Adoptive cancer immunotherapy highlighting adoptive cellular immunotherapy adoptive. Medical search. Frequent questions

While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types. (aacr.org)
We now need to know how we can improve the current immunotherapy strategies so that not only a subset of patients respond, but even more patients can benefit from these therapies," Sharma said. (aacr.org)
These include personalized anti-cancer vaccines (dendritic cell based) and chimeric antigen receptor (CAR)-T cell therapies for gastrointestinal and hepatobiliary cancers. (mayo.edu)
Transgenic T-cell receptor (TCR) T cell-based adoptive cell therapies for solid tumors are associated with dramatic initial response rates, but there remain many instances of treatment failure and disease relapse. (bvsalud.org)
Melanoma is a skin cancer with permanently increasing incidence and resistance to therapies in advanced stages. (mdpi.com)
Advances in adoptive cell therapies have led to a transformative change in immuno-oncology, providing personalized and effective treatment options for patients with relapsed or refractory cancers. (medpagetoday.com)
Hematologic malignancies have enjoyed the highest degrees of success thus far in the world of adoptive cell therapies with multiple FDA approvals for CAR T cell therapies for a variety of indications. (medpagetoday.com)
in their recent article in the ASCO Educational Book reflect on the recent advances in adoptive cell therapies and the lessons that can be learned for the development of future cellular products. (medpagetoday.com)
and next-generation adoptive cell therapies. (uchicagomedicine.org)
Besides, recent efforts have focused on developing targeted therapies for pancreatic cancer, including drugs that target specific molecular alterations like the KRAS oncogene, which is frequently mutated in pancreatic cancer ( 9 - 11 ). (frontiersin.org)
Today, new approaches such as immunotherapies and targeted therapies are becoming available, with many more in research and development. (duke.edu)
In precision cancer medicine - the right therapy for the right patient at the right time - all these things come together, the targeted therapies, the immunotherapy, even standard chemotherapy, all of that is part of precision cancer medicine. (duke.edu)
Dr. Knutson is the principal investigator of a $13.3 million, five-year Breakthrough Award grant from the Department of Defense to test a vaccine designed to prevent the recurrence of triple-negative breast cancer, a subset of breast cancer for which there are no targeted therapies. (mayo.edu)
Dr. Knutson's research is aimed at preventing patients with cancer from relapsing after receiving optimal conventional therapies. (mayo.edu)
He went on to publish multiple papers highlighting the role of regulatory T cells in restricting immunity and immune-based therapies for patients with brain tumors. (wikipedia.org)
However, despite the success of checkpoint inhibitors and the advent of cellular therapies, novel strategies need to be explored to (1) improve treatment in patients where these approaches fail and (2) make such treatments widely and financially accessible. (mdpi.com)
This highlights the need for novel therapies with curative potential," said Scott Carmer, President and CEO of NexImmune. (themmrf.org)
The researchers plan to do further studies with solid tumors such as lung, liver and colon cancers, which, compared with blood tumors such as leukemia, have been harder to achieve complete success with T cell-based therapies. (medicalxpress.com)
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)
Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
GEMoaB is developing a rapidly switchable universal CAR-T platform, UniCAR, to improve the therapeutic window and increase efficacy and safety of CAR-T cell [3] therapies in more challenging cancers, including solid tumors. (avencell.com)
While their initial research studied melanoma, Forsberg is interested to study other cancers and combination therapies in this mouse model 1 . (taconic.com)
We are also interested to test other types of immunotherapies and combination therapies in this model. (taconic.com)
Moreover, immunotherapy is highly effective for patients who have melanoma cancer when other radiation therapies and chemotherapy do not work. (medgadget.com)
And many of these mutations may make prostate cancers particularly vulnerable to certain therapies such as PARP inhibitors and platinum chemotherapy. (cancerhealth.com)
The number of immuno-oncology (IO) therapies in clinical development and volume of clinical investigations testing these therapies for the treatment of cancer patients continue to grow, and will undoubtedly fulfill unmet needs in both hematological cancers and solid tumors over the next five to ten years. (cancerresearch.org)
highlights the rapid growth and diversity in the preclinical and clinical landscape of IO therapies with 91% growth as compared to the data published in 2017. (cancerresearch.org)
The largest increase is observed in the development of cellular therapies in the past two years. (cancerresearch.org)
On a global level, the overall number of trials for all adoptive cell therapeutics are fewer in comparison to trials for immune checkpoint inhibitors and other IO therapies, but rapid growth in clinical investigations for adoptive cell therapies in particular was seen after 2015. (cancerresearch.org)
Thus, we have defined a mechanism of NK cell-mediated control of metastases in vivo that may help develop NK cell-dependent cancer therapies. (bioxcell.com)
The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)
PD-1 and CTLA-4 targeting therapies increase average life expectancy for cancer patients. (biomedcentral.com)
Actinium Pharmaceuticals Inc. is focused on improving patient access and outcomes to cellular therapies such as bone marrow transplant (BMT) and CAR-T with its proprietary, chemotherapy free or sparing, targeted conditioning technology. (actiniumpharma.com)
Actinium's Iomab-ACT program is designed to be a universal lymphodepletion technology intended to eliminate the need for chemotherapy-based conditioning prior to CAR-T or other adoptive cellular therapies. (actiniumpharma.com)
Actinium's Iomab-ACT program is an expansion of its CD45 program that is intended to be a universal, chemotherapy-free solution for targeted lymphodepletion prior to CAR-T. Through targeted lymphodepletion, the Iomab-ACT program is expected to improve CAR-T cell expansion, reduce CAR-T related toxicities and expand patient access to CAR-T treatment and potentially other adoptive cell therapies. (actiniumpharma.com)
This CME reviews the latest advances in cancer treatment options including surgical techniques, and radiation and systemic therapies. (pennmedicine.org)
Researchers have engineered T cells to help develop new cancer immunotherapies, called adoptive T-cell therapies. (fredhutch.org)
Spurred by preclinical and correlative studies to understand mechanisms of non-response to the PD-(L)1 antagonists and by combination studies in animal tumor models, many drug development programs were designed to combine anti-PD-(L)1 with a variety of approved and investigational chemotherapies, tumor-targeted therapies, antiangiogenic therapies, and other immunotherapies. (emory.edu)
Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
OVs provide a number of potential advantages as cancer vaccines over conventional therapies. (biomedcentral.com)
The deal will nalso support the development of BioNTech's expanding pipeline of novel cell therapies, including cancer product candidates based on its CAR-T Cell amplifying mRNA vaccine (CARVac) and NEOSTIM platforms as well as the newly acquired individualized neoantigen TCR program. (biopharma-reporter.com)
"The development of individualized cancer therapies is at the core of our work at BioNTech," said Ugur Sahin, M.D., CEO and Co-founder of BioNTech. (biopharma-reporter.com)
It also strengthens our presence in the US, building on our successful integration of adoptive T-cell and neoantigen TCR therapies as part of our acquisition of Neon Therapeutics last year. (biopharma-reporter.com)

