AntimetaboliteAntimetabolitesAdverse effectsFludarabineDrugsChemotherapeutic agentsAntiemeticIndicationsAntibodiesDoseInjectionChemotherapy agentsSystemic administrationRadiotherapyCyclophosphamideCisplatinTesticular cancerPrecautionsUrineMedication errorsParenteral administrationCytotoxic chemotherapyConcomitantPharmacologicalIntravenous administrationTreatmentOccupational Safety and HeaPatients with relapsed or refractoryVaccinesImmuneAlkylatingSubcutaneousTherapyCancerOralDosesOncologyIrinotecanMetronomicFood and Drug AdminDescribeHealthDefineBacteriaCell
Antimetabolite1
- Antimetabolite antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
Antimetabolites2
- It belongs to a class of drugs known as antimetabolites and is considered as a cytotoxic chemotherapy agent. (gminsights.com)
- Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
Adverse effects1
- Like other folate antagonists, pemetrexed may cause various adverse effects such as nausea, vomiting, fatigue, diarrhea, anorexia, rashes and bone marrow suppression when used as a single agent. (admaconcology.com)
Fludarabine3
- Prior therapy with alkylating agents and fludarabine. (pocketdrugguide.com)
- Patients relapsed after or were refractory to alkylating agents and failed to achieve a PR with their last fludarabine-based therapy. (pocketdrugguide.com)
- FLUDARA (fludarabine) FOR INJECTION should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. (rxlist.com)
Drugs5
- Our studies suggest that investigational drugs such as TAK-285 that have strong antitumor activity and are not Pgp substrates may be useful in the development of agents with the potential to treat brain metastases. (jcancer.org)
- or may result from the systemic administration of cytotoxic drugs, e.g., antineoplastic agents, which damage not only tumor cells, but all rapidly dividing normal cell populations. (dentalcare.com)
- It has also been used as a chemical intermediate in the textile industry to impart wash and wear properties to fabrics, as a cosolvent with drugs, and, for a brief period, as an antineoplastic agent for the treatment of chronic leukemia and multiple myeloma. (nih.gov)
- The risks associated with the compounding and administration of hazardous drugs are well known and documented. (equashield.com)
- 7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)
Chemotherapeutic agents2
- The exact biological mechanism(s) by which the BBB limits drug exposure is not clear, but in addition to epithelial tight junctions, enhanced efflux of chemotherapeutic agents out of the CNS space by endothelial cell membrane transporters in brain blood vessels plays a primary role ( 2 ). (jcancer.org)
- Caution: Irinotecan should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. (rxmed.com)
Antiemetic1
- Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
Indications2
- Although the US Food and Drug Administration (FDA) has approved this agent only for the treatment of testicular cancer, it has several off-label indications, including treatment of cervical cancer. (medscape.com)
- There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
Antibodies1
- Administration of long acting (defined as administered once per week or less frequently) immunosuppressants, including monoclonal antibodies since birth and/or planned use at any time during the study period. (who.int)
Dose7
- These findings indicate that, the continuous low-dose administration of GEM and GEM+CDDP can promote tumorigenesis and tumor progression in vivo by inhibiting apoptosis, mobilizing BMDCs, and promoting angiogenesis in certain dose ranges. (researchsquare.com)
- These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
- This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
- However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)
- Urethane in combination with ethanol was nominated by the U.S. Food and Drug Administration for in-depth toxicological evaluation by the NTP because of the widespread exposure to urethane in alcoholic beverages and a lack of adequate dose-response carcinogenicity data to conduct meaningful risk assessments. (nih.gov)
- Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)
- refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
Injection3
- It is formulated as injection solution, concentrate solution for intravenous route o administration. (globaldata.com)
- Alteplase may be administered as the reconstituted 1 mg/mL solution or further diluted immediately prior to administration in an equal volume of 0.9% Sodium Chloride Injection or 5% Dextrose Injection to a concentration of 0.5 mg/mL. (pdr.net)
- Known hypersensitivity to bupivacaine or to any local anesthetic agent of the amide-type or to other components of bupivacaine hydrochloride injection. (nih.gov)
Chemotherapy agents3
- Alkylating chemotherapy agents inhibit cell growth and proliferation. (medscape.com)
- BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC). (lu.se)
- The use of two or more chemotherapy agents is referred to as combination therapy 6. (studylib.net)
