Adrenergic agonists. Medical search. Frequent questions

An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. (wikipedia.org)
The five main categories of adrenergic receptors are: α1, α2, β1, β2, and β3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively. (wikipedia.org)
Alternatively, it may refer to something which is susceptible to epinephrine, or similar substances, such as a biological receptor (specifically, the adrenergic receptors). (wikipedia.org)
Directly acting adrenergic agonists act on adrenergic receptors. (wikipedia.org)
All adrenergic receptors are G-protein coupled, activating signal transduction pathways. (wikipedia.org)
The receptors are classed physiologically, though pharmacological selectivity for receptor subtypes exists and is important in the clinical application of adrenergic agonists (and, indeed, antagonists). (wikipedia.org)
Inhibitors of these enzymes act as indirect agonists of adrenergic receptors as they prolong the action of catecholamines at the receptors. (wikipedia.org)
A great number of drugs are available which can affect adrenergic receptors. (wikipedia.org)
The following headings provide some useful examples to illustrate the various ways in which drugs can enhance the effects of adrenergic receptors. (wikipedia.org)
These drugs act directly on one or more adrenergic receptors. (wikipedia.org)
these are: Adrenaline (almost all adrenergic receptors). (wikipedia.org)
Selectively blocks beta1-adrenergic receptors with little or no effect on beta2-receptors. (medscape.com)
In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
In this study we examined the role of alpha 1-adrenergic receptors. (nih.gov)
What are the 4 basic categories of adrenergic receptors? (brainscape.com)
What type of receptor are adrenergic receptors? (brainscape.com)
What are the 4 main factors that can alter the degree to which an adrenergic receptors respond to a stimulus? (brainscape.com)
Glucorticoids and adrenergic stimulation are both thought to control the development of beta-adrenergic receptors/responses. (rti.org)
Release of endogenous catecholamines and activation of the beta-adrenergic receptors (b-AR) have also been shown to be involved in ischaemic preconditioning. (sun.ac.za)
the respective roles of the A1-, A2-, A3-adenosine receptors as well as the involvement of the PI3-K/PKB/Akt and ERKp44/p42 signal transduction pathways, in the cardioprotective phenomemon of -adrenergic preconditioning and (iv) the contribution of the mitochondrial KATP channels (mKATP), reactive oxygen species and NO to the mechanism of -AR-induced cardioprotection. (sun.ac.za)
They express a high level of beta2-adrenergic receptors but their function is unknown. (mysciencework.com)
There are many adrenergic receptors. (basicmedicalkey.com)
The alpha-adrenergic receptors are located in the blood vessels, eyes, bladder, and prostate. (basicmedicalkey.com)
Other adrenergic receptors are dopaminergic and are located in the renal, mesenteric, coronary, and cerebral arteries. (basicmedicalkey.com)
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. (pharmacycode.com)
Signaling is regulated by the interactions between receptors and their ligands, it can be stimulated by agonists, or inhibited by antagonists or inverse agonists. (biomedcentral.com)
To date, however, mutagenesis studies with the beta 2-adrenergic receptor have not clarified this question since mutant receptors with impaired abilities to activate Gs have generally possessed a diminished capacity to form the ternary complex as assessed in binding assays. (duke.edu)
Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (ebi.ac.uk)
An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)
Both GABA and baclofen, but not isoguvacine, altered βAR agonist binding by increasing the affinity of both the low‐ and high‐affinity binding sites and by increasing the proportion of low‐affinity receptors. (johnshopkins.edu)
To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. (bvsalud.org)
This especially applies to the use of ß or a adrenergic receptors agonists/antagonists (e.g., ß-blockers). (who.int)
It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent. (bvsalud.org)

Beta-adrenergic receptor agonists delay while antagonists acce. (mysciencework.com)
Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. (mysciencework.com)
Conversely, beta-adrenergic receptor antagonists accelerate CEC migration, enhance electric field-mediated directional migration, and promote corneal wound repair. (mysciencework.com)
This chapter discusses two groups of drugs that affect the sympathetic nervous system-adrenergic agonists, or sympathomimetics , and adrenergic antagonists, also called adrenergic blockers or sympatholytics -along with their dosages and uses. (basicmedicalkey.com)
Intravenous (IV) adrenergic agonists and antagonists are high-alert medications because they can cause significant harm to a patient in the event of a medication error. (basicmedicalkey.com)
Topical β-adrenergic antagonists, or β-blocker agents, must be used with caution in children. (aao.org)
Machine learning well suits this purpose by extracting complex relationship from experimental data and classification algorithms are typically adapted to distinguish agonists from antagonists [ 4 , 5 ]. (biomedcentral.com)
However, their application is limited to well-studied protein targets with many known agonists and antagonists. (biomedcentral.com)
While agonist ligands are known to have a higher binding affinity for the active state, and antagonists for the inactive state[ 12 ], the structures of the binding pocket in both states tend to be very similar [ 11 ]. (biomedcentral.com)
These include α-2 adrenergic agonists, such as clonidine and guanfacine , and dopamine antagonists (antipsychotics). (medscape.com)