The third plenary session of the AACR Annual Meeting 2019 , titled "Manipulating the Immune System in Cancer Therapy," focused on recent advances in the field of immunotherapy. (aacr.org)
Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
As we continue to unravel the complexities of the immune system, such innovative approaches hold promise for revolutionizing the field of immunotherapy. (medicalxpress.com)
This is an exciting time for NexImmune, as we remain focused on progressing the development of novel approaches in the field of immunotherapy," said Kristi Jones, NexImmune's CEO. (neximmune.com)

Juan Ápiz Saab, a member of the laboratory of Alexander Muir, PhD , Assistant Professor in the Ben May Department for Cancer Research, who studies cancer metabolism, gave a talk that described how myeloid-derived arginase depletes microenvironmental arginine in pancreatic ductal adenocarcinoma tumors and leads to activation of arginine de novo biosynthesis in cancer cells. (uchicagomedicine.org)
Among the most exciting immunotherapy work being facilitated by the center involves removing a patient's own T cells (a type of lymphocyte), manipulating them in the lab to make them more effective against tumors, then injecting them back into the patient. (duke.edu)
Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
In this area, he wrote his first article in 2002 describing clinical immunotherapies for brain tumors. (wikipedia.org)
Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
GEMoaB, a biopharmaceutical company focused on the development of next-generation immunotherapies for hard-to-treat cancers, today announced acceptance of three presentations on pre-clinical data for its proprietary universal CAR-T platform (UniCAR) targeting acute leukemia and solid tumors at the 2020 Virtual Annual Meeting of the American Association for Cancer Research (AACR II) being held from June 22-24. (avencell.com)
8 - Using a PSMA-specific low-molecular-weight compound for prostate cancer treatment with rapidly switchable universal CAR-T cells: Overcoming the challenges of cellular immunotherapies in solid tumors. (avencell.com)
Its clinical stage assets GEM333, a T-cell engaging bispecific antibody (TCE) with binding specificity to CD33 in relapsed/refractory AML, and GEM3PSCA, a TCE with binding specificity to PSCA for the treatment of castrate-resistant metastatic prostate cancer and other PSCA expressing late stage solid tumors, are currently investigated in Phase I studies and globally partnered with Bristol-Myers Squibb. (avencell.com)
Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
Scientists want to extend these successes to solid tumors like breast and lung cancer. (fredhutch.org)
Research has shown that patients with a robust T-cell response against their solid tumors often fare better than patients whose immune systems aren't mounting a good anti-cancer response, but so far results using engineered T cells against solid tumors have been disappointing. (fredhutch.org)
Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
TIL therapy is a type of adoptive cellular therapy leveraging the patient's own immune system to treat tumors. (biomedcentral.com)
TCR therapy is a type of cellular immunotherapy designed to redirect the patient's immune system in order to recognize and target tumors. (biopharma-reporter.com)

