Administration of chemotherapy studies protected from chemotherapy induced. Medical search. Frequent questions

Bicyclol, a hepatoprotective and anti-inflammatory drug that has been approved in China since 2001, can inhibit the expression and activity of several inflammatory factors induced by liver injury, relieve oxidative stress, inhibit hepatocyte apoptosis, stabilize hepatocyte plasma membrane, improve mitochondrial function and protect the structure and function of liver nuclear DNA. (medscape.com)
which otherwise induce apoptosis of the cells. (wikipedia.org)
Radiotherapies and chemotherapies can cause apoptosis of ovarian follicles, causing premature ovarian failure, and so S1P is of great interest in fertility preservation. (wikipedia.org)
However, its mechanism of inhibiting the sphingomyelin apoptotic pathway may also interfere with the apoptosis action of chemotherapy drugs. (wikipedia.org)
Coculture of APL luc cells with M2-10B4 stromal cells protected the leukemia cells from chemotherapy-induced apoptosis in vitro. (wustl.edu)
34. Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. (nih.gov)
According to recent studies, CBD products help inhibit cancer cell growth by inducing apoptosis, killing cancer cells. (programminginsider.com)
Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. (spandidos-publications.com)
These biological findings identified deguelin as a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention and chemotherapy. (spandidos-publications.com)
In the comprehensive signaling network of tumorigenesis, metastasis, apoptosis and angiogenesis, deguelin is pivotal in inducing apoptotic cell death and prohibiting their malignant transformation. (spandidos-publications.com)
Deguelin is known to induce apoptosis by disrupting anti-apoptosis signaling, such as the PI3K/Akt pathway in lung and breast cancer. (spandidos-publications.com)
This study examined the in vitro or in vivo anti-tumor, apoptosis, and anti-metastasis activities of CoQ 0 (0-20 μM) through inhibition of Wnt/β-catenin signaling pathway. (oncotarget.com)
Furthermore, CoQ 0 treatment induced apoptosis through caspase-9/-3 activation, PARP degradation, Bcl-2/Bax dysregulation, and p53 expression. (oncotarget.com)
YAP overexpression safeguarded while YAP knock-down sensitized UCC cells to chemotherapy and radiation effects via improved build up of DNA damage and apoptosis. (techblessing.com)
To examine the potential dichotomous part of YAP in DNA-damage induced apoptosis we generated and UCC models of cisplatin resistance. (techblessing.com)
With this study we statement that genetic and pharmacological YAP inhibition sensitizes UCC cells to DNA damage-induced apoptosis. (techblessing.com)
DOX-induced oxidative damage, inflammation accumulation, and myocardial apoptosis were largely attenuated by the treatment of Mul. (hindawi.com)
DOX-dependent oxidative damage induced the release of cytochrome C and subsequent activation of caspase 3, causing myocardial apoptosis [ 9 ]. (hindawi.com)
The attenuation of DOX-induced myocardial apoptosis could protect against DOX-induced cardiotoxicity [ 10 ]. (hindawi.com)
Mul reduced spinal cord injury-induced apoptosis and inflammation and attenuated hepatic fibrosis by targeting nuclear factor E2-related factor 2 (Nrf2) in mice [ 11 , 12 ]. (hindawi.com)

In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
Treatment of leukemic mice with chemotherapy plus AMD3100 resulted in decreased tumor burden and improved overall survival compared with mice treated with chemotherapy alone. (wustl.edu)
Chemotherapy affects both normal and tumor cells. (cancer.org)
As if my wife's complications with Radiation Necrosis, brought on by Whole Brain Radiation and Taxol/Carboplatin chemotherapy weren't enough, she was subjected to improper medical protocol for brain and spinal MRI's for metastatic disease(unenhanced instead of enchanced-contrast), which left an undiagnosed tumor on her spine. (cancer.org)
Numerous studies confirmed that deguelin activated the virus signaling pathway for inhibiting tumor cell proliferation with no or less toxicity ( 5 - 8 ), while demonstrating the highest activity in inhibiting DMBA-induced tumorigenesis compared with tephrosin, 13α-hydroxytephrosin and 13α-hydroxydeguelin. (spandidos-publications.com)
Furthermore, the in vivo study results revealed that CoQ 0 treatment inhibited the tumor growth in B16F10 xenografted nude mice. (oncotarget.com)
In conclusion these results suggest that YAP activation exerts a protecting part and signifies a pharmacological target to enhance the anti-tumor effects of DNA damaging modalities in the treatment of UCC. (techblessing.com)
The study was designed to evaluate Anktiva in combination with rituximab in patients with iNHL, to explore the potential of Anktiva to enhance tumor-targeting of anti-CD20 therapeutic antibodies, and to determine the safety and efficacy of subcutaneous (SQ) versus intravenous (IV) administration. (checkorphan.org)
Aspirin blocks the enzyme COX-2, which is responsible for the production of prostaglandin E2, a substance involved in inflammation that induces tumor-associated angiogenesis as well as aromatase expression. (lifeextension.com)

