine, an α 2 noradrenergic (NE) agonist, which is incompletely studied, but is thought to act to depress dorsal horn interneuron excitability [ 14 ]. (biomedcentral.com)
Clonidine5
  • Intrathecal injection of clonidine and dexmedetomidine produce behavioral analgesia by an alpha 2-adrenergic mechanism. (nih.gov)
  • A retrospective review of clinic records was undertaken to determine the efficacy and adverse effects of the centrally acting adrenergic agonists methyldopa and clonidine, the alpha-1 antagonist prazosin, and the direct vasodilator hydralazine in patients with mild and moderate hypertension. (nih.gov)
  • Alpha-2-adrenergic agonists(e.g. clonidine and guanfacine) are non-stimulant treatments for ADHD which may help reduce the "fight or flight" response to anxiety in disinhibited children. (aap.org)
  • Studies have consistently demonstrated that centrally acting alpha-adrenergic agonists, such as clonidine, are effective in relieving symptoms of mild to moderate withdrawal. (aafp.org)
  • US research has tended toward alpha-2 adrenergic agonists , which is an anesthetic and relaxant drug family used mainly in veterinary applications, but also in psychotherapy for humans (e.g. clonidine). (metafilter.com)
Epinephrine3
  • Alpha adrenoreceptor ligands mimic the action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity. (wikipedia.org)
  • Xylometazoline Oxymetazoline Apraclonidine[citation needed] Cirazoline Epinephrine The following agents are also listed as agonists by MeSH. (wikipedia.org)
  • Adrenaclick contains epinephrine, a non-selective alpha and beta-adrenergic receptor agonist, indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis. (drugs.com)
Antagonist1
  • Whereas midodrine acts as a selective, peripheral alpha1-receptor agonist, DHE displays complex pharmacology and can behave as an alpha-adrenergic receptor agonist or antagonist. (hal.science)
Alpha2-adrenergic1
  • Nitrergic and alpha2-adrenergic modulation of gastric sensory and motor function were assessed in this study. (nih.gov)
Selective2
Blockers3
  • Alpha-adrenergic agonists have the opposite function of alpha blockers. (wikipedia.org)
  • Beta-adrenergic blockers have yellow or blue bottle caps. (aphconnectcenter.org)
  • Due to possible ↓ in BP, use cautiously with antihypertensives , beta-adrenergic blockers , digoxin . (unboundmedicine.com)
Adrenoceptor agonist1
  • UPNEEQ (oxymetazoline hydrochloride ophthalmic solution), 0.1% contains oxymetazoline hydrochloride, an alpha adrenoceptor agonist. (globalrph.com)
Guanfacine1
Brimonidine1
  • Brimonidine topical gel, 0.33% is an alpha adrenergic agonist indicated for the topical treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years of age or older. (nih.gov)
Tics2
  • Alpha-2-adrenergic agonists may also help to address associated problems in attention, hyperactivity, and impulsivity as well as helping decrease tics. (aap.org)
  • treatment may include Comprehensive Behavioral Intervention for Tics and alpha-adrenergic agonists or antipsychotics. (msdmanuals.com)
Hypotension4
  • The reduction of the stress response caused by alpha 2 agonists were theorised to be beneficial peri operatively by reducing cardiac complications, however this has shown not to be clinically effective as there was no reduction in cardiac events or mortality but there was an increased incidence of hypotension and bradycardia. (wikipedia.org)
  • Emerphed ( ephedrine sulfate) is an alpha- and beta- adrenergic agonist and a norepinephrine-releasing agent used to treat clinically important low blood pressure ( hypotension ) occurring in the setting of anesthesia . (rxlist.com)
  • BIORPHEN injection is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. (nih.gov)
  • Hypotension is a side effect due to alpha-receptor blockade after therapeutic use. (antidepressantsfacts.com)
Xylazine3
  • Xylazine is an alpha-2 adrenergic receptor agonist with sedative and analgesic properties that is FDA-approved for veterinary use. (nih.gov)
  • Xylazine may also affect the clinical presentation of opioid withdrawal as adrenergic withdrawal somewhat resembles opioid withdrawal symptoms, and xylazine has a very short pharmacological half-life (in animals). (nih.gov)
  • Adrenergic therapies are used to treat opioid withdrawal syndrome, and so it is uncertain whether prolonged xylazine exposure will affect SUD treatment protocols and / or the therapeutics employed. (nih.gov)
Class1
  • Midodrine is in a class of medications called alpha-adrenergic agonists. (medlineplus.gov)
Sedation1
  • Because alpha-2-adrenergic agonists can cause sedation, their daytime use may be limited, but they can be helpful for children who struggle with sleep. (aap.org)
Norepinephrine2
  • Intrathecal alpha 2-adrenergic agonists stimulate acetylcholine and norepinephrine release from the spinal cord dorsal horn in sheep. (nih.gov)
  • Akovaz, an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent, must be diluted before it is intravenously delivered to patients. (pharmacytimes.com)
Rats1
  • A large body of experimental data has shown that lead raises blood pressure and increases responsiveness to alpha-adrenergic agonists in rats and pigeons. (nih.gov)
Propranolol1
  • Propranolol is a nonselective beta-adrenergic receptor blocking agent. (medscape.com)
Veterinary1
  • even if you address the opiate issue, you still have the alpha 2 agonist effects, and if their using a veterinary medicine preparation, all bets are off as to the extent of those effects. (emtlife.com)
Blood pressure2
  • Similar declines in blood pressure levels occurred when hydralazine was used with an alpha-2 adrenergic agonist or beta-adrenoceptor blocking agent. (nih.gov)
  • Alpha-2 adrenergic agonists can lower blood pressure. (nih.gov)
Injection1
  • This hypothesis was directly tested by measuring extracellular acetylcholine concentrations in spinal cord interstitial fluid by means of microdialysis after intrathecal injection of these alpha 2-adrenergic agonists in sheep. (nih.gov)
Acts1
  • These results strongly suggest that DHE really acts in vivo as an alpha1-adrenoceptor partial agonist. (hal.science)