• The important causes of morbidity and mortality in patients with acute pancreatitis include shock and cardiovascular dysfunction, respiratory and renalfailure etc. (nii.ac.jp)
  • Mental factors such as depressive symptoms or anxiety disorders are associated with an elevated risk of postoperative morbidity and mortality in patients treated for heart disease. (aerzteblatt.de)
  • This hypermetabolism causes increased carbon dioxide production, metabolic and respiratory acidosis, accelerated oxygen consumption, heat production, activation of the sympathetic nervous system, hyperkalemia, disseminated intravascular coagulation (DIC), and multiple organ dysfunction and failure. (medscape.com)
  • The final stage of sepsis can lead to septic shock, multiple organ failure, and death. (kth.se)
  • Rapid diagnosis of sepsis is crucial as there is an exponential increase in mortality for every hour delay in the appropriate antibiotics administration. (kth.se)
  • 2016). Therefore, sepsis is a life-threatening immunological condition that occurs when microorganisms enter the human body, causing a severe internal response that poses the danger of malfunction to major body organs, sepsis shock, and death. (ivoryresearch.com)
  • In critically ill patients, sepsis is a major trigger for death, making the condition a primary cause of mortalities associated with kidney failure, heart attack, and paralysis. (ivoryresearch.com)
  • One main cause of the high mortality among patients with CSAMI is the development of prolonged shock leading to systemic inflammatory response syndrome (SIRS) and even sepsis, 3,7-9 with consecutive development of deleterious multiple organ dysfunction syndrome (MODS). (icrjournal.com)
  • Kidneys are among the organs most susceptible to sepsis-induced damage [ 3 ]. (hindawi.com)
  • Patients with persisting organ failure, signs of sepsis, or deterioration in clinical status 6-10 days after admission will require computed tomography (recommendation grade B). (bmj.com)
  • 12. Zhao H, Zhao M, Wang Y, Li F, Zhang Z. Glycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in Rats. (ac.ir)
  • However, given the deadly nature of COVID‑19 and the large population of critically ill patients included in the study, the mortality rate does not appear excessive, the researchers say. (asdafnews.com)
  • Cardiovascular therapy has to be accompanied by best general intensive care of these critically ill patients with high mortality. (icrjournal.com)
  • Critically ill patients have elevated levels of ADMA which proved to be a strong and independent risk factor for ICU mortality. (eur.nl)
  • In conclusion, in critically ill patients plasma ADMA levels were elevated and associated with the extent of multiple organ failure, but no significant ADMA-lowering effect of the PPAR-gamma agonist rosiglitazone was observed. (eur.nl)
  • Furthermore, according to the report published by the Council of Europe in 2019, 41,000 patients underwent organ transplantation in 2018 in Europe. (grandviewresearch.com)
  • Similarly, as per the report published by the National Institute of Diabetes and Digestive and Kidney Diseases in 2019, around 661,000 Americans suffer from kidney failure of which 468,000 patients are on dialysis and around 193,000 underwent kidney transplant. (grandviewresearch.com)
  • A prospective study of trauma patients found that the presence of either a prolonged PT and/or aPTT was a strong and independent predictor of mortality [ 9 ]. (biomedcentral.com)
  • Patients with organ dysfunction resulting from secondary factors other than an infection face the risk of misdiagnosis, especially if their condition comes as an emergency (Fan et al. (ivoryresearch.com)
  • Such clinical misdiagnosis can easily mislead physicians to administer antibiotics to patients under critical care, such as the intensive care unit (ICU), leading to untimely death or permanent organ failure. (ivoryresearch.com)
  • In most cases, a septic attack occurs as an emergency that requires an immediate medical response, without which patients face the risk of acute kidney failure, heart attack, or even death. (ivoryresearch.com)
  • Patients are at high risk of severe disease progression with ARDS and/or multiple organ failure, and at high risk of mortality. (who.int)
  • Sixty-six percent of the patients were in an ICU, and nearly 20% carried the diagnosis of multi-organ dysfunction or failure. (asdafnews.com)
  • The researchers note that while the study was not designed to evaluate the efficacy of convalescent plasma, a seven-day incidence of mortality of 14.9% in this number of patients indicates "no signal of toxicity beyond what is expected in plasma use in severely ill patients. (asdafnews.com)
  • These patients can suffer organ damage from the disease and iron overload, so there's an important need for new treatment approaches beyond allogeneic hematopoietic stem cell transplant (HSCT). (fool.com)
  • HSCT can treat the underlying cause of beta-thalassemia, but it exposes patients to risks, including treatment-related mortality, graft failure, graft versus host disease, and infection. (fool.com)
