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  • hybridomas
  • Enhancing lysosomal proteolysis by the presence of protease-specific cleavage sites ( 12 ) or by destabilizing proteins also favored presentation to T cell hybridomas ( 13 - 15 ). (rupress.org)
  • viral
  • This viral protein not only confers structural stability and homogeneity to virosome-based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. (wikipedia.org)
  • However, the classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the case of HIV-1. (wikipedia.org)
  • sequence
  • Although CSPs share no sequence similarity with OBPs, these two groups of carrier proteins are characterized structurally by a hydrophilic surface and a hydrophobic core, respectively, to make them soluble in the sensillar lymph and to enable them to bind and carry olfactory ligands. (thefreedictionary.com)
  • binds
  • A generic term for a protein that reversibly binds to various small molecules, including amino acids, sugars, inorganic ions, vitamins and other molecules. (thefreedictionary.com)
  • The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. (wikipedia.org)
  • molecules
  • In addition to this structural similarity the "Cip/Kip" proteins share the functional characteristic of being able to bind several different classes of Cyclin and Cdk molecules. (wikipedia.org)
  • Extracellular
  • Extracellular environmental factors also affect vesicle formation, either by regulating Gvp protein production or by directly disturbing the vesicle structure. (wikipedia.org)
  • Protein DAMPs include intracellular proteins, such as heat-shock proteins or HMGB1 (high-mobility group box 1), and proteins derived from the extracellular matrix that are generated following tissue injury, such as hyaluronan fragments. (wikipedia.org)
  • S100 is a multigenic family of calcium modulated proteins involved in intracellular and extracellular regulatory activities with a connection to cancer as well as tissue, particularly neuronal, injury. (wikipedia.org)
  • amino acids
  • Both encode large glycosylated proteins consisting of around 3400 amino acids and a molecular weight of around 390,000 Daltons, excluding the glycosylation. (wikipedia.org)
  • vesicle
  • Serratia sp, flagella-based motility and gas vesicle production are regulated oppositely by a single RNA binding protein, RsmA, suggesting alternate modes of environmental adaptation which would have developed into different taxons through regulation of the development between motility and flotation. (wikipedia.org)
  • Larger vesicles can hold more air and use less protein making them the most economic in terms of resource use, however, the larger a vesicle is the structurally weaker it is under pressure and the less pressure required before the vesicle would collapse. (wikipedia.org)
  • Organisms have evolved to be the most efficient with protein use and use the largest maximum vesicle diameter that will withstand the pressure the organism could be exposed to. (wikipedia.org)
  • There are at least two proteins that compose a cyanobacterium's gas vesicle: GvpA, and GvpC. (wikipedia.org)
  • albumin
  • 6) This is a significant number on its own, but the situation may be even worse when accounting for the fact that the majority of the hormone is bound to carrier proteins including sex hormone binding globulin (SHBG) and albumin and, as such, may not be available for tissues to use. (thefreedictionary.com)
  • nuclear
  • A subset of DAMPs are nuclear or cytosolic proteins. (wikipedia.org)
  • Transcription for p27 is activated by FoxO in response to cytokines, promyelocytic leukaemia proteins, and nuclear Akt signaling. (wikipedia.org)
  • This occurs when p27 is phosphorylated on Ser(10) which allows for CRM1, a nuclear export carrier protein, to bind to and remove p27 from the nucleus. (wikipedia.org)
  • ions
  • If the protein becomes denatured or if the copper ions are lost in the purification process, the opalescent blue color disappears and the solution becomes a dull grayish color. (wikipedia.org)
  • immune system
  • The cat can fight off the infection and become totally immune, can become a healthy carrier that never gets sick itself but can infect other cats, or a mid-level case in which the cat has a compromised immune system. (wikipedia.org)
  • induce
  • This antibody is able to induce an anti-idiotypic IgG response and B-T idiotypic cascade, even in the absence of any adjuvant or carrier protein. (hindawi.com)
  • The hapten-carrier complex, unlike free hapten, can act as an immunogen and can induce an immune response. (wikipedia.org)
  • Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types. (wikipedia.org)
  • Although it is thought that virus protein has to be present to induce lymphomas in cats, newer evidence shows that a high percentage of FeLV-Antigen negative lymphomas contain FeLV-DNA, indicating a "hit-and-run" mechanism of virus-induced tumor development. (wikipedia.org)
  • residues
  • In doing so p27Kip1 inhibits the catalytic activity of Cdk4, which means that it prevents Cdk4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein. (wikipedia.org)
  • cell
  • 2. A membrane protein for facilitated diffusion of a specific substance into a cell. (thefreedictionary.com)
