• Surgical resection is the predominant treatment method for this disease, and negative margins must be achieved to improve survival rate ( 1 , 3 , 4 ). (spandidos-publications.com)
  • The standard GBM treatment includes surgical resection with adjuvant radiotherapy and chemotherapy 2 . (nature.com)
  • Patients with low-grade pineocytomas can be observed cautiously after complete surgical resection without adjuvant radiation because no clear evidence shows that radiotherapy is beneficial. (medscape.com)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • [1] It is also relatively resistant to chemotherapy and radiotherapy, and the most effective therapy is complete surgical resection. (ganzemedizin.at)
  • Surgical resection and adjuvant therapy have limited effects on the overall survival of PDAC patients. (biomedcentral.com)
  • Furthermore, chemotherapy and radiotherapy have not substantially improved the survival of patients over the last several years [ 4 ]. (biomedcentral.com)
  • Current treatment protocols for patients older than 3 years who have malignant pineal region tumors include radiotherapy. (medscape.com)
  • Since 1953, at least 35 cases of radiation-induced meningioma have been reported in children after radiotherapy for pineal region tumors. (medscape.com)
  • Standard radiotherapy protocols for children with malignant pineal cell tumors use 4000 cGy of whole brain radiation followed by 1500 cGy to the pineal region. (medscape.com)
  • For children with malignant germ cell tumors, standard treatment is focal radiotherapy followed by radiation to the ventricular field. (medscape.com)
  • Craniospinal radiotherapy for nongerminomatous germ cell tumors is controversial but used routinely in some countries. (medscape.com)
  • As with radiotherapy, the response to chemotherapy for patients with pineal region tumors varies according to tumor histology. (medscape.com)
  • Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. (aacrjournals.org)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • They treated 61 patients, 40 with adjuvant androgen deprivation therapy, 23 also received radiation to the pelvic lymph nodes. (prostatecancer.news)
  • Among those 391 men who started on RP, 14 (4%) had adjuvant or salvage radiation, and 1 went on lifelong androgen deprivation therapy (ADT) within a year. (prostatecancer.news)
  • Surgical excision, radiotherapy, and/or systemic treatments can be selected depending on patient's status and tumour stage. (unav.edu)
  • The excision of the clipped node (92.0%), use of dual tracer (73.2%), and axillary US (65.9%) after treatment were the most important variables considered by respondents, to increase the accuracy of SLNB in cN + patients. (unav.edu)
  • SRT with a BED value of 30 Gy delivered to keloidectomy excision sites immediately following excision was well-tolerated and resulted in markedly fewer long-term recurrences than reported following keloidectomy alone. (jcadonline.com)
  • Calibration appeared acceptable for the clinical trial patient-based MC calculator, but restricted tool applicability (stage III patients, ≥12 examined lymph nodes, receiving adjuvant treatment) limited the sample size. (edu.au)
  • CD1d blockade restored the number of DC in WT mice, improved T cell priming in draining lymph nodes and significantly enhanced response to treatment. (biomedcentral.com)
  • Nivolumab was started as an adjuvant therapy on the 2nd postoperative months. (bvsalud.org)
  • Patients from the intervention groups of two separate randomized controlled trials were included: patients with breast cancer receiving neoadjuvant chemotherapy (n=74) and patients with locally advanced prostate cancer receiving treatment with radiotherapy (n=75). (jmir.org)
  • The current treatments for melanoma are surgery, which is performed in the early stages of the disease, and neoadjuvant treatments for advanced patients, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and combination therapy [ 2 , 3 ]. (medsci.org)
  • neoadjuvant or adjuvant chemotherapy can be considered as well. (jhoponline.com)
  • 10 Although effective, such treatments are not curative, and the use of chemotherapy for cutaneous angiosarcoma in the neoadjuvant and adjuvant settings has not been investigated in a randomized clinical trial. (jhoponline.com)
