Adjuvant breast cancer therapy. Medical search. Frequent questions

Impairments in sexual function are common among breast cancer survivors (BCSs), particularly in BCSs receiving adjuvant endocrine therapy (AET). (aau.dk)

The panel also recommended hormonal therapy for women whose tumors have estrogen receptors, and radiation therapy for women who have had mastectomies and who are at high risk for recurrence of cancer. (pharmexec.com)
Patients at high risk for recurrence should be evaluated for adjuvant treatment with CDK4/6 inhibitors. (medscape.com)
Postmenopausal women at high risk for recurrence can be evaluated for adjuvant treatment with a bisphosphonate. (medscape.com)
The primary end point was invasive disease-free survival (defined as freedom from ipsilateral invasive breast tumor recurrence, ipsilateral locoregional invasive breast cancer recurrence, contralateral invasive breast cancer, distant recurrence, or death from any cause). (nih.gov)
Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
Introduction: Despite evidence of the efficacy of adjuvant endocrine therapy (AET) in reducing the risk of recurrence and mortality after treatment for primary breast cancer, adherence to AET is suboptimal. (edgehill.ac.uk)
Conclusion: Provision of timely information to prepare women for the potential side effects of AET and education on medication management strategies are needed, including provision of timely and accurate information on the efficacy of AET in reducing breast cancer recurrence and on potential side effects and ways to manage these should they arise. (edgehill.ac.uk)
Background Anthracyclines and taxanes are chemotherapeutic agents widely used in a sequential regimen in the adjuvant and neoadjuvant treatment of early breast cancer to reduce the risk of cancer recurrence. (mendeley.com)
Do not report hormonal therapy that was undertaken to treat breast cancer progression, recurrence, or second primary cancer. (medical-data-models.org)
Anti-cancer drugs used in combination with surgery and/or radiation to destroy residual cancer cells to prevent or delay recurrence. (ucsfhealth.org)
Excess weight may also raise your risk for breast cancer recurrence following treatment. (healthline.com)
Weight gain may also increase the risk of cancer recurrence. (healthline.com)
Also, the extra fat cells may cause or exacerbate chronic low-grade inflammation , which is linked to a greater risk of breast cancer recurrence, according to Breastcancer.org . (healthline.com)
Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. (hindawi.com)
Oncotype DX breast cancer recurrence score) and outperformed prediction for both high- and low-risk groups. (nature.com)
A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
In general, cancer recurrence and metastasis are the result of the interactions of multiple mutated genes. (nature.com)
Women with breast cancer at more than one site can undergo breast-conserving therapy and still have local recurrence rates well under the acceptable threshold of risk, suggest the results of first prospective study of this issue. (medscape.com)
Although the numbers were small, the data indicated that preoperative MRI to evaluate disease extent, and adjuvant endocrine therapy in women with ER+ disease, were associated with lower recurrence rates. (medscape.com)
Although historical, retrospective studies have shown high rates of local regional recurrences with breast-conserving therapy in women with more than one foci of breast cancer, more recent analyses have indicated that the approach is associated with "acceptable" recurrence rates. (medscape.com)
High risk of in-breast tumor recurrence after BRCA1/2-associated breast cancer. (lu.se)
Endpoints were local recurrence as first recurrence (LR), overall survival (OS), breast cancer death, and distant recurrence. (lu.se)
There were no significant differences between BCT and M for OS, breast cancer death, or distant recurrence. (lu.se)

Time to initiation of adjuvant endocrine therapy was the number of days from date of last treatment (surgery, radiotherapy, or chemotherapy) to the first date of adjuvant endocrine therapy prescription fill. (ascopost.com)
Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I-IIA breast cancer. (lu.se)
One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. (wikipedia.org)
We offer the most advanced breast cancer treatments available, including chemotherapy, radiotherapy and more. (cromwellhospital.com)
Chemotherapy , along with surgery and radiotherapy , is the most effective treatment for triple negative breast cancer. (macmillan.org.uk)
A 2018 article concludes that animal and in vitro studies suggest the potential benefits of ozone therapy for cancer treatment, alongside conventional treatments such as radiotherapy or chemotherapy. (medicalnewstoday.com)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
2.Patient has received extended-field radiotherapy or limited field radiotherapy = 2 weeks prior to randomization, and has not recovered to grade 1 or better from related side effects of such therapy (with the exception of alopecia or other toxicities not considered a safety risk for the patient at investigator's discretion). (who.int)
Introduction: Adjuvant radiotherapy is considered one of treatment options for treatment of locally advanced breast cancer. (bvsalud.org)
group (I) conventional two-dimensional radiotherapy of SC node and Group (II) three-dimensional conformal radiation therapy (3DCRT) planning of SC node. (bvsalud.org)

