• Pretreatment with 50 micrograms capsaicin for 7 to 11 days (which reduced substance P immunoreactivity in the superficial layers of the dorsal spinal cord) produced a slight increase in the action of NECA and CHA, and reduced the action on morphine in the hot plate test but not in the tail flick test. (aspetjournals.org)
  • Pretreatment with 50 to 100 micrograms 6-hydroxydopamine for 7 to 14 days (which reduced spinal cord noradrenaline levels by 54-65%) reduced spinal antinociception by NECA and CHA but not that by morphine. (aspetjournals.org)
  • Pretreatment with 50 micrograms 5,7-dihydroxytryptamine (which reduced spinal cord serotonin levels by 74-89%) had no effect on any agent. (aspetjournals.org)
  • Intracerebroventricular administration of 150 micrograms/20 microliters 5,7-dihydroxytryptamine, which markedly depleted serotonin in the brain, did not modify the effect of 10 mg/kg tianeptine on the extracellular concentrations of dopamine and HVA in the nucleus accumbens but reduced the effect on DOPAC. (tianeptine.com)
  • 6. Intracerebroventricular injection with 5,7-dihydroxytryptamine caused a marked reduction in brain 5-HT content, but the treatment affected neither basal NA levels nor the MKC-242-induced increase in NA release. (biopsychiatry.com)
  • Therefore, the author investigated the effect of an intracerebroventricular (i.c.v.) administration of p-OHA on the changes of locomotor activity and prepulse inhibition (PPI) in the acoustic startle response in rodents. (bvsalud.org)
  • p-OHA-induced PPI disruptions were also improved by a serotonin (5-HT)2A receptor antagonist, a 5-HT synthesis inhibitor or a 5-HT neurotoxin. (bvsalud.org)
  • We showed that the 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), reduces brain tissue 5-HT, decreases expression of 5-HT transporter (SERT) protein and increases expression of glial fibrillary acidic protein (GFAP). (erowid.org)
  • Male Sprague-Dawley rats were bilaterally microinjected with vehicle or the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), into the dorsal or ventral hippocampus using a stereotaxic approach. (interleukinreceptor.com)
  • 4. The effects of MKC-242 and 8-OH-DPAT in the hypothalamus were antagonized by pretreatment with WAY100135 (10 mg kg-1), a silent 5-HT1A receptor antagonist. (biopsychiatry.com)
  • 5. Local administration of 8-OH-DPAT (10-100 microM), citalopram (1 microM), a 5-HT reuptake inhibitor, and MDL72222 (10 microM), a 5-HT3 receptor antagonist, into the hypothalamus, had no effect on NA release. (biopsychiatry.com)
  • 1. 5-Hydroxytryptamine (5-HT) plays a role in the regulation of noradrenergic neurones in the brain, but the precise mechanism of regulation of noradrenaline (NA) release by 5-HT1A receptors has not been defined. (biopsychiatry.com)
  • These results suggest that p-OHA-induced PPI disruptions were mediated by DA and 5-HT release and subsequent stimulation of D2, D4 and 5-HT2A receptors. (bvsalud.org)
  • The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. (illumina.com)
  • The effects of intrathecal pretreatment with the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine on spinal antinociception by adenosine analogs (NECA, 5'-N-ethylcarboxamido adenosine and CHA, N6-cyclohexyl adenosine) and morphine were examined using the rat tail flick and hot plate tests. (aspetjournals.org)
  • Vallöf D, Ulenius L, Egecioglu E, Engel JA , Jerlhag E. Central administration of the anorexigenic peptide neuromedin U decreases alcohol intake and attenuates alcohol-induced reward in rodents. (neurotree.org)
  • In contrast, doses of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) that decrease brain tissue 5-HT fail to alter expression of SERT or GFAP. (erowid.org)
  • Rat brain tissues (caudate, cortex, hippocampus) were collected 3 days and 2 weeks after MDMA (7.5 mg/kg i.p., q 2hr x 3 doses) or 5,7-DHT (150 microg/rat, icv) administration. (erowid.org)