MARLBOROUGH, Mass. , Sept. 12, 2022 - Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a clinical stage biotechnology company developing the next generation of therapeutics based on its proprietary self-delivering RNAi (INTASYL™) therapeutic platform, today announced that six abstracts have been accepted for poster presentations at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), which will be held in Boston, MA from November 10 - 12, 2022. (phiopharma.com)

During a plenary session on precision medicine for immuno-oncology and the promise for the future, Thomas Gajewski, MD, PhD , AbbVie Foundation Professor of Cancer Immunotherapy, described how germline and microbiome variants impact immunotherapy efficacy through modulation of myeloid cells. (uchicagomedicine.org)
Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)

Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Through iMATCH, the team is running trials for TIL therapy to treat patients with melanoma (skin cancer). (manchester.ac.uk)
First, we searched in The Cancer Genome Atlas for commercially available CAR-T targets and found ERBB2 (HER2) to be the most highly expressed for both cutaneous and uveal melanoma. (taconic.com)
We are interested to study other types of cancer in the immune-humanized mouse model to see if it is possible to model diseases other than melanoma. (taconic.com)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Penn Medicine and the Abramson Cancer Center's Tara Miller Melanoma Center present a case-based discussion led by a multidisciplinary team of melanoma and cutaneous oncology experts from medical oncology, surgery, dermatology, and radiation oncology. (pennmedicine.org)
Several immunotherapy combinations improved survival outcomes in a variety of indications including melanoma, lung, kidney, and liver cancer, among others. (emory.edu)

Chemotherapy and radiation therapy are the cornerstone of therapy for unresectable pancreatic cancer. (frontiersin.org)
Presently, the standard first-line treatment for advanced pancreatic cancer is gemcitabine-based chemotherapy. (frontiersin.org)
Combination chemotherapy regimens, such as FOLFIRINOX and nab-paclitaxel plus gemcitabine, have demonstrated improved survival rates in advanced pancreatic cancer ( 7 , 8 ). (frontiersin.org)
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
Actinium is developing its CD33 program for hematologic indications including Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Multiple Myeloma (MM). Today's call will highlight Actinium's post-Phase 2 development plans following completion of its Actimab-A trial in patients newly diagnosed with AML who are over the age of 60 and unfit for intensive chemotherapy. (actiniumpharma.com)
Actinium is focused on applying its CD33 program at low doses in combination with other therapeutic modalities including chemotherapy, targeted agents and immunotherapies. (actiniumpharma.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)

Those sobering 2019 American Cancer Society statistics highlight the ongoing burden of prostate cancer in the U.S., said Pete Nelson, MD, as he kicked off Saturday's eighth annual symposium of the Institute for Prostate Cancer Research, a joint program of Fred Hutchinson Cancer Research Center and UW Medicine. (cancerhealth.com)

Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)
Rosenberg is beginning to develop a library of TCRs that can recognize shared mutations in the hope of utilizing them for TCR T-cell therapy for patients across a variety of tumor types, especially those with common epithelial cancers. (aacr.org)
In another approach, called tumor-infiltrating lymphocyte (TIL) adoptive cell therapy, the subset of a patient's T cells that have already managed to find their way into the tumor are extracted and then grown to large numbers before being returned to the patient. (duke.edu)
Adoptive T cell therapy. (mayo.edu)
A second strategy under investigation is adoptive T cell therapy, which involves infusing high numbers of T cells into patients with active bulky malignancy. (mayo.edu)
We developed adoptive cell therapy (ACT) which uses a patient's own immune cells to fight cancer. (manchester.ac.uk)
Our research revealed how to manipulate the immune system in order to achieve the best anti-cancer response - known as adoptive cell therapy (ACT) - and the team set up the infrastructure to deliver this as a therapy to patients. (manchester.ac.uk)
One of the first UK clinical trials of adoptive cell therapy for lymphoma (a type of blood cancer) took place in Manchester. (manchester.ac.uk)
These preclinical findings support further development of FT536 as a universal adoptive cell therapy. (sitcancer.org)
Entering clinical development with our first adoptive cell therapy program is a significant step for Immatics, and highlights the ability of the XPRESIDENT platform to identify novel and true tumor antigens directly from a patient's tumor," said Harpreet Singh, PhD, chief scientific officer and CEO at Immatics US. (pharmacytimes.com)
PO.IM02.02 - Adoptive Cell Therapy 2, June 22, 2020, 9:00 AM - 6:00 PM (EDT). (avencell.com)
We have worked intensely over the past year to advance our programs evaluating the potential of INTASYL treatment in immuno-oncology and adoptive cell therapy in vitro and in well-established animal models. (phiopharma.com)
One of the advantages with adoptive T-cell therapy is that we have a lot of engineering strategies," she said. (fredhutch.org)
Dr O'Rourke reviews brain cancer vaccine trials at Penn Medicine, focusing on the EGFRvIII peptide vaccine, offers a synopsis of the application at Penn of adoptive T cell therapy to the brain cancers and considers GBM--surface antigens for CAR therapy in glioma. (pennmedicine.org)
The company now highlights its ambitions to strengthen its cell therapy pipeline by accelerating individualized solid tumor neoantigen TCR cell therapy R&D, and adding a manufacturing footprint in North America, via this month's deal with Kite. (biopharma-reporter.com)
Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)

The modification enables these cells to express the chimeric antigen receptor (CAR) on the cellular surface, directing the CAR T cells to recognize and kill cells expressing the target protein. (taconic.com)
The Food and Drug Administration has approved several examples of a specific type of engineered T cell, known as a chimeric antigen receptor T cell, or CAR T cell, for use against certain blood cancers. (fredhutch.org)

Dr. Knutson and colleagues conduct research on cancer vaccines focused on augmenting CD4 helper T cell immunity using peptide epitopes. (mayo.edu)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
With this favorable immune backdrop, genetic engineering of OVs and rational combinations further potentiate OVs as cancer vaccines. (biomedcentral.com)
In summary, OVs properly armed or in rational combinations are potent therapeutic cancer vaccines. (biomedcentral.com)
Cancer vaccines are designed to boost the body's immune system to protect itself from carcinogenesis and progression of cancer. (biomedcentral.com)
The Food and Drug Administration of the USA has approved both prophylactic and therapeutic vaccines for cancer in the last few years. (biomedcentral.com)
The prophylactic vaccines are against the hepatitis B virus, which can cause liver cancer, and against human papillomavirus types 16 and 18, which are responsible for about 70 percent of cervical cancer cases. (biomedcentral.com)
These anti-viral vaccines are highly effective in curbing virus infections and onset of cancer. (biomedcentral.com)
In contrast, therapeutic cancer vaccines are difficult to develop and much less effective. (biomedcentral.com)
The approval of Provenge has stimulated interest in development of other therapeutic cancer vaccines. (biomedcentral.com)
First, OVs are tumor-selective, thus in situ cancer vaccines, providing higher cancer specificity and better safety margin. (biomedcentral.com)
However, just like other immunotherapeutic regimens, a number of challenges remain for OVs-mediated cancer vaccines. (biomedcentral.com)

Bryan Hancock, PhD (Fate Therapeutics) previewed the preclinical studies supporting the investigational new drug application for FT536, a CAR NK cell product derived from an inducible pluripotent stem-cell line engineered for enhanced effector cell functionality, persistence, and multi-antigen targeting capabilities through CD16-mediated antibody dependent cellular cytotoxicity (ADCC). (sitcancer.org)
Jessica D. Mackert, PhD (Wake Forest University) described preclinical data supporting CD47 as a target for the treatment of brain metastases in triple-negative breast cancer (TNBC). (sitcancer.org)
In preclinical studies , aAPCs have demonstrated potential utility as both injectable and cellular therapeutic agents. (themmrf.org)
Q: How do you see this model/approach impacting preclinical CAR-T and immunotherapy development? (taconic.com)
This fact has huge implications for research focusing on preclinical CAR-T (or other immunotherapy) development. (taconic.com)
Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
In the last few years, there is mounting evidence that OVs are effective in treating cancer in both preclinical models and clinical trials with human patients[ 1 - 3 ]. (biomedcentral.com)