Neratinib: A tyrosine kinase inhibitor approved for the extended adjuvant treatment of patients with early-stage Her2Neu-positive breast cancer, following adjuvant trastuzumab-based therapy. (medscape.com)
Clinical impact of interruption in adjuvant Trastuzumab therapy in patients with operable HER-2 positive breast cancer. (osu.edu)
In the adjuvant setting, the monoclonal antibody trastuzumab has been evaluated in six randomized trials including more than 10,000 patients. (unimore.it)
To date, one year of trastuzumab in combination or after chemotherapy is the standard adjuvant therapy for patients with HER2 overexpressing tumors. (unimore.it)
Trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine (DM1), a maytansine derivative and microtubule inhibitor, provides benefit in patients with metastatic breast cancer that was previously treated with chemotherapy plus HER2-targeted therapy. (nih.gov)
We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
Patients were randomly assigned to receive adjuvant T-DM1 or trastuzumab for 14 cycles. (nih.gov)
Herzuma (trastuzumab-pkrb) is a HER2 /neu receptor antagonist indicated for the treatment of HER2-overexpressing breast cancer . (rxlist.com)
Select patients for therapy based on an FDA-approved companion diagnostic for a trastuzumab product [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
We accepted that hormone receptor status (ER) for hormonal therapy such as tamoxifen and prediction of response to trastuzumab by HER2 did not require systematic review, as the mechanism of action of these drugs requires intact receptors. (ox.ac.uk)
There are no data regarding single agent trastuzumab as adjuvant therapy, and the existing studies (FinHER, SOLD) suggest that much of the benefit occurs during the chemotherapy phase. (themednet.org)
Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging (TBCRC 003). (curehunter.com)

Major Cancer and Leukemia Group B (CALGB) chemotherapy clinical trials have consistently shown that chemotherapy produces significantly better disease-free and overall survival, particularly in patients with ER-negative disease. (medscape.com)
Clinical trials over the past ten years have contributed an enormous amount of new information about adjuvant therapies,' said panel chair Patricia Eifel, professor of radiation oncology at M.D. Anderson Cancer Center in Houston. (pharmexec.com)
The panel added that whether women with one to three cancerous lymph nodes benefit from radiation therapy is unclear, and that this question should be tested in a randomized clinical trial. (pharmexec.com)
Winer EP, Hudis C, Burstein HJ, Wolff AC, Pritchard KI, Ingle JN, Chlebowski RT, Gelber R, Edge SB, Gralow J et al (2005) American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004. (springer.com)
American Society of Clinical Oncology clinical practice guideline: Update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. (ons.org)
A retrospective cohort of women diagnosed with invasive, nonmetastatic breast cancer and potentially eligible for these clinical trials was used. (nih.gov)
In the breast cancer clinical trials evaluated for the present study, no criterion precluding recruitment was shared by many or all trials and no specific eligibility criterion was consistently the reason for patients' ineligibility. (nih.gov)
Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
Clinical Cancer Research , 26 (1), 171-182. (lu.se)
Cardiac safety is still a major clinical issue, in particular in the treatment of early breast cancer. (unimore.it)
Search methods We searched Cochrane Breast Cancer's Specialised Register, CENTRAL, MEDLINE, Embase, theWorld Health Organization's International Clinical Trials Registry Platform (WHO ICTRP) and ClinicalTrials.gov on 1 February 2018. (mendeley.com)
The aims of the study are to compare male and female breast cancer (FBC) in terms of cancer clinical and anatomopathological features and treatment approach, and to identify differences between male BC and FBC in terms of survival. (mdpi.com)
Adherence to current clinical guidelines for the evaluation of postmenopausal bleeding may result in systematic underdiagnosis of endometrial cancer (EC) in Black women, according to a study published online July 15 in JAMA Oncology. (dryouramnassirmd.com)
A survey of clinical practice in UK cancer centres and units. (ox.ac.uk)
A survey of clinical practice in UK cancer centres and units was carried out to ensure that conclusions drawn from the report could be implemented. (ox.ac.uk)
Dr. Marlana Orloff gives an update on targeted therapies currently being studied in clinical trials. (slideshare.net)
SEER Summary Stage 2000 † was used to characterize cancers as localized, regional, distant, or unknown stage using clinical and pathologic tumor characteristics such as tumor size, depth of invasion and extension to regional or distant tissues, involvement of regional lymph nodes, and distant metastases. (cdc.gov)
As part of our commitment to delivering innovative therapies to patients worldwide, Novartis believes in the need to support ethical independent clinical and non-clinical research conducted by qualified third-party investigators. (novartis.com)
Dr. Carla Falkson is the Director of the Breast Oncology Clinical Research Program and Breast Cancer Service Line at the UR Medicine Wilmot Cancer Institute. (rochester.edu)
Dr. Falkson delivers the best care, which often entails cutting-edge therapies and clinical trials. (rochester.edu)
A 2019 review article only found four clinical studies on ozone therapy for solid tumors within the past 30 years. (medicalnewstoday.com)
The article concludes that there is currently a lack of clinical research to show whether ozone therapy is effective as an additional cancer treatment. (medicalnewstoday.com)
The inclusion criteria were articles that addressed only breast cancer in women, were randomized clinical trials, and interventions involving physical training with Consort ≥80. (frontiersin.org)
HER2 Low Breast Cancer: New Clinical Entity or Testing Artifact? (medscape.com)
Opening the debate was Giuseppe Curigliano, MD, PhD, director of new drugs and early drug development for the Innovative Therapies Division at the European Institute of Oncology, Milan, Italy, who argued the case that HER2 low is a separate clinical entity. (medscape.com)
We have investigated to what extent cDNA microarray measurements could distinguish the likelihood of recurrences after adjuvant CMF (cyclophosphamide, methotrexate and 5-fluorouracil) treatment of premenopausal, lymph node positive breast cancer patients, and have also compared with the corresponding performance using conventional clinical variables. (lu.se)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Based on this evidence, guidelines published by the American Society of Clinical Oncology and the European Organisation for Research and Treatment of Cancer state that when the overall risk of FN is 20% or greater, especially on "dose dense" regimens, primary prophylaxis with G-CSFs is justified [ 10 , 13 ]. (hindawi.com)
Germline variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. (nature.com)
The challenge remains in using these inherited germline variants to predict clinical outcomes of cancer patient population. (nature.com)
9 Here we reasoned that the collective impact of germline variants in cancer patients might largely determine tumorigenesis, evolution, and even clinical outcomes. (nature.com)
Therapy should be individualized based on each patient's clinical scenario, with the risks and benefits of treatment discussed between the clinician and patient. (medscape.com)
The guidelines differ in their recommendations regarding breast self-examination and clinical breast examination, use of screening mammography in women 40-49 years old, age at which to discontinue screening mammography, and MRI mammography. (medscape.com)
Six digitally enabled therapies can be used as treatment options for adults with anxiety disorders while further evidence is generated on their clinical and cost effectiveness, once they have appropriate approval. (bvsalud.org)

