• The addition of radiotherapy significantly reduced the local recurrence rate from 55% (17 patients) to 3% (1 patient). (nih.gov)
  • Adjuvant radiotherapy reduced the risk of distant failure and death in patients with disease confined to the uterus but did not impact distant recurrence or survival in stage III patients. (nih.gov)
  • The relative risk of local recurrence of unirradiated patients versus irradiated patients was 17.54 (P = 0.0055) after adjusting for nuclear grade of the epithelial component. (nih.gov)
  • Brain metastasis is observed in 10% of breast cancer patients with metastatic properties Many of the breast cancer therapies (like targeted antibodies) fail to penetrate the blood-brain barrier, hence allowing for tumor recurrence in the central nervous system. (wikipedia.org)
  • The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
  • However, from 30% to 55% of patients who undergo surgery with curative intent ultimately experience recurrence and die from their disease. (medscape.com)
  • Targeting JMY could thus open the way to the development of new therapeutic strategies to improve the efficacy of radiotherapy and prevent glioma recurrence. (nature.com)
  • Targeted treatment with ribociclib plus hormone therapy provided significant invasive disease-free survival benefits in patients with early-stage hormone receptor-positive, HER2-negative breast cancer at risk of disease recurrence. (ascopost.com)
  • Two out of the three patients did not develop local recurrence or distant metastasis during the observation period. (hindawi.com)
  • However, recurrence was detected in the bladder of one patient 22 months after the treatment. (hindawi.com)
  • A sample size of 2100 patients provides an 80% power to detect a non-inferiority of 3% in the 5-year locoregional recurrence rate with a one-sided type I error of 2.5%, assuming that the locoregional recurrence rate in the control arm is 5% at 5 years (corresponding to a hazard ratio of 1.63). (authorea.com)
  • in the imaging control 3.5 years after the surgical resection, local recurrence was identified, and the patient was submitted to a local radiation protocol. (thieme-connect.de)
  • The evidence produced by these three well-conducted trials suggests that recurrence of a woman's cancer and her chances of dying from breast cancer are similar regardless of the order of the treatments, provided that both radiotherapy and chemotherapy are commenced within seven months of the surgery. (cochrane.org)
  • There were no significant differences between the various methods of sequencing adjuvant therapy for local recurrence-free survival, overall survival, relapse-free survival and metastasis-free survival based on 1166 randomised women in three trials. (cochrane.org)
  • However, recurrence is seen in 7-30% of patients. (bmj.com)
  • 2 These patients continue to attend general neurology clinics and, therefore, it is necessary that neurologists are alert to the possibility of a thymoma recurrence. (bmj.com)
  • We describe five patients with MG who had undergone a thymectomy but developed late recurrence of thymoma. (bmj.com)
  • At five years post-surgery, researchers found the recurrence of cancer in the breast was only 2.3 per cent without radiotherapy. (news-medical.net)
  • After surgery, patients may undergo adjuvant chemotherapy and/or radiotherapy to reduce the risk of recurrence. (sgh.com.sg)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • This may involve chemotherapy or radiotherapy to improve symptoms and reduce the tumour size. (sgh.com.sg)
  • Additional treatment in the form of chemotherapy or radiotherapy given after surgery to reduce the risk of the tumour coming back. (christie.nhs.uk)
  • We evaluated decision regret and physical and psychological well-being among breast cancer patients who underwent adjuvant radiotherapy and explored their associations with patient , tumor , treatment , and symptom characteristics. (bvsalud.org)
  • Over a 10-year period from January 2002 to December 2011, a total number of thirteen patients underwent a SLNB for nonmelanoma skin cancer at the University Hospital of Lausanne, Switzerland. (hindawi.com)
  • 21 patients (51%) underwent trimodal therapy with 655 days (63-2,567 days) of median follow-up. (smw.ch)
  • Patients who underwent oncoplastic breast surgery with curative intent from 2011 and 2012 were included in this study. (scielo.org.za)
  • evaluated quality of life scores in 350 patients who underwent BCS. (scielo.org.za)
  • The patient underwent a prompt right mastectomy with sentinel lymph node biopsy, which was negative for cancer spread. (gponline.com)
  • Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to December 2008. (cun.es)
  • Methods: Patients screened for inclusion underwent primary surgery of a histopathologically verified diffuse WHO grade II glioma in the time period 2012 through 2017. (lu.se)
