Loading...
  • poly
  • The etiology of secondary brain injury is multi-factorial, with a host of likely inter-related processes including mitochondrial energy failure, excessive generation of reactive oxygen species, activation of destructive enzymes such as poly (ADP-ribose) polymerase (PARP) and caspase family of proteases, membrane disruption, neuronal death, thrombosis due to intravascular coagulation in small vessels, increased synaptic concentrations of excitatory amino acids, and activation of innate inflammatory responses ( Schouten, 2007 ). (frontiersin.org)
  • 1. Cloning of cDNA coding for poly (ADP-ribose) synthetase : A complete amino acid sequence of bovine poly (ADP-ribose) synthetase was determined by cDNA cloning. (nii.ac.jp)
  • We also found that vitamin K as well as novobiocin was much more specific for mono- than poly (ADP-ribosyl) action. (nii.ac.jp)
  • 3. Induction of tumor cell differentiation : We succeeded in inducing differentiation of teratocarcinoma cells in culture by administrating our new inhibitors of poly (ADP-ribosyl) ation, such as 4-hydroxyquinazoline and arachidonic acid. (nii.ac.jp)
  • Publications] Banasik,M.: 'specific inhibitors of poly(ADPーribose)synthetase and mono(ADPーribosyl)transferase' J.Biol.Chem. (nii.ac.jp)
  • Cloning of a full-length cDNA encoding bovine thymus poly (ADP-ribose) synthetase : evolutionarily conserved segments and their potential functions. (nii.ac.jp)
  • The best known enzyme of this type is poly(ADP-ribose) polymerase 1 (PARP1), which has been implicated in the regulation of several important processes including DNA repair, transcription, apoptosis, neoplastic transformation and others. (ingentaconnect.com)
  • arginine ADP-ribosyl-transferases, while ARH3 hydrolyzes poly(ADP-ribose) and O -acetyl-ADP-ribose, resulting from the action of poly(ADP-ribose) polymerases and sirtuins, respectively. (springer.com)
  • Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO (2009) Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. (springer.com)
  • Bock FJ, Chang P (2016) New directions in poly(ADP-ribose) polymerase biology. (springer.com)
  • Recently we proposed the importance of oxidant-induced DNA strand breakage and activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) in the pathogenesis of diabetic endothelial dysfunction. (ahajournals.org)
  • Poly(ADP-ribose) polymerase (PARP) is an abundant nuclear enzyme that has been implicated in the cellular response to DNA injury. (ahajournals.org)
  • We analyzed the interleukin-6 (IL-6) levels as an inflammation marker and the expression of caspase-3 and poly (ADP-ribose) polymerase 1 (PARP-1) as apoptosis markers. (molvis.org)
  • The ADP-ribosyltransferase ( ADPRT ) gene encodes a zinc-finger DNA-binding protein, poly(ADP-ribose) polymerase-1 (PARP-1), that modifies various nuclear proteins by poly(ADP-ribosyl)ation and functions as a key enzyme in the base excision repair pathway. (aacrjournals.org)
  • Because adenosine diphosphate ribosyl transferase/poly(ADP-ribose) polymerase-1 (ADPRT/PARP-1) plays a critical role in both BER and maintaining the genomic stability of cells exposed to genotoxic stress and because previous studies associated higher ADPRT/PARP-1 enzyme activation with lower human cancer risk (8 , 9) , we hypothesize that genetic polymorphisms of ADPRT may contribute to lower enzyme activity and CaP risk. (aacrjournals.org)
  • In studies aimed at identifying other signalling pathways that promote class switching, we discovered that inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) increase lipopolysaccharide (LPS)-induced switching to IgA in the B cell lymphoma I.29μ and to IgG 1 in LPS + IL-4-treated splenic B cells. (umassmed.edu)
  • PARP, which binds to and is activated by DNA strand breaks, catalyzes the removal of ADP-ribose from NAD + and poly(ADP-ribosylation) of chromatin-associated acceptor proteins. (umassmed.edu)
  • Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. (uniprot.org)
  • Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. (uniprot.org)
  • Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner. (uniprot.org)
  • diphtheria toxin
  • In our body, the Diphtheria Toxin (Corynebacterium Diphtheriae Toxin) , an exogenous ADP-ribosylating polypeptidee , produced by the toxigenic bacteria Corynebacterium diphtheriae , which can cause myocarditis, polyneuritis, and other systemic toxic effects. (wellnessadvocate.com)
  • catalytic
  • 3. The modified cholera toxin of claim 1, which is obtained by site-specific mutagenesis resulting in a mutation of catalytic subunit A which is less active or essentially inactive as determined by assay of ADP-ribosyltransferase activity. (freepatentsonline.com)
  • 7. The improved vaccine of claim 5, wherein the modified cholera toxin has been derived by site-specific mutagenesis resulting in a mutation of catalytic subunit A which has less or essentially no ADP-ribosyltransferase activity. (freepatentsonline.com)
  • regulation
  • Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D (2005) Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. (springer.com)
  • functions
  • Gupte R, Liu Z, Kraus WL (2017) PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. (springer.com)