Five years of tamoxifen is currently the standard adjuvant hormonal therapy. (pharmexec.com)
McCowan C, Shearer J, Donnan PT, Dewar JA, Crilly M, Thompson AM, Fahey TP (2008) Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer. (springer.com)
Bryant J, Fisher B, Dignam J (2001) Duration of adjuvant tamoxifen therapy. (springer.com)
Quality of life of postmenopausal women in the ATAC ("Arimidex," tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer. (ons.org)
Consider risk-reduction therapy with tamoxifen 20 mg PO qDay (in pre- and postmenopausal women) or raloxifene 60 mg PO qDay (in postmenopausal women) for 5 years in patients with estrogen receptor (ER)-positive DCIS. (medscape.com)
Tamoxifen can be given at a lower dose (5 mg daily) in patients with noninvasive breast cancer as shown by the babytam trial. (medscape.com)
Patients with invasive breast cancer that is ER+ or progesterone receptor positive (PR+) should be considered for adjuvant endocrine therapy with tamoxifen or aromatase inhibitors (AIs). (medscape.com)
Breast cancer medication Tamoxifen has been used for more than 20 years to treat patients with advanced breast cancer. (doctorsolve.com)
Tamoxifen is used as additional therapy after primary treatment for early-stage breast cancer . (doctorsolve.com)
Tamoxifen greatly reduces the possibility of developing breast cancer in women who have a greater chance of developing breast cancer. (doctorsolve.com)
While being studied to help in the treatment of other cancers, it is important to note that Tamoxifen can be used to treat men with breast cancer. (doctorsolve.com)
What is the effect of Tamoxifen on breast cancer? (doctorsolve.com)
Breast cancer medication Tamoxifen fights against the effects of estrogen, which promotes the growth of breast cancer cells. (doctorsolve.com)
As an adjuvant (additional) therapy, Tamoxifen helps prevent the original breast cancer from returning, while also preventing the development of new cancers in the other breast. (doctorsolve.com)
BACKGROUND: The purpose of this study was to compare the rates of all-cause and breast cancer-specific mortality after breast-conserving surgery (BCS) only, BCS plus radiation therapy (RT), mastectomy, and the receipt of adjuvant tamoxifen in a large population-based cohort of older women with early-stage disease. (healthpartners.com)
In the subset of 886 chemotherapy-naive women treated with tamoxifen, those treated with tamoxifen for less than 1 year had a substantially higher breast cancer mortality rate than those exposed 5 years or more (adjusted HR=6.26, 95% CI, 3.10 to 12.64). (healthpartners.com)
CONCLUSIONS: Our findings indicate that older women receiving BCS alone have higher rates of breast cancer death than those receiving BCS + RT or mastectomy and that the survival benefit from tamoxifen increases with increasing duration of treatment. (healthpartners.com)
Patients who received = 14 days of tamoxifen or a NSAI (letrozole or anastrozole) with or without LHRH agonist for advanced breast cancer prior to randomization are eligible. (who.int)
Patients who are receiving = 14 days of tamoxifen or NSAI or LHRH agonists = 28 days for advanced breast cancer prior to randomization are eligible. (who.int)

