Adjuvant chemotherapy with fluorouracil. Medical search. Frequent questions

The aims of this study were to analyse complication and mortality rates after neoadjuvant chemotherapy using a modified regimen of folinic acid, 5-fluorouracil and oxaliplatin (mFOLFOX6) for locally advanced gastric cancer (AGC), compared with rates in patients who underwent surgery without neoadjuvant chemotherapy. (nih.gov)
Most chemotherapy regimens consist of 5-fluorouracil (5-FU), alone or in combination with a variety of other agents like doxorubicin, cisplatin, mitomycin C, cyclophosphamide and oxaliplatin. (cochrane.org)
Oxaliplatin/5FU/LV in adjuvant colon cancer: updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years [abstract]. (medscape.org)
Returning to this case, the patient was scheduled to begin chemotherapy with a combination of capecitabine and oxaliplatin. (medscape.com)
We used the pancreatic adenocarcinoma cell line PANC-1 as a model to apply different chemotherapeutic protocols (monotherapy and combined therapy) using 5-Fluorouracil, Oxaliplatin, Irinotecan, Gemcitabine and Abraxane. (isciii.es)
After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them. (isciii.es)
The results show that gemcitabine monotherapy and oxaliplatin monotherapy increase these markers while the combination of 5-fluorouracil and irinotecan (FOLFIRI) decreases them. (isciii.es)
Potentially, the multi-agent FOLFIRINOX regimen (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) may further improve outcomes in the neoadjuvant setting for localized pancreatic cancer, but randomized studies are needed. (nih.gov)
The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. (biomedcentral.com)
Thus, we conducted a phase II trial of 5-FU, folinic acid and oxaliplatin (a modified FOLFOX-6 regimen) in advanced gastric cancer (AGC) patients as a first line palliative chemotherapy. (biomedcentral.com)
Adjuvant modified FOLFIRINOX (fluorouracil, leucovorin, irinotecan and oxaliplatin) and gemcitabine plus capecitabine are the preferred chemotherapy regimens as adjuvant chemotherapy for patients with resected PDAC based on their improved survival outcomes compared to gemcitabine monotherapy in phase 3 trials [ 5 - 7 ]. (e-crt.org)
First-line treatment with 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) and second-line treatment including 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) plus panitumumab showed inefficiency in controlling disease progression. (karger.com)
BACKGROUND: Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in the proportion of rectal cancer patients with a pathological complete response. (elsevierpure.com)
97 males, 47.8%) receiving adjuvant chemotherapy (Oxaliplatin and/or 5-Fluorouracil) were retrospectively evaluated. (bvsalud.org)
The first patient was a 61-year-old woman with colorectal carcinoma and liver metastasis, who underwent chemotherapy consisting of 6 cycles of oxaliplatin (the FOLFOX scheme, a chemotherapy regimen consisting of fluorouracil [5 FU], folinic acid, and oxaliplatin). (cdc.gov)

Adjuvant chemotherapy consisted of four cycles of fluorouracil-based regimens. (bepress.com)
85% for historical regimens (ie, cyclophosphamide/methotrexate/fluorouracil) are known to affect breast cancer survival. (jnccn.org)
Pancreatic cancer treatment in advanced stages is based on different chemotherapy regimens. (isciii.es)
Two recent randomized trials have suggested benefit of neoadjuvant chemoradiotherapy over upfront surgery, both including single-agent chemotherapy regimens. (nih.gov)

Neoadjuvant chemotherapy has been shown to improve the rate of complete (R0) resection and downstaging in patients with localized gastric cancer. (nih.gov)
Among 51 patients who received neoadjuvant chemotherapy, there were no deaths and a morbidity rate of 24 per cent after surgery. (nih.gov)
Combined resection was the only risk factor for postoperative morbidity after neoadjuvant chemotherapy. (nih.gov)
Neoadjuvant chemotherapy with mFOLFOX is a safe treatment for patients with localized AGC, and does not increase postoperative morbidity or mortality. (nih.gov)
For metastatic colon cancer, systemic chemotherapy is standard, with neoadjuvant chemotherapy used to convert unresectable isolated liver metastases to resectable liver metastases. (medscape.com)
Neoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
They were all treated with Intensity-modulated radiation therapy (IMRT) combined with systemic treatments, including radiotherapy alone (RT alone), neoadjuvant chemotherapy followed by radiotherapy (NACT+RT), CCRT, NACT+CCRT, NACT followed by radiotherapy and adjuvant chemotherapy (NACT+RT+AC), CCRT+AC and NACT+CCRT+AC. (oncotarget.com)
Recently, neoadjuvant chemotherapy has been widely used for the management of patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) [ 8 - 13 ]. (e-crt.org)
There is limited evidence to recommend a specific neoadjuvant chemotherapy regimen because of the lack of prospective comparative trials. (e-crt.org)
Mismatch Repair Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy. (cdc.gov)