  • Banerjee A, Vaidya VA (2020), Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor. (hutmentlab.com)
  • Using a new and highly sensitive anti-SERT antibody, we determined if MDMA alters the subcellular distribution of SERT protein by measuring SERT expression in endosomes and plasma membranes 2 weeks after MDMA administration. (erowid.org)
  • At both 3 days and 2 weeks post-injection, MDMA decreased tissue 5-HT (60%) and had no effect on GFAP expression. (erowid.org)
  • These findings indicate that a dosing regimen of MDMA that depletes brain 5-HT does not alter SERT protein expression or the distribution of SERT between endosomes and the plasma membrane, and does not produce detectable evidence for neurotoxicity. (erowid.org)
  • When a variety of pharmacologic or surgical procedures were used to decrease DA content prior to administration of METH, the effects of METH were attenuated. (erowid.org)
  • JPET articles become freely available 12 months after publication, and remain freely available for 5 years. (aspetjournals.org)
  • The present study describes the effect of a highly potent and selective 5-HT1A receptor agonist, 5-(3-[[(2S)-1,4-benzodioxan-2-ylmethyl)]amino]propoxy)-1,3-b enzodioxole HC1 (MKC-242), on NA release in the hypothalamus using microdialysis in the freely moving rat. (biopsychiatry.com)
  • p-Hydroxyamphetamine (p-OHA) is an active metabolite of amphetamine (AMPH) and methamphetamine (METH), and can be detected in the brain for a relatively long period after high-dose administration of AMPH in rodents. (bvsalud.org)
  • p-OHA may be involved in the abnormal behavior observed during the withdrawal period after a chronic administration of AMPH or METH. (bvsalud.org)
  • Next, the author tested the effects of the i.c.v. administration of p-OHA on PPI in mice. (bvsalud.org)
  • 5,7-DHT decreased SERT expression (33%) at 2-weeks but not at 3-days. (erowid.org)
  • 7. The effect of MKC-242 in increasing NA release was not attenuated by repeated treatment with the drug (0.5 mg kg-1, once a day for 2 weeks). (biopsychiatry.com)
  • 3. The 5-HT1A receptor agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) (0.2 mg kg-1) and buspirone (3 mg kg-1) mimicked the effect of MKC-242 in increasing NA release in the hypothalamus. (biopsychiatry.com)
  • Taken together, our present data suggest that TRPC1, but not TRPC3 or 5, is involved in hypoxia-induced VEGF expression in U-87 MG cells. (interleukinreceptor.com)
  • [ 34 ] Administration of tranylcypromine, the TCA desipramine, the SSRI sertraline or the noradrenergic and specific serotonergic antidepressant mianserin for 3 weeks increased brain-derived neurotrophic factor expression in rat hippocampus. (medscape.com)
  • Microiontophoretic application of tianeptine onto dorsal hippocampus CA3 pyramidal neurons, as well as its intravenous administration (2 mg/kg), increased their firing frequency. (tianeptine.com)
  • 2 Stress-induced responses of the HPA system involve afferent inputs from numerous other brain regions including noradrenergic innervation from the brainstem A1 and A2 cell groups and the pontine locus coeruleus, 3 the amygdala, 4 , 5 cerebral cortex and hippocampus. (jpn.ca)
  • The development of potent and selective antagonists of the 5-HT 2 receptor, such as ketanserin, facilitated the assignment of certain effects mediated by 5-HT to the 5-HT 2 receptor. (nih.gov)
  • The development of potent selective antagonists and an agonist, 2-methyl-5-HT, provided useful tools for the pharmacological characterization of 5-HT 3 receptors. (nih.gov)
  • However, in rats that had received tianeptine for 14 days (20 mg/kg/day, s.c.), the recovery time from the suppressant effect of microiontophoretic applications of 5-HT was reduced by 40% and the effectiveness of paroxetine (1 mg/kg, i.v.) was decreased. (tianeptine.com)