  • Additionally, three patients with pigmented villonodular synovitis in the tibiotalar and subtalar joints who were successfully treated with arthroscopically assisted synovectomy are reported.Three patients with pigmented villonodular synovitis in the tibiotalar and subtalar joints underwent arthroscopically assisted synovectomy without adjuvant radiotherapy. (medscape.com)
  • Ottawa 0101 randomly assigned patients to neoadjuvant or concurrent versus concurrent or adjuvant short-term ADT. (wustl.edu)
  • Radiation Therapy Oncology Group 9413, a 2 × 2 factorial trial, included a random assignment of neoadjuvant or concurrent versus adjuvant short-term ADT. (wustl.edu)
  • The neoadjuvant or concurrent ADT arms of both trials were combined into the neoadjuvant group, and the arms receiving adjuvant ADT were combined into the adjuvant group. (wustl.edu)
  • Overall, 1,065 patients were included (531 neoadjuvant and 534 adjuvant). (wustl.edu)
  • Our findings favor use of an adjuvant over a neoadjuvant approach, without any increase in long-term toxicity. (wustl.edu)
  • Neoadjuvant IO has multiple theoretical advantages of over adjuvant IO," commented Carbone. (medscape.com)
  • 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
  • Patients from the intervention groups of two separate randomized controlled trials were included: patients with breast cancer receiving neoadjuvant chemotherapy (n=74) and patients with locally advanced prostate cancer receiving treatment with radiotherapy (n=75). (jmir.org)
  • The standard of care for patients with newly diagnosed GBM comprises maximum safe resection of the tumor followed by radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy [ 3 , 4 ]. (springer.com)
  • The standard GBM treatment includes surgical resection with adjuvant radiotherapy and chemotherapy 2 . (nature.com)
  • PRINCIPLES: Trimodal therapy results in long term survival in a small fraction of patients with malignant pleural mesothelioma, particularly in patients having epithelial histology, R0-resection and no nodal involvement. (smw.ch)
  • CONCLUSIONS: The majority of patients considered for surgical resection of malignant pleural mesothelioma have regionally advanced disease. (smw.ch)
  • Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. (smw.ch)
  • Following resection with radiotherapy increased survival rates for patients compared with those who did not receive the additional treatment. (curetoday.com)
  • Additionally, the complications of organ resection have more impact on patients. (spandidos-publications.com)
  • The patient received complete resection of the liposarcoma and the right kidney was preserved. (spandidos-publications.com)
  • One week later, the patient was submitted to subtotal tumor resection, and remained asymptomatic in the post-operative period. (thieme-connect.de)
  • Gross total resection followed by radiotherapy is the current standard of care. (thieme-connect.de)
  • Complete surgical removal forms the cornerstone of treatment regimes with adjuvant radiotherapy recommended in cases of incomplete resection. (bmj.com)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • Therefore, accurately diagnosing early GC and effectively treating AGC patients who have lost the chance of radical surgical resection are two serious health problems worldwide. (frontiersin.org)
  • A multimodal radiotherapy-containing approach is a well-tolerated component of treatment for patients with osteosarcomas undergoing programed resection, allowing low toxicity rates while maintaining high local control rates. (cun.es)
  • Tumor diameter, pelvic lymph node metastasis, vascular invasion, deep stromal invasion and close resection margins are most often used to target adjuvant treatment to those patients with highest risk of relapse [ 4 - 7 ]. (medsci.org)
  • Patients suffering glioblastoma have a short median overall survival time despite extensive surgical resection and adjuvant chemo- and radiotherapy. (lu.se)
  • The treatment of choice is surgical resection, with radiotherapy given postoperatively when poor prognostic factors are present. (bvsalud.org)
  • Studies addressing the effect of timing of RT on survival suffer from considerable bias, such as inhomogeneous patient populations, inhomogenous treatment protocols or disregard for tumor location, EOR, and RTV. (springer.com)
  • The purpose of this study was to evaluate the timing of RT as a prognostic factor on a homogeneous patient population with only newly diagnosed primary GBM treated with the same treatment scheme, also taking important prognostic factors such as tumor location, MGMT methylation status, EOR and RTV into account. (springer.com)
  • We retrospectively analyzed all adult patients with a newly diagnosed primary GBM treated according to the EORTC 22981/26981 protocol [ 3 ] at the Brain Tumor Center of the University Hospital of Cologne, Germany between 2010 and 2015. (springer.com)
  • Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes. (rush.edu)
  • Chondrosarcoma is the most common primary malignant bone tumor in patients older than 25 years [ 35 ]. (lww.com)