Adjuvant chemotherapy using CPT-11, leucovorin plus bolus 5-fluorouracil and radiotherapy in patients with rectal cancer. (ucy.ac.cy)

We aimed to evaluate the safety and efficacy of adding capecitabine (a known radiosensitizer by direct and abscopal effects) to concurrent radiation in the adjuvant setting after resection of pancreatic adenocarcinoma. (iiarjournals.org)
Patients and Methods: We conducted a retrospective study of 63 patients diagnosed from 2004-2013 with histopathologically-confirmed stage I/II pancreatic cancer treated with a surgical resection followed by adjuvant concurrent chemoradiation to at least 45 Gy using 3D planning and capecitabine at 1,600 mg/m 2 /day (Monday-Friday) for 6 weeks. (iiarjournals.org)
Conclusion: Concurrent chemoradiation using capecitabine as a radiosensitizer in the adjuvant setting for pancreatic cancer was completed by the vast majority of patients in this series. (iiarjournals.org)
Third-line chemotherapy combining capecitabine plus bevacizumab was started, achieving good control of the tumour growth and a minor response in the second computed tomography scan. (karger.com)
All You Need to Know About DPYD Genetic Testing for Patients Treated With Fluorouracil and Capecitabine: A Practitioner-Friendly Guide. (cdc.gov)

In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
This study sought to retrospectively characterize outcomes for patients with node-negative and node-positive breast cancer receiving adjuvant trastuzumab in combination with docetaxel/cyclophosphamide (DCH), docetaxel/carboplatin/trastuzumab (TCH), or fluorouracil/epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (FEC-DH) chemotherapy in Alberta, Canada, from 2007 through 2014. (jnccn.org)
We have investigated to what extent cDNA microarray measurements could distinguish the likelihood of recurrences after adjuvant CMF (cyclophosphamide, methotrexate and 5-fluorouracil) treatment of premenopausal, lymph node positive breast cancer patients, and have also compared with the corresponding performance using conventional clinical variables. (lu.se)
The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)

Health-related quality of life results from the PRODIGE 5/ACCORD 17 randomised trial of FOLFOX versus fluorouracil-cisplatin regimen in oesophageal cancer. (canceropole-est.org)
Cost-Effectiveness Analysis of a New Second-Line Treatment Regimen for Advanced Intrahepatic Cholangiocarcinoma: Biomarker-Driven Targeted Therapy of Pemigatinib Versus 5-FU Chemotherapy. (cdc.gov)
Although can- number of positive axillary lymph nodes cer incidence is increasing in the developing and chemotherapy regimen. (who.int)

Higher expression of GOLPH3 is reported to be associated with greater sensitivity of colorectal cancer to Fluorouracil therapy. (wikipedia.org)
First relapse rate after adjuvant therapy was 71% (n=49) and median time to relapse was about 30 months. (bepress.com)
Adjuvant (postoperative) therapy is used in selected patients with stage II colon cancer who are at high risk of recurrence, and is standard for stage III colon cancer. (medscape.com)
Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. (medscape.org)
Effective surgical adjuvant therapy for high-risk rectal carcinoma. (medscape.org)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
Chemotherapy, as the most common and indispensable adjuvant therapy, is updated constantly with advances in research. (frontiersin.org)
20 - 25 ] A major pooled analysis evaluating the impact of T and N stage and treatment on survival and relapse in patients with rectal cancer who are treated with adjuvant therapy confirmed these findings. (cancer.gov)
Treatment protocols for colon cancer are provided below, including adjuvant and neoadjuvant therapy for resectable disease and therapy for advanced or metastatic colon cancer. (medscape.com)
however, adjuvant therapy may be considered in patients with high-risk disease. (medscape.com)
Of the 10-20% of patients who present with resectable tumors, the 5-year surviva rate is still only about 20%, with a median survival of around 23-43 months with adjuvant therapy ( 2 - 4 ). (iiarjournals.org)
Therapy is usually through surgery, with many cases also requiring chemotherapy. (symptoms101.com)
Of particular interest are adjuvant therapy, treatment of metastatic disease, methods for treatment of locally advanced breast cancer and inflammatory breast cancer. (stanford.edu)
It is not yet known whether chemotherapy is effective in treating women who have undergone surgery and radiation therapy for relapsed breast cancer. (stanford.edu)
Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy. (cdc.gov)
Treatment is surgical resection and adjuvant chemotherapy and radiation therapy. (msdmanuals.com)

