However, borneol-induced inward currents were partially decreased in the presence of picrotoxin, a γ-aminobutyric acid (GABA) A receptor antagonist, or strychnine, a glycine receptor antagonist, and was almost suppressed in the presence of picrotoxin and strychnine. (kjpp.net)
Spontaneous EPSCs were recorded in the presence of GABA A receptor antagonist, picrotoxin (100 μM) and spontaneous IPSCs were recorded in the presence of a NMDA receptor antagonist, AP5 (100 μM) and a non-NMDA receptor antagonist, CNQX (20 μM). (biomedcentral.com)
Convulsion2
The anti-epileptic activity of the PETO and METO was evaluated using Picrotoxin, Isoniazid, and NMDA induced convulsion models. (ijpsr.com)
Prochlorperazine Edisylate Injection, an antiemetic and antipsychotic, is a sterile solution intended for intramuscular or intravenous administration. (drugs.com)
They found that dilute intravenous solutions of picrotoxin (cocculin)-- a neurostimulatory plant product-were effective as an antidote in that setting. (wikipedia.org)
Intraperitoneal1
2016). Within these studies, a range of routes of administration have been assessed, including systemic (intraperitoneal or subcutaneous) (Batista et al. (researchgate.net)
Tablet for oral administration contains1
Each tablet for oral administration contains trifluoperazine hydrochloride equivalent to 1 mg, 2 mg, 5 mg, or 10 mg trifluoperazine. (nih.gov)
Dosage1
Outpatients - Select route of administration according to severity of patient's condition and increase dosage gradually as required. (genesight.com)
Models2
The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhing, tail flick assay, pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures models. (bvsalud.org)
Also, the oil from Ocimum basilicum L., (BO) has been proven scientifically to significantly block clonic seizures induced by PTZ and picrotoxin in seizure models. (coping-with-epilepsy.com)
Oral administration2
It is available in tablets for oral administration. (nih.gov)
After oral administration, a small part of the dose may pass through the GI tract unchanged into the faeces. (sgpharma.com)
Symptoms1
In more severe cases, the administration of an antiparkinsonism agent, except levodopa (see PDR), usually produces rapid reversal of symptoms. (drugcentral.org)
Food & Drug Administration established tips in 2007 to inform customers ought to dispose of pharmaceuticals. (livestrong.xyz)
Action1
Following intramuscular administration of prochlorperazine edisylate, the drug has an onset of action within ten to twenty minutes and a duration of action of three to four hours. (drugs.com)
Increasing doses of picrotoxin (2, 3 and 4 mg/kg), given in succession to the rat with the reflex abolished by baclofen resulted in occurrence of single twitches preceding the death of animals. (erowid.org)
The use of the system is illustrated by application to rats given subconvulsive doses of picrotoxin to induce a seizure-prone state analogous to epilepsy: levels of the neuronal activity marker c-Fos in the frontal and piriform cortex of picrotoxin-treated rats exposed to 900 MHz GSM radiation were twice as high as those of unexposed animals. (jpier.org)
TETS3
Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. (nih.gov)
However, TETS is approximately 100 × more lethal than picrotoxin. (nih.gov)
Whole-cell patch-clamp demonstrated that brain and serum extracts prepared from mice at 2 and 14 days after TETS administration significantly blocked heterologously expressed α2β3γ2 GABAA-receptors confirming that TETS remains pharmacodynamically active in vivo. (nih.gov)
Induce1
However, over time, the narrow therapeutic window associated with picrotoxin administration-which can also induce seizures-resulted in its disuse. (wikipedia.org)
Rats2
The effect on picrotoxin-induced convulsions was tested in rats pretreated with 5 mg/kg i.p. baclofen (Lioresal, ClBA-Geigy) and 1 hr later with 6 mg/kg s.c. picrotoxin (Fluke). (erowid.org)
Baclofen did not protect either intact nor spinal rats against picrotoxin-induced convulsions. (erowid.org)
Dose1
The high dose of baclofen (5 mg/kg) completely antagonized the stimulatory action of picrotoxin abolishing the flexor reflex and prevented the stimulation induced by this compound. (erowid.org)
Therapeutic1
Psychiatrists of that era who used this form of shock therapy believed that the fear and terror produced were therapeutic because the "feeling of horror" before the onset of convulsion following injection of camphor, pentetrazol, triazole, picrotoxin, or ammonium chloride rendered the patients different after the experience. (healthyplace.com)
Injection2
The action of picrotoxin commenced a few minutes after the injection and lasted for 0.5-1 hr. (erowid.org)
Administration of increasing doses of the latter drug (0.5, 0.75 and 1 mg/kg) did not cause stimulation of the flexor reflex already abolished by previous injection of baclofen. (erowid.org)
Mice1
Here, we directly compared the toxicokinetics of the two compounds following intraperitoneal administration in mice. (nih.gov)
Tablet1
Each tablet, for oral administration, contains 0.5 mg, 1 mg or 2 mg of benztropine mesylate. (nih.gov)
Agent1
In more severe cases, the administration of an anti-parkinsonism agent, except levodopa (see PDR), usually produces rapid reversal of symptoms. (drugcentral.org)
Found1
Using LC/MS analysis we found that picrotoxinin, the active component of picrotoxin, hydrolyses quickly into picrotoxic acid, has a short in vivo half-life, and is moderately brain penetrant (brain/plasma ratio 0.3). (nih.gov)