  • of tumorigenesis for some brain tumor entities, raising the However, it is a critical point that circumferences of treating possibility that such an understanding may contribute to patients with WHO grade III gliomas in Korea are much dif- new classification of these tumors [4]. (bvsalud.org)
  • Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)
  • Considerable inter-hospital variations were observed in preoperative work-up, tumor diagnostics, surgical strategies, techniques for intraoperative guidance, as well as choice and timing of adjuvant therapy. (lu.se)
  • Oncological outcomes at a median follow-up of 2.9 years reported 249/271 (91.9%) patients alive and free from any event and 5 (1.8%) isolated locoregional recurrences. (nih.gov)
  • Decision regret regarding the radiotherapy was assessed using the Ottawa Decision Regret Scale, physical and psychological well-being were assessed using the PROMIS Global Health -10 questionnaire , and patients were asked about their treatment outcomes and symptoms. (bvsalud.org)
  • PURPOSEThere remains a lack of clarity regarding the influence of sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) on outcomes in prostate cancer (PCa). (wustl.edu)
  • Event-free survival was improved in patients with a pathological complete response compared with those without, suggesting pCR is a surrogate endpoint for long-term outcomes in resectable non-small cell lung cancer, and this is the first time [this has been shown] in a randomized phase 3 study," he said. (medscape.com)
  • Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study. (smw.ch)
  • Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable 5-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the 2023 San. (ascopost.com)
  • Susan G. Komen presented its 2023 Breast Cancer Awards to four physician-scientists and one research advocate for their contributions to advancing breast cancer discoveries and improving patient outcomes. (ascopost.com)
  • Breast-conserving surgery (BCS) using oncoplastic techniques results in favourable oncological outcomes in patients treated in a resource-constrained setting. (scielo.org.za)
  • This improves subjective patient outcomes regarding body image, psychosocial score and return to work function. (scielo.org.za)
  • To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. (cun.es)
  • Using mobile technology for symptom management and self-care can improve patient-clinician communication and clinical outcomes in patients with cancer. (jmir.org)
  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
  • Neuropathological diagnosis was performed in accordance with the 2016 WHO classification and patients with a mutation encoding for the isocitrate dehydrogenase (IDH) were not included, since they most probably represented secondary GBM with a completely different prognosis [ 23 , 24 ]. (springer.com)
  • Adjuvant radiotherapy should be considered since the prognosis is uncertain. (thieme-connect.com)
  • The present study reported a case with retroperitoneal liposarcoma managed at Guihang Guiyang Hospital (Guiyang, China), and also performed a literature review on presentation, management and prognosis of this patient. (spandidos-publications.com)
  • Therefore, it is important to make individualized treatment procedures in order to reduce negative side effects for patients with a good prognosis. (medsci.org)
  • Similar to adjuvant RT, the indication for ADT is based on tumour-related factors such as PSA levels, tumour stage, and surgical margins. (wjgnet.com)
  • Even though surgical oncology community is divided in believers and nonbelievers regarding its application, data show that SLNB has already changed the treatments modalities in melanoma and breast cancer patients, at least with respect to TNM classification. (hindawi.com)
  • In view of the time consuming and intensive treatment it should be offered only in carefully selected patients as new surgical approaches such as pleurectomy/decortication have shown high efficacy rates regarding patients' survival. (smw.ch)
  • Twelve patients (27%) developed surgical site infection (SSI), eight of which were classified as deep SSI with wound breakdown. (scielo.org.za)
  • Treatment of chondrosarcoma is predominantly surgical because adjuvant chemotherapy and radiotherapy are generally ineffective with the exception of dedifferentiated subtypes [ 11, 18 ]. (lww.com)
  • Arthroscopically assisted synovectomy in patients with pigmented villonodular synovitis of the ankle and hindfoot is an effective treatment option, providing adequate visualization for complete excision while minimizing soft-tissue complications related to larger surgical exposures. (medscape.com)
  • [ 1 ] Radiotherapy and oral medications are used as adjunctive therapies or as primary treatment when complete surgical excision is not possible. (medscape.com)
  • What criteria should be used to select patients to receive adjuvant therapy? (medscape.com)