Systemic administration2
- Most antineoplastic agents have limited access to the central nervous system (CNS) following systemic administration. (jcancer.org)
- These transport systems are responsible for the rapid removal of therapeutic agents from the CNS following local or systemic administration and thus contribute to relatively ineffective concentrations in the brain that characterize many antineoplastic agents. (jcancer.org)
Radiotherapy2
- This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. (scirp.org)
- Abnormal function of the immune system resulting from clinical conditions, or administration of antineoplastic and immunomodulating agents or radiotherapy for any duration from birth or autoimmune disorders (including, but not limited to: blood, endocrine, hepatic, muscular, nervous system or skin autoimmune disorders) or immunodeficiency syndromes (including, but not limited to: acquired immunodeficiency syndromes and primary immunodeficiency syndromes). (who.int)
Cyclophosphamide2
- Cyclophosphamide is an alkylating agent. (pocketdrugguide.com)
- Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)
Cisplatin2
- Cisplatin is the agent used most commonly, although 5-fluorouracil also is used frequently. (medscape.com)
- For patients with metastatic disease, cisplatin remains the most active agent. (medscape.com)
Testicular cancer1
- IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. (guidelinecentral.com)
Precautions1
- Describe administration guidelines, monitoring and precautions for antineoplastic chemotherapeutic and biotherapeutic agents. (aphon.org)
Urine2
- NOVANTRONE â may impart a blue-green color to the urine for 24 hours after administration, and patients should be advised to expect this during therapy. (pharmacycode.com)
- In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)
Medication errors2
- American Society of Health-System Pharmacists: ASHP guidelines on preventing medication errors with antineoplastic agents. (ons.org)
- To reduce the potential for fatal medication errors due to incorrect route of administration proper dilution, product labeling and packaging is necessary. (drugs.com)
Parenteral administration2
- Before parenteral administration, the substance must be completely dissolved. (guidelinecentral.com)
- Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)
Cytotoxic chemotherapy1
- BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
Concomitant2
- Comment: Concomitant administration increases risk of agranulocytosis. (medscape.com)
- Overdosage (possibly occurring with trimetrexate doses above 90 mg/m2 without concomitant administration of calcium folinate): after stopping trimetrexate, calcium folinate 40 mg/m2 IV every 6 hours for 3 days. (janusinfo.se)
Pharmacological1
- One of the primary reasons for restricted drug access to the CNS is the blood-brain barrier (BBB), which limits the exposure to the CNS and, therefore limits the effectiveness of pharmacological agents in neuronal tissue. (jcancer.org)
Intravenous administration2
- This is reflected in a number of outbreaks of viral hepatitis and bacterial bloodstream infections that resulted from breaches in basic infection prevention practices (e.g., syringe reuse, mishandling of intravenous administration sets) [7-10]. (cdc.gov)
- Pemibenz lyophilized powder offers a rapid and enhanced dissolution which ultimately provides ease of intravenous administration. (admaconcology.com)
Treatment7
- Bleomycin sulfate is an antineoplastic agent used for the treatment of lymphomas, testicular tumors, and squamous cell carcinoma. (dentalcare.com)
- Sex hormones used only in the treatment of neoplastic diseases (often selected strengths) are classified in L - Antineoplastic and immunomodulating agents. (whocc.no)
- Clinical Trials: Data from 3 single-agent studies, involving a total of 304 patients support the use of irinotecan in the treatment of patients with metastatic cancer of the colon or rectum that has recurred or progressed following treatment with 5-FU-based therapy. (rxmed.com)
- It is classified as a disease-modifying anti-rheumatic drug (DMARD) when used for autoimmune diseases and as a chemotherapeutic agent for cancer treatment. (gminsights.com)
- Because of this peculiar way of administration, MC can be viewed as a form of long-term 'maintenance' treatment, and can be integrated with standard and conventional chemotherapy in a 'chemo-switching' strategy. (unica.it)
- 14 However, a 1999 study that examined surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United States found measurable amounts of antineoplastic agents in 75% of pharmacy samples and 65% of the administration samples. (equashield.com)
- Nursing Interventions/Patient Teaching Evaluation Monitor labs (CBC, blood urea nitrogen [BUN], creatinine, liver panel, and electrolytes) before drug administration and during treatment. (studylib.net)
Occupational Safety and Hea2
- In 1981, the Occupational Safety and Health Administration cited a northern California hospital for failure to provide protection to pharmacists preparing chemotherapy. (equashield.com)