Ziller V, Kalder M, Albert US, Holzhauer W, Ziller M, Wagner U, Hadji P (2009) Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer. (springer.com)
Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis. (ons.org)

Hormonal therapy was recommended by the panel for women whose breast tumors contain estrogen receptors, regardless of age, menopausal status, tumor size or whether the cancer has spread to nearby lymph nodes. (pharmexec.com)
The panel emphasized that hormonal therapy is not indicated for women whose tumors do not have hormone receptors. (pharmexec.com)
Despite the benefit of adjuvant hormonal therapy (HT) on mortality among women with breast cancer (BC), many women are non-adherent with its use. (springer.com)
Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. (springer.com)
For women with ER and/or PgR positive tumors, the report should be submitted annually through 6 years on study, even if all postoperative adjuvant hormonal treatment is reported to have ended. (medical-data-models.org)
Since being entered on study, has the patient received any postoperative adjuvant hormonal treatment? (medical-data-models.org)
If these receptors are found, you are usually treated with hormonal or targeted therapies . (macmillan.org.uk)
This means treatment with hormonal or targeted therapy will not work. (macmillan.org.uk)
6.Patients must have not received any prior hormonal therapy and chemotherapy for advanced breast cancer, except LHRH agonist. (who.int)
1.Patient has received prior systemic anti-cancer therapy (including hormonal therapy and chemotherapy, or any CDK4/6 inhibitor for advanced breast cancer. (who.int)

[ 2 ] Abemaciclib, palbociclib, and ribociclib are approved for initial and second-line therapy of HR-positive advanced and metastatic breast cancer. (medscape.com)
Treatment that is given before there is any indication that the cancer has spread to prevent or delay the development of metastatic breast cancer administered after surgery and/or radiation. (ucsfhealth.org)
Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N063H (Alliance). (curehunter.com)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)
Dr. Hy Muss reviews potential benefits of treatment for advanced, metastatic breast cancer, as well as the value of functional assessment of patients to predict treatment tolerability. (feedburner.com)
4.Women with advanced (locoregionally recurrent or metastatic) breast cancer not amenable to curative therapy. (who.int)

Partridge AH, LaFountain A, Mayer E, Taylor BS, Winer E, Asnis-Alibozek A (2008) Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer. (springer.com)
Chlebowski RT, Geller ML (2006) Adherence to endocrine therapy for breast cancer. (springer.com)
Partridge AH, Avorn J, Wang PS, Winer EP (2002) Adherence to therapy with oral antineoplastic agents. (springer.com)
Interpretation: By exploring AET-related symptom experiences, nurses may be able to promote AET adherence in breast cancer survivors. (ons.org)
Influence of patient and treatment factors on adherence to adjuvant endocrine therapy in breast cancer. (ons.org)
In a population-based retrospective cohort study reported in JAMA Network Open , Sood et al found that longer time to adjuvant endocrine therapy initiation in Medicaid-insured women with breast cancer was associated with a reduced likelihood of short- and long-term adherence to treatment. (ascopost.com)
As stated by the investigators, "Though adjuvant endocrine therapy has proven efficacy in treating hormone receptor-positive breast cancer, patient adherence to adjuvant endocrine therapy and continuation of treatment as recommended by guidelines remain suboptimal, especially for low-income patients. (ascopost.com)
Adherence was defined as a medication possession ratio of ≥ 80%, and continuation of adjuvant endocrine therapy was defined as no gap in medication supply for at least 90 days. (ascopost.com)
The investigators concluded, "In this cohort study, longer time to adjuvant endocrine therapy initiation was associated with lower odds of short-term and long-term adherence to adjuvant endocrine therapy in Medicaid-insured patients with breast cancer. (ascopost.com)
This study aimed to explore factors that influence adherence and nonadherence to AET following breast cancer to inform the development of supportive interventions. (edgehill.ac.uk)

Pneumocystis jiroveci pneumonia (PCP) in patients receiving neoadjuvant and adjuvant anthracycline-based chemotherapy for breast cancer: incidence and risk factors. (curehunter.com)

Breast Cancer Res Treat;2023 Oct 03. (bvsalud.org)
A 2023 study found differences in the breast cancer cells of women with a BMI over 30 and breast cancer cells in women with lower BMIs. (healthline.com)