The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
Accordingly, Dr. Cunningham and her colleagues are currently planning a clinical trial to test this preventive strategy in patients undergoing cisplatin chemotherapy. (nih.gov)
Animal studies demonstrate that, in binding to 5-HT 3 receptors, granisetron blocks serotonin stimulation and subsequent vomiting after emetogenic stimuli such as cisplatin. (nih.gov)
To our knowledge this is the 1st reported UCC PDX model where cisplatin-resistance was achieved by chronic dose-intense drug administration. (techblessing.com)
The aim of the study was to evaluate orally administered MGN-3 against gross pathological changes and weight loss produced by a single intraperitoneal dose of cisplatin or doxorubicin by daily oral dosing of 5 or 50 mg/kg MGN-3. (researchgate.net)

27. Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity. (nih.gov)
4. It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)
A number of studies have demonstrated the effectiveness of CoQ10 in reducing the risk of cardiac injury due to the toxicity that comes with the use of a variety of chemotherapy agents (e.g. (ndnr.com)
DOX-induced oxidative damage and cardiomyocyte loss have been recognized as the potential causative mechanisms of this cardiac toxicity. (hindawi.com)
Activated protein kinase B (AKT) activation was essential for the protective effects of Mul against DOX-induced cardiac toxicity, and AKT inactivation abolished Mul-mediated protective effects against DOX cardiotoxicity. (hindawi.com)
In conclusion, Mul treatment attenuated DOX-induced cardiac toxicity via activation of the AKT signaling pathway. (hindawi.com)
Mul might be a promising therapeutic agent against DOX-induced cardiac toxicity. (hindawi.com)

In 2017, a committee of the National Academies of Sciences, Engineering and Medicine concluded there is "conclusive or substantial" evidence that cannabis or cannabinoids may be helpful in treating chronic pain, chemotherapy-induced nausea, and spasticity related to multiple sclerosis. (nih.gov)
Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
There is strong evidence that cannabis is useful in chronic pain, treating nausea in chemotherapy patients, and muscle spasms in multiple sclerosis. (kuow.org)
A three-judge CAFC panel invalidated four patents held by Helsinn Healthcare covering injection formulations of Aloxi® (palonosetron hydrochloride), a drug for reducing chemotherapy-induced nausea and vomiting. (genengnews.com)

One of the most psychologically and socially devastating side effects of chemotherapy is hair loss. (qualityhealth.com)

The multiple antitumorigenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies. (cbdcrew.org)
Growing attention has been focused on the application of natural flavonoids in the chemoprevention and chemotherapy of malignant diseases. (spandidos-publications.com)

Antioxidants and natural compounds can improve the effectiveness of radiotherapy and chemotherapy. (canceractive.com)
Recently, I was asked by a lady with Breast cancer about taking antioxidants at the same time as chemotherapy or radiotherapy. (canceractive.com)
One of the most stupid phrases you will hear uttered by doctors and nurses is that an antioxidant protects cells and that they don't want cancer cells 'protected' while they use chemotherapy or radiotherapy. (canceractive.com)
Many 'treatments' sensitise cancer cells, ensuring MORE are killed by chemotherapy or radiotherapy. (canceractive.com)
Many chemotherapies - and also radiotherapy - are less effective at killing cancer cells when oxygen levels are low. (oasisofhope.com)