  • In June, bluebird bio stole the show at the American Society of Clinical Oncology conference when it reported that bb2121 delivered a 100% response rate in evaluable, heavily pre-treated, multiple myeloma patients. (fool.com)
  • It's likely that response rates will slip over time, as more patients are evaluated, but it appears that the trial was a success given that bluebird bio's collaboration partner , Celgene ( CELG ) is set to begin enrolling patients in a phase 2 trial soon that could allow for an accelerated Food and Drug Administration approval. (fool.com)
  • In patients with severe ARDS, does the early initiation of Extracorporeal Membrane Oxygenation (ECMO), compared to standard care, improve mortality at day 60? (thebottomline.org.uk)
  • Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients. (who.int)
  • La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
  • A study recently published in The New England Journal of Medicine found that administering plasma from COVID-19 convalescents with neutralizing antibody titers ≥1:160 to patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 , within 5 days of starting invasive mechanical ventilation significantly reduced mortality. (postsen.com)
  • Dispersing the tablet in water may facilitate administration in patients in lower weight-bands and avoids fractioning solid formulations, although bioavailability is uncertain (use of dispersible tablets is preferred if available). (who.int)
  • Guidelines for evidence-based management of patients with cardiogenic shock after acute myocardial infarction focuses on early revascularisation of the occluded coronary artery as well as on support of cardiac failure and improvement of impaired organ perfusion. (icrjournal.com)
  • 4 This disappointing situation explains the urgent search for better treatment concepts 5 to lower this unacceptably high mortality of patients with cardiogenic shock complicating myocardial infarction. (icrjournal.com)
  • Figure 1 shows the time course of cardiac index, brain-type natriuretic peptide (BNP), interleukin-6 (IL-6) and Acute Physiology and Chronic Health Evaluation II (APACHE II) score in surviving and non-surviving patients with cardiogenic shock due to left ventricular failure complicating MI. (icrjournal.com)
  • KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved KEYTRUDA, Merck's anti-PD-1 therapy, for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions. (merck.com)
  • As a result, the two hospitals using the MATH+ formula had mortality rates of no higher than 6%, when most hospitals lost as many as 80% of their seriously ill COVID patients. (notaakhirzaman.com)
  • Treatment strategies for the prevention, reduction, and reversal of organ injury are warranted to improve morbidity in these patients. (biomedcentral.com)
  • Early identification and treatment of organ dysfunction, along with hemodynamic stabilization, are key components of the management of patients with CS. (biomedcentral.com)
  • Vital organ dysfunction is thought to be directly linked to poor prognosis in patients with CS. (biomedcentral.com)
  • After autologous BMT in patients with NHL, ALL, or Hodgkin's disease, LEUKINE has been found to be safe and effective in accelerating myeloid engraftment, decreasing median duration of antibiotic administration, reducing the median duration of infectious episodes and shortening the median duration of hospitalization. (druglib.com)
  • LEUKINE has been found to be safe and effective in prolonging survival of patients who are experiencing graft failure or engraftment delay, in the presence or absence of infection, following autologous or allogeneic BMT. (druglib.com)
  • Survival benefit may be relatively greater in those patients who demonstrate one or more of the following characteristics: autologous BMT failure or engraftment delay, no previous total body irradiation, malignancy other than leukemia or a multiple organ failure (MOF) score ≤ two (see CLINICAL EXPERIENCE ). (druglib.com)
  • Based on Phase II data suggesting the best therapeutic effects could be achieved in patients at highest risk for severe infections and mortality while neutropenic, the Phase III clinical trial was conducted in older patients. (druglib.com)
  • While there is no Ebola virus-specific therapy proven to be effective in clinical trials, mortality has been dramatically lower among EVD patients managed with supportive intensive care in highly resourced settings, allowing for the avoidance of hypovolemia, correction of electrolyte and metabolic abnormalities, and the provision of oxygen, ventilation, vasopressors, and dialysis when indicated. (biomedcentral.com)
  • If patients with SCD crisis are being transported by emergency medical services (EMS), they should receive supplemental oxygen and intravenous hydration en route to the hospital. (medscape.com)
  • In 2017, the US Food & Drug Administration (FDA) approved L-glutamine oral powder (Endari) for patients age 5 years and older to reduce severe complications of SCD. (medscape.com)
