• Scholars@Duke publication: beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)
  • We have identified a novel G protein-coupled receptor kinase-interacting protein, GIT1, that is a GTPase-activating protein (GAP) for the ADP ribosylation factor (ARF) family of small GTP-binding proteins. (duke.edu)
  • ADP ribosylation factor like GTPase 13A is a protein that in humans is encoded by the ARL13A gene. (wikipedia.org)
  • Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
  • Patrick A. Lewis ABSTRACT Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual guanosine triphosphatase ( GTPase ) and kinase enzymatic activities, providing this protein with the capacity to regulate a multitude of signalling pathways. (biologists.com)
  • Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
  • Probable ADP-ribosylation factor GTPase-activating protein AGD5 OS=Arabidopsis thaliana GN=AGD5 PE=1. (yeastrc.org)
  • Probable ADP-ribosylation factor GTPase-activating protein AGD6 OS=Arabidopsis thaliana GN=AGD6 PE=1. (yeastrc.org)
  • Rho GTPase activating protein 45 [S. (gsea-msigdb.org)
  • GIT1 is a GTPase-activating protein for the ADP ribosylation factor family. (antibodiesinc.com)
  • The GTPase Rab11 regulates endosomal protein trafficking and previous work has shown that loss of Rab11 caused intestinal inflammation and hyperplasia in mice and flies. (sdbonline.org)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Rho GTPase activating protein 32 [Sour. (gsea-msigdb.org)
  • The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. (utsouthwestern.edu)
  • The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. (utsouthwestern.edu)
  • ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1 (ARL2L1), is a protein that in humans is encoded by the ARL13B gene. (nsjbio.com)
  • The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. (nsjbio.com)
  • Research in the Byrd laboratory focuses on protein-protein interactions in the ubiquitin-proteasome regulation pathway and the area of ADP-ribosylation factor (Arf) family of GTP-binding proteins and their regulators, the Arf GTPase-activating proteins (Arf GAPs). (nih.gov)
  • Morinaga, N., Tsai, S.-C., Moss, J. & Vaughan, M. Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. (nature.com)
  • Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. (embl.de)
  • Classical GAP proteins accelerate GTPase activity by supplying an arginine finger to the active site. (embl.de)
  • ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins recognized as critical components in intracellular vesicular transport and phospholipase D activation. (embl.de)
  • Both guanine nucleotide-exchange proteins and GTPase-activating proteins (GAPs) for ARFs have been cloned recently. (embl.de)
  • These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. (appliedbioinfo.com)
  • This gene encodes a member of the ADP-ribosylation factor-like family. (nsjbio.com)
  • This gene is a member of the human ADP-ribosylation factor (ARF) gene family. (appliedbioinfo.com)
  • The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs. (embl.de)
  • ADP-ribosylation factor family members (Arfs) in mice possess GTPase activities, and some members have been found to function in meiosis. (appliedbioinfo.com)
  • This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation. (biologists.com)
  • Small ribosomal subunit biogenesis GTPase RsgA (EC 3.6.1. (weizmann.ac.il)
  • Canis lupus familiaris ADP ribosylation factor like GTPase 3 (ARL3), mRNA. (genscript.com)
  • In a survey of trafficking regulators required for developmental dendrite pruning in Drosophila sensory neurons, the small GTPase Rab11 was identified as a regulator of recycling endosomes. (sdbonline.org)
  • engagement triggers rapid GTP-loading of the small GTPase Rac as a master regulator of cytoskeletal rearrangements and lamellipodia-driven internalization. (biologists.com)
  • In this review, we will summarize the earlier work establishing the ability of cAMP to dampen mTORC1 activation in response to insulin and growth factors and then discuss our recent findings demonstrating the regulation of mTOR signaling by the PKA- and PKG-dependent signaling pathways. (bvsalud.org)
  • TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. (gsea-msigdb.org)
  • Jackson, C. L. & Casanova, J. E. Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. (nature.com)
  • ADP-ribosylation factor GTPase Glucose deprivation Cell invasion Ministry of Education http. (biologists.com)