Early diagnosis is crucial for improving the outcomes of pancreatic cancer, yet it remains a challenge due to the manifestation of non-specific symptoms primarily in the advanced stages of the disease. (frontiersin.org)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)

Persistent increases in serum levels of interferon gamma and granzyme B were observed in both Arms (6/20 patients in Arm 4 and 2/20 patients in Arm B). These data suggest that the generation of tumor-antigen-specific T cells through vaccination may help overcome primary resistance to anti-PD-1 monotherapy in prostate cancer. (sitcancer.org)
Overall, their experiments show that introducing a mutation in the TSC2 gene acts as a molecular "volume knob" to dial up or down the T cells' regulatory pathway when it's actively responding to immune challenges such as a virus or a cancer antigen. (medicalxpress.com)
The R&D activities are further resulting in the advent of mAbs, which have effects like antigen specificity, adaptive immunity, and antibody-dependent cellular toxicity. (medgadget.com)

Sean Pitroda, MD , Assistant Professor of Radiation and Cellular Oncology, spoke at a major symposium on "integrated molecular subtyping to personalize radiation therapy for oligometastatic disease. (uchicagomedicine.org)
Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Research is now focused on exploring the cells and structures in and around a tumour to make TIL therapy safer and more effective for use in other cancers. (manchester.ac.uk)
That's why we are very excited to partner with the MMRF to make our AIM adoptive cellular therapy (ACT) available to this specific patient population. (themmrf.org)
Immatics recently announced patient enrollment into a phase 1 clinical trial of its adoptive cellular therapy (ACT) IMA101, which uses its ACTolog approach. (pharmacytimes.com)
This discovery, Kass says, raises the possibility of enhancing a therapy known as CAR-T, in which T cells are genetically engineered to better recognize a particular cancer. (medicalxpress.com)
Chirag H. Patel et al, TSC2 S1365A mutation potently regulates CD8+T cell function and differentiation improving adoptive cellular cancer therapy, JCI-Insight (2023). (medicalxpress.com)
Overall, this review highlights the possibilities of synergistic therapy by building on existing research. (nature.com)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)
CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. (taconic.com)
PH-762, our lead clinical compound targeting PD-1, is being developed as a standalone drug therapy with local intratumoral administration to a tumor as well as a critical component of cellular immunotherapy, more specifically to improve tumor cell killing capability of adoptively transferred tumor infiltrating lymphocyte (TIL) therapy. (phiopharma.com)
Clinical applications of our research involves wound healing, cardiac tissue regeneration, ocular disease, and cancer imaging and therapy. (stanford.edu)

Kunle Odunsi, MD, PhD , AbbVie Foundation Director of the Comprehensive Cancer Center, chaired a town hall meeting and networking reception for the Cancer Immunology Working Group. (uchicagomedicine.org)
The research interests of Keith L. Knutson, Ph.D., focus on the immunology and immunotherapy of breast and ovarian cancers, both the basic immunobiology and clinical translation, including clinical trials. (mayo.edu)
Fecci's research centers around brain tumor immunology and immunotherapy, and T cell dysfunction in glioblastoma and other intracranial cancers. (wikipedia.org)
Fecci has curated a body of research focused on brain tumor immunology and immunotherapy. (wikipedia.org)
Cancer Immunology and Immunotherapies. (qaraco.com)
She is a member of the Cancer Biology, Biophysics, and Immunology graduate programs. (stanford.edu)

IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)

Founded in 1998 by Kathy Giusti, a multiple myeloma patient, and her twin sister Karen Andrews as a 501(c)(3) nonprofit organization, the MMRF is a world-recognized leader in cancer research, launching over 70 clinical trials and leading to 10 FDA-approved drugs. (themmrf.org)
With this, the MMRF, a pioneer in precision medicine , continues to disrupt the industry today, building CoMMpass Study , the single largest genomic dataset for any cancer, and launching MyDRUG, the first platform trial in multiple myeloma. (themmrf.org)
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)

These genes - including BRCA1 and BRCA2 - are often recognized as being important for breast and ovarian cancer risk. (cancerhealth.com)

