Adjuvant chemotherapy chemotherapy adjuvant. Medical search. Frequent questions

To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. (cun.es)
Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to December 2008. (cun.es)
To evaluate the effectiveness and safety of adjuvant chemotherapy compared with radiotherapy or chemoradiation, and to determine which chemotherapy agents are most effective in women presenting with advanced endometrial cancer (FIGO stage III/IV). (unboundmedicine.com)
Randomised controlled trials (RCTs) of adjuvant chemotherapy compared with radiotherapy or chemoradiation in women with FIGO stage III and IV endometrial cancer. (unboundmedicine.com)
RR 5.73, 95% CI 2.45 to 13.36), than those receiving adjuvant radiotherapy. (unboundmedicine.com)
There is moderate quality evidence that chemotherapy increases survival time after primary surgery by approximately 25% relative to radiotherapy in stage III and IV endometrial cancer. (unboundmedicine.com)
Further research is needed to determine which chemotherapy regimen(s) are the most effective and least toxic, and whether the addition of radiotherapy further improves outcomes. (unboundmedicine.com)
The other study, PORTEC (Post-Operative Radiation Therapy in Endometrial Carcinoma), compared the standard of care with adjuvant chemotherapy during and after radiotherapy for patients with high-risk endometrial cancer. (medpagetoday.com)