Regarding the use of corticosteroids for the treatment of DILI, patients with drug-induced autoimmune hepatitis [ 12 , 13 ] and immune checkpoint inhibitor-induced hepatotoxicity [ 14 ] usually can benefit from corticosteroid use. (medscape.com)
[ 5 , 15-19 ] Intravenous injection of N-acetylcysteine (NAC) during early treatment could be beneficial to patients with non-APAP-induced ALF. (medscape.com)
More patients are currently undergoing liver resection following neoadjuvant chemotherapy, which has been increasingly established within the framework of curative-indented treatment strategies. (nih.gov)
In the present study, we investigated the effects of SARS-CoV-2 infection on ovarian function by comparing follicular fluid (FF) from control and recovered coronavirus disease 2019 (COVID-19) patients and by evaluating the influence of these FF on human endothelial and non-luteinized granulosa cell cultures. (bvsalud.org)
In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
We met a number of other patients that didn't make it through their chemotherapy treatments. (cancer.org)
Pharmacokinetic studies have been performed in adult leukemia patients with normal renal and hepatic function following intravenous administration of 10 to 12 mg/m 2 of idarubicin daily for 3 to 4 days as a single agent or combined with cytarabine. (nih.gov)
Studies of cellular (nucleated blood and bone marrow cells) drug concentrations in leukemia patients have shown that peak cellular idarubicin concentrations are reached a few minutes after injection. (nih.gov)
First Kansa Medical School in 2012, and then Ohio State Medical School in 2016 have shown that Intravenous vitamin C used with chemotherapy drugs actually produces a significant increase in survival times, the latter work being done in full clinical trials on patients with brain tumours and non-small cell lung cancer. (canceractive.com)
NIJMEGEN, The Netherlands, July 15, 2020 / B3C newswire / -- Byondis B.V. (formerly Synthon Biopharmaceuticals B.V.) today announced that the first patients have started treatment in its Phase II study evaluating the safety and efficacy of its investigational antibody-drug conjugate (ADC) [vic-]trastuzumab duocarmazine (SYD985) in patients with HER2-expressing recurrent, advanced or metastatic endometrial (uterine) cancer. (b3cnewswire.com)
A Single-arm Phase II Trial to Evaluate the Safety and Efficacy of the Antibody-Drug Conjugate (ADC) [vic-]trastuzumab duocarmazine (SYD985) in Patients With HER2-Expressing Endometrial Carcinoma Who Previously Progressed on or After First-Line Platinum-based Chemotherapy (SYD985.003) will enroll approximately 60 patients in up to 40 clinical sites in the United States, Europe and Asia-Pacific. (b3cnewswire.com)
Previously, the U.S. Food & Drug Administration granted SYD985 fast track designation based on promising data from heavily pre-treated last-line HER2-positive metastatic breast cancer patients participating in a two-part Phase I clinical trial (SYD985.001). (b3cnewswire.com)
SYD985.003 is an open-label, single-arm study in patients with HER2-expressing recurrent, advanced or metastatic endometrial carcinoma. (b3cnewswire.com)
Eligible patients for this study should have progressed on or after first-line platinum-based chemotherapy. (b3cnewswire.com)
Patients who have had two or more lines of chemotherapy for advanced/metastatic disease are not eligible. (b3cnewswire.com)
Hyperthermic intraperitoneal chemotherapy (HIPEC), commonly referred to as the chemo bath," may offer an alternative option for patients with advanced forms of abdominal cancer. (qualityhealth.com)
Many patients undergoing chemotherapy are in need of platelets. (qualityhealth.com)
In a study with 24 patients suffering from chronic low back pain intake of a CBD-rich sublingual extract had no pain relieving effects, while the inhalation of a THC-rich cannabis flower resulted in significant pain reduction. (cannabis-med.org)
Three patients dropped out of extract therapy treatment but resumed study participation to receive THC rich smoking therapy. (cannabis-med.org)
The new chemotherapy drugs were effective against some cancers, especially leukemia and lymphoma, but for many cancer patients, including those with breast cancer, existing chemotherapy drugs fell short. (sciencefriday.com)
In one study, a group of 30 patients with cancer was randomized to receive IL-2 injected subcutaneously for 5 days/week for 4-6 weeks alone or in combination with 1000mg daily of L-carnitine. (ndnr.com)
In an investigation of adoptive immunotherapy, the National Cancer Institute (NCI) enlisted patients with metastatic malignant melanoma, hypernephroma and colon carcinoma for an extramural group study. (ndnr.com)
The peer-reviewed article titled "Phase 1 trial of N-803, an IL-15 receptor agonist, with rituximab in patients with indolent non-Hodgkin lymphoma" (see link HERE ) published in the American Association for Cancer Research journal Clinical Cancer Research, highlights safety, efficacy, and translational data from the Company's ongoing open-label, multi-center, dose-escalation Phase 1 study (NCT02384954). (checkorphan.org)
Therefore, caution should be exercised with the administration of fludarabine in these patients. (medscape.co.uk)
We propose, in agreement with earlier findings for prostate-, breast- colon cancer and Hodgkins lymphoma, that a high level of sun-induced 25-hydroxyvitamin D can be a prognostic advantage for certain groups of lung cancer patients, notably for young men. (cdc.gov)
Does Transplantation Induce Aging In Patients? (medicaldaily.com)
The active ingredient in cannabis can improve the appetites and sense of taste in cancer patients, according to a new study published online in the cancer journal, Annals of Oncology . (medicaldaily.com)
In recent years, there have been several new therapies approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with CLL, giving patients more treatment options than ever before, including a few targeted therapies that can be taken orally. (eonco.info)

Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
Taurine has been shown to be depleted in people taking chemotherapy. (peacehealth.org)
It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)

This study shows for the first time that Metformin protects the hearts against Sunitinib-induced cardiotoxicity via AMPK activation which was attenuated with NBTI. (bmj.com)
In addition, reactive oxygen species have an important role in DXR-induced cardiotoxicity. (fusabil.org)
The onset of DOX-induced cardiotoxicity can be acute, occurring within 2-3 days or be chronic until several months after the end of chemotherapy [ 3 ]. (hindawi.com)
Current studies pay more attention to DOX-related chronic cardiomyopathy but lose sight of the clinical importance of DOX-induced acute cardiotoxicity. (hindawi.com)
Currently, there are no molecules with an actual cardioprotective effect on DOX-induced acute cardiotoxicity. (hindawi.com)
It is therefore important to find an approach for preventing DOX-induced cardiotoxicity in the clinic. (hindawi.com)
Overexpression of antioxidant enzymes can ameliorate DOX-induced cardiotoxicity in mice [ 7 , 8 ]. (hindawi.com)
Therefore, we designed this study to explore the effect of Mul treatment on DOX-derived cardiotoxicity. (hindawi.com)

Evidence for using bicyclol in drug-induced liver injury (DILI) is limited. (medscape.com)
Drug-induced liver injury (DILI) may lead to acute hepatitis [ 1 ] or acute liver failure (ALF). (medscape.com)

Furthermore, animal studies have demonstrated the capability of these compounds to suppress invasion, metastasis and angiogenesis in vivo , suggesting that administration of Vitamin D derivatives may be used as adjuvant therapy for lung cancer. (cdc.gov)

Additionally, RBAC has been shown to ameliorate irritable bowel syndrome and protect against liver injury caused by hepatitis or nonalcoholic fatty liver disease. (researchgate.net)

Administration of S1P has been shown to protect oocytes from chemotherapeutic agents in vitro, as well as in vivo from chemotherapeutic and radiation therapies. (wikipedia.org)

Mice exposed to noise before drug administration lost significantly less hearing compared with those not exposed. (nih.gov)
The aim of the present study is to assess whether low level laser therapy (LLLT) can protect ovaries from chemotherapy-induced gonadotoxicity using a mice model of premature ovarian failure induced by cyclophosphamide (CTX). (bvsalud.org)
Administration of AMD3100 to leukemic mice induced a 1.6-fold increase in total leukocytes and a 9-fold increase of circulating APL blast counts, which peak at 3 hours and return to baseline by 12 hours. (wustl.edu)
Protects against weight gain - NR supplementation in mice increased NAD+ levels and activated SIRT1 and SIRT3, leading to enhanced oxidative metabolism and protecting against metabolic abnormalities, including obesity. (wakeup-world.com)
Heart failure - In a mouse study, NR preserved cardiac function in mice with heart failure. (wakeup-world.com)
These findings suggest that acute administration of the (+)-limonene epoxide exerts an anxiolytic-like effect on mice, and it could serve as a new approach for the treatment anxiety, since it practically does not produce toxic effects. (cbdcrew.org)
Based on these reports, we speculated that Mul might protect against DOX-related cardiac injury in mice. (hindawi.com)
Researchers at the Medical College of Virginia found that THC slowed the growth of three kinds of cancer in mice: lung and breast cancer, as well as virus-induced leukemia. (naturalnews.com)

28. Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo. (nih.gov)

Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
In addition, some of its components may improve the effectiveness of chemotherapy against breast and ovarian cancer cells. (healthline.com)
Several types of immunotherapy are either approved for use by the Food and Drug Administration or are under study in clinical trials to determine their effectiveness in treating various types of cancer. (lls.org)

It also acts as a powerful antioxidant, protecting the skin from free radicals and environmental stressors that contribute to premature aging and promote a healthier complexion. (programminginsider.com)
At Oasis of Hope, we use multiple sessions of O3-AHT to optimize the body's antioxidant defenses prior to administration of cytotoxic chemotherapies. (oasisofhope.com)
Hence, pre-treatment with drugs having anti-inflammatory, antioxidant and restorative properties along with cytochrome 2E1 modulating ability is the first right step in preventing Ethyl Alcohol (EtOH) induced gastric ulcer. (ijpsonline.com)
In addition, it is an important fat-soluble antioxidant tasked with protecting lipoproteins and cell membranes against oxidative damage. (fusabil.org)
The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)

35. Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. (nih.gov)
Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. (cbdcrew.org)
Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. (cbdcrew.org)

Reversal of chemotherapy-induced neuropathy - In rats, oral NR not only promoted resistance to chemotherapeutic neuropathy but also prompted its reversal. (wakeup-world.com)
The infusion of ozone into rats or humans induces oxidative stress in the body's tissues. (oasisofhope.com)
Then the extract (100, 150 and 200 mg/kg) was evaluated against ethanol-induced stomach ulcer in rats using 1-(1-propanoylpiperidin-4-yl)-3-(4-trifluoromethoxy)phenyl) urea (1 mg/kg) and omeprazole (20 mg/ kg) as reference standards. (ijpsonline.com)

Other studies suggest that DHEA helps reduce inflammation in the arteries and reduce arterial stiffness. (stlukes-stl.com)

The study concluded that silibinin might be "an effective adjuvant drug to produce a better chemo preventive response for the cancer therapy. (healthline.com)
O3-AHT has an additional benefit that makes it especially appropriate as an adjuvant for chemotherapy. (oasisofhope.com)

This study aimed to explore the efficacy and safety of bicyclol in acute DILI. (medscape.com)
There are also reports of animals fed with a high-fat diet to induce nonalcoholic steatohepatitis (NASH) and evaluate its efficacy in the progression of liver cancer [37] . (researchgate.net)
Efficacy of omeprazole in practical dyspepsia: double-blind, randomized, placebocontrolled trials (the Bond and Opera studies). (dnahelix.com)
We amplify the efficacy of the procedure by also exposing the ozonated blood to UV light, which, like ozone, induces oxidative stress in the withdrawn blood. (oasisofhope.com)

Recently, Clinical Cancer Research published the final results of this same study (2), which confirmed trastuzumab with chemotherapy improves survival rates for women with USC whose tumors expressed high levels of the HER2 protein. (b3cnewswire.com)

In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
Do chemotherapy drugs prevent antioxidants working? (canceractive.com)
Ethanol- induced gastric ulcer mediated through the free radical generation that leads to depletion of endogenous antioxidants and increases the lipid peroxide levels in mucosa[ 3 ]. (ijpsonline.com)
However, to treat ethanol-induced gastric ulcers, antioxidants are used, as the gastric damage is caused due to the direct action of epithelium which causes lipid peroxidation. (ijpsonline.com)

The findings of this study showed that the consumption of carrots could lower the risk of gastric cancer. (greenmedinfo.com)
Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in people. (dnahelix.com)

Robinson D, Ritter S, Yassin M. Comparing Sublingual and Inhaled Cannabis Therapies for Low Back Pain: An Observational Open-Label Study. (cannabis-med.org)
These and several other therapies are being actively studied in clinical trials. (eonco.info)

Cytotoxic chemotherapies present a significant physical challenge to the body - in large part because they expose the body's healthy tissues to severe oxidative stress. (oasisofhope.com)

Several phase III studies have demonstrated the superiority of gefitinib, erlotinib (first generation of TKIs) or afatinib (second generation) to chemotherapy in progression-free survival and response rates. (nih.gov)
Sloan Kettering showed that using melatonin with chemotherapy produced a 40 per cent increased one year survival, and a 93 per cent better chance of the tumour disappearing. (canceractive.com)
The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. (nature.com)

The body's immune system helps protect us against disease and infection. (lls.org)
This is well documented in many studies - and makes just plain common sense: It would be surprising if the body's tissues didn't respond to a mild oxidative stress by increasing their defenses. (oasisofhope.com)
In this way, the body's healthy tissues achieve a state of tolerance to the oxidative stress imposed by chemotherapy. (oasisofhope.com)

My wife had previous chemotherapy treatments of Taxol and Carboplatin. (cancer.org)

According to a recent study, over 20% of adults in the United States suffer from chronic pain, which limits their productivity and causes physical and mental distress. (programminginsider.com)

The infusion's goal is to attack or suppress leukemia cells by inducing an intense immune reaction against the patient's cancer cells. (lls.org)

While THC is the major cannabinoid responsible for some of the adverse effects of marijuana-induced anxiety, paranoia, and hallucinations, CBD has emerged as having good therapeutic potential in these areas. (medicalcannabisreport.com)