  • mTOR activity is subjected to tight regulation in response to external nutrition and growth factor stimulation. (bvsalud.org)
  • The HIFs are transcription factors with a very broad biological significance to many cell and tissue types [ 27 ]. (biomedcentral.com)
  • FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells. (or.jp)
  • Cardiac hypertrophy is an important and independent risk factor for the development of cardiac myopathy that may lead to heart failure. (mdpi.com)
  • Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). (biomedcentral.com)
  • ADP ribosylation factor like GTPase 13A is a protein that in humans is encoded by the ARL13A gene. (wikipedia.org)
  • Orthologous to human ARL6IP6 (ADP ribosylation factor like GTPase 6 interacting protein 6). (nih.gov)
  • A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (nih.gov)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing small_GTPase domain in the selected taxonomic class. (embl-heidelberg.de)
  • Complexes between structurally unrelated GTPase-activating proteins with complementary G proteins suggest common mechanisms by which GTP hydrolysis is stimulated via direct interactions with conformationally labile switch regions of the G protein. (embl-heidelberg.de)
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)
  • Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
  • These include BET1 (Golgi vesicular membrane-trafficking protein), ADAM10 (ADAM metallopeptidase domain 10), and ARFGAP3 (ADP-ribosylation factor GTPase-activating protein 3). (nih.gov)
  • Analysis of the resultant clones result in tour target protein as ADP ribosylation factor like 4 (Arl4). (nih.gov)
  • ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. (thermofisher.com)
  • Rho GTPase activating protein 26 [S. (gsea-msigdb.org)
  • The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. (nih.gov)
  • Primary cilia are critical for a number of signaling pathways: Wnt signaling, calcium signaling, growth factor signaling, Shh signaling, G-protein coupled receptor signaling and receptor tyrosine kinase signaling ((2) https://ciliajournal.biomedcentral.com/articles/10.1186/2046-2530-1-4). (bladeresearchinc.com)
  • Here, we show that binding of ADP-ribosylation factor (ARF)-GTPase-activating protein (GAP) to ER-Golgi v-SNAREs is an essential step for recruitment of Arf1p and coatomer, proteins that together form the COPI coat. (uni-luebeck.de)
  • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. (nih.gov)
  • The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network. (nih.gov)
  • These proteins, called ADP-ribosylation factors, or Arfs, have recently been found to 1) interact with specific lipid components of membranes, 2) modify the lipid composition and release potential second messengers through activation of phospholipase D (PLD), and 3) regulate the assembly of at least a subset of protein complexes or membrane coats (for reviews, see refs. (nih.gov)
  • In two of these cases (intra-Golgi transport and nuclear vesicle fusion), the cytosolic factor was purified to homogeneity and shown unambiguously to be an Arf protein. (nih.gov)
  • Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. (nih.gov)
  • Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (nih.gov)
  • ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. (bvsalud.org)
  • In the past funding period we have demonstrated that the GTPase ADP-ribosylation factor related protein 1 (ARFRP1) recruits the GRIP domain-containing Golgins Golgin-97 and Golgin-245 to the trans -Golgi network (TGN), a process required for regulating lipid droplet protein composition in intestinal cells (Werno et al. (sfb958.de)
  • The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells. (sfb958.de)
  • ADP-ribosylation factor-like protein [Arabido. (cornell.edu)
  • One tumor kinases such as insulin-like growth factor I receptor (IGFIR) and expressed significant levels of EGFR protein and erlotinib had insulin receptor (1, 2). (nih.gov)
  • Rab3 GTPase-activating protein non-catalytic subun. (wfleabase.org)
  • ADP-ribosylation factor-binding protein GGA3,Golgi. (wfleabase.org)
  • We analyzed the different phenotypes of the arf1-3 arf2 Δ vps13 ∆ strain, with reduced activity of the Arf1 GTPase, the master regulator of Golgi function and entirely devoid of Vps13. (nih.gov)
  • We learned this from in vitro assays of membrane traffic, including those for intra-Golgi transport and nuclear vesicle and endosome fusion, which are inhibited by GTPgS and require the addition of cytosol or a cytosolic factor (7,8). (nih.gov)