Most chemotherapy regimens consist of 5-fluorouracil (5-FU), alone or in combination with a variety of other agents like doxorubicin, cisplatin, mitomycin C, cyclophosphamide and oxaliplatin. (cochrane.org)
The random stratification factors include adjuvant chemotherapeutic regimens (XELOX versus SOX) and tumor anatomical sites (gastric adenocarcinoma versus gastroesophageal junction adenocarcinoma). (centerwatch.com)
Adjuvant modified FOLFIRINOX (fluorouracil, leucovorin, irinotecan and oxaliplatin) and gemcitabine plus capecitabine are the preferred chemotherapy regimens as adjuvant chemotherapy for patients with resected PDAC based on their improved survival outcomes compared to gemcitabine monotherapy in phase 3 trials [ 5 - 7 ]. (e-crt.org)
Adjuvant chemotherapy is standard for UICC III colon cancer using fluoropyrimidines or intensified regimens including oxaliplatin. (practical-oncology.ru)
Thirty-one patients with Stage I or II uterine sarcomas, referred to our center for adjuvant chemotherapy, received anthracycline-based regimens. (imrpress.com)
On the other hand, chemotherapy provides limited clinical added benefits and is typically connected with serious side effects[2], calling for the improvement of option treatment regimens. (m-entrepreneurship.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment. (cochrane.org)
We carried out a multicenter, open randomized trial to determine whether adjuvant chemotherapy would improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer. (nih.gov)
These results suggest that platinum-based adjuvant chemotherapy improves survival and delays recurrence in patients with early-stage ovarian cancer. (nih.gov)
As reported in The New England Journal of Medicine by Heather Wakelee, MD , and colleagues, an interim analysis of the phase III KEYNOTE-671 trial showed that the addition of neoadjuvant pembrolizumab to cisplatin-based chemotherapy followed by adjuvant pembrolizumab improved pathologic response and event-free survival in patients undergoing resection of early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
The investigators concluded, "Among patients with resectable, early-stage NSCLC, neoadjuvant pembrolizumab plus chemotherapy followed by resection and adjuvant pembrolizumab significantly improved event-free survival, major pathological response, and pathological complete response as compared with neoadjuvant chemotherapy alone followed by surgery. (ascopost.com)
The main purpose of the study is to examine if periadjuvant (neoadjuvant, then adjuvant) immunotherapy will prolong event free survival in participants with early stage non-small cell lung cancer. (lung.org)
In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
85% for adjuvant FEC-D affects breast cancer survival. (jnccn.org)
Treatment of early-stage breast cancer with adjuvant chemotherapy has improved survival. (jnccn.org)
Scholars@Duke publication: Adjuvant chemotherapy for osteosarcoma may not increase survival after neoadjuvant chemotherapy and surgical resection. (duke.edu)
CONCLUSIONS: The use of adjuvant chemotherapy in the treatment of localized osteosarcoma of bone did not increase survival after neoadjuvant therapy and definitive surgical therapy. (duke.edu)
Adjuvant Therapy and Prognosticators of Survival in Head and Neck Mucosal Melanoma. (rush.edu)
This study examined the association between overall survival and Glutathione S-transferase Pi (GST Pi) expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy. (biomedcentral.com)
Predictive biomarkers, on the other hand, can indicate the likely effect of specific adjuvant treatment on patient outcomes such as tumour recurrence or survival. (biomedcentral.com)
However this would fail to take account of the factors leading to selection or rejection for chemotherapy, which are themselves likely to be associated with survival potential. (biomedcentral.com)
Combined multimodality treatments, including radiation, chemotherapy, and total mesorectal excision have been studied extensively over the past few decades, with efforts toward improving rates of locoregional recurrence and disease-free and overall survival in rectal cancer. (northwestern.edu)
Predictive and prognostic markers to adjuvant systemic chemotherapy have been identified, with the goal of tailoring therapy and continuing improvement in survival. (northwestern.edu)
Vergo, M, Nimeiri, H & Benson, AB 2009, ' Adjuvant chemotherapy after neoadjuvant chemoradiation and surgery: A quest to improve survival for stage II and III rectal cancer ', Current Colorectal Cancer Reports , vol. 5, no. 3, pp. 151-157. (northwestern.edu)
MADRID - Disease-free survival (DFS) in resectable ALK -positive non-small cell lung cancer (NSCLC) improved by 76% with adjuvant alectinib (Alecensa) compared with chemotherapy, according to a randomized trial. (newshealth.biz)
Treatment with adjuvant alectinib resulted in a statistically significant and clinically meaningful improvement in disease-free survival compared with chemotherapy. (newshealth.biz)
I think we should discuss it with the patients, because we have to remember that chemotherapy is the regimen that showed an increase in terms of overall survival in the overall population. (newshealth.biz)
Furthermore, treatment may even result in a net health loss for some types of patients, as small survival gains from chemotherapy are offset by reductions in health related quality of life attributable to the treatment's side effects. (ox.ac.uk)
Among women with advanced-stage disease, optimal debulking surgery, as well as platinum/taxane-based adjuvant therapy prolongs disease-free and median survival. (cancernetwork.com)
Population-based survival and costs of pancreas adenocarcinoma patients receiving adjuvant chemoradiation and chemotherapy following pancreaticoduodenectomy are poorly understood. (hopkinsacg.org)
Kaplan-Meier and Cox proportional hazards regression survival analyses were used to determine associations between adjuvant treatment approach and survival, while stratifying by margin status. (hopkinsacg.org)
Median survival was 19 months for chemoradiation and 22 months for chemotherapy. (hopkinsacg.org)
Chemotherapy and chemoradiation yielded similar survival, but chemoradiation resulted in higher costs. (hopkinsacg.org)
This study aimed to assess the survival benefit of adjuvant chemotherapy in this patient population. (e-crt.org)
The association of adjuvant chemotherapy with disease-free survival (DFS) and overall survival (OS) was evaluated in overall patients and in the propensity score matched (PSM) cohort. (e-crt.org)
Among PDAC patients who underwent surgery following neoadjuvant FOLFIRINOX, adjuvant chemotherapy may be associated with improved survival. (e-crt.org)
Adjuvant chemotherapy with 5-fluorouracil (5-FU) and folinic acid (FA) clearly increases survival in colon cancer UICC stage III. (practical-oncology.ru)
Time to begin adjuvant chemotherapy and survival in breast cancer patients: a retrospective observational study using latent class analysis. (bvsalud.org)
The association between time to begin adjuvant chemotherapy after breast cancer surgery and survival was investigated using both "traditional" regression analysis and LCA. (bvsalud.org)
LCA identified a group of 13-15% of women for whom a longer time to begin chemotherapy had an adverse effect on survival . (bvsalud.org)
Adjuvant pembrolizumab significantly improves disease-free survival (DFS) compared to placebo in patients with early-stage non-small cell lung cancer (NSCLC) who have undergone complete resection, according to findings from the phase 3 PEARLS/KEYNOTE-091 (PEARLS) study. (medscape.com)
Among the treatments for improving survival in women with high-risk and early-stage endometrial cancer are radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)
The first study was the Phase III randomized Gynecologic Oncology Group (GOG)-249 trial, which compared vaginal cuff brachytherapy plus chemotherapy with pelvic radiation therapy for endometrial cancer, with a principal focus on recurrence-free survival. (medpagetoday.com)
The results showed an increase in failure-free survival, 75.5% in the chemoradiotherapy arm, compared with 68.6% in the patients treated with radiation only, but the 5-year survival rate did not improve with the addition of adjuvant chemotherapy. (medpagetoday.com)
Improving survival in women with high-risk, early-stage (stages I-II) endometrial cancer has been the goal of research exploring various modalities such as radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)
Results of the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial (n=12,834), based on 3-year disease-free survival (DFS), showed that FOLFOX narrowly failed to meet the prespecified noninferiority threshold. (medscape.com)
Chemotherapy is also used to improve symptoms and prolong survival in people with stage IV colon cancer. (medlineplus.gov)