No suitable evidence was found to determine the role of adjuvant chemotherapy, when compared with placebo or any other or no adjuvant treatment, in the management of adenocarcinoma of the small intestine. (cochrane.org)

5 Both trials reported benefits from the addition of PD-1 inhibitors regardless of PD-L1 expression, suggesting the addition of immunotherapy to chemotherapy may soon become standard of care for patients with nasopharyngeal carcinoma in both curative and recurrent/metastatic disease. (ascopost.com)
Concurrent chemoradiotherapy followed by adjuvant cisplatin-gemcitabine versus cisplatin-5-fluorouracil chemotherapy for N2-3 nasopharyngeal carcinoma: A multicentre, open-label, randomized, controlled, phase 3 trial. (altaioncology.com)

Cancer is a notable deadly disease involving such as fluorouracil, methotrexate and several other diseases. (who.int)

Studies that have evaluated the role of multimodality treatment options for these patients include postoperative chemoradiation and perioperative chemotherapy. (medscape.com)
Neo-adjuvant chemotherapy followed by chemoradiation and surgery with and without cetuximab in patients with resectable esophageal cancer: a randomized, open-label, phase III trial (SAKK 75/08). (canceropole-est.org)

Results of the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial (n=12,834), based on 3-year disease-free survival (DFS), showed that FOLFOX narrowly failed to meet the prespecified noninferiority threshold. (medscape.com)
Modified FOLFOX-6 chemotherapy appears to be active and well tolerated as first line chemotherapy in AGC patients. (biomedcentral.com)
The mean number of total chemotherapy cycles differed among the 4 groups (p = 0.002), because one third of patients in the group assigned to no preoperative FOLFOX did not receive any adjuvant chemotherapy. (elsevierpure.com)

Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
Patients receive 8 cycles of neoadjuvant FOLFIRINOX chemotherapy followed by surgery without adjuvant treatment (arm A), or 3 cycles of neoadjuvant gemcitabine with hypofractionated radiotherapy (36 Gy in 15 fractions) during the second cycle, followed by surgery and 4 cycles of adjuvant gemcitabine (arm B). The primary endpoint is OS by intention-to-treat. (nih.gov)
CHICAGO - Many patients with locally advanced rectal cancer who do not have high-risk disease can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy alone and then surgery, say researchers reporting results from the PROSPECT trial. (medscape.com)

Therefore, the identification of reliable criteria and/or novel biomarkers for predicting a risk of recurrence is needed to identify the patients who should receive postoperative adjuvant chemotherapy. (spandidos-publications.com)

For metastatic disease, chemotherapy is mainly palliative. (medscape.com)
In a patient who had been diagnosed in 2006 with appendiceal adenocarcinoma with peritoneal metastases after an incomplete surgery, palliative chemotherapy was administered. (karger.com)

[ 24 ] The MAGIC (Medical Research Council Adjuvant Gastric Infusional Chemotherapy) trial showed that patients treated with perioperative epirubicin, cisplatin, and 5-fluorouracil had a significantly higher overall survival rate compared with patients treated with surgery alone. (medscape.com)

The PREOPANC-2 trial investigates whether neoadjuvant FOLFIRINOX improves OS compared with neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine in resectable and borderline resectable pancreatic cancer patients. (nih.gov)

Among them, new adjuvant chemoradiotherapy followed by selective radical resection of rectal cancer is one of the generally recognized methods for the treatment of advanced rectal cancer [ 13 - 15 ]. (hindawi.com)
Although surgical resection can be applied when the tumor is well defined (20% of cases) 1 , most patients with pancreatic cancer are treated with chemotherapy. (isciii.es)
However, even after curative-intent resection, approximately 75% of patients develop recurrence within 2 years, and recurrence occurs more frequently in the absence of adjuvant chemotherapy [ 1 ]. (e-crt.org)
PURPOSE: Randomized phase III trial to determine the effectiveness of adjuvant chemotherapy in treating women who have undergone resection for local and/or regional relapsed breast cancer. (stanford.edu)
he was seen in March 2004 with a fever up to 39°C. An adenocarcinoma of the ileum had been diagnosed in June 2002 in this patient, and an ileocecal resection was performed followed by adjuvant chemotherapy. (cdc.gov)