  • A more pronounced enlargement in plasma PHT concentrations in comparison to CSF concen- trations with increasing always doses were observed ample to a cut upper run to the leader as a result of the autoinduction exerted by way of PHT. (daubnet.com)
  • Surgical techniques and adjuvant chemotherapy have markedly improved the prognosis of patients with hepatoblastoma. (medscape.com)
  • Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)
  • Prognosis after progression of a HGG remains poor, with an unmet need to improve therapy. (surgicalneurologyint.com)
  • However, even if an R0 resection is achieved, the local recurrence rate remains markedly high. (spandidos-publications.com)
  • S-1 was started as adjuvant chemotherapy, and she remains alive without recurrence 8 months after surgery. (bvsalud.org)
  • It was found that in noninvasive bladder cancer, administering intravesical bacillus Calmette-Guérin (BCG) would delay tumor recurrence, and some studies suggested that BCG actually improves survival. (ascopost.com)
  • Targeting JMY could thus open the way to the development of new therapeutic strategies to improve the efficacy of radiotherapy and prevent glioma recurrence. (nature.com)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
  • To determine if the improved response to treatment in the absence of iNKT cells was independent from the immunotherapy employed, 4T1-tumor bearing WT and iNKT −/− mice were treated with local radiotherapy in combination with antibody-mediated CD137 co-stimulation. (biomedcentral.com)
  • Since survival rates markedly increased over the last 4 decades, leading to 70%-85% of cure rate in pediatric patients with medulloblastoma or PNET [ 3 ], regular monitoring of long-term complications related to radiotherapy and chemotherapy is needed to improve quality of life. (e-apem.org)
  • 5 Cutaneous angiosarcomas are typically markedly infiltrative through the dermis and deeper tissues. (jhoponline.com)
  • Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
  • While there were no differences in 10-year mortality when patients were randomized to surgery (RP), external beam radiotherapy (EBRT), and active surveillance (AS) ( see this link ), the side effects patients suffered from those treatments differed markedly. (prostatecancer.news)
  • [1] Thus metronomic therapies, which are known to be directed toward the tumor microenvironment [2] may play an important role in improving the outcome of patients with CCa. (ganzemedizin.at)
  • I collaborate with Stanford scientists to detect this disease earlier, and with our breast and lung oncologists to improve outcomes for patients. (stanford.edu)
  • PURPOSE: As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. (bvsalud.org)
  • Adjuvant treatment as well as postoperative follow-up should be chosen carefully. (cancernetwork.com)
  • Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. (unav.edu)
  • High-grade glioma (HGG) are optimally treated with maximum safe surgery, followed by radiotherapy (RT) and/or systemic chemotherapy (CT). (surgicalneurologyint.com)
  • A combination of conservative surgery and careful patient selection for nodal radiotherapy may reduce the incidence of postmastectomy lymphedema ( 8 ), particularly when these therapies are combined with sentinel node biopsy, but their impact on the incidence of postsurgical lymphatic insufficiency has not yet been adequately assessed. (snmjournals.org)
  • Anal cancer is a rare disease, but its incidence has been increasing steadily. (bvsalud.org)
  • however, its incidence has been steadily increasing. (bvsalud.org)
  • Melanoma is the most malignant and lethal skin tumor owing to its high metastatic ability and the incidence of melanoma has been increasing over the years. (medsci.org)
  • The survival rate of melanoma patients with increasing stage ranges from 85% to 25% due to the high incidence of metastasis [ 1 ]. (medsci.org)
  • Incidence has remained steady over the last 8 years (it had previously been increasing at a faster rate than any other malignant tumor). (msdmanuals.com)
  • Using mobile technology for symptom management and self-care can improve patient-clinician communication and clinical outcomes in patients with cancer. (jmir.org)
  • Early clinical trials of patients treated with radiotherapy reported significant mortality. (medscape.com)
  • We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). (e-apem.org)