In 10-20% of cases, this may reveal invasive cancer or DCIS that requires additional local or systemic therapy. (medscape.com)
however, patients with LCIS have about a 5% 5-y risk and a 20-30% lifetime risk of developing invasive breast cancer, which may be ipsilateral or contralateral and may be ductal or lobular in origin. (medscape.com)
Patients who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 (HER2)-targeted therapy have a worse prognosis than those who have no residual cancer. (nih.gov)
he addition of palbociclib to a 2-year course of adjuvant endocrine therapy did not meaningfully improve invasive disease-free survival (DFS) over endocrine therapy alone in patients with early-stage breast cancer, according to an interim analysis of a phase 3 trial published in The Lancet Oncology . (dryouramnassirmd.com)
There are several types of breast cancer, and they're broken into two main categories: invasive and noninvasive. (healthline.com)
While invasive cancer has spread from the breast ducts or glands to other parts of the breast, noninvasive cancer has not spread from the original tissue. (healthline.com)
Invasive ductal carcinoma (IDC) is the most common type of breast cancer. (healthline.com)
Data on new cases of invasive breast cancer diagnosed during 2005-2009 were obtained from population-based cancer registries affiliated with the NPCR and SEER programs, which combined cover all of the US population. (cdc.gov)
To date, a prospective cohort study from the Women's Health Initiative Study has used the DII to assess the association between post-diagnosis dietary inflammatory potential and survival of invasive breast cancer patients, indicating that consuming a more anti-inflammatory diet after breast cancer diagnosis reduced risk of death from cardiovascular disease 18 . (nature.com)
Another study presented at SABCS 2022, which involved patients with early-stage invasive lobular carcinoma of the breast, suggested that HER2 low status was associated with worse DFS when compared to HER2-negative status, as well as progesterone receptor positivity. (medscape.com)
Hence, germline genomic information could be used for developing non-invasive genomic tests for predicting patients' outcomes in breast cancer. (nature.com)
Development and External Validation of a Novel 12-Gene Signature for Prediction of Overall Survival in Muscle-Invasive Bladder Cancer. (cdc.gov)
Semen miRNAs Contained in Exosomes as Non-Invasive Biomarkers for Prostate Cancer Diagnosis. (cdc.gov)
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer. (cdc.gov)
Women with invasive breast cancer and a pathogenic mutation in BRCA1 or BRCA2 were included in the study (n = 162). (lu.se)

In some cases, magnetic resonance imaging can predict the response of a patient to neoadjuvant therapy, for example in ovarian cancer. (wikipedia.org)
What's the Latest in Clear Cell Ovarian Cancer? (slideshare.net)
A total of 1064 female breast cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) Trial prospective cohort, were included in this analysis if they had completed the diet history questionnaire (DHQ). (nature.com)
That fat tissue produces even more estrogen, which can fuel the growth of hormone-receptor-positive breast cancers , as well as endometrial, ovarian, and other cancers. (healthline.com)

The best candidates for neoadjuvant chemotherapy are patients with ER-negative and/or Her2Neu-positive expressing tumors, whose pathologically complete response (pCR) rates can approach 65% (in Her2Neu-positive cancers) and predict long-term survival. (medscape.com)
The CDK4/6 inhibitor abemaciclib (Verzenio) has been approved for use in hormone receptor (HR)-positive, Her2Neu-negative early breast cancer, for patients who have high-risk, node-positive disease and whose tumors have a Ki-67 score of ≥20%, as determined by a US Food and Drug Administration (FDA)-approved test. (medscape.com)
Male breast cancer (BC) represents less than 1% of male tumors. (mdpi.com)
In cancer, the development of blood vessels can feed tumors and allow them to grow, and drugs that block angiogenesis are being tested as cancer treatment. (ucsfhealth.org)
SAN ANTONIO - Should breast cancer patients with low but not negative tumor expression of HER2 be considered a distinct patient group that can be treated differently from patients with tumors that are HER2 negative or HER2 positive? (medscape.com)
There were no prospective data out there telling us that doing two lumpectomies in the breast was safe, so a lot of times, women were getting mastectomy for these multiple tumors, even if women had two small tumors in the breast and could easily undergo a lumpectomy with a good cosmetic result," she said. (medscape.com)
So this data provides very strong evidence that we can begin treating women with small tumors in the breast who can undergo lumpectomy with a good cosmetic results without needing a mastectomy," Barrio continued. (medscape.com)
Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)

2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
People with BRCA mutation-positive HER2‑negative high-risk early breast cancer usually have chemotherapy followed by surgery (neoadjuvant chemotherapy), or surgery followed by chemotherapy (adjuvant chemotherapy). (bvsalud.org)