  • 2016). Unfortunately, there lacks a clear indicator that can singly identify the root source of organ failure or shock to a septic attack, according to Zhang (2015). (ivoryresearch.com)
  • The research protocol defines severe or life-threatening as dyspnea, decreased blood oxygen saturation, respiratory failure, septic shock, and multiple organ dysfunction or failure. (asdafnews.com)
  • The clinical manifestations of MERS-CoV infections range from asymptomatic infection to severe pneumonia, often complicated by ARDS, septic shock, and multi-organ failure leading to death. (who.int)
  • A mortality prediction model for septic AKI and a risk stratification scoring approach were developed, and the emergency intensive care unit (eICU) database was used for external validation. (hindawi.com)
  • In addition, we built a mortality prediction model for septic AKI and compare it to the validation dataset from the emergency intensive care unit (eICU). (hindawi.com)
  • Although minor bleeding manifestations are common, hypovolemic and septic shock complicated by multisystem organ dysfunction appear the most frequent causes of death. (biomedcentral.com)
  • Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality rate than pulmonary manifestations. (jci.org)
  • The severe form of the disease is characterized by marked haemolytic anaemia, severe acid-base abnormalities with frequent secondary multiple organ failure and complications such as acute renal failure (ARF), hepatopathy with marked icterus, hypoglycaemia, acute respiratory distress syndrome (ARDS), cerebral pathology and additional immune-mediated red blood cell destruction. (vin.com)
  • Clinical manifestations include acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), venous thromboembolic disease (VTE), and Multiple Organ Failure (MOF), and cerebral edema and ongoing cellular death after TBI. (mtec-sc.org)
  • The global organ preservation market size was valued at USD 202.8 million in 2019 and is expected to grow at a compound annual growth rate (CAGR) of 6.5% from 2020 to 2027. (grandviewresearch.com)
  • The increasing cases of kidney failures and chronic kidney diseases are expected to surge the kidney transplant rate. (grandviewresearch.com)
  • It was also referred to as "traumatic wet lung", "congestive atelectasis", or "Da Nang lung" and had a high mortality rate. (org.pk)
  • COVID-19 spreads throughout the world and has a mortality rate of about 7.1% [1]. (scirp.org)
  • Toxic epidermal necrolysis is a severe acute mucocutaneous condition usually induced by drugs associated with a high rate of morbidity and mortality. (rbcp.org.br)
  • At day 28 from study entry, the mortality rate was 35.4% in the group receiving convalescent plasma compared with 45.0% in the group receiving usual care, the difference being statistically significant. (postsen.com)
  • The rate of serious adverse events did not differ significantly between the two groups and were attributed to either COVID-19 or multiple organ failure unrelated to plasma administration. (postsen.com)
  • explain how in the absence of a specific antiviral cure for COVID-19, the goal of treatment must be to the fight the symptoms, lowering the mortality rate through intensive maintenance of organ function, for example an artificial liver blood purification system or renal replacement therapy to filtrate the blood through mechanical means. (bajaprogofficial.com)
  • these effects are associated with an increased mortality rate. (biomedcentral.com)
  • There is no cure for this disease, and no change in its mortality rate in 30 years. (noveome.com)
  • Here, we create a murine model of SARS-CoV-2-induced severe systemic toxicity and multiorgan involvement by expressing the human ACE2 transgene in multiple tissues via viral delivery, followed by systemic administration of SARS-CoV-2. (jci.org)
  • Our model suggests that SARS-CoV-2-induced metabolic reprogramming and epigenetic changes in internal organs could contribute to systemic toxicity and lethality in COVID-19. (jci.org)
  • Hypoxia and ventilation failure occurs most often with severe illness and may be exacerbated by substantial fluid requirements for intravascular volume repletion and some degree of systemic capillary leak. (biomedcentral.com)
  • No major visceral organ toxicity was documented. (nih.gov)
  • According to the report published by the American Heart Association in 2018, around 92.1 million Americans are living with some form of CVD and CVD is the most common cause for mortality in the country as compared to cancer and other chronic diseases. (grandviewresearch.com)
  • The platelet count was shown to be a stronger independent predictor for ICU mortality than standard composite scoring systems, such as the Acute Physiology and Chronic Evaluation (APACHE) II score. (biomedcentral.com)
  • Predictors of mortality include older age and chronic lung disease. (who.int)