  • Patients in the control arm will receive adjuvant radiotherapy to the breast or chest wall (with/without regional nodes) to a dose of 40 Gy / 15 fractions / 3 weeks, while those in the experimental arm will receive a dose of 26 Gy / 5 fractions / 1 week (to the same volume). (authorea.com)
  • Most transcriptomic signatures were highly prognostic for distant metastasis, but considerable discordance was observed on the individual patient level. (lu.se)
  • Within the MET141 low-risk subgroup (lowest 25th percentile of scores), 95% of patients were free of metastasis at 15 years, even in the absence of adjuvant endocrine therapy. (lu.se)
  • The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)
  • 20 years ago [ 1 ], sentinel lymph node biopsy (SLNB) was introduced for melanoma patients and later for numerous other tumors with lymphatic metastatic propensity. (hindawi.com)
  • Treatment with a CAR-M cell therapy plus Keytruda is being assessed in a phase 1 study in patients with HER2-overexpressed tumors. (curetoday.com)
  • Genomic testing has allowed patients to receive more specific drugs that target mutations in their tumors. (curetoday.com)
  • Although intermediate- and high-grade tumors have a survival rate of 40% to 60%, low-grade tumors result in long-term survival in as much as 90% of patients [ 11, 13, 14, 18, 20, 37 ]. (lww.com)
  • Breast cancer patients often engage in shared decision -making to select an individualized treatment regimen from multiple options. (bvsalud.org)
  • Although most patients reported little or no decision regret , we identified several patient , treatment , and symptom characteristics associated with more decision regret . (bvsalud.org)
  • Our findings suggest that psychological well-being influences patients ' satisfaction with therapy decisions, implying that practitioners should pay special attention to maintaining psychological well-being during shared decision -making and ensuring that psychological assessment and treatment is provided after cancer therapy to deal with long-term effects of radiotherapy . (bvsalud.org)
  • It is estimated that more than half of cancer patients undergo radiotherapy during the course of their treatment. (unboundmedicine.com)
  • NEW ORLEANS - For patients with resectable non-small cell lung cancer (NSCLC), further clinical data continue to show benefit from preoperative treatment with the immune checkpoint inhibitor nivolumab (Opdivo) with chemotherapy. (medscape.com)
  • The radiotherapy treatment usually consists of five consecutive sessions of 2 Gy rate per week for six weeks, the total treatment being 60 Gy 2 . (nature.com)
  • However, the majority of patients relapse and only 3 to 5% survive more than three years following treatment 3 . (nature.com)
  • Although great strides have been made in treating cancers, a significant number of patients still reach the point at which no curative treatment is. (annals.edu.sg)
  • It has allowed a better understanding of disease progression and response to treatment in patients with comparable staging groups. (hindawi.com)
  • SBRT may become one of the treatment options for inoperable or surgery-rejected UTCC patients. (hindawi.com)
  • The patient died from the exacerbation of rheumatism 33 months after the radiation treatment. (hindawi.com)
  • The patient died of severe bacterial pneumonia 13 months after the radiation treatment. (hindawi.com)
  • Patients with unresectable hepatocellular carcinoma, a type of liver cancer, obtained a survival benefit over four years of follow-up with a treatment regimen of Imfinzi and Imjudo. (curetoday.com)
  • Patients with this liver cancer subtype do not need to be hospitalized to receive this treatment and, according to the agent's manufacturer, Boston Scientific, can typically receive the therapy in approximately an hour during an outpatient procedure. (curetoday.com)
  • There are multiple treatment patients for patients with cholangiocarcinoma, here's what you need to know about them. (curetoday.com)
  • If a five-fraction regimen of breast cancer is proven to be non-inferior, this will result in a significant improvement in the access to radiotherapy, as well as reduced costs of treatment. (authorea.com)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • If I cannot, my focus is to lead patients and their families through the treatment process, with an emphasis on providing clear, straightforward communication. (stanfordchildrens.org)
  • Treatment of oesophageal cancer should be tailored to each patient depending on the location of the cancer, the stage of the cancer, the patient's general health and state of nutrition. (sgh.com.sg)
  • Consequently, endocrine therapy, including tamoxifen or aromatase inhibitors (AIs), has become an effective treatment for these patients. (spandidos-publications.com)
  • For decades, 5-year tamoxifen administration was the gold standard for the adjuvant endocrine treatment of breast cancer ( 9 ). (spandidos-publications.com)
