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  • proliferation
  • The success of adoptive T cell-based immunotherapy (ACT) in cancer is limited in part by the accumulation of myeloid-derived suppressor cells (MDSC), which block several T cell functions, including proliferation and expression of effector mediators. (biomedcentral.com)
  • Ideally, these antigens should be preferentially or uniquely expressed by malignant cells, play essential roles on tumor cell survival or proliferation, or be broadly expressed on tumors, and their reactive T-cell repertoire should be spared from negative selection or functional inactivation ( 13 ). (aacrjournals.org)
  • Survivin is important for the survival and proliferation of tumor cells and may therefore provide a target for immunotherapy. (biomedcentral.com)
  • As designed, the gene-modified Tandem T cells exhibit the new property of being resistant to AICD, showing instead an accelerated proliferation on tumor contact. (aacrjournals.org)
  • murine model
  • Using a well-characterized murine model of adoptive T cell immunotherapy for established malignancy, we have demonstrated the feasibility of eliminating disseminated leukemia using T cells genetically modified by TCR gene transfer.We next examined the potential of targeting a clinically relevant tumor antigen, the transcription factor WT1, for which the expression patterns in normal and malignant cells are similar in mouse and man. (washington.edu)
  • unsorted tumor cell
  • In particular, splenocytes isolated from the host subjected to CSC-DC vaccine produced significantly higher amount of IFNγ and GM-CSF than splenocytes isolated from the host subjected to unsorted tumor cell lysate pulsed-DC vaccine. (jove.com)
  • malignant
  • Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors," International Journal of Cancer , vol. 115, no. 5, pp. 684-689, 2005. (hindawi.com)
  • efficient tumor
  • The TCRs from these T cells are being used as templates for in vitro mutagenesis and selection of higher affinity TCRs by yeast display to determine the threshold required for efficient tumor recognition without targeting normal tissues. (washington.edu)
  • lymph nodes
  • Optimal skin-DC targeting in combination with adequate adjuvant delivery facilitates DC maturation and migration to draining lymph nodes and enhances antigen cross-presentation and T cell priming. (frontiersin.org)
  • protein
  • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers," The American Journal of Pathology , vol. 164, no. 2, pp. 689-699, 2004. (hindawi.com)
  • transfer
  • Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers," Journal of Experimental Medicine , vol. 202, no. 3, pp. 379-386, 2005. (hindawi.com)
  • Also called adoptive cell therapy, adoptive cell transfer, and T-cell transfer therapy. (cancer.gov)
  • tissue
  • Patients who might benefit from this approach are currently identified based on expression analyses of IDO-1/-2 or TDO2 in tumor tissue and/or enzymatic activity assessed by kynurenine/tryptophan ratios in the serum. (jove.com)
  • Treating physicians must appreciate that SBRT comes at a bigger danger of normal tissue injury and chance of geographic tumor miss. (jove.com)
  • In cancer therapy, T cells are usually taken from the patient's own blood or tumor tissue, grown in large numbers in the laboratory, and then given back to the patient to help the immune system fight the cancer. (cancer.gov)
  • vasculature
  • The contribution of endogenous brain pericytes to the tumor vasculature in GBM is, however, unclear. (jove.com)
  • clinically
  • This lack of autoimmunity may be due to the fact that only low CTL activities present for a relatively short time were sufficient to control and clear these early and small tumors without or before causing clinically apparent autoimmune disease. (rupress.org)
  • In contrast, clinically established tumors seem to require a strong and sustained CTL response to guarantee complete remission of more sizeable tumors ( 21 ). (rupress.org)
  • necrosis
  • Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) has been considered a promising and reliable selective inducer of apoptosis in cancerous cells. (jove.com)
  • Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs. (semanticscholar.org)
  • article{Corti2004TumorVT, title={Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs. (semanticscholar.org)