[ 2 , 5 ] Thus, currently, only a few drugs are being studied in RCTs with a focus on the management of DILI, and research progress in the treatment of acute DILI is slow. (medscape.com)
These guidelines divide 59 solvents that can be used to manufacture herbal medicines and other drug products into three different classes: those that should be avoided, those that should be limited, and those that may be regarded as safer than the others on the list because existing data indicate that they are "less toxic in acute or short-term studies and negative in genotoxicity studies. (nih.gov)

In 2018, preliminary data from Professor Santin's Phase II study (1) led to the inclusion of the chemotherapy-trastuzumab combination for new treatment of women with HER2-positive USC in the National Comprehensive Cancer Network (NCCN) guidelines. (b3cnewswire.com)

Unlike vaccines, which require time to induce protective immunity and depend on the host's ability to mount an immune response, passive antibody can theoretically confer protection regardless of the immune status of the host. (cdc.gov)
However, during simultaneous administration, the vaccines should be given at separate injection sites. (cdc.gov)
Other treatments used to stimulate the immune system in a general way and used in combination with monoclonal antibodies, vaccines or chemotherapy are substances called cytokines - hormones produced by the body that help the immune system function. (lls.org)

However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
Scalp hypothermia is cooling the scalp with ice packs or cooling caps (cold caps) for a period of time before, during, and after each chemotherapy (chemo) treatment to try to prevent or reduce hair loss . (cancer.org)
Newer versions of these devices use a two-piece cooling cap system that is controlled by a computer, which helps circulate a cooled liquid through a cap a person wears during each chemotherapy treatment. (cancer.org)
We investigated whether treatment of rat langendorff hearts with Metformin attenuated Sunitinib-induced cytotoxicity via AMPK. (bmj.com)
The pulmonary route hasn't worked so well for omalizumab, a mAb that is approved for subcutaneous administration in the treatment of asthma. (genengnews.com)
Treatment with general control nonderepressible 2 inhibitor (GCN2ib) alleviates adipocyte-mediated translational repression and rescues ALL cell quiescence thereby significantly reducing the cytoprotective effect of adipocytes against chemotherapy and other extrinsic stressors. (nature.com)
These findings indicate that niches in the BMM may differ dynamically during primary disease and after chemotherapy treatment 18 , 19 . (nature.com)
This new data was carried over into an animal model, showing that CBD pre-treatment was able to protect and restore the long-term potentiation deficits (LTP) critical to memory function within the hippocampus of the brain. (medicalcannabisreport.com)
There are two main types of lung cancer: small cell lung cancer for which chemotherapy is the primary treatment and non-small cell lung cancer, which in its early stages is treated primarily with surgery. (cdc.gov)
Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)
Treatment options include chemotherapy Treatment with drugs to stop the growth of rapidly dividing cancer cells, including lymphoma cells. (eonco.info)

The data suggest that CoQ 0 unveils a novel mechanism by down-regulating Wnt/β-catenin pathways and could be used as a potential lead compound for melanoma chemotherapy. (oncotarget.com)

Previous experiments from Dr. Cunningham's lab indicated that protective proteins released by stressed supporting cells in the inner ear could be enlisted to protect hair cells from the damage caused by ototoxic drugs-drugs that cause hearing loss because they damage hair cells. (nih.gov)
Vaccination can reduce the susceptibility of a population against specific threats provided that a safe vaccine exists that can induce a protective response. (cdc.gov)
Unfortunately, inducing a protective response by vaccination may take longer than the time between exposure and onset of disease. (cdc.gov)
Immunogenicity studies have indicated that virtually 100% of children, adolescents, and adults develop protective levels of antibody to hepatitis A virus (anti-HAV) after completing the vaccine series (1,2). (cdc.gov)
This study is the first to examine whether the protective effect of aspirin against breast cancer demonstrated by earlier research varies with hormone receptor status. (lifeextension.com)

In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)