Lly managed by surgery, followed by adjuvant endocrine therapy chemotherapy. (m-entrepreneurship.com)
Treatment usually includes surgical excision, often with radiation therapy, and with or without adjuvant chemotherapy, endocrine therapy, or both. (msdmanuals.com)
Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. (lu.se)
Ninety-two percent of patients were untreated by both adjuvant endocrine therapy and chemotherapy. (lu.se)
Within the MET141 low-risk subgroup (lowest 25th percentile of scores), 95% of patients were free of metastasis at 15 years, even in the absence of adjuvant endocrine therapy. (lu.se)

AGO Vulva CaRE-1 multicenter study - adjuvant radio(chemo)therapy in vulvar cancer. (uni-koeln.de)
Current therapy includes neoadjuvant chemotherapy, surgery, and postoperative (adjuvant) chemotherapy. (duke.edu)
Four patients in the adjuvant therapy group died of secondary malignancy compared with none of the no adjuvant therapy group. (duke.edu)
Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment. (rush.edu)
However, an important role exists for the use of chemotherapy and/or radiation therapy in an adjuvant or neoadjuvant setting, and in the treatment of patients with unresectable disease. (medscape.com)
this is known as adjuvant therapy. (melbendo.com.au)
The standard treatment of advanced endometrial cancer consists of cytoreductive surgery followed by radiation therapy, or chemotherapy, or both. (unboundmedicine.com)
The randomized, open-label ALINA trial compared alectinib and chemotherapy as adjuvant therapy for patients with resected stage IB-IIIA ALK+ NSCLC. (newshealth.biz)
This 'hybrid' model was built in Microsoft Excel with a user friendly interface, and so has the potential to be used as a tool to help inform decisions about the use of adjuvant therapy in patients for whom the net benefits are uncertain. (ox.ac.uk)
In this podcast, we'll run through research updates spanning from early treatment to post-adjuvant therapy and a taste of the ethical considerations involved in recruiting for clinical trials. (vjoncology.com)
This study aimed to examine how biomarker information would impact patients' preferences and physicians' recommendations for adjuvant breast cancer therapy. (blogspot.com)
In these cases palliative treatments may include surgical resection, chemotherapy, radiation therapy, and stenting procedures. (wikipedia.org)
Even when surgical removal is successful chemotherapy and radiation therapy are generally recommended. (wikipedia.org)
Effects of screening and systemic adjuvant therapy on ER-specific US breast cancer mortality. (m-entrepreneurship.com)
The Phase III randomized Gynecologic Oncology Group (GOG)-249 trial, presented at the most recent American Society for Radiation Oncology (ASTRO) annual meeting , compared vaginal cuff brachytherapy plus chemotherapy with pelvic radiation therapy for the treatment of stage I-II high-risk, early-stage endometrial cancer. (medpagetoday.com)
Of the 601 patients accrued, 301 were assigned to the pelvic external-beam radiation therapy (PXRT) arm and 300 were assigned to the vaginal cuff brachytherapy and chemotherapy (VCB/C) arm. (medpagetoday.com)
Treatment may consist of some combination of surgery, chemotherapy, and radiation therapy. (wikipedia.org)
Treatment protocols for colon cancer are provided below, including adjuvant and neoadjuvant therapy for resectable disease and therapy for advanced or metastatic colon cancer. (medscape.com)
however, adjuvant therapy may be considered in patients with high-risk disease. (medscape.com)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)