Selective FP prostanoid receptor agonist believed to reduce IOP by increasing uveoscleral outflow. (medscape.com)
We demonstrate that CECs express key enzymes required for epinephrine (beta-adrenergic receptor agonist) synthesis in the cytoplasm and can detect epinephrine in cell extracts. (mysciencework.com)
Patients with acetylcholine receptor deficiency can also benefit from the addition of a β2-adrenergic receptor agonist to their medication. (ox.ac.uk)
Terbutaline Sulfate Injection is a beta-adrenergic receptor agonist used for the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema . (rxlist.com)

Drugs that stimulate the sympathetic nervous system are called adrenergic agonists, adrenergics, or sympathomimetics because they mimic the sympathetic neurotransmitters norepinephrine and epinephrine. (basicmedicalkey.com)
Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)

We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. (mysciencework.com)
This study aims to investigate the association between prenatal exposure to terbutaline and other beta2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). (kaiserpermanente.org)

Combivent (ipratropium bromide and albuterol sulfate ) is an inhaler that is a combination of an anticholinergic bronchodilator and a selective beta2-adrenergic bronchodilator used to treat and prevent symptoms ( wheezing and shortness of breath) caused by ongoing lung disease ( chronic obstructive pulmonary disease - COPD which includes bronchitis and emphysema ). (rxlist.com)
Albuterol sulfate, chemically known as (1,3-benzenedimethanol, α'-[[(1,1dimethylethyl) amino] methyl]-4-hydroxy, sulfate (2:1)(salt), (±)- is a relatively selective beta 2 -adrenergic bronchodilator. (rxlist.com)
Terbutaline sulfate injection, USP is a beta-adrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. (rxlist.com)
The preferred bronchodilator has changed from methylxanthines, and anticholinergics methylxanthines to beta -adrenergic agonists. (cdc.gov)

Here, we report the long-term follow-up for the addition of β2-adrenergic agonists for a cohort of patients with acetylcholine receptor deficiency on anticholinesterase medication that demonstrates a sustained quantitative improvement. (ox.ac.uk)
Coincidently we used a disease model to mirror the treatment of acetylcholine receptor deficiency, and demonstrate improved muscle fatigue, improved neuromuscular transmission and improved synaptic structure resulting from the addition of the β2-adrenergic agonist salbutamol to the anticholinesterase medication pyridostigmine. (ox.ac.uk)

An adrenergic agent is a drug, or other substance, which has effects similar to, or the same as, epinephrine (adrenaline). (wikipedia.org)

Issues for future research include the effects of the newer long-acting beta-agonists, large versus small airway effects, and combination effects with other inhaled therapeutic agents (eg, steroids and ion-channel blockers). (nih.gov)
Thus, glucocorticoids and beta-agonists can participate in the programming of development of postsynaptic reactivity by exerting actions upon post-receptor coupling mechanisms. (rti.org)

Noradrenergic agonists (≥ 100 μM), norepinephrine and clonidine, only slightly depolarize the type B cell but clearly prolong its depolarizing response to light. (bgu.ac.il)
Aged animals showed an attenuated entrainment response to noradrenergic stimulation as well as decreased adrenergic receptor mRNA expression in target peripheral organs. (nature.com)
The present study focuses on tizanidine, an α 2 noradrenergic (NE) agonist, which is incompletely studied, but is thought to act to depress dorsal horn interneuron excitability [ 14 ]. (biomedcentral.com)

The indirect agonist properties of ephedrine may be due to peripheral postsynaptic norepinephrine release, or by inhibition of norepinephrine reuptake.Ephedrine is commonly used as a vasopressor during anesthesia. (brainkart.com)

More selective agonists are more useful in pharmacology. (wikipedia.org)

Different conditions were tested: low to high affinity agonists, varying simulation duration, considering or ignoring hydrophobic contacts, and tuning of the classifier parametrization. (biomedcentral.com)
Scholars@Duke publication: A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. (duke.edu)
Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. (duke.edu)
Nevertheless, D267-273 exhibited high affinity agonist binding identical to that of the wild-type receptor. (duke.edu)
These findings indicate that the formation of high affinity agonist-receptor-Gs complexes is not sufficient to fully activate Gs. (duke.edu)

We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. (bvsalud.org)

ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to repetitive short episodes of ischaemia and reperfusion. (sun.ac.za)

Two uptake mechanisms exist for terminating the action of adrenergic catecholamines - uptake 1 and uptake 2. (wikipedia.org)
Other drugs affect the uptake and storage mechanisms of adrenergic catecholamines, prolonging their action. (wikipedia.org)