Automated administrative databases, medical records, and tumor registries were used to identify women aged 65 years or older who received BCS or mastectomy to treat stage I or II breast cancer diagnosed from January 1, 1990, through December 31, 1994. (healthpartners.com)
Compared with women receiving mastectomy, those receiving BCS without RT were twice as likely to die of breast cancer (adjusted hazards ratio [HR]=2.19, 95% confidence interval [CI], 1.51 to 3.18). (healthpartners.com)
Breast cancer mortality rates were similar between women receiving BCS plus RT and women receiving mastectomy (adjusted HR=1.08, 95% CI, 0.79 to 1.48). (healthpartners.com)
This type of radiation is delivered by an x-ray machine that delivers a precise area of radiation either to the whole breast, or the chest wall (if done after mastectomy). (medlineplus.gov)
Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer. (curehunter.com)
Lumpectomy with radiation therapy is often preferred to mastectomy, as it is a smaller operation with quicker recovery, resulting in better patient satisfaction and cosmetic outcomes," Boughey commented in a statement. (medscape.com)
We knew that in patients who have a single site tumor in the breast, that outcomes between lumpectomy and mastectomy are the same… But none of those trials are enrolled women with multiple sites. (medscape.com)
The purpose of the study was to compare breast-conserving therapy (BCT) and mastectomy (M) in BRCA1/2 mutation carriers. (lu.se)

This study provides important information for clinicians to discuss with patients who have two or three foci of breast cancer in one breast, as it may allow more patients to consider breast-conserving therapy as an option," said study presenter Judy C. Boughey, MD, chair of the Division of Breast and Melanoma Surgical Oncology at the Mayo Clinic, Rochester, Minnesota. (medscape.com)
Oncology experts summarize current and emerging issues in cancer management for patients and caregivers. (feedburner.com)
Dr. Hy Muss, expert in breast cancer and geriatric oncology at the University of North Carolina at Chapel Hill, discusses leading surgery options for breast cancer and how we estimate the value of post-operative therapy. (feedburner.com)
Dr. Hy Muss, expert in breast cancer and geriatric oncology at the University of North Carolina at Chapel Hill, discusses considerations around prevention, screening, and treatment considerations for older women with breast cancer. (feedburner.com)
Dr. Hy Muss, expert in breast cancer and geriatric oncology at the University of North Carolina at Chapel Hill, reviews the demographics of breast cancer and the relevance of age in management issues. (feedburner.com)

citation needed] This systemic therapy (chemotherapy, immunotherapy or hormone therapy) or radiation therapy is commonly used in cancers that are locally advanced, and clinicians plan an operation at a later stage, such as pancreatic cancer. (wikipedia.org)
Whole breast radiation therapy uses high-powered x-rays to kill breast cancer cells. (medlineplus.gov)
With this type of directed radiation therapy, the whole breast (or chest wall if the breast was removed) receives the radiation treatment. (medlineplus.gov)
Because radiation is most harmful to quickly growing cells, radiation therapy damages cancer cells more than it damages the slower growing normal cells. (medlineplus.gov)
This is a doctor who specializes in radiation therapy. (medlineplus.gov)
Sometimes the doctor will recommend small skin marks called "tattoos" to help line you up and improve the accuracy of the radiation therapy. (medlineplus.gov)
Adding radiation therapy can kill the remaining cancer cells and lower the risk of the cancer growing back. (medlineplus.gov)
Radiation therapy, like any cancer therapy, can also damage or kill healthy cells. (medlineplus.gov)
For the treatment of breast cancer, some patients undergo chemotherapy, radiation therapy, or hormone therapy. (frontiersin.org)
Treatment usually includes surgical excision, often with radiation therapy, and with or without adjuvant chemotherapy, endocrine therapy, or both. (msdmanuals.com)
Thyroid gland is not considered an organ at risk in supraclavicular (SC) nodal radiation therapy (RT) for breast cancer. (bvsalud.org)

OBJECTIVES: To investigate the cost-effectiveness of using prognostic information to identify patients with breast cancer who should receive adjuvant therapy. (ox.ac.uk)

Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)

If the prior neo (adjuvant) therapy included aromatase inhibitors, the disease free interval must be greater than 12 months from the completion of aromatase inhibitor treatment until randomization. (who.int)

Objectives To assess whether the sequence in which anthracyclines and taxanes are administered affects outcomes for people with early breast cancer receiving adjuvant or neoadjuvant therapy. (mendeley.com)
Main outcomes were disease-free survival (DFS), overall survival (OS), grade ≥ 3 adverse events (AEs), and contralateral breast cancer (CBC). (bvsalud.org)
Large retrospective dataset containing data on prognostic factors, treatments and outcomes for women with early breast cancer treated in Oxford. (ox.ac.uk)
This framework was applied to a large retrospective dataset containing data on prognostic factors, treatments and outcomes for women with early breast cancer treated in Oxford. (ox.ac.uk)
Can weight affect breast cancer outcomes? (healthline.com)
Weight gain can have a negative impact on breast cancer outcomes. (healthline.com)
In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
Physical and psychological outcomes among women in a telephone‑based exercise intervention during adjuvant therapy for early stage breast cancer. (bvsalud.org)