  • This issue is extremely relevant given the growing number of clinical trials testing the ability of radiotherapy to increase the efficacy of ICBs. (aacrjournals.org)
  • Here, we discuss the rationale for an optimized use of radiotherapy as well as candidate biomarkers that may predict clinical responses to radiotherapy combined with ICBs. (aacrjournals.org)
  • Our analyses of blood, tissue, and/or fluids may lead to improved diagnosis and treatment of cancer by the identification of markers that predict clinical outcome, markers that predict response to specific therapies, and the identification of targets for new therapies. (stanford.edu)
  • The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti-CTLA-4 treatment. (aacrjournals.org)
  • Due to improved diagnostic tools as well as the establishment of various adjuvant treatment options, the mortality of testicular cancer generally decreased in the last decades. (cancernetwork.com)
  • Among the patients treated for prostate cancer, higher age ( P =.01) and higher education level ( P =.04), predicted an increase in total views on self-care advice, while higher comorbidity ( P =.004) predicted a decrease in total views on self-care advice. (jmir.org)
  • The aim of the present study was to eluci- date the biology and prognostic role of the second ER, ERh, in patients treated with adjuvant tamoxifen. (lu.se)
  • She underwent a radical mastectomy with adjuvant chemotherapy, consisting of carboplatinum and gemcitabine, and consecutive radiotherapy. (bjmo.be)
  • The disease free interval gradually shortened with increasing numbers of recurrences. (biomedcentral.com)
  • Ten treated keloidectomy sites (10.4%) had recurrences (i.e., presence of any new tissue growth on the surgical scar) within 12 months increasing to 11 (12.7%) at 18 months. (jcadonline.com)
  • Bloom syndrome, a rare autosomal recessive genetic disorder caused by biallelic mutations in the BLM gene, is associated with a markedly increased risk of developing a variety of cancers at a young age (most commonly leukaemia, lymphomas and gastrointestinal tract tumours). (bjmo.be)
  • CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterial-derived adjuvant VSSP. (researchsquare.com)
  • This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
  • It is estimated that the 9vHPV vaccine can increase prevention of cervical high-grade squamous intraepithelial lesions in up to 90% of cases compared with the quadrivalent HPV vaccine. (medscape.com)
  • Pseudotumor cerebri (also known as idiopathic intracranial hypertension) is a syndrome of increased intracranial pressure without a discernable cause. (aetna.com)
  • Because CAR T-cell-induced brainstem inflammation can result in obstructive hydrocephalus, increased intracranial pressure, and dangerous tissue shifts, neurocritical care precautions were incorporated. (stanfordchildrens.org)
  • The radiotherapy treatment usually consists of five consecutive sessions of 2 Gy rate per week for six weeks, the total treatment being 60 Gy 2 . (nature.com)
  • Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. (oaepublish.com)
  • Surgery is the only treatment that can cure pancreatic adenocarcinoma, and may also be done to improve quality of life without the potential for cure. (wikipedia.org)
  • The investigators concluded that optic nerve decompression surgery is not an effective treatment for NAION, and in fact, may increase the risk of progressive visual loss in NAION patients. (aetna.com)
  • Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
  • Patients with a personal history of melanoma have an increased risk of additional melanomas. (msdmanuals.com)
  • People who have one or more first-degree relatives with a history of melanoma have an increased risk (up to 6 or 8 times) over those without a family history. (msdmanuals.com)
  • The median overall survival (OS) is merely 14.6 months with the majority of patients surviving less than two years, even with the current standard of care with maximal surgical debulking followed by adjuvant radiotherapy and oral temozolomide [ 1 , 2 ]. (oncotarget.com)
  • As modern improvements in surgical and adjuvant therapy are reflected in long-term survival, the rates of spinal metastasis will likely drop significantly, making the need for spinal irradiation obsolete. (medscape.com)