  • More recently, postmenopausal patients have also had the option of receiving AIs as an alternative to tamoxifen, or following tamoxifen treatment ( 10 ). (spandidos-publications.com)
  • Not generally used in the treatment of patients who have had surgery for a NET. (christie.nhs.uk)
  • A study that explores whether a treatment or device is safe and effective in humans, or to compare the results of patients taking a new treatment with the results of patients taking the standard treatment to determine if one treatment is better than the other. (christie.nhs.uk)
  • SAN ANTONIO-In the treatment of breast cancer, cardiomyopathy has represented a possible barrier to the use of trastuzumab (Herceptin) in the adjuvant setting. (cancernetwork.com)
  • Patients were randomized to paclitaxel 175 mg/m² every 3 weeks for 4 weeks plus trastuzumab for 10 weeks followed by AC (60/600 mg/m²) every 3 weeks for 4 weeks, or to the same treatment with trastuzumab given for 52 weeks. (cancernetwork.com)
  • At 15 months median follow-up, there were four cases of clinical CHF during treatment (1.7%), including one patient during TH and three after receiving the AC regimen. (cancernetwork.com)
  • Six patients (8%) developed grade ⩾3 treatment-related chronic toxicity events. (cun.es)
  • Nearly half of patients present with stage I disease and about one third of patients treated with surgery received adjuvant treatment [ 2 ]. (medsci.org)
  • This adjuvant treatment is accompanied by considerable morbidity [ 3 ]. (medsci.org)
  • This study aimed to describe engagement with the Interaktor app among patients with breast or prostate cancer during treatment. (jmir.org)
  • Requests were made for advice on diet and psychological symptoms, as well as for more comprehensive and detailed information as the patient progressed through treatment. (jmir.org)
  • DDW treatment in combination with, or as an extension of conventional therapies noticeably prolonged the median survival time (MST) in different study populations of cancer patients. (positivehealth.com)
  • Retrospective evaluation of different subgroups of cancer patients allowed us to study which life skills, dietary factors, dietary supplements have the greatest impact on the efficacy of DDW treatment. (positivehealth.com)
  • Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)
  • In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
  • The USPSTF advises that screening is more likely to benefit older patients who have never been screened than those who have undergone screening, and is more likely to benefit patients who are healthy enough to undergo treatment for colorectal cancer treatment and who do not have other medical conditions limiting their life expectancy. (medscape.com)
  • The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
  • The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)
  • Background: Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected "high-risk"patients. (lu.se)
  • Segelman J, Singnomklao T, Hellborg H, Martling A. Differences in MDT assessment and treatment between patients with stage IV colon and rectal cancer. (cancercentrum.se)
  • Roughly 70% of all patients living with advanced breast cancer have bone metastases Very often bone metastases can be successfully managed for a long time. (wikipedia.org)
  • Patients without distant metastases who merit adjuvant radiotherapy will be eligible for inclusion in the study. (authorea.com)
  • In patients with breast cancer and imaging findings suggestive of skeletal metastases, it is important to keep a broad differential diagnosis and consider bone biopsy for a definitive diagnosis. (cmaj.ca)
  • No patient had metastases develop or died of disease. (lww.com)
  • The potential for improved outcome in patients with hepatic metastases from colon cancer: A population-based study. (cancercentrum.se)
  • To determine the maximum tolerated dose of irinotecan when administrated with temozolomide every 28 days, in patients with recurrent malignant glioma who were also receiving CYP450 enzyme-inducing antiepileptic drugs (EIAED), and to characterize the pharmacokinetics of irinotecan and its metabolites. (aacrjournals.org)
  • Patients with recurrent malignant glioma received a fixed dose of temozolomide (150 mg/m 2 ) daily for 5 days from days 1 to 5 every 28 days, and an i.v. infusion of irinotecan on days 1 and 15 of each cycle. (aacrjournals.org)
  • Although there are clear criteria (pT3-pT4 disease and/or positive margins) for the use of adjuvant radiotherapy, no specific clinical or tumour-related criteria have yet been defined for SRT. (wjgnet.com)
  • From a biological point of view, there are arguments to support an early as well as a late initiation of RT: οn the one hand, an early start of RT could have a negative impact on survival due to reduced radiosensitivity secondary to postoperative hypoxia or due to the "second-impact" effect leading to a further deterioration of the clinical condition of an already compromised patient [ 19 , 20 ]. (springer.com)