Depending on each large tumours and/or histologically proven patient's education level, the questionnaire axillary lymph node involvement requiring was either self-completed or administered adjuvant cytotoxic chemotherapy. (who.int)

therefore, trastuzumab in combination with chemotherapy is a treatment option for patients with HER2-positive advanced gastric cancer. (medscape.com)

The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. (e-crt.org)
Among PDAC patients who underwent surgery following neoadjuvant FOLFIRINOX, adjuvant chemotherapy may be associated with improved survival. (e-crt.org)
For patients who undergo upfront surgery for localized PDAC, adjuvant chemotherapy is the standard of care [ 4 ]. (e-crt.org)
Treatments include surgery, radiation, and chemotherapy. (rxwiki.com)
Patients were recommended to receive adjuvant chemotherapy after surgery to complete a total of 8 cycles of modified FOLFOX6. (elsevierpure.com)
We analyzed registry data for 3,291 women and 3,009 men diagnosed with colon cancer between 1996 and 2000 and followed until 2011 on lymph node investigation, stage at diagnosis, surgery, chemotherapy, wait times and survival. (cdc.gov)

Tras analizar mediante RT-qPCR diferentes marcadores de células madre tumorales (SOX2, OCT4, CD133, CD44 y CD24) en células de cáncer de páncreas tratadas con diferentes protocolos quimioterapéuticos, el Oxaliplatino y la Gemcitabina en monoterapia fueron los quimioterápicos que seleccionaron en mayor medida las células madre cancerosas mientras que el protocolo FOLFIRI las disminuyó. (isciii.es)

The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment. (cochrane.org)
85% for adjuvant FEC-D affects breast cancer survival. (jnccn.org)
This study aimed to assess the survival benefit of adjuvant chemotherapy in this patient population. (e-crt.org)
The association of adjuvant chemotherapy with disease-free survival (DFS) and overall survival (OS) was evaluated in overall patients and in the propensity score matched (PSM) cohort. (e-crt.org)
CONCLUSIONS: Adding modified FOLFOX6 after chemoradiotherapy and before total mesorectal excision increases compliance with systemic chemotherapy and disease-free survival in patients with locally advanced rectal cancer. (elsevierpure.com)
The study will also evaluate the toxic effects of the chemotherapy combination, including effects on the heart, and will determine survival and progression-free survival 5 years after treatment. (stanford.edu)

Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. (isciii.es)

This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer. (canceropole-est.org)

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common reasons that colorectal cancer patients cannot maintain their routine chemotherapy schedules. (kjco.org)

Until now, a series of novel adjuvant chemoradiotherapy have been recommended for patients with TNM stage rectal cancer [ 16 ]. (hindawi.com)

An all-chemotherapy approach may make curative intent treatment accessible for patients in these resource-constrained settings. (medscape.com)

Strategies being investigated include reductions in radiation dose, response-tailored dose reduction after induction chemotherapy, and use of novel biomarkers such as HPV circulating tumor DNA to guide treatment. (ascopost.com)
INTERVENTION: All of the patients received 50 Gy of radiation with concurrent continuous infusion of fluorouracil for 5 weeks. (elsevierpure.com)

Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)

Cost-effectiveness of DPYD Genotyping Prior to Fluoropyrimidine-based Adjuvant Chemotherapy for Colon Cancer. (cdc.gov)
In the United States, people with colon cancer who lived in low-income areas experienced less thorough lymph node evaluations and were less likely to receive indicated chemotherapies or to survive. (cdc.gov)

Severe 5‐fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. (elsevierpure.com)
Dive into the research topics of 'Severe 5‐fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. (elsevierpure.com)

It limits a dose of chemotherapy and even interferes the regular schedule of chemotherapy potentially [ 1 - 3 ]. (kjco.org)

To assess the feasibility of QOL assessment in a cohort of Tunisian cancer patients, the EORTC QLQ-C30 questionnaire was administered to 23 women treated with adjuvant chemotherapy for early breast cancer on an outpatient basis at baseline and during the 3rd cycle of chemotherapy. (who.int)
The case-group underwent oral hygiene control associated with the use of chamomile tea before starting the first cycle of chemotherapy, while the control group, there were no previous guidelines and prescriptions. (bvsalud.org)

Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)

Comparative real-world outcomes for patients with HER2-positive (HER2+) breast cancer receiving adjuvant trastuzumab outside of clinical trials are lacking. (jnccn.org)