  • Purple Halobacterium species owe their color to bacteriorhodopsin, a light-sensitive protein which provides chemical energy for the cell by using sunlight to pump protons out of the cell. (wikipedia.org)
  • The resulting proton gradient across the cell membrane is used to drive the synthesis of the energy carrier ATP. (wikipedia.org)
  • It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle. (wikipedia.org)
  • Increased levels of the p27Kip1 protein typically cause cells to arrest in the G1 phase of the cell cycle. (wikipedia.org)
  • Protein levels continue to fall rapidly as the cell continues through G1 and enters S phase. (wikipedia.org)
  • Although RB1 interacts with over 100 cell proteins, its negative regulator effect on the cell cycle principally arises from binding and inactivation of the transcription factor E2F, thus repressing the transcription of genes which are required for the S phase. (wikipedia.org)
  • often
  • and Transfer of mycolic acids to arabinogalactan and other acceptors such as trehalose via the antigen 85 complex The fatty acid synthase-I and fatty acid synthase-II pathways producing mycolic acids are linked by the beta-ketoacyl-(acyl-carrier-protein) synthase III enzyme, often designated as mtFabH. (wikipedia.org)
  • Asymptomatic carriers will show no signs of disease, often for many years. (wikipedia.org)
  • thus
  • In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms. (wikipedia.org)
  • cells
  • This approach is used because there is a unique protein called an "idiotype" expressed exclusively on the cancerous B-cells. (wikipedia.org)
  • The chromatin-associated protein high-mobility group box 1 (HMGB1) is a prototypical leaderless secreted protein [LSP] secreted by hematopoietic cells through a lysosome-mediated pathway. (wikipedia.org)
  • different
  • For the new study, the researchers investigated how 20 different carrier protein/adjuvant combinations worked, including shelf stability based on temperature and storage time and whether the formulation was a liquid or powder. (scripps.edu)
  • Antigen
  • The antigen cannot elicit the immune response without the help of an immunologic adjuvant. (wikipedia.org)
  • It has been shown that a physical association between the virosome and the antigen of interest is necessary for the full adjuvant effect of virosomes. (wikipedia.org)
  • and Transfer of mycolic acids to arabinogalactan and other acceptors such as trehalose via the antigen 85 complex The fatty acid synthase-I and fatty acid synthase-II pathways producing mycolic acids are linked by the beta-ketoacyl-(acyl-carrier-protein) synthase III enzyme, often designated as mtFabH. (wikipedia.org)
  • clinical
  • Join us in February 2019, as SMi's RNA Therapeutics Conference brings together industry experts from leading RNA therapeutics companies to discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies , and present an overview of the applications of RNA-based drugs for modulation of gene and protein expression, and genome editing. (smi-online.co.uk)
  • Additionally, overexpression of TP53 is associated with better clinical outcome whereas an absence of the p53 protein is linked to an increased risk of HGSC tumour recurrence. (wikipedia.org)
  • family
  • This interest has been fueled in part by the recent discovery of a family of highly conserved pattern recognition receptor proteins known as Toll-like receptors (TLRs) believed to be involved in innate immunity as receptors for pathogen- associated molecular patterns (PAMPs). (allindianpatents.com)
  • treatment
  • Since this medication is safe, inexpensive, and with low unwanted effects, it could be considered as a satisfactory choice or adjuvant treatment to opioid analgesics in renal colic . (biobeds.info)
  • formation
  • The use of reconstituted virally derived proteins in the formation of the virosome allows for the utilization of what would otherwise be the immunogenic properties of a live-attenuated virus, but is instead a safely killed virus. (wikipedia.org)
  • present
  • He argues that the vital microbial exposures are not colds, influenza, measles and other common childhood infections which have evolved relatively recently over the last 10,000 years, but rather the microbes already present during mammalian and human evolution, that could persist in small hunter gatherer groups as microbiota, tolerated latent infections or carrier states. (wikipedia.org)
  • test
  • The technique is particularly useful in performing immunoassays for protein analytes, such as a glycosylated protein, in aqueous test samples. (google.com)
  • important
  • In dealing with protein pre-formulation, the important aspect is to understand the solution behavior of a given protein under a variety of stress conditions such as freeze/thaw, temperature, shear stress among others to identify mechanisms of degradation and therefore its mitigation. (wikipedia.org)
  • either
  • The genetic variant(s) can be inherited from either the father or the mother, and can be passed along to both sons (who may be asymptomatic carriers or may have symptoms such as early baldness and/or excessive hair) and daughters, who will show signs of PCOS. (wikipedia.org)
  • claim
  • 64. A pharmaceutical composition comprising the binding compound of claim 47 in combination with a pharmaceutically acceptable carrier or diluent. (patentsencyclopedia.com)