Treatment with a combination of chemotherapy drugs improves survival and should be recommended for most women with localized breast cancer, according to a consensus panel convened by the NIH. (pharmexec.com)
one of the four adjuvant studies collected overall survival data. (mendeley.com)
Only one adjuvant study collected data on overall survival and disease-free survival but did not report data. (mendeley.com)
When detected in its early stages, breast cancer is highly treatable with good survival rates. (cromwellhospital.com)
Advances in screening and treatment have improved survival for U.S. women with breast cancer. (cdc.gov)
Inflammation-modulating nutrients and inflammatory markers are established cancer risk factors, however, evidence regarding the association between post-diagnosis diet-associated inflammation and breast cancer survival is relatively sparse. (nature.com)
Long-term anti-inflammatory diet might be a means of improving survival of breast cancer survivors. (nature.com)
Racial and Ethnic Differences in Breast Cancer Survival: Mediating Effect of Tumor Characteristics and Sociodemographic and Treatment Factors. (curehunter.com)
He admitted that, while there have been many studies, the majority have found no overall survival difference between breast cancer patients whose disease could be classified as HER2 low as opposed to HER2 negative or zero. (medscape.com)
There was a 2% difference in 5-year overall survival among patients with advanced triple-negative breast cancer. (medscape.com)
Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. (smw.ch)
85% for historical regimens (ie, cyclophosphamide/methotrexate/fluorouracil) are known to affect breast cancer survival. (jnccn.org)
85% for adjuvant FEC-D affects breast cancer survival. (jnccn.org)
Treatment of early-stage breast cancer with adjuvant chemotherapy has improved survival. (jnccn.org)

65 years at diagnosis of hormone receptor-positive breast cancer between January 2007 and December 2013 and followed for 5 years after the first use of adjuvant endocrine therapy through December 2018. (ascopost.com)
Methods: Interviews were conducted with 32 women who had been prescribed AET, 2-4 years following their diagnosis of breast cancer. (edgehill.ac.uk)
If you (or a loved one) are dealing with a breast cancer diagnosis, or breast cancer treatment or recovery, check this list of related medical terms to better understand what it's all about. (ucsfhealth.org)
Breast cancer incidence, stage at diagnosis, and mortality rates for 2005-2009 for women in the United States and for each state were calculated using United States Cancer Statistics (USCS) data. (cdc.gov)
However, black women experience inequities in breast cancer screening, follow-up, and treatment after diagnosis, leading to greater mortality. (cdc.gov)
The MIR represents the number of breast cancer deaths per 100 breast cancers diagnosed and is an indication of prognosis after diagnosis. (cdc.gov)
We aimed to examine the association between post-diagnosis dietary inflammatory index (DII®) and risks of all-cause and breast cancer-specific mortality. (nature.com)
The post-diagnosis E-DII was statistically significantly associated with mortality risk among breast cancer survivors. (nature.com)
When receiving a breast cancer diagnosis, many people have a long list of questions about why, how, and what's next. (healthline.com)
Why do women gain weight after receiving a breast cancer diagnosis? (healthline.com)
Researchers believe it's common for people with breast cancer to gain some weight after receiving a diagnosis of breast cancer. (healthline.com)
Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis. (smw.ch)
In recent years, there has been increased diagnosis of multiple foci of ipsilateral breast cancer, Boughey said in her presentation. (medscape.com)
2.Patient has a histologically and/or cytologically confirmed diagnosis of estrogen-receptor positive and/or progesterone receptor positive breast cancer based on the most recently analyzed tissue sample and all tested by local laboratory. (who.int)
Following M, all local recurrences were seen in the first 5 years after breast cancer diagnosis. (lu.se)

Since the introduction of anti-Her2 agents, the prognosis of HER2 positive breast cancer patients significantly improved. (unimore.it)

Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)

Landmark meta-analyses by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) initially showed a 20% to 25% relative risk reduction in breast cancer mortality for first-generation regimens (ie, cyclophosphamide/methotrexate/fluorouracil [CMF]) and increased benefit with the addition of anthracyclines and taxanes. (jnccn.org)

Selection criteria Randomised controlled trials comparing administering a taxane prior to an anthracycline with taxane following anthracycline to people with early breast cancer receiving chemotherapy. (mendeley.com)

The ACOSOG-Z11102 trial involved more than 200 women with primarily endocrine receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer and up to three disease foci, all of whom underwent lumpectomy with nodal staging followed by whole-breast irradiation, then systemic therapy at the oncologist's discretion. (medscape.com)
this may be in part because they have a higher rate of triple-negative breast cancer (negative for estrogen and progesterone receptors and human epidermal growth factor receptor [HER2] oncogene), which has a poorer prognosis than other types. (msdmanuals.com)