  • Along with a tolerable safety profile and supportive quality of life, these final efficacy results demonstrate the clinical benefit of (Tibsovo) in (previously treated patients with IDH1-mutant cholangiocarcinoma), for which there is an urgent need for new therapies," said an expert from Massachusetts General Hospital, who presented the data. (curetoday.com)
  • In conclusion, the homozygous minor allele (GG) of CYP19A1 rs1008805 was identified to be significantly associated with an inferior clinical outcome of hormone therapy in postmenopausal hormone receptor‑positive patients with early breast cancer. (spandidos-publications.com)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
  • Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
  • In March 1998, the patient was found to have multiple polys in the vaginal posterior fornix and a fistula that was at the posterior fornix and extended to the pelvic cavity. (scirp.org)
  • Results: In SweBCG91-RT, 454 patients were node-negative, postmenopausal, and systemically untreated with ER-positive, HER2-negative cancers, which constitutes a low-risk subgroup and potential candidates for therapy omission. (lu.se)
  • However, some patients cannot undergo this procedure for several reasons. (hindawi.com)
  • However, some patients do not undergo RNU due to comorbidities or refusal of the procedure. (hindawi.com)
  • He went on to have a staging CT thorax, abdomen and pelvis, a nuclear bone scan and echocardiogram, before discussing systemic chemotherapy and chest wall radiotherapy. (gponline.com)
  • In a clinically low-risk subgroup of the METABRIC cohort not treated with systemic therapy, no breast cancer death occurred among the MET141 low-risk patients. (lu.se)
  • Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)
  • All patients but one completed the planned radiation schedule. (unict.it)
  • Two randomized phase III trials were identified, and individual patient data were obtained: Ottawa 0101 and NRG Oncology's Radiation Therapy Oncology Group 9413. (wustl.edu)
  • BACKGROUND: The purpose of this study was to compare the rates of all-cause and breast cancer-specific mortality after breast-conserving surgery (BCS) only, BCS plus radiation therapy (RT), mastectomy, and the receipt of adjuvant tamoxifen in a large population-based cohort of older women with early-stage disease. (healthpartners.com)
  • However, because of its low morbidity when compared to empiric elective lymph node dissection or radiation therapy of lymphatic basins, SLNB has allowed sparing a lot of morbidity and could therefore be used in nonmelanoma skin cancer patients, even though a significant impact on survival has not been demonstrated. (hindawi.com)
  • HYPOfractionated Radiation Therapy comparing a standard radiotherapy schedule (over three weeks) with a novel one week schedule in Adjuvant breast cancer: An open-label randomised controlled study (HYPORT- Adjuvant): study protocol for a multicenter, randomized phase III trial. (authorea.com)
  • But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. (scirp.org)
  • However, radiation can be costly, inconvenient for the patient and associated with both short-term side effects - such as tiredness and skin irritation - and long-term side effects - such as breast pain and thickening of the breast tissue, which can affect how the breast looks and a woman's quality of life. (news-medical.net)
  • Eighty-two patients received radiotherapy in combination with 5 years of hormone therapy with tamoxifen or aromatase inhibitor. (unict.it)
  • A retrospective review of 60 patients receiving definitive therapy for carcinosarcoma of the uterus was undertaken at a single institution. (nih.gov)
  • More decision regret was associated with volumetric modulated arc therapy , chest wall irradiation, use of docetaxel as a chemotherapy agent, lymphangiosis carcinomatosa, new heart disease after radiotherapy , and lower psychological well-being . (bvsalud.org)
  • Second, although not mandated for this trial, approximately 20% of the patients received postoperative therapy. (medscape.com)
  • Is adjuvant therapy necessary? (medscape.com)
  • In those receiving trimodal therapy long term survival is achieved only in a minority of patients. (smw.ch)
  • If they are used sequentially, the radiotherapy or the chemotherapy could be used first and concerns have been expressed that the effectiveness of the therapy that is delayed might be reduced. (cochrane.org)
  • However, the best sequence of administering these two types of adjuvant therapy for early-stage breast cancer is unclear. (cochrane.org)
  • To the best of our knowledge, our case is the sixth case that primary adenosarcomas arising in vaginal endometriosis and it is the first case living without chemo-therapy or radiotherapy. (scirp.org)
  • Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
  • Chemotherapy, as the most common and indispensable adjuvant therapy, is updated constantly with advances in research. (frontiersin.org)