Our trial clearly demonstrates that adjuvant pelvic radiation should remain the standard of care for high-risk, early-stage endometrial cancer patients," the lead author of the study, Marcus Randall, MD, of the University of Kentucky College of Medicine in Lexington, said in an ASTRO news release. (medpagetoday.com)
It also suggests that the trend in our field of abandoning pelvic radiation in favor of chemotherapy-brachytherapy combinations for high-risk patients is premature and not supported by clinical evidence. (medpagetoday.com)

In the present study, the clinicopathological features of 173 patients with stage III CRC who underwent radical resection and adjuvant chemotherapy with the fluoropyrimidine/folinic acid, and oxaliplatin (FOLFOX) regimen, and their prognostic values of EGFR expression were retrospectively analyzed. (oncotarget.com)
We believe that pembrolizumab has the potential to become a new adjuvant treatment option for patient with [stage IB to IIIA] non-small cell lung cancer following complete resection and adjuvant chemotherapy when recommended," concluded first author Luis Paz-Ares, MD , chair of the clinical research unit at Hospital Universitario 12 de Octubre, CNIO & Universidad Complutense, Madrid. (medscape.com)

Chemotherapy is often used alongside surgery to treat cancer. (rockymountaincancercenters.com)
If your cancer treatment plan includes adjuvant chemotherapy or neoadjuvant chemotherapy, that means you will be receiving both chemotherapy and surgery to treat your cancer. (rockymountaincancercenters.com)
Neoadjuvant chemotherapy is delivered before surgery with the goal of shrinking a tumor or stopping the spread of cancer to make surgery less invasive and more effective. (rockymountaincancercenters.com)
Adjuvant chemotherapy is administered after surgery to kill any remaining cancer cells with the goal of reducing the chances of recurrence. (rockymountaincancercenters.com)
For example, a woman with invasive breast cancer or a very large tumor may undergo neoadjuvant chemotherapy to shrink a tumor before breast surgery so a lumpectomy (surgery to remove only the cancer and surrounding tissue) can be performed instead of a mastectomy (removal of the entire breast). (rockymountaincancercenters.com)
Or, she may receive adjuvant chemotherapy after breast surgery to kill any cancer cells that may have been too small to detect during surgery to keep them from growing and spreading. (rockymountaincancercenters.com)
If your cancer treatment plan includes neoadjuvant chemotherapy, you are likely to begin chemotherapy very quickly so that surgery can be performed. (rockymountaincancercenters.com)
If your treatment plan includes adjuvant chemotherapy, you'll likely begin treatments within 30 days following surgery. (rockymountaincancercenters.com)
Between August 1991 and January 2000, 477 patients in 84 centers in five countries were randomly assigned to receive either adjuvant chemotherapy immediately following surgery (n = 241) or no adjuvant chemotherapy until clinically indicated (n = 236). (nih.gov)
all received second-line chemotherapy and surgery and three remained recurrence-free at 5 yr. (nih.gov)
following surgery, patients received adjuvant pembrolizumab at 200 mg or placebo every 3 weeks for up to 13 cycles. (ascopost.com)
Treatment-related death occurred in four patients (1.0%) in the pembrolizumab group, due to immune-mediated lung disease, pneumonia, and sudden cardiac death in one patient each during the neoadjuvant/surgery phase and atrial fibrillation in one patient during the adjuvant phase. (ascopost.com)
Thirty-five patients received chemotherapy after surgery (adjuvant group) and nineteen patients were followed without postoperative chemotherapy (no adjuvant group). (duke.edu)
The current standard of care for resectable ALK+ NSCLC is surgery followed by adjuvant platinum-containing chemotherapy. (newshealth.biz)
The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. (e-crt.org)
For patients who undergo upfront surgery for localized PDAC, adjuvant chemotherapy is the standard of care [ 4 ]. (e-crt.org)
Overall risk reduction by adjuvant treatment is overestimated due to better pre-operative staging (CT) and quality of surgery and pathology resulting in less local recurrence and stage migration. (practical-oncology.ru)
Especially after the use of neoadjuvant radiochemotherapy in combination with high quality surgery effects of additional adjuvant treatment still have to be clearly established. (practical-oncology.ru)
Women with breast cancer undergoing surgery and subsequent adjuvant chemotherapy in two English regions between January 01, 1998 and December 31, 2004 were identified from a linked cancer registry - Hospital Episode Statistics dataset (n = 10,366). (bvsalud.org)
Short answer is none - all patients who have undergone surgery for pancreatic cancer benefit from adjuvant chemotherapy, as long as they can tolerate it.But to be a bit more detailed: Both the Neoptolemos, ESPAC-4 adjuvant trial of gem+cap, and the Conroy PRODIGE 24-ACCORD adjuvant trial of F. (themednet.org)
Most people with stage III colon cancer receive chemotherapy after surgery for 3 to 6 months. (medlineplus.gov)