  • We showed that Vps13 binds to the Arf1 GTPase through its C-terminal Pleckstrin homology (PH)-like domain. (nih.gov)
  • ADP-ribosylation factor 1 (Arf1) is a member of the Ras small GTPase family and is involved in regulating lots of essential physiological processes. (news-medical.net)
  • ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. (cancerindex.org)
  • Others that could not be classified in this way are predicted to be members of the small GTPase superfamily without predictions of the subfamily. (embl-heidelberg.de)
  • The small GTPase ADP-ribosylation factor 6 (Arf6) belongs to the Arf subfamily of Ras superfamily GTPases. (cytoskeleton.com)
  • The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs. (embl.de)
  • We show that in the absence of AP-2, the AP-1 adaptor complex appears to functionally substitute for AP-2 but results in complex internalization kinetics that are now sensitive to the guanine-nucleotide exchange factor for ADP-ribosylation factor GTPase (ARF-GEF) inhibitor brefeldin-A (BFA). (cornell.edu)
  • Like other regulatory GTPases, Rho requires GDP/GTP exchange dependent on guanine nucleotide exchange factors (GEFs) for its activation [ 5 ]. (biomedcentral.com)
  • The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. (nih.gov)
  • 5. ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer. (nih.gov)
  • Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. (gsea-msigdb.org)
  • However, glioma cell lines whose cilia overexpress WT but not guanine exchange factor-deficient ARL13B, display reduced INPP5e, a ciliary membrane component whose depletion may favor SMO/GLI2 enrichment. (bvsalud.org)
  • 13. Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. (nih.gov)
  • 16. Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma. (nih.gov)
  • 18. Regulation of α(2B)-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1. (nih.gov)
  • epidermal growth factor receptor pa. (gsea-msigdb.org)
  • In addition, it has been found that the epidermal growth factor receptor gene (EGFR) is frequently over-expressed and amplified in primary GBs. (cancerindex.org)
  • Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high five year mortality which is partly due to the lack of therapeutic target specificity on common breast cancer receptors such as oestrogen receptor (ER), progesterone receptor (PR) or the human epidermal growth factor receptor 2 (HER2) [ 1 ]. (biomedcentral.com)
  • Purpose:To delineate gene expression patterns and profile changes in metastatic tumor biopsies at baseline and1month after treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib in patients with metastatic breast cancer. (nih.gov)
  • Erlotinib is a selective small-molecule inhibitor of the and these mutations cause hypersensitivity to growth inhibition epidermal growth factor receptor tyrosine kinase (EGFR-TK). (nih.gov)
  • Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. (thermofisher.com)
  • Migration inhibitory factor activity was not detected in cultures of splenic leukocytes from ts 1 survivors of CVB3(m)-inoculated ts 1 survivors, but it was readily detected in cultures of splenic leukocytes from CVB3(m)-inoculated normal adolescent mice. (nih.gov)
  • We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. (gsea-msigdb.org)
  • The name ADP-ribosylation factor derives from the discovery, in 1984, of the factor that confers sensitivity of the stimulator of adenylate cyclase (Gs) to cholera toxin, an ADP-ribosyltransferase (4). (nih.gov)
  • ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. (nih.gov)
  • 7. ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. (nih.gov)
  • The capacity for production of migration inhibitory factor was assessed by the agarose droplet cell migration inhibition assay, using peritoneal exudate cells and a CVB3(m) cell lysate or KCl extracted antigens from heart tissues of CVB3(m)-inoculated mice. (nih.gov)
  • Elongation factor 2 kinase,eEF-2 kinase,Calcium/ca. (wfleabase.org)
  • Although many molecules, including inflammatory cytokines such as IL-1, tumor necrosis factor (TNF), and IL-6 and growth factors, have been implicated as pathogenic factors in RA, the coagulation system is also involved in the inflammatory processes in RA synovitis. (biomedcentral.com)
  • 19 The oligomerization domain of NPM also contains a highly conserved motif that appears critical for mediating ADP-ribosylation factor (ARF) binding in vivo . (haematologica.org)
  • Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans. (sfb958.de)