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  • mucosa
  • 17. An aqueous insulin solution for intranasal administration comprising an effective amount of insulin, glycyrrhetinic acid in an amount effective for enhancing permeation of said insulin across the nasal mucosa, and a basic salt of an amino acid as an adjuvant for dissolving said glycyrrhetinic acid. (google.com.au)
  • Intranasal administration may be preferable to oral for individuals experiencing nausea and/or vomiting, although it is primarily absorbed in the gut, not the nasal mucosa. (ox.ac.uk)
  • placebo
  • In Part B subjects were randomized to receive a single intranasal dose of 15 mg ketorolac tromethamine containing 0% lidocaine hydrochloride into one nostril and either placebo or a single intranasal dose of 15 mg ketorolac tromethamine containing 0%, 4% or 6% lidocaine hydrochloride into the other nostril. (clinicaltrials.gov)
  • SELECTION CRITERIA: We included randomised, double-blind, placebo- and/or active-controlled studies using intranasal sumatriptan to treat a migraine headache episode, with at least 10 participants per treatment arm. (ox.ac.uk)
  • MAIN RESULTS: Twelve studies (4755 participants) compared intranasal sumatriptan with placebo or an active comparator. (ox.ac.uk)
  • delivery
  • Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K. Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease. (rush.edu)
  • In the present study, we examined the effect of intranasal delivery of the TLR7 agonist, imiquimod or its topical formulation Aldara, on the inflammation and pathogenesis caused by IAV infection. (flu.org.cn)
  • responses
  • The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. (edu.au)
  • effective
  • We concluded that intranasal imiquimod facilitates a more effective immune response, which can limit the pathology associated with influenza A virus infection. (flu.org.cn)
  • regulatory cells
  • Intranasal supplementation of L. paracasei NCC2461 was more potent than intragastric application in limiting the allergic response and possibly linked to an increase in T regulatory cells in the lungs. (hindawi.com)
  • avoid
  • To avoid pain and anxiety caused by IM injections in children, intranasal route have been evaluated for the induction of sedation or analgesia. (ivsajournals.com)
  • Study
  • This is the first study to explore the absorption of AR, and comprehensively analyze the absorbed constituents after intranasal administration of TCM. (mdpi.com)
  • This is an open-label, multicenter study designed to assess the safety of intranasal administration of 400 μg of fluticasone propionate twice a day delivered by the OptiNose device in subjects with chronic sinusitis with or without nasal polyps. (clinicaltrials.gov)
  • lung
  • Then, the coumarin distribution after MPEG-PCL-Tat administration in non-targeted tissues (lung, liver, heart, kidney and spleen) was lower than that after coumarin administration without nanomicelles. (springer.com)