- q A commemoration of the 35th anniversary of the occupational safety and health act which established both NIOSH and the Occupational Safety and Health Administration (OSHA). (cdc.gov)
Patients with relapsed or refractory1
- Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)
Vaccines1
- Remind patients to consult with a health care provider before administration of any vaccines. (studylib.net)
Immune1
- This agent also participates in the breakage of chromosomes and modulation of immune response. (medscape.com)
Alkylating1
- Prior therapy with alkylating agents either alone or in combination. (pocketdrugguide.com)
Subcutaneous1
- BT-ON014 trade name] intravenous formulation is not intended for subcutaneous administration and should be administered via an intravenous infusion only. (who.int)
Therapy2
- This agent is used in combination with radiation therapy. (medscape.com)
- American Society of Clinical Oncology: Criteria for facilities and personnel for the administration of parenteral systemic antineoplastic therapy. (ons.org)
Cancer7
- This request asked NIOSH to evaluate the efficacy of exposure controls during the administration of an experimental antineoplastic agent, 9-nitrocamptothecin (9-NC), to cancer patients, as an aerosol through breathing treatments. (cdc.gov)
- The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
- Adherence to ASCO and ONS standards for safe chemotherapy administration should be a goal of all providers of adult cancer care. (ons.org)
- Clinical Oncological Society of Australia: Guidelines for the Safe Prescribing, Dispensing and Administration of Cancer Chemotherapy. (ons.org)
- 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
- la prise en charge du cancer col métastatique s'est enrichie depuis 2017 par la disponibilité des thérapies ciblées dans notre pays. (bvsalud.org)
- Cette étude avait pour objectifs de déterminer les caractéristiques épidémiologiques, cliniques et thérapeutiques des patientes prises en charge pour cancer du col métastatique dans notre structure. (bvsalud.org)
Oral3
- It is formulated as film-coated tablets for the oral route of administration. (pharmaceutical-technology.com)
- Absorption following oral administration is rapid. (pharmacycode.com)
- Prolonged oral antimicrobial administration prevents. (ncsu.edu)
Doses2
- During the NIOSH evaluation, experimental work was in the clinical trial stage, and the doses and administration method were agreed upon by the Food and Drug Administration (FDA) as part of their approval process. (cdc.gov)
- While maximum doses of 7 mg/kg (550 mg) have been administered without adverse effect, these are not recommended, except in exceptional circumstances and under no circumstances should the administration be repeated at intervals of less than 1 1/2 hours. (pfizermedicalinformation.com)
Oncology2
- In 2008, the American Society of Clinical Oncology (ASCO) and the Oncology Nursing Society (ONS) invited a broad range of stakeholders to create a set of standards for the administration of chemotherapy to adult patients in the outpatient setting. (ons.org)
- Shulman LN, Miller RS, Ambinder EP, et al: Principles of safe practice using an oncology EHR system for chemotherapy ordering, preparation, and administration, part 1 of 2. (ons.org)
Irinotecan3
- Early diarrhea (occurring during or within 24 hours of irinotecan administration) may be preceded by sweats and abdominal cramping. (rxmed.com)
- Late diarrhea (occurring more than 24 hours after irinotecan administration) can be prolonged. (rxmed.com)
- Irinotecan HCl trihydrate is an antineoplastic agent of the topoisomerase I inhibitor class. (rxmed.com)
Metronomic1
- Metronomic chemotherapy (MC) refers to the close administration of a chemotherapeutic drug for a long time with no extended drug-free breaks. (unica.it)
Food and Drug Admin2
- Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
- Food and Drug Administration. (rxwiki.com)
Describe1
- Describe INS and ONS standards of practice related to vesicant administration. (pedagogyeducation.com)
Health2
- the researchers were interested in evaluating the potential for exposure to health care workers during administration of the drug. (cdc.gov)
- NIOSH along with the State of West Virginia and the Mine Safety and Health Administration (MSHA) will cosponsor an international Mining Health and Safety Symposium April 20-22 at Wheeling Jesuit University in Wheeling, WV. (cdc.gov)
Define1
- 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 1 Define the following terms: 1. (studylib.net)
Bacteria1
- 21,22,24 Antibacterial agents kill bacteria allowing candidal species to successfully compete for nutrients. (dentalcare.com)
Cell3
- Antimicrotubular antineoplastic agents prevent cell growth and proliferation. (medscape.com)
- These agents inhibit cell growth and proliferation. (medscape.com)
- These agents alkylate DNA bases, thereby producing "cross-links" that covalently link the two DNA strands and prevent cell replication. (pocketdrugguide.com)