  • Some patients who have significant medical conditions not compatible with major surgery, or patients with cancers in the cervical oesophagus (neck) may be treated with definitive chemoradiation therapy. (sgh.com.sg)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. (lu.se)
  • Ninety-two percent of patients were untreated by both adjuvant endocrine therapy and chemotherapy. (lu.se)
  • Researchers have revealed significant differences in the genetic characteristics of HER2-low advanced breast cancers, which may lead to the development of novel therapeutics for patients, according to recent findings presented by Kahn et al at the 2023 San Antonio Breast Cancer Symposium (Abstract. (ascopost.com)
  • From July 2011 to July 2018, BC patients receiving 5.7 Gy once a week for 5 weeks to the whole breast after breast-conserving surgery were considered for the study. (nih.gov)
  • From January 2000 to December 2007, 131 consecutive patients aged 75 years or older received adjuvant radiotherapy after breast conserving surgery. (unict.it)
  • RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery. (springer.com)
  • Most patients undergoing sphincter preserving surgery (ie, without permanent colostomy) experience bowel dysfunction. (bmj.com)
  • In the case reports described herein, we performed stereotactic body radiotherapy (SBRT) on three patients with inoperable or surgery-rejected localized UTCC. (hindawi.com)
  • The patient refused surgery and was referred to our department. (hindawi.com)
  • This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. (rush.edu)
  • 6 A volume replacement procedure is performed in laterally placed tumours where the patient declines contralateral surgery. (scielo.org.za)
  • This review examined the current evidence on the best way to administer chemotherapy and radiotherapy following breast-conserving surgery. (cochrane.org)
  • After surgery for localised breast cancer, radiotherapy (RT) improves both local control and breast cancer-specific survival. (cochrane.org)
  • After the surgery, the patient had recurrent vaginal stump polyps for 10 years. (scirp.org)
  • Soon after the surgery, her dysmenorrhea was aggravating, and the patient was diagnosed as endometriosis. (scirp.org)
  • Some women with early-stage, low-risk breast cancer may not need radiotherapy after breast conserving surgery according to new research led by McMaster University, BC Cancer, Hamilton Heath Sciences, and the University of British Columbia. (news-medical.net)
  • Patients with advanced oesophageal cancer or those with poor general health may still be candidates for curative surgery after a period of tube feeding or intravenous feeding combined with neo-adjuvant chemotherapy and/or radiotherapy. (sgh.com.sg)
  • Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I-IIA breast cancer. (lu.se)
  • Decompression surgery and postoperative radiotherapy was mostly palliative. (bvsalud.org)
  • Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers. (cdc.gov)
  • Conclusions: This study shows a high prevalence of hypertension among patients attending the HIV clinic at KBTH,associated with exposure to ART and increasing duration of this exposure. (bvsalud.org)
  • Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer. (cdc.gov)
  • The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients. (cdc.gov)
  • The purpose of the study was to evaluate the toxicity, local control, overall and disease-free survival of elderly breast cancer (BC) patients treated with adjuvant once-weekly ultra-hypofractionated radiotherapy (RT) either with intensity-modulated RT (IMRT) or 3D conformal RT (3DCRT). (nih.gov)
  • SBRT was performed by coplanar dynamic conformal radiotherapy with a linear accelerator (LINAC) (EXL-15DP, Mitsubishi Electric, Tokyo, Japan). (hindawi.com)
  • Patients with unresectable hepatocellular carcinoma treated with the STRIDE regimen, consisting of Imjudo and Imfinzi, experienced manageable immune-related side effects with improvements in overall survival. (curetoday.com)
  • In a phase 2 study of 24 patients with biliary cancer, Aliqopa in combination with Gemzar and chemotherapy led to a six-month progression-free survival rate of 51% with a median overall survival of 13.7 months. (curetoday.com)
  • The NSABP B-6 trial found no significant difference in overall survival (OS) or disease-free survival (DFS) between patients undergoing lumpectomy or a modified radical mastectomy for early breast cancer. (scielo.org.za)
  • Male patients, those with contraindications to breast conservation, and those with metastatic disease were excluded. (scielo.org.za)
  • In patients at risk of harbouring micro-metastatic disease, adjuvant chemotherapy (CT) improves 15-year survival. (cochrane.org)
  • The level of this hormone can be raised in patients with a diagnosis of NET, or in patients taking proton pump inhibitors (tablets to reduce acid production in the stomach) and can be measured in the blood. (christie.nhs.uk)
