Portal VeinHypertension, PortalPortal SystemPortal PressureAdministration, OralLiver CirculationLiverInjections, IntravenousDrug Administration SchedulePortasystemic Shunt, SurgicalRats, Sprague-DawleyUnited States Food and Drug AdministrationEsophageal and Gastric VaricesTime FactorsSplenic VeinDose-Response Relationship, DrugHepatic ArteryHepatic VeinsDrug Administration RoutesMesenteric VeinsRats, WistarLiver CirrhosisPortographyPortacaval Shunt, SurgicalDisease Models, AnimalAdministration, IntranasalInjections, IntraperitonealDogsSplanchnic CirculationGastrointestinal HemorrhageInfusions, IntravenousSplenorenal Shunt, SurgicalInjections, SubcutaneousAdministration, RectalMice, Inbred C57BLLigationVenous PressureBiological AvailabilityTreatment OutcomeRats, Inbred StrainsHalf-LifeInjections, IntramuscularArea Under CurveAdministration, TopicalDrug InteractionsVenous ThrombosisBlood PressureLiver TransplantationAdministration, IntravenousHepatectomyHemodynamicsLiver NeoplasmsLiver Cirrhosis, ExperimentalPortasystemic Shunt, Transjugular IntrahepaticMice, Inbred BALB CLiver DiseasesInjections, IntraventricularTissue DistributionSplenic ArteryHypersplenismRegional Blood FlowRandom AllocationInfusions, ParenteralRabbitsOrgan SizeAscitesSplenectomyAdministration, CutaneousKidneyBody WeightDouble-Blind MethodIntestinal AbsorptionCross-Over StudiesBlood GlucoseBrainAdministration, SublingualLiver Diseases, ParasiticMetabolic Clearance RateInjectionsRNA, MessengerAdministration, InhalationHepatic EncephalopathyAnalysis of VarianceNorepinephrineInsulinSplenomegalyRecombinant ProteinsBile DuctsBehavior, AnimalLiver Function TestsPlant ExtractsDrug ToleranceIntestinesVena Cava, InferiorMorphineLungRats, Inbred F344Chromatography, High Pressure LiquidCarcinoma, HepatocellularInjections, Intra-Arterial