While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
The antitumor immunity helps eliminate the uninfected cancer cells in primary and metastatic nodules, and enforce micrometastases in dormant state. (biomedcentral.com)

This session was chaired by Padmanee Sharma, MD, PhD , professor in the Department of Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center, who opened the plenary by highlighting the incredible breakthrough of checkpoint inhibitors, which are helping many patients to have durable responses. (aacr.org)
This approach has proven efficacious in some patients with epithelial cancers, and has been shown to synergize with checkpoint inhibition. (aacr.org)
Purpose: Neoadjuvant combination immune checkpoint blockade and intralesional oncolytic virotherapy have the potential to activate antitumor responses in patients with breast cancer. (bvsalud.org)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
He was the first to explore immune checkpoint blockade as an immunotherapeutic strategy in brain tumor models: "Systemic blockade of CTLA-4 ameliorates glioma-induced changes to the CD4 T-cell compartment without affecting regulatory T-cell function" was published in Clinical Cancer Research in 2007. (wikipedia.org)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)

The new tools, though varied, all represent advances in personalized cancer medicine. (duke.edu)
As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)

Immatics expects to enroll up to 20 patients with relapsed and/or refractory solid cancers that have no current treatment options, according to the release. (pharmacytimes.com)

Immunotherapy biomarkers. (mayo.edu)
These immunotherapy biomarkers would ultimately help risk stratify patients and optimize the timing and design of combinatorial approaches. (mayo.edu)
Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)
This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
This immunotherapy renaissance, however, has led to many combinations being advanced to late-stage development without definitive predictive biomarkers, limited phase I and phase II data, or clinical trial designs that are not optimized for demonstrating the unique attributes of immune-related antitumor activity-for example, landmark progression-free survival and overall survival. (emory.edu)

Cancer Immunotherapy Market Size to reach $101.6 billion at 14.8% CAGR by 2023. (medgadget.com)
The cancer immunotherapy market is anticipated to surpass a valuation of USD 101.6 billion, attaining a CAGR of 14.8% during the forecast period (2016-2023), Market Research Future (MRFR) unveils in a detailed report. (medgadget.com)

Surgical resection is currently the sole curative treatment for pancreatic cancer. (frontiersin.org)

In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)

However, while ACT has successfully treated certain blood cancers, it has proved much harder to develop for solid tumours in organs. (manchester.ac.uk)

Hepatocellular carcinoma (HCC) continues to be a leading cause of cancer-related death in the United States. (bvsalud.org)
Investigators evaluated the effects of PEGylated interferon-α2a and 5-fluorouracil on the expression of cancer stem cell (CSC) markers and on specific pathways that contribute to the propagation of CSCs in hepatocellular carcinoma. (stemcellsciencenews.com)

We previously published an immune-humanized mouse model in which we transplanted tumor cells and autologous tumor-infiltrating lymphocytes (TILs) from patients in a clinical trial of adoptive T cell transfer (ACT) in Herlev, Denmark - and demonstrated that responses in IL-2 transgenic NOG mice correlated to the responses of the patients in the trial 2 . (taconic.com)
Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)

Some immunotherapies take personalization even further, by manipulating a patient's own immune cells to create a treatment for that individual alone. (duke.edu)
While the concept of using a patient's own immune cells to fight cancer was theoretically possible, the technologies required had not been established prior to 2000. (manchester.ac.uk)

Antonia and his colleagues recently published a paper demonstrating the effectiveness of TIL expansion in lung cancer. (duke.edu)
Intracranial metastases are common in nonsmall-cell lung cancer (NSCLC) patients, whose prognosis is very poor. (bvsalud.org)
Of these, the lung cancer segment is predicted to gain prominence due to the soaring prevalence of cancer across the globe. (medgadget.com)
They demonstrated that miR-214 overexpression enhances stem-like properties in lung adenocarcinoma (LAC) cells and that miR-214 shows increased expression in cancer stem-like cells derived from primary tumor tissue and from two LAC cell lines. (stemcellsciencenews.com)
Combination of IL-2/15/21 can enhance TIL expansion in lung and colorectal cancer and promote CD8+ T cell percentage as well as TCR clone diversity compared to IL-2 alone [ 13 ]. (biomedcentral.com)

Investments made by the Myeloma Investment Fund underscore the commitment of the MMRF to bring the most promising immunotherapy agents to myeloma patients as quickly as possible," commented Paul Giusti, President and CEO of the MMRF. (themmrf.org)