  • These conditions include acute impairment of cardiac performance (e.g., acute coronary syndrome [ACS] and acute myocarditis) or acute or chronic impairment of cardiac performance (exacerbation of chronic decompensated heart failure [HF] and/or natural progression of advanced HF). (biomedcentral.com)
  • 1-4 Controlling the cytokine storm triggered by COVID-19 is critical to lowering mortality, especially in the elderly and those with chronic conditions such as diabetes, acute respiratory distress syndrome, hypertension and cardiovascular disease. (noveome.com)
  • A high level of suspicion is necessary for an adequate diagnosis and risk stratification, and early support measures and treatment should be performed by a multidisciplinary team trained to minimize damage and mortality. (rbcp.org.br)
  • Also of great importance is effective treatment of shock complications, especially acute respiratory failure and other forms of multiple organ dysfunction syndrome (MODS). (icrjournal.com)
  • Acute lung injury (ALI) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems. (nih.gov)
  • B -F) GO analysis demonstrates pathways enriched by differentially upregulated genes in the heart ( B ), kidney ( C ), liver ( D ), lung ( E ), and adipose tissue ( F ). ( G and H ) Pathways enriched by differentially upregulated genes that are common to the above organs ( G ) and pathways enriched by differentially downregulated genes that are common to the above organs ( H ). (jci.org)
  • Notable histopathology findings included increased cellularity in hematologic organs and heart and lung tissues. (nih.gov)
  • Severe hypoxemia, diffuse pulmonary infiltrates, poor lung compliance and absence of left heart failure characterize this condition. (org.pk)
  • Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. (ac.ir)
  • The body's response to COVID-19 infection can be a dangerous inflammatory overreaction known as a "cytokine storm," that can lead to acute lung injury, fibrosis, multiple organ failure and death. (noveome.com)
  • The purpose of this Notice of Funding Opportunity (NOFO) is to support early to mid-stage research focused on development of candidate medical countermeasures (MCMs) with post-radiation exposure administration data demonstrating efficacy to mitigate and/or treat radiation injuries. (nih.gov)
  • B10.BR mice were used to further characterize efficacy and immune responses following co-administration of Ad-CAGoptZGP with the most effective treatment: AdHu5 expressing recombinant IFN-α (hereafter termed DEF201) after challenge with a lethal dose of mouse adapted-ZEBOV (MA-ZEBOV). (omicsonline.org)
  • Immune-mediated adverse reactions can occur at any time during or after treatment with KEYTRUDA, including pneumonitis, colitis, hepatitis, endocrinopathies, nephritis, dermatologic reactions, solid organ transplant rejection, and complications of allogeneic hematopoietic stem cell transplantation. (merck.com)
  • The most aggressive strain identified is the Zaire Ebola virus (ZEBOV) with mortality rates reported to be as high as 90% [ 2 ]. (omicsonline.org)
  • To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. (analesdepediatria.org)
  • Moreover, high CVP should not be ignored because elevated values have proved to be strongly associated with mortality [ 8 ]. (hindawi.com)
  • While the current case fatality proportion in West Africa is approximately 40 %, it has varied substantially over time (highest near the outbreak onset) according to available resources (40-90 % mortality in West Africa compared to under 20 % in Western Europe and the USA), by age (near universal among neonates and high among older adults), and by Ebola viral load at admission. (biomedcentral.com)
  • Regardless of the etiology, CS is characterized by inadequate cardiac output leading to hypotension and signs and/or symptoms of end-organ hypoperfusion, such as inadequate renal perfusion (i.e., oliguria) [ 8 ]. (biomedcentral.com)
  • Anti-spasmodic effect on isolated organs (intestinal and uterine muscles) using new method of Modular Single Chamber Organ Bath were carried out on experimental animals. (civilenvironjournal.com)
  • Effects of tempol, a membrane-permeable radical scavenger, on local and remote organ injuries caused by intestinal ischemia/reperfusion in rats. (ac.ir)
  • In RCC, Merck has a broad clinical development program exploring KEYTRUDA, as monotherapy or in combination, as well as other investigational products across multiple settings and stages of RCC, including adjuvant and advanced or metastatic disease. (merck.com)
  • As the illness progresses, a person may experience vomiting, fever and low blood pressure, all potentially culminating in multisystem organ failure and death. (bioedonline.org)
  • With an adequate stratification and supportive care, a reduction in its morbidity and mortality is possible. (rbcp.org.br)
  • Publications listed below range from large scale observational studies demonstrating large impacts on mortality in the prior pandemics of SARS and H1N1, through the landmark RECOVERY trial done in the United Kingdom against COVID-19, to numerous and increasing COVID-19 retrospective cohort studies published from Italy, China, Spain, and the United States. (notaakhirzaman.com)