  • As yet, there is uncertainty about the correct management of this rare and aggressive type of cancer, but there is growing evidence that adjuvant platinum-based regimens, especially cisplatinum, might be effective in inducing long-term complete remission. (bjmo.be)
  • In contrast, efforts to improve the current standard of care of newly diagnosed glioblastoma (GB) with, for example, the addition of bevacizumab (BEV), have been largely disappointing and furthermore molecular characterization has not changed therapy except in elderly patients. (surgicalneurologyint.com)
  • [ 1 , 3 ] A statistically significant improvement in overall survival (OS) and an increase in the rate of tumor shrinkage was shown in women treated with bevacizumab plus chemotherapy compared with chemotherapy alone. (medscape.com)
  • Angiogenesis is the formation of new blood vessels from the existing vasculature, and it is significantly increased during tumor development with the aim to supply nutrients and oxygen that support the high rate proliferation of tumor cells. (researchsquare.com)
  • It also did not differ significantly whether they received adjuvant ADT (55% did). (prostatecancer.news)
  • SBRT boost therapy seems to increase toxicity significantly more than SBRT monotherapy. (prostatecancer.news)
  • Improving lifelong health one pregnancy at a time. (ehd.org)
  • Adjuvant chemotherapy, with any regimen, remains unproven, with only modestly improved survival trends despite decades of study. (ascopost.com)
  • The role of adjuvant radiotherapy and chemotherapy remains uncertain and use of hormonal therapy has not been fully investigated. (hindawi.com)
  • An ERh gene expression profile was identified and was markedly different from the ERa signature. (lu.se)
  • Surprisingly, we previously found that mice deficient in iNKT cells developed spontaneous CD8 + T cells responses partially effective at inhibiting metastases in mice bearing the 4T1 mammary carcinoma, and showed a markedly improved response to treatment with local radiotherapy and anti-CTLA-4 antibody compared to wild type (WT) mice. (biomedcentral.com)
  • The effects of antibody-mediated blockade of CD1d on DC number and phenotype, priming of anti-tumor T cells, and tumor response to treatment with local radiotherapy and anti-CTLA-4 antibody were evaluated. (biomedcentral.com)
  • 12-18 months of adjuvant ADT were used in both groups. (prostatecancer.news)
  • And it was given together with short term (3-6 months) of ADT, which would certainly increase the early sexual side effects. (prostatecancer.news)
  • Appropriate literature justifying a combination of biological treatment with chemotherapeutic agents to improve the outcome of patients with CCa has been reviewed. (ganzemedizin.at)
  • Chemotherapy, as the most common and indispensable adjuvant therapy, is updated constantly with advances in research. (frontiersin.org)
  • Immunofluorescent staining further disclosed that Notch1 downregulation markedly increased the number of γH2AX foci and radiosensitized GBM cells. (oncotarget.com)
  • Recent data demonstrate that the recruitment of dendritic cells to neoplastic lesions (and hence the priming of tumor-specific CD8 + T cells) is highly dependent on radiotherapy dose and fractionation through a mechanism that involves the accumulation of double-stranded DNA in the cytoplasm of cancer cells and consequent type I IFN release. (aacrjournals.org)
  • Consistently, priming of T cells to a tumor-specific CD8 T cell epitope in mice treated with radiotherapy and anti-CTLA-4 or anti-CD137 was markedly enhanced in iNKT −/− compared to WT mice. (biomedcentral.com)
  • Our results demonstrate the utility for multi-feature survival calculators to improve OS predictions but highlight the importance for performance assessment of tools prior to implementation in an external health care setting. (edu.au)
  • R ecently,h ospital -Increase consciousness amongth e publicand U V th erapy h as beensurprisingly effective. (ehd.org)
  • These results may be highly clinically significant, because in the United States alone, f10,000 women are diagnosed annually with ERa-negative/ERh-positive breast carcinoma and may benefit from adjuvant tamoxifen. (lu.se)
  • The prerequisite results in increased end-organ feeling to low levels of circulating sex hormones and leads to untimely pubic whisker and breast development. (daubnet.com)