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  • dose
  • 1. A patient is using a metered-dose inhaler containing albuterol for asthma. (testbanksuccess.com)
  • The starting dose is 0.5 mg/day for days 1-3, followed by 1.5mg/day for days 4-7, followed by 2 mg/day for days 8-12, followed by 2.5 mg/day for days 13-15, followed by 3 mg/day from day 16 to remainder of study. (clinicaltrials.gov)
  • The starting dose is 12.5 mg/day for day 1, followed by 25 mg/day for days 2-3, followed by 50 mg from days 4 to the end of the study. (clinicaltrials.gov)
  • Benicar Hct Dose Range 1 benicar dosing recommendations 390.31 allows that records, except those requiring a signature, may be maintained through the use of computer. (phonecover.tk)
  • dose was found to be linear down to 10 units/ml of alpha-interferon (6-7 X10-12 M). (deephair.info)
  • mechanisms
  • Our approach is two-fold: 1) We will use intradermal microdialysis and laser Doppler flowmetry (LDF) to delineate the microvascular mechanisms of NO modulation of noradrenergic neurotransmission free of confounding systemic reflex changes. (clinicaltrials.gov)
  • Collectively these Aims will establish a broader understanding of human cardiac alpha-1-AR biology and the mechanisms of HF. (grantome.com)
  • effect
  • Alpha1-Blockers: May diminish the vasoconstricting effect of Alpha1-Agonists. (drugs.com)
  • Ergot Derivatives: May enhance the hypertensive effect of Alpha1-Agonists. (drugs.com)
  • Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Alpha1-Agonists. (drugs.com)
  • This stimulating effect results in a significant dampening of appetite in man, as well as a swift increase in energy expenditure (1). (anabolicminds.com)
  • cardiac
  • Dr. Simpson is highly respected in the field of molecular cardiology and internationally-recognized for his contributions to our understanding of cardiac hypertrophy and alpha-1-adrenergic receptor (AR) biology. (grantome.com)
  • Surprisingly, the function of the human cardiac alpha-1-AR subtypes is unknown, and alpha-1-ARs have never been studied in human heart cells. (grantome.com)
  • 1 KO of the two main myocardial α1-AR subtypes, the α1A and α1B, impairs normal post-natal cardiac growth, and causes severe dilated cardiomyopathy and death after pressure overload. (pubmedcentralcanada.ca)
  • α1-AR gain-of-function in cardiac transgenic models generally supports the KO results, although phenotypes vary greatly with receptor level, promoter, and absence or presence of an activating mutation. (pubmedcentralcanada.ca)
  • show
  • Abundant data from animal studies, including knockout mouse models created by the mentor, show that the alpha-1 A and alpha-IB subtypes play beneficial roles in the heart and protect against HF. (grantome.com)
  • Abundant data from cell and animal studies show that alpha-1-adrenergic receptors (ARs) play beneficial roles in the heart and protect against heart failure (HF), but little is known about these receptors in the human heart. (grantome.com)
  • time
  • cerebral perfusion (rSO2) measured using Near Infrared Spectroscopy [ Time Frame: (day 1) Monitoring will take place only on the day of operation. (clinicaltrials.gov)
  • Time Frame: 1 year. (clinicaltrials.gov)
  • heart
  • The research plan follows naturally from the applicant's recent novel work identifying the tissue distribution of the 3 alpha-1-AR subtypes in the human heart. (grantome.com)
  • The proposed work will expand significantly our knowledge of alpha-1-ARs in the human heart and is essential to the long-term aim of the project, which is the development of a novel therapy for HF targeting alpha-1-ARs. (grantome.com)