Two relatively recent NCDB studies looked at the benefit of adjuvant chemo f. (themednet.org)

However, even after curative-intent resection, approximately 75% of patients develop recurrence within 2 years, and recurrence occurs more frequently in the absence of adjuvant chemotherapy [ 1 ]. (e-crt.org)

There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. (cochrane.org)
By synthesising both prognostic and health economic models she generated a model able to make assessments of the effectiveness and cost-effectiveness of adjuvant chemotherapy for women with differing prognoses. (ox.ac.uk)

We have investigated to what extent cDNA microarray measurements could distinguish the likelihood of recurrences after adjuvant CMF (cyclophosphamide, methotrexate and 5-fluorouracil) treatment of premenopausal, lymph node positive breast cancer patients, and have also compared with the corresponding performance using conventional clinical variables. (lu.se)
Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

Other methods of administering chemotherapy may also include intra-muscular injections, tablets or creams. (melbendo.com.au)
Methods: Symptoms were identified in a sample (n = 219) at three times: baseline (prior to the first adjuvant CTX treatment), 1 month after the last CTX (approximately 6 months after baseline), and 1 year after baseline. (nebraska.edu)

To present oral melanoma with pulmonary metastasis in two dogs applying carboplatin chemotherapy and treatment follow up. (vin.com)

We set out to determine the impact of adjuvant cisplatin-based chemotherapy (AC) in a cohort of lymph node positive patients following RC. (canjurol.com)
862 TNM I-III CRC validation cohort, and 2912 TNM II-III CRC adjuvant chemotherapy cohort (TransSCOT). (ox.ac.uk)
Median DFS had yet to be reached in the alectinib cohort versus 41.3 months with chemotherapy. (newshealth.biz)
This retrospective cohort study used linked administrative and pathological datasets to identify all patients diagnosed with pancreas adenocarcinoma and undergoing pancreaticoduodenectomy in Ontario between April 2004 and March 2014, who received postoperative chemoradiation or chemotherapy. (hopkinsacg.org)