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)
Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. (jci.org)
report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. (jci.org)

Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
Usage information: Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis. (jci.org)

Tizanidine is a central alpha-2-adrenergic agonist indicated for the management of spasticity. (nih.gov)

The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
agonist triggers signaling, unlike antagonist and inverse agonist (henceforth referred to as antagonist too, for simplicity). (biomedcentral.com)

The G-protein receptor can affect the function of adenylate cyclase or phospholipase C, an agonist of the receptor will upregulate the effects on the downstream pathway (it will not necessarily upregulate the pathway itself). (wikipedia.org)

The role and mechanism of action of α₁-adrenoceptors in adrenergic spinal antinociception is uncertain. (mun.ca)
Recently, we showed that intrathecal (i.t.) α₁-agonists potentiate α₂-induced spinal antinociception in the rat by a δ-receptor mediated, enkephalin-dependent process. (mun.ca)
DADLE), but not to μ-agonists (i.e. morphine), in the spinal cord. (mun.ca)

Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)

Indirectly acting adrenergic agonists affect the uptake and storage mechanisms involved in adrenergic signalling. (wikipedia.org)

Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. (kaiserpermanente.org)

Beta-adrenergic receptor agonists delay CEC migration via a protein phosphatase 2A-mediated mechanism and decrease both electric field-directed migration and corneal wound healing. (mysciencework.com)
In the case of the beta 2-adrenergic receptor, multiple regions of the molecule have been implicated in coupling to the stimulatory G protein Gs. (duke.edu)

Agonists of each class of receptor elicit these downstream responses. (wikipedia.org)

Adrenergic agents can produce constriction of skeletal and vascular muscle. (medscape.com)
Beta -adrenergic agonists, 2 inflammatory agents. (cdc.gov)

Hearts were preconditioned with 5 min isoproterenol 0.1 μM ( 1/ 2-AR agonist), or formoterol 1 nM ( 2-AR agonist) or BRL 37344 1 μM ( 3-AR agonist) followed by 5 min reperfusion. (sun.ac.za)
The interaction of isoproterenol with β‐adrenergic receptor (βAR) binding sites was measured in membranes prepared from rat brain cerebral cortical slices previously incubated in the presence or absence of γ‐aminobutyric acid (GABA) receptor agonists. (johnshopkins.edu)

Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. (kaiserpermanente.org)
The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). (kaiserpermanente.org)

Little is known about chronic effects, but studies with dosing for up to a week also suggest an enhancement of mucociliary clearance, primarily by agonists that are lipophilic. (nih.gov)
A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. (ebi.ac.uk)

To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. (bvsalud.org)

We have expressed in a mammalian cell line a mutant beta 2-adrenergic receptor comprising a seven-amino acid deletion in the carboxyl-terminal region of its third cytoplasmic loop (D267-273), a region proposed to be critically involved in coupling to Gs. (duke.edu)

Further, experimental evidence in spinalized cats demonstrate marked improvements in locomotor capacity following intrathecal delivery of α 2 NE agonists [ 20 ]. (biomedcentral.com)

Unlike direct-acting α1-agonists, ephedrine is believed not to decrease uterine blood flow, and thus was regarded as the preferred vasopressor for most obstetric uses. (brainkart.com)

However, there are also other mechanisms of adrenergic agonism. (wikipedia.org)

Isoflurane anesthesia does not add to the bronchodilating effect of a beta 2-adrenergic agonist after tracheal intubation. (druglib.com)
This double-blind study investigates whether isoflurane/N2O anesthesia adds to the bronchodilating effect of the beta 2-adrenergic agonist, fenoterol, after an endotracheal tube (ETT)-induced increase in airway resistance. (druglib.com)
β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure. (ox.ac.uk)

Interactions patterns between a reference agonist and the receptor, here exemplified on the β2 adrenergic receptor, were extracted from molecular dynamics simulations of the agonist/receptor complex and encoded in graphs used to train a one-class machine learning classifier. (biomedcentral.com)

hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. (bvsalud.org)

Anatomy22

Organisms11

Diseases5

Chemicals and Drugs177

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology2

Phenomena and Processes31

Information Science1

Health Care3

Receptors35

Antagonists10

Receptor agonist4

Sympathomimetics2

Beta2-adrenergic receptor2

Bronchodilator4

Medication2

Epinephrine1

Beta-agonists2

Noradrenergic3

Norepinephrine1

Pharmacology1

Affinity5

Stimulate1

Endogenous1

Catecholamines2

Mirabegron3

Disorders of glucose homeostasis3

Tizanidine1

Antagonist2

Adenylate cyclase1

Spinal3

Alpha3

Indirectly1

Terbutaline1

Protein2

Responses1

Agents2

Isoproterenol2

Exposure2

Effects2

Rats1

Mammalian1

Intrathecal1

Decrease1

Mechanisms1

Effect3

Interactions1

Tend1