  • Male rats chronically exposed to 5 or 10 mg/kg ATR in the diet for 6 months exhibited persistent hyperactivity and altered behavioral responsivity to amphetamine. (nih.gov)
  • concentrations of dopamine (DA) and 5-hydroxytryptamine (5HT) and their respective metabolites were decreased in parallel with the decline in activity of the enzymes. (erowid.org)
  • 7 the type I or mineralocorticoid receptor (MR) and the type II or glucocorticoid receptor (GR). The MR is mainly expressed either alone or together with the GR in hippocampal neurons, whereas the GR is more ubiquitously distributed in the brain, 8 particularly in neurons. (jpn.ca)
  • Many subsequent experiments have shown that the D receptor and the 5-HT 2 receptor are pharmacologically indistinguishable. (nih.gov)
  • The binding of [ 3 H] 5-HT to 5-HT 1 receptors was shown to be displaced by spiperone in a biphasic manner, suggesting that what was termed the 5-HT 1 receptor might be a heterogeneous population of receptors. (nih.gov)
  • Subsequently, a fourth binding site for [ 3 H]5-HT was identified in bovine brain and called the 5-HT 1D receptor. (nih.gov)
  • The 5-HT 1D receptor was identified by pharmacological criteria only in brains of species devoid of the 5-HT 1B receptor, such as pig, cow, guinea pig and human. (nih.gov)
  • Bradley and associates renamed this the 5-HT 3 receptor. (nih.gov)
  • Drugs whose systemic and/or central administration induce suppression or stimulation of prolactin secretion are reviewed. (nih.gov)
  • Episodic GH secretion reappeared 36 h after the last administration of reserpine, at which time the behavioral inhibition and blepharospasm induced by the drug was less pronounced than after 24 h, but brain levels of CAs and 5-HT were still markedly reduced. (nih.gov)
  • 12, 4, and 2 h before experiments) inhibited episodic GH secretion and caused marked inhibition of motor activity and brain levels of CAs but not 5-HT. (nih.gov)
  • 72, 48, and 24 h before experiments) had no effect on episodic GH secretion, whereas brain levels of 5-HT and 5-HT synthesis were markedly reduced. (nih.gov)
  • I n the present study, in vivo extracellular unitary recordings, in vitro [3H]5-HT uptake and [3H]cyanoimipramine binding assays were used to assess the effect of acute and prolonged administration of the putative antidepressant tianeptine, on the 5-hydroxytryptamine (5-HT) transporter. (tianeptine.com)
  • The effects of the various drug treatments on motor activity and brain levels of catecholamines (CAs) and 5-hydroxytryptamine (5-HT) as well as the synthesis of the biogenic amines were also studied. (nih.gov)
  • In keeping with this observation, the acute administration of tianeptine did not change the effectiveness of the 5-HT reuptake blocker paroxetine (1 mg/kg, i.v.) in prolonging the suppressant effect of microiontophoretically-applied 5-HT. (tianeptine.com)
  • Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. (keyopinionleaders.com)
  • 30 min before experiments) than with alpha-MT but was not as complete as that found 12 h after administration of reserpine. (nih.gov)
  • A high density of binding sites for [ 3 H]5-HT was found in the choroid plexus. (nih.gov)
  • MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. (aspetjournals.org)
  • These [ 3 H]5-HT-binding sites were termed the 5-HT 1C subtype as they did not show the pharmacological characteristics used to classify the 5-HT 1A , 5-HT 1B or 5-HT 2 binding sites. (nih.gov)
  • Furthermore, in spite of its activating effect on CA3 pyramidal neuron firing frequency, the intravenous administration of tianeptine did not alter the time of recovery of these neurons from microiontophoretic applications of 5-HT, an index of 5-HT uptake activity. (tianeptine.com)