  • As a result, the military requires therapies which can mitigate the potential impacts of severe injuries and delays to surgical interventions in order to prevent mortality from combat wounds. (mtec-sc.org)
  • This has to be taken in mind when trying to improve prognosis and reduce mortality by simply increasing cardiac output and stabilising blood pressure. (icrjournal.com)
  • Organ dysfunction has traditionally been attributed to the hypoperfusion of the organ due to either progressive impairment of the cardiac output or intravascular volume depletion secondary to CS. (biomedcentral.com)
  • However, research attention has recently shifted from this cardiac output ("forward failure") to venous congestion ("backward failure") as the most important hemodynamic determinant. (biomedcentral.com)
  • Cardiogenic shock (CS) is caused by primary cardiac dysfunction, resulting in an inadequate cardiac output due to multiple conditions. (biomedcentral.com)
  • Reports of pulmonary physiopathological insults following severe trauma resulting in respiratory failure are not new in medical literature 1,2 . (org.pk)
  • The diverse biologic properties and modes of administration of ST266 enable exceptionally broad therapeutic utility for ophthalmic indications. (noveome.com)
  • 6 In this article we will mainly focus on cardiogenic shock due to left ventricular failure after AMI. (icrjournal.com)
  • The patient had multiple organ failure, but this was successfully reversed and the infection treated with antifungal drugs. (wikipedia.org)
  • Pattern of gene expression changes in multiple organs in hACE2/SARS-CoV-2 animals compared with eGFP/SARS-CoV-2 animals at 3 days after SARS-CoV-2 infection. (jci.org)
  • A ) Principal component (PC) analysis of differentially expressed genes in multiple organs shows separation of organs according to viral infection by PC6 ( n = 3/group). (jci.org)
  • Infection is the ma- jor cause of morbidity and mortality in burns. (who.int)
  • In addition, total sequential organ failure assessment (SOFA score), kidney function and liver function were determined. (eur.nl)
  • Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue and can affect more than one body system simultaneously. (merck.com)
  • Cumulative evidence now also supports a role for alcohol-induced immune alterations, in particular inflammation, in a wide range of alcohol related illnesses involving organ or tissue injury. (nih.gov)
  • Moreover, it reflects tissue hypoxia and alterations in cellular metabolism, leading to organ dysfunction. (biomedcentral.com)
  • A susceptible individual may undergo anesthesia with MH-triggering agents on multiple occasions without incident but may still react to such agents on a subsequent occasion. (medscape.com)
  • The physiological symptoms of ricin poisoning depend on the method and timing of administration, as well as the dosage. (bioedonline.org)
  • Each year, NIOSH collaborates with the staff of CDC's Mortality and Morbidity Weekly Report (MMWR ) to publish the most recent annual statistics , NIOSH analyses of occupational illness and injuries, and investigations of occupational hazards. (cdc.gov)
  • U.S. Occupational Safety and Health Administration. (cdc.gov)
  • NIOSH is also collaborating with the Occupational Safety and Health Administration (OSHA) and its stakeholders, including the NORA Construction Sector Council, in the " Safety Pays, Falls Cost" Campaign to Prevent Falls in Construction . (cdc.gov)
  • Cardiovascular Diseases (CVD) have become one of the major causes of mortality and morbidity over the last three decades. (grandviewresearch.com)
  • Coronary artery disease, arrhythmias, peripheral vascular disease, heart failure, and congenital heart defects are the major cardiovascular diseases prevalent across the globe. (grandviewresearch.com)
  • Shock is a manifestation of acute circulatory failure, in which the circulatory system fails to provide cells/tissues with sufficient oxygenated blood to optimally perform their functions [ 1 ]. (biomedcentral.com)
  • According to DeVos (2018), diagnostic measures should include a series of intense laboratory tests that can predict the emergence of both mild and acute organ dysfunction. (ivoryresearch.com)
  • Without adequate treatment, the process may progress to multiple organ failure and death. (medscape.com)
  • Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
  • The mean serum concentrations of florfenicol alone were markedly lower when compared with florfenicol pre-treated with vit E after single and multiple dosing. (civilenvironjournal.com)
  • SARS-CoV-2 organising pneumonia: 'Has there been a widespread failure to identify and treat this prevalent condition in COVID-19? (notaakhirzaman.com)
  • MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
  • A substantial proportion of the remaining morbidity and mortality from vaccine-preventable diseases presently occurs among older adolescents and adults. (cdc.gov)