A key area of Dr. Kankeu Fonkoua's research endeavors is to identify mechanisms of resistance to immunotherapy. (mayo.edu)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)

Everett E. Vokes, MD , John E. Ultmann Professor and Chair of Medicine, chaired a special joint AACR-ASCO session on pathophysiology and new treatments for cancer-associated thrombosis. (uchicagomedicine.org)
Duke's Center for Cancer Immunotherapy supports these efforts by identifying promising basic science discoveries and building teams to translate those ideas into treatments. (duke.edu)
Despite improvements in the treatment of many early-stage cancers, there remains a pressing need for effective treatments for patients with advanced cancer that has returned after initial treatment. (manchester.ac.uk)
In addition, intracranial progression is common during systemic treatments due to the inability to penetrate central nervous system (CNS) barriers, whereas the intracranial effects of cancer immunotherapies remain unclear. (bvsalud.org)

Ralph Weichselbaum, MD , Daniel K. Ludwig Distinguished Service Professor and Chair of Radiation and Cellular Oncology, moderated a forum on oligometastatic disease. (uchicagomedicine.org)
During the forum, Steven Chmura, MD, PhD , Associate Professor of Radiation and Cellular Oncology, gave an update on the current landscape for oligometastases clinical trials. (uchicagomedicine.org)

A number of different mechanisms and several areas of immune escape are being investigated, including cellular reprogramming (for example, epithelial to mesenchymal transition) and recruitment of regulatory T cells and myeloid derived suppressor cells into the tumor microenvironment. (mayo.edu)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
The anticancer activities of OVs are derived from multimodal cancer killing mechanisms. (biomedcentral.com)

To kick off the session, Sharma introduced Steven Rosenberg, MD, PhD , chief of surgery at the National Cancer Institute, to deliver his talk, "T-cells targeting unique cancer mutations. (aacr.org)
While most of the neoantigens identified through these screening efforts have been unique, a few were common neoantigens that correspond to "hotspot mutations" in KRAS and p53, two genes that are frequently mutated in cancer. (aacr.org)
A small but important percentage of men with prostate cancer have mutations in key genes that are involved in repairing damage to DNA. (cancerhealth.com)
Having one of these rare but important gene mutations may also tell a patient's family members something about their own cancer risk, Cheng said. (cancerhealth.com)
That's why men with a strong family history of cancer or certain types of especially aggressive prostate cancers should talk to their doctor and/or a genetic counselor about screening for these mutations, she said. (cancerhealth.com)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
Neoantigens are immune targets derived from somatic mutations displayed by cancer cells offering the potential for more targeted anti-tumor activity. (biopharma-reporter.com)

The basic and translational science components of the meeting centered around the tumor microenvironment, microbiome, cancer metabolism, machine learning, and much more. (uchicagomedicine.org)
Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)

The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
Globally, the three regions with the highest age-standardized incidence rates of pancreatic cancer are Western Europe (17.2 per100,000 person-years), Eastern Europe (15.5 per100,000 person-years), and North America (16.2 per100,000 person-years), followed by Australia (14.6 per100,000 person-years) and East Asia (11.8 per100,000 person-years) ( 1 - 3 ). (frontiersin.org)
Currently, early diagnosis of pancreatic cancer relies on serum markers, such as CA 19-9 and CEA, as well as imaging techniques like CT and MRI. (frontiersin.org)
Furthermore, patients with advanced pancreatic cancer commonly experience a range of complications including pain, biliary obstruction, cachexia, and venous thromboembolism ( 12 ). (frontiersin.org)
Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
The anticancer activity of 3, 4-difluorobenzylidene curcumin loaded nano-micelles against MiaPaCa-2 and AsPC-1 human pancreatic cancer cells revealed dose-dependent cell killing. (stemcellsciencenews.com)
Results of cellular internalization further confirmed better uptake of hyaluronic acid engineered nano-micelles in triple-marker positive pancreatic cancer stem-like cells compared with triple-marker negative counterparts. (stemcellsciencenews.com)