No suitable evidence was found to determine the role of adjuvant chemotherapy, when compared with placebo or any other or no adjuvant treatment, in the management of adenocarcinoma of the small intestine. (cochrane.org)
Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment. (cochrane.org)
Adjuvant chemotherapy and neoadjuvant chemotherapy are frequently used in the treatment of breast, colon, lung, bladder, and prostate cancers. (rockymountaincancercenters.com)
Some adjuvant chemotherapy is administered in a few treatment cycles while others are administered for up to 10 years. (rockymountaincancercenters.com)
The side effects of adjuvant and neoadjuvant chemotherapy are the same as when chemotherapy is the only treatment. (rockymountaincancercenters.com)
Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. (curehunter.com)
A standard additional treatment in Europe is two cycles of chemotherapy to eradicate these. (nih.gov)
Carboplatin adjuvant chemotherapy is a palliative treatment that can reduce burden and improve quality of life of melanoma affected dogs. (vin.com)
A large proportion of breast cancer patients are treated with adjuvant chemotherapy after the primary operation, but some will recur in spite of this treatment. (lu.se)
However, in most cases, the patients had received palliative treatment for advanced metastatic disease rather than adjuvant treatment in earlier stages and in most reports there was no random allocation to different treatments. (biomedcentral.com)
If biomarkers able to predict the results of chemotherapy were found, this could lead to more accurate targeting of treatment to those stage C patients most likely to benefit and to avoidance of inappropriate treatment, with its costs and possible toxicity, in those unlikely gain any advantage. (biomedcentral.com)
Adjuvant chemotherapy can be used before the main treatment to help make the tumour smaller, or after treatment, to kill residual cancer cells that may cause problems later in treatment. (melbendo.com.au)
There is currently little agreement about which adjuvant treatment is the safest and most effective. (unboundmedicine.com)
In contrast, a trial of adjuvant erlotinib (Tarceva) showed an "impressive" PFS benefit after 2 years of treatment. (newshealth.biz)
It disrupts the tumor microenvironment and may prove effective as an adjuvant treatment with chemotherapy. (blogspot.com)
Background: Suboptimal completion of chemotherapy, which may involve reduced patient adherence, remains a serious issue and leads to reduced treatment efficacy. (elsevierpure.com)
This study assessed the completion rates, risk factors for noncompletion, and cost impact for noncompletion in patients on capecitabine monotherapy (Cape) or capecitabine with oxaliplatin (CAPOX) for the adjuvant treatment of early-stage colon cancer. (elsevierpure.com)
Noncompletion was associated with CAPOX treatment and higher healthcare costs within 6 months prior to chemotherapy. (elsevierpure.com)
Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
and (2) after learning that they tested positive for a "B-receptor" which modestly increased both the benefit and toxicity expected with chemotherapy A+B. We performed a cross-sectional analysis of the prospectively collected survey data and used the McNemar's test to examine changes in treatment preferences. (blogspot.com)
Information about a positive biomarker indicating increased benefit and toxicity from additional chemotherapy did not change many participants' preferred treatment. (blogspot.com)
However, many patients receive adjuvant treatment without benefit but suffer from toxicity, in case of oxaliplatin even from life-long chronic neurotoxicity. (practical-oncology.ru)
The aim of this overview is to summarize data for adjuvant treatment of colon and rectal cancer with special focus on UICC substage and age and to discuss points of criticism from a surgical point of view. (practical-oncology.ru)
Older patients (≥ 70 years of age) should receive adjuvant treatment as well, because they benefit to the same extent as younger patients. (practical-oncology.ru)
The effects of adjuvant treatment in rectal cancer are less pronounced compared to colon cancer. (practical-oncology.ru)
In summary, adjuvant treatment for colon cancer is well established and should include old patients as well. (practical-oncology.ru)
To reduce side effects and increase efficacy adjuvant treatment should be individualized on the basis of UICC substaging and clinical risk factors, maybe also including molecular subtyping. (practical-oncology.ru)
BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

We are seeing the first signals of efficacy for adjuvant immunotherapy in two large, randomized trials," Reck said. (medscape.com)
Immunotherapy has different side effects than chemotherapy. (medlineplus.gov)

This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
Belani, CP 2003, ' Early-stage non-small-cell lung cancer: Adjuvant versus neoadjuvant chemotherapy ', Clinical Lung Cancer , vol. 5, no. 1, pp. 11-12. (psu.edu)
At first glance one might simply search for a statistical interaction between the marker and chemotherapy by comparing outcome in four categories of patients: those with a low (or negative) value of the marker who did versus did not receive chemotherapy and those with a high (or positive) value who did versus did not receive chemotherapy. (biomedcentral.com)
A large trial evaluating the benefits and risks of adjuvant chemoradiation versus chemotherapy in advanced endometrial cancer is ongoing. (unboundmedicine.com)