On the basis of this background, we retrospectively explored the possible treatment option and hypothesized that patients with bulky lymph nodes would benefit from additional chemotherapy other than the concurrent modality. (oncotarget.com)

Chemotherapy-induced peripheral neuropathy (CIPN) is a dysesthesia or pain of peripheral nerve caused by anticancer drugs during chemotherapy. (kjco.org)

Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. (curehunter.com)
Women with stage I-III, hormone receptor-positive/negative, HER2-negative breast cancer treated with adjuvant FEC-D chemotherapy from 2007 through 2014 in Alberta, Canada, were included. (jnccn.org)
A large proportion of breast cancer patients are treated with adjuvant chemotherapy after the primary operation, but some will recur in spite of this treatment. (lu.se)
Maintaining Bone Density in Patients Undergoing Treatment for Breast Cancer: Is There and Adjuvant Benefit? (abcsg.org)
Trials include participation in the national breast cancer study groups, ECOG and NSABP, as well as the development of new chemotherapy programs. (stanford.edu)
The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)
This research evaluated executive functions in women with breast cancer undergoing chemotherapy. (bvsalud.org)
It is concluded that there were impairments in executive functions related to working memory, focused attention, inhibitory control and general impulsivity in the group of women with breast cancer who received chemotherapy. (bvsalud.org)

The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
TDM in colorectal cancer can reduce toxicity, improve efficacy and clinical outcome, and can be routinely used in 5-FU-based chemotherapy. (medscimonit.com)

There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. (cochrane.org)
Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment. (cochrane.org)
Singhal N, Singhal D. Adjuvant chemotherapy for small intestine adenocarcinoma. (cochrane.org)

There are limited data of randomized clinical trials with adjuvant chemotherapy to support evidence-based decision-making [ 6 - 8 ]. (oncotarget.com)
5-fluorouracil (5-FU) remains the main chemotherapeutic agent for the treatment of gastric cancer, and combination chemotherapy with 5-FU has shown an improved clinical outcomes [ 1 ]. (biomedcentral.com)
Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer. (cdc.gov)

The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. (altaioncology.com)

According to the systemic treatment modalities delivered, we classified all 547 patients into non-adjuvant chemotherapy (non-AC) group (341 patients) and adjuvant chemotherapy (AC) group (206 patients). (oncotarget.com)

This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug‐induced toxicity in a patient receiving 5‐fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma. (elsevierpure.com)
Monitoring DPD activity may be important in the management of patients experiencing severe toxicity secondary to FUra chemotherapy. (elsevierpure.com)
For fluorouracil: Patients with dihydropyrimidine dehydrogenase (DPD) deficiency are unable to metabolize fluorouracil normally and may have severe unexpected toxicity to fluorouracil. (medscape.com)

With a median follow-up time of 53.8 months, adjuvant chemotherapy significantly decreased the risk of distant metastasis (HR 0.413, 95% CI 0.194-0.881, p = 0.022) as well as significantly increased the OS (HR 0.398, 95% CI 0.187-0.848, p = 0.017) in patients with N3 disease. (oncotarget.com)

Fluoropyrimidine carbamate prodrug of 5-fluorouracil (5-FU). (medscape.com)

Despite improvements in the early detection of gastric cancer, a significant proportion of patients present with inoperable stages where chemotherapy is required. (biomedcentral.com)

Anatomy6

Organisms1

Diseases67

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Psychiatry and Psychology1

Phenomena and Processes15

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science4

Health Care38

Geographicals1

Oxaliplatin15

Regimens4

Neoadjuvant chemotherapy12

Leucovorin1

Capecitabine5

Cyclophosphamide4

Regimen3

Therapy17

Role of adjuvant chemotherapy1

Nasopharyngeal carcinoma2

Methotrexate1

Chemoradiation2

Folfox3

Radiotherapy3

Postoperative1

Palliative2

Cisplatin1

Gemcitabine1

Resection5

Cytotoxic chemotherapy1

Trastuzumab in combination1

Surgery6

FOLFIRI1

Survival6

Recurrence1

Versus2

Colorectal cancer patients1

Rectal cancer1

Curative-intent1

Radiation2

Cycles1

Colon2

Dihydropyrimidine dehydrogen2

Dose of chemotherapy1

Cycle of chemotherapy2

Doxorubicin1

Patients with HER2-positive1

Lymph1

Anticancer1

Breast cancer8

Efficacy2

Adenocarcinoma3

Clinical3

Protocols2

Systemic1

Toxicity3

Metastasis1

Prodrug1

Gastric cancer1