This treatment utilizes a patient's own immune system to recognize and attack cancer cells. (aacr.org)
Antonia believes immunotherapy has the potential to revolutionize cancer treatment, but more work remains to be done to realize its promise. (duke.edu)
Life sciences professionals believe that immunotherapy will revolutionize cancer treatment. (hindawi.com)
We believe that attacking multiple cancer targets simultaneously using our tailored approach may lead to promising new treatment options for cancer patients with significant unmet medical need. (pharmacytimes.com)
By advancing its proprietary UniCAR, RevCAR and TCE platforms, the company will discover, develop, manufacture and commercialize next-generation immunotherapies for the treatment of cancer patients with a high unmet medical need. (avencell.com)
However, PD-1 and CTLA-4 blocking agents are not effective in all patients, and even those patients who do respond initially can relapse, highlighting the need for improved treatment regimens. (biomedcentral.com)
This live, case-based panel discussion will cover the basics of high risk thyroid cancer from presentation and diagnosis to treatment. (pennmedicine.org)
As a benchmark, Provenge, a cancer vaccine designed to treat advanced prostate cancer, demonstrated an increase in survival and thus gained approval from the FDA for use in the treatment of advanced prostate cancer patients in 2010[ 10 ]. (biomedcentral.com)

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8 + T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer. (medicalxpress.com)

Our results indicate that cancer immunotherapies can prevent intracranial progression, maintaining long-term effects intracranially as well as systemically. (bvsalud.org)

These areas highlight some of the many challenges of the currently available CAR T cell products, which rely on high-quality autologous cells to be re-engineered and eventually reinfused, in an often costly, labor-intensive process which suffers from unanticipated delays and slow turnaround times. (medpagetoday.com)
That can mean activating the immune system, energizing exhausted immune cells, or helping immune cells find cancer cells by guiding them there or by removing cancer's "good guy" disguises. (duke.edu)
His PhD thesis highlighted the role of regulatory T cells in restricting anti-tumor responses against glioblastoma. (wikipedia.org)
For the current study, Kass and his team focused on CD8 + T cells, the circulating immune system "soldiers" responsible for identifying and fighting infections and cancer cells . (medicalxpress.com)
If these T cells also had the mutation in the TSC2 gene, the T cells could be more active against the tumor by multiplying, but could also persist longer, enhancing the T cells' effectiveness to kill cancer. (medicalxpress.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
This type of immunotherapeutic utilizes T cells extracted from patient blood which are subsequently modified to target cancer cells. (taconic.com)
Cancer immunotherapy enables the immune system to target cancerous tumor cells. (medgadget.com)
The authors investigated the potential of curcumin to reduce breast cancer stem cell (BCSC) population for sensitizing breast cancer cells to mitomycin C both in vitro and in vivo . (stemcellsciencenews.com)
Cancer stem-like cells and nonstem-like cancer cells were co-cultured, and defined cell types were chosen and irradiated, respectively, with proton microbeam. (stemcellsciencenews.com)
The authors review and summarize advantages and limitations of tumor transplantation and lineage-tracing assays in support of a combinatorial approach to accurately define the roles of both cancer-initiating and cancer-propagating cells. (stemcellsciencenews.com)
They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. (biomedcentral.com)
The first is the direct oncolysis of cancer cells by the virus, which is, in most cases a mixture of apoptosis, necrosis, pyroptosis and autophagic cell death, often with one as predominant for a particular OV. (biomedcentral.com)

He has advocated for new approaches to categorizing and addressing T cell dysfunction in cancer, a viewpoint advanced in his 2018 Clinical Cancer Research review: "T cell dysfunction in glioblastoma: Applying a new framework. (wikipedia.org)

The ACTolog approach targets tumor-specific antigens to fight cancer. (pharmacytimes.com)

It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [ 15 ]. (hindawi.com)

Conclusions: This triple immunotherapy regimen provided responses in patients with advanced or relapsed HER2-negative breast cancer, at the expense of long-term toxicities. (bvsalud.org)

Anatomy11

Organisms3

Diseases10

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes5

Health Care1

Therapies45

Field of immunotherapy4

Tumors16

Society for Immunotherapy of Cancer1

Efficacy2

Melanoma8

Chemotherapy8

20191

Cell therapy16

Chimeric antigen receptor2

Vaccines12

Preclinical7

Outcomes2

Antigen3

Therapy14

Immunology6

Head and neck squamous cell carc1

Multiple myeloma3

Breast and ovarian1

Immunity6

Checkpoint6

Advances2

Patients with relapsed1

Biomarkers5

20232

Curative1

Refractory1

Certain blood cancers1

Hepatocellular carcinoma2

Lymphocytes2

Patient's own immune cells2

Lung5

Myeloma1

Resistance3

Treatments4

Radiation2

Mechanisms3

Mutations7

Tumor microenvironment3

Pancreatic cancer9

Treatment8

Genetically1

Intracranial1

Cells14

Approaches1

Targets1

Prognosis1

Responses1