6 Evidence is less clear for the many other conditions treated with cannabis, partly because the drug's illegal status has made it difficult to study. (nih.gov)
7 As a result, neither the Food and Drug Administration nor the Environmental Protection Agency has provided any guidance on how to regulate contaminants or on which cannabis-related exposures can be considered safe. (nih.gov)
States have had to determine on their own how to protect millions 8 of cannabis users, and they have come up with widely varying responses. (nih.gov)
In fact, the results of 48 studies show that kids who regularly use cannabis are much likelier to leave school before graduating or earning degrees. (healthychildren.org)
In the study by investigators of Hasharon Hospital of Rabin Medical Center Petah Tikva, Israel, participants first received the CBD extract for 10 months and after one month wash out THC-rich smoked cannabis for 12 months. (cannabis-med.org)
In this multicentre study from the USA investigators examined the relationships of self-reported substance use (alcohol, cannabis, and nicotine use), gender, and age with self-reports of walking, moderate physical activity, and vigorous physical activity. (cannabis-med.org)
Solid research about cannabis is hard to come by, largely because the federal government has made it so difficult to study - even requiring researchers to apply for a license with the Drug Enforcement Administration. (kuow.org)
from Texas A&M and UConn discussed a new technique of studying and characterizing compounds within cannabis (and beyond) that may affect the CB1 receptor differently than THC. (medicalcannabisreport.com)
After seeing the astonishing results with his own eyes, Dr. Courtney pointed out that the success of the cannabis approach means that children and adults no longer need to undergo the cruelties of surgery and long-term side effects that come from very high doses of chemotherapy or radiation. (naturalnews.com)

Following administration, the spike protein of SARS-CoV-2, and other viral surface antigens, stimulate both neutralizing and other functional binding antibodies, as well as cellular immune responses (Th1) directed against the spike and other surface proteins, which are thought to contribute to protection against COVID-19. (who.int)
Antibodies to beta-actin provide a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton. (thermofisher.com)

During chemotherapy that induces vomiting, mucosal enterochromaffin cells release serotonin, which stimulates 5-HT 3 receptors. (nih.gov)

In vitro studies have found that oxidized vitamin C, or dehydroascorbic acid, enters cells via some facilitated glucose transporters and is then reduced internally to ascorbic acid. (nih.gov)

Necrotizing leukoencephalopathy is the form of diffuse white matter injury that follows chemotherapy, as well as a suppressed immune system. (cancer.org)
Immune cells from the patient or a transplant donor are used to attack residual leukemia, lymphoma or myeloma cells that remain after chemotherapy. (lls.org)

In a study published in the journal Aging Cell, Martens and colleagues found that NR supplementation increases NAD+ levels and lowers biomarkers of neurodegeneration in plasma extracellular vesicles enriched for neuronal origin (NEVs). (wakeup-world.com)

My wife almost didn't make it through her chemotherapy treatments. (cancer.org)
As with many other promising natural treatments for cancer, research moves slowly, as the pharmaceutical cancer industry, backed up by governments, isn't too keen on shutting down its multi-billion dollar chemotherapy business . (naturalnews.com)

Results from pharmacokinetic studies indicate that oral doses of 1.25 g/day ascorbic acid produce mean peak plasma vitamin C concentrations of 135 micromol/L, which are about two times higher than those produced by consuming 200-300 mg/day ascorbic acid from vitamin C-rich foods [ 10 ]. (nih.gov)

If intraocular administration occurs, cell death leading to corneal infarction, retinal infarction, and ciliary body atrophy may result. (nih.gov)
26. Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. (nih.gov)
What protects a healthy cell is unlikely to afford any protection to a cancer cell. (canceractive.com)
We further investigated the cotreatment of Metformin with Sunitinib using HepG2 and HL60 cancer cell lines to reveal if potential adjunctive therapy drugs interfere with and prevent the anti-cancer activity of chemotherapy agents. (bmj.com)
A separate study on the effects of silibinin on MCF-7 human breast cancer cells also found it causes cell death and a loss of viability. (healthline.com)
Most chemotherapy drugs developed in the lab induced cancer cells' death by damaging DNA or inhibiting specific enzymes essential to cell division. (sciencefriday.com)
An in-vitro study using taurine in a physiological dose equivalent of 5g daily intravenously measured endothelial cell responses including NK and LAK activity, cytotoxicity, endothelial cell adherence and lymphocyte production. (ndnr.com)
Study results demonstrated an increase in cell lysis by IL-2-activated NK and LAK cells, and a reduction in endothelial cell injury by taurine. (ndnr.com)
Current standard of care for muscle-invasive urothelial cell carcinoma (UCC) is definitely surgery along with perioperative platinum-based chemotherapy. (techblessing.com)
Many studies argue that vitamin E is the first line of defense against oxidation in cell membranes 3 . (fusabil.org)

25. Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts. (nih.gov)

The vaccine is licensed in adult and pediatric formulations, with different dosages and administration schedules Table 1 and should be administered by intramuscular injection into the deltoid muscle. (cdc.gov)

Exposing people to what researchers have called a "scapegoat stimulus" just before the administration of chemotherapy can direct the food aversion to the "scapegoat" food instead of more important parts of the diet. (peacehealth.org)
Researchers at Columbia University and the University of North Carolina at Chapel Hill examined data obtained from the Long Island Breast Cancer Study Project. (lifeextension.com)
In 1991, researchers at the Institute for Hormone Research announced that they had been able to induce the body to convert the stronger form of estrogen (estradiol) into the weaker form (estriol) without using drugs. (lifeextension.com)