Median overall health system costs were calculated at 1 and 3 years for chemoradiation and chemotherapy, and differences were tested using the Kruskal-Wallis test. (hopkinsacg.org)
Patients receiving chemoradiation were more likely to have positive margins: 47.7% compared with 19.2% in chemotherapy. (hopkinsacg.org)
Overall 1-year health system costs were significantly higher for chemoradiation (USD $70,047) than chemotherapy (USD $54,005) ( p ≤ 0.001). (hopkinsacg.org)

Adjuvant Cisplatin Plus Gemcitabine in Operable Cholangiocellular Carcinoma. (cancercentrum.se)

The question of whether platinum-based adjuvant chemotherapy can improve outcomes in patients with early-stage epithelial ovarian cancer is an important one. (nih.gov)

Kaplan-Meier analysis revealed the use of postoperative chemotherapy was not a predictor of improved outcome. (duke.edu)

Patients meeting the inclusion criteria will be 1:1 randomized into JS001-chemotherapy group and placebo-chemotherapy group. (centerwatch.com)

Adjuvant chemotherapeutic protocol, carboplatin at a dosage of 250 mg/m 2 and doxorubicin at a dosage of 60 mg/m 2 , alternating combination of a 3-week interval was given for 6 treatments. (vin.com)

Conclusions: The real-world completion rates for adjuvant capecitabine-based chemotherapy in early-stage colon cancer patients are low. (elsevierpure.com)

Even though the tumor was removed, chemotherapy is given to treat any cancer cells that may remain. (medlineplus.gov)

There is limited evidence to recommend a specific neoadjuvant chemotherapy regimen because of the lack of prospective comparative trials. (e-crt.org)

In colorectal cancer, the prognostic or predictive value of GST Pi expression or genomic polymorphisms for outcomes after chemotherapy has been examined in several studies. (biomedcentral.com)

Individual tumour foci treated with laser hyperthermia were also coded for laser parameters including power settings, number of treatments, and concomitant administration of systemic chemotherapy (chemothermotherapy). (bmj.com)
Laser settings, number of hyperthermia treatments, and the concomitant use of systemic chemotherapy (chemothermotherapy) were not associated with higher rates of vitreous relapse. (bmj.com)

From an initial 104 patients treated with chemotherapy and 104 matched controls, 26 were excluded because of non-informative immunohistochemistry, leaving 95 in the treated group and 87 controls. (biomedcentral.com)
Across disease stages IB-IIIA, alectinib led to a hazard ratio of 0.24, as more than three times as many clinical events occurred in patients treated with chemotherapy. (newshealth.biz)

Standard management in the UK for high-risk stage 1 nonseminoma germ cell tumours of the testis (NSGCTT) is two cycles of adjuvant bleomycin, etoposide (360 mg/m 2 ), and cisplatin (BE 360 P) chemotherapy, or surveillance. (nih.gov)

The ability of a tumour marker to predict response to chemotherapy cannot be determined from a patient series in which some patients were specifically selected for chemotherapy and others were not. (biomedcentral.com)
Title : The Influence of Non-Clinical Patient Factors on Medical Oncologists' Decisions to Recommend Breast Cancer Adjuvant Chemotherapy Personal Author(s) : Pini, T. May;Hawley, Sarah T.;Li, Yun;Katz, Steven J.;Griggs, Jennifer J. (cdc.gov)
Given this potential inconsistency, Reck called for further follow-up in this patient population and for studies in larger groups of patients to further delineate the role of PD-L1 as well as EGFR mutations and adjuvant chemotherapy in patients with early NSCLC. (medscape.com)

Results: Preoperative skeletal muscle mass was analysed in 225 patients, of whom 97 underwent neoadjuvant chemotherapy. (lu.se)