  • The hormone serotonin is broken down in the liver to 5-HIAA, and the levels of this can be raised in the blood or urine of patients with a diagnosis of NET. (christie.nhs.uk)
  • As a result, the trials do not assess the modern types of radiotherapy, and new types of chemotherapy (such as taxanes) or other drugs (such as Herceptin). (cochrane.org)
  • Patients who got Herceptin for 10 weeks probably still had a significant amount of Herceptin on board when they got AC. (cancernetwork.com)
  • Local failure represents a significant site of failure in the absence of adjuvant radiotherapy. (nih.gov)
  • METHODS: From 2000 to 2005 41 patients with histologically verified malignant pleural mesothelioma were included. (smw.ch)
  • Objectives:To determine the pattern of ocular disorders among stroke patients in Federal Teaching Hospital, Lokoja (FTHL).Materials and Methods:Consecutive new stroke patients seen at the Federal Teaching Hospital, Lokoja over a 3-month period were studied. (bvsalud.org)
  • In various human cancers poor outcome for the patients has been associated with increase expression of EphA2 and EphrinA-1 [ 16 , 17 , 19 , 24 , 26 ]. (medsci.org)
  • A population-based study on the management and outcome in patients with locally recurrent rectal cancer. (cancercentrum.se)
  • Further hypofractionation may be possible but remains to be investigated in non-caucasian populations with more advanced disease, with a higher proportion of patients requiring mastectomy as well as tumour bed boost. (authorea.com)
  • Patients-- Commercially-insured women aged 18-64 years with ICD-9-CM procedure or CPT-4 codes for mastectomy from 1/1/2004-12/31/2011. (cdc.gov)
  • No difference in acute and late toxicity rates was found between patients with different ACE-27 (Adult Comorbidity Evaluation-27) indexes and for different age. (unict.it)
  • We conclude that compliance with adjuvant radiotherapy is good and rate of toxicity is acceptable in elderly patients. (unict.it)
  • 13 patients (62%) had postoperative complications. (smw.ch)
  • Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
  • The patient received adjuvant third-generation chemotherapy with a taxane and an anthracycline, followed by radiotherapy to the breast, supraclavicular fossa and axilla. (cmaj.ca)
  • Replacement of the daily fluid intake of patients with deuterium-depleted water (DDW) results in a shortage of deuterium (D) in the body, and might exert an anticancer effect. (positivehealth.com)
  • Univariate analyses were presented in the form of frequencies, percentages, means, ranges, and standard deviations, charts and tables.Results:Eighty-three patients were recruited with an age range of 40-71 years, a mean age of 55.3(±7.1) years. (bvsalud.org)
  • Results: A total of 642 patients were included (male:female ratio 1:4), and annual age-standardized incidence rates were 0.9 and 0.8 per 100 000 in Norway and Sweden, respectively. (lu.se)
  • Patients with no or mild co-morbidities have a significantly better survival. (unict.it)
  • PFS was significantly improved in the adjuvant group (15-year PFS, 29% v 36%, hazard ratio [HR], 1.25 [95% CI, 1.07 to 1.47], P =.01). (wustl.edu)
  • A total of 19.1% of the patients had no co-morbidity, 57.38% mild, 19.8% moderate, and 3.8% had severe co-morbidities. (unict.it)
  • Increasing severity of co-morbidity may sufficiently shorten remaining life expectancy to cancel gains with adjuvant radiotherapy. (unict.it)
  • Myasthenic symptoms often remain after removal of a thymoma, with over 80% of the patients requiring continued immunosuppression. (bmj.com)
  • At the time, the patient had no respiratory symptoms or skin findings of sarcoidosis, and her calcium level was within the normal range. (cmaj.ca)
  • The patients reported their symptoms daily. (jmir.org)
  • Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
  • González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)
  • Among the patients treated for prostate cancer, higher age ( P =.01) and higher education level ( P =.04), predicted an increase in total views on self-care advice, while higher comorbidity ( P =.004) predicted a decrease in total views on self-care advice. (jmir.org)
  • The role of adjuvant radiotherapy in the setting of uterine carcinosarcoma has not been clearly established. (nih.gov)
  • The improvement in local failure rates with the addition of radiotherapy translates into an improvement in distant failure rates and survival only for patients with stage I/II disease. (nih.gov)
  • Indications for pancreatoduodenectomy in patients undergoing lymphadenectomy for advanced gallbladder carcinoma. (cancercentrum.se)
  • The use of sentinel lymph node biopsy (SLNB) could be a promising procedure to assess this risk in clinically N0 patients. (hindawi.com)
  • To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. (springer.com)
  • Rivoceranib plus Airuika demonstrates improvement for survival in patients with unresectable hepatocellular carcinoma, a subset of liver cancer. (curetoday.com)