And although S1P is known to be blood borne, no one realized until this study that S1P is supplied by red blood cells to control blood vessel growth. (wikipedia.org)
New research from the lab of Lisa Cunningham, Ph.D. , at the National Institute on Deafness and Other Communication Disorders (NIDCD) hints at a new way to protect sensory hair cells in the inner ear from potentially damaging drugs: controlled noise exposure before the drug is administered. (nih.gov)
Some believe that the scalp cooling might protect cancer cells there and allow them to survive the chemo and keep growing. (cancer.org)
The effect on normal cells is the cause of side effects from chemotherapy. (cancer.org)
Curcumin does protect healthy cells. (canceractive.com)
But it damages cancer cells and it sensitises them, which makes chemotherapy work better. (canceractive.com)
The fact is that no chemotherapy drug kills off the cancer stem cells - the 3% of cancer cells in the heart of the tumour that control everything. (canceractive.com)
NAD+ is essential for cells to create energy and there is strong evidence from animal studies that aging and metabolic dysfunction results in a depletion of NAD+ within cells. (wakeup-world.com)
One study on the effects of silibinin on MCF-7 breast cancer cells suggests the compound inhibits the cells' growth and induces their death. (healthline.com)
The cells are then returned to the patient following chemotherapy. (lls.org)
So O3-AHT, while protecting healthy tissues, may make cancer cells more vulnerable to chemo therapeutic assault. (oasisofhope.com)
Functionally, adipocyte niches elicit a fate switch in ALL cells towards slow-proliferation and cellular quiescence, highlighting the critical contribution of the adipocyte dynamic to disease establishment and chemotherapy resistance. (nature.com)

Controlled studies of older forms of scalp hypothermia (such as using ice packs) have had conflicting results. (cancer.org)
24. Combination of bevacizumab, irinotecan, and temozolomide for refractory or relapsed neuroblastoma: Results of a phase II study. (nih.gov)
A]lthough we do not have direct evidence, the results of our study suggest that it is having an effect on the brain and also changing the metabolism of molecular pathways known to be involved in Alzheimer's disease. (wakeup-world.com)
While the exact mechanism by which CBD treats seizure activity is not fully understood, numerous studies have indicated that CBD can significantly reduce the frequency and severity of seizures, even in cases where traditional antiepileptic drugs fail to produce satisfactory results. (programminginsider.com)
It generally results in fewer short-term side effects than chemotherapy does. (lls.org)
In one recent study, disappointing results for the aerosolization of omalizumab were attributed to the pulmonary route's failure to deliver enough of the drug to neutralize free systemic immunoglobulin E. (genengnews.com)
Studies using DHEA to treat overweight people have found conflicting results. (stlukes-stl.com)
Preliminary results from the DHEAge study in France suggested DHEA may slow bone loss, improve skin health, and improve sex drive in women over 70. (stlukes-stl.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
Without any mention in the mainstream media, the Drug Enforcement Administration (DEA) quickly shut down the study and destroyed its results. (naturalnews.com)

Nevertheless, further research in both basic studies and human clinical trials are required to investigate the clinical applications, mechanisms, and effects of RBAC. (researchgate.net)

Anatomy5

Organisms5

Diseases74

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment82

Phenomena and Processes13

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science2

Health Care32

Apoptosis20

Tumor9

Cisplatin10

Toxicity7

Nausea4

Side effects of c1

Chemoprevention and chemotherapy2

Radiotherapy5

Patients28

People taking chemo4

Cardiotoxicity8

Drug-induced liver injury2

Angiogenesis1

Liver injury1

Chemotherapeutic agents1

Mice8

Vivo1

Effectiveness3

Antioxidant5

Inhibition3

Rats3

Inflammation1

Adjuvant2

Efficacy4

Tumors1

Antioxidants5

Gastric2

Therapies2

Cytotoxic1

Survival3

Body's3

Carboplatin1

Chronic1

Leukemia cells1

Adverse Effects1

Acute2

Trastuzumab1

Vaccines3

Treatment11

Melanoma1

Protective5

Damage1

Cannabis9

Antibodies2

Stimulates1

Vitro studies1

Immune2

Neurodegeneration1

Treatments2

Pharmacokinetic1

Cell10

Enhances1

Injection1

Researchers3

Cells12

Results10

Clinical Trials1