Delayed initiation of adjuvant chemotherapy in older women with breast cancer. (physiciansweekly.com)
Women with stage I-III, hormone receptor-positive/negative, HER2-negative breast cancer treated with adjuvant FEC-D chemotherapy from 2007 through 2014 in Alberta, Canada, were included. (jnccn.org)
Title : Black-white differences in receipt and completion of adjuvant chemotherapy among breast cancer patients in a rural region of the US Personal Author(s) : Lipscomb, Joseph;Gillespie, Theresa W.;Goodman, Michael;Richardson, Lisa C.;Pollack, Lori A.;Ryerson, A. Blythe;Ward, Kevin C. (cdc.gov)
Some of the breast cancer chemotherapy trials conducted during the past 25 years were reviewed. (jamanetwork.com)
CIENCIASMEDICASNEWS: Does biomarker information impact breast cancer patients' preferences and physician recommendation for adjuvant chemotherapy? (blogspot.com)
Evidence is scant regarding symptom clusters and quality of life (QOL) over 1 year in women who receive adjuvant breast cancer chemotherapy (CTX). (nebraska.edu)
Our purpose was to identify the prevalence and severity of individual symptoms, symptom clusters, and QOL in women receiving adjuvant breast cancer CTX from baseline over 1 year. (nebraska.edu)
Cognitive function in women with breast cancer receiving adjuvant chemotherapy and healthy controls. (bvsalud.org)

Exploratory endpoint was adjuvant chemotherapy interaction.ResultsGMS independently associated with DFS (p = 0.001) and RFS (p interaction = 0.013), but not duration (p = 0.64) was dependent on GMS. (ox.ac.uk)

Despite an "impressive" win for the ALK inhibitor, the results should not be interpreted as a death knell for adjuvant chemotherapy in ALK+ NSCLC, said ESMO invited discussant Marina Chiara Garassino, MD, of the University of Chicago. (newshealth.biz)

Recently, neoadjuvant chemotherapy has been widely used for the management of patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) [ 8 - 13 ]. (e-crt.org)

Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study. (rush.edu)

Stage C colon cancer patients with low GST Pi did not benefit from 5-fluourouracil-based adjuvant chemotherapy whereas those with high GST Pi did. (biomedcentral.com)

Singhal N, Singhal D. Adjuvant chemotherapy for small intestine adenocarcinoma. (cochrane.org)

Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)

5% during neoadjuvant chemotherapy were less likely to undergo adjuvant chemotherapy than others (68% vs 85%, p = 0.048). (lu.se)

Results from the model suggest that the cost-effectiveness of chemotherapy decreases as prognosis improves. (ox.ac.uk)

Our data suggest a potential role for anthracycline- and ifosfamide-containing chemotherapy in the adjuvant setting for early-stage uterine sarcomas. (imrpress.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)

Eyes that developed vitreous relapse were coded with regard to Reese-Ellsworth Group, laterality, time to relapse, type of relapse (vitreous base or non-vitreous base relapse), treatments used (including adjuvant diode laser), and ocular preservation. (bmj.com)

Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)

Anatomy4

Organisms1

Diseases73

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Psychiatry and Psychology1

Phenomena and Processes12

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science4

Health Care40

Geographicals1

Radiotherapy8

Regimens7

Survival41

Endocrine therapy6

Therapy21

Radiation2

Resection and adjuvant chemotherapy2

Surgery21

Benefit of adjuvant1

Absence of adjuvant1

Effectiveness of adjuvant2

Cyclophosphamide2

Methods2

Metastasis1

Cohort4

Treatment28

Immunotherapy2

Versus5

Chemoradiation3

Gemcitabine1

Ovarian cancer1

Postoperative1

Placebo1

Chemotherapeutic1

Conclusions1

Tumor1

Regimen1

Prognostic1

Systemic chemotherapy2

Patients treated with chemotherapy2

Cisplatin1

Patient3

Underwent1

Breast cancer8

0.0011

NSCLC1

Resectable1

Efficacy1

Colon1

Adenocarcinoma1

Cycles1

Undergo1

Improves1

Anthracycline2

Treatments1

Doxorubicin1