Comparative efficacy and safety of extended adjuvant endocrine therapy for hormone receptor-positive early breast cancer: a Bayesian network meta-analysis. (bvsalud.org)
In this network meta-analysis (NMA), the efficacy and safety of all available extended adjuvant ETs were compared and ranked. (bvsalud.org)
Extended 10 year AI therapy may be optimal for HR + early breast cancer given its relatively high efficacy and safety . (bvsalud.org)
Controversy exists regarding the definition of HER2 positivity (HER2+) and the type of test that may best predict the efficacy of anti-HER2 therapy. (slideplayer.com)
This helps the body fight cancer and may potentially support the efficacy of other cancer treatments. (medicalnewstoday.com)
Does the source of death information affect cancer screening efficacy results? (smw.ch)
Recontacting patients for multigene panel testing in hereditary cancer: Efficacy and insights. (cdc.gov)

Research from 2019 found that 35% of participants receiving adjuvant therapy for breast cancer gained approximately 2 or more kg (4.4 lb) after 2 years. (healthline.com)

Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer. (curehunter.com)

Clin Cancer Res (2018) 24 (15): 3486-3491. (aacrjournals.org)

After the first three deaths in August, the ANSM launched a pharmacovigilance investigation of all docetaxel-based therapies. (medscape.com)
As a precaution, given the occurrence within an unusually short period of time, of these two similar cases at the Institut Curie and those at other healthcare facilities in France, the Institut Curie has stopped using docetaxel to treat breast cancer. (medscape.com)

Other molecules such pertuzumab, which binds the HER2 dimerization domain, or the pan-erbB TK inhibitor neratinib are under evaluation in the (neo)-adjuvant setting. (unimore.it)

The goal of neoadjuvant treatment is to induce a tumor response before surgery and enable breast conservation. (medscape.com)
Patient who undergo upfront surgery can qualify for adjuvant chemotherapy based on gene expression profiling such as the Oncotype DX, MammaPrint, or Prosigna. (medscape.com)
A surgical guidance system used to accurately pinpoint the location of a tumour in the breast before surgery. (cromwellhospital.com)
Amounts of 49 males and 680 postmenopausal females with primary non-metastatic BC who underwent breast surgery at Mauriziano Hospital or IRCCS Candiolo (TO-Italy) were included. (mdpi.com)
A specialist breast cancer doctor takes a sample of cancer cells during a biopsy or surgery to test for these receptors. (macmillan.org.uk)
You may be more likely to have chemotherapy as your first treatment before surgery to remove the cancer. (macmillan.org.uk)
After surgery, cancer cells may remain in the breast tissue or lymph nodes. (medlineplus.gov)
When radiation is delivered after surgery is performed, it is called adjuvant (additional) treatment. (medlineplus.gov)
These results are "exciting to see, as they provide important information that breast-conserving surgery is safe in these patients, and that we can now share the results of this study with patients when we discuss with them their surgical options. (medscape.com)
Hereditary breast cancer: screening and risk reducing surgery. (cdc.gov)

According to a 2022 article , the aim of ozone therapy is to increase oxygen levels in the blood by administering ozone into the body. (medicalnewstoday.com)
And a 2022 study of breast cancer survivors found that weight increased over time by approximately .79 kg (1.74 lb) at 1 year to 1.23 kg (2.71 lb) at 3 years. (healthline.com)
That was the question posed during a session at the recent San Antonio Breast Cancer Symposium (SABCS) 2022. (medscape.com)
The new findings were presented at the San Antonio Breast Cancer Symposium (SABCS) 2022 on December 9. (medscape.com)

For more information, see Breast Cancer , HER2 Breast Cancer , and Breast Cancer Treatment Protocols . (medscape.com)

Participants: 14 breast cancer survivors, aged 50 years or older, with AET-related symptoms. (ons.org)
Moderate or high-intensity exercise sessions have been shown to benefit women survivors of breast cancer. (frontiersin.org)
Physical training performed at a moderate or high intensity (aerobic or anaerobic) can reduce fatigue, improve quality of life, improve sleep quality, and increase bone mineral density in women survivors of breast cancer. (frontiersin.org)

These findings suggest the combination should not be considered an effective regimen for adjuvant therapy, according to the researchers. (dryouramnassirmd.com)

Lapatinib is under evaluation in a large adjuvant trial, and in several neoadjuvant studies. (unimore.it)

This report summarizes disparities in breast cancer incidence and mortality between white and black women in the United States, using data from USCS for 2005-2009. (cdc.gov)
USCS includes mortality data from the National Vital Statistics System (NVSS) and incidence data from the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) program. (cdc.gov)
Annual breast cancer incidence and mortality rates per 100,000 women were age-adjusted by the direct method to the 2000 U.S. standard population (19 age groups), and corresponding 95% confidence intervals (CIs) were calculated. (cdc.gov)
Cox regression and competing risk models were used to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by E-DII tertile (T) for all-cause and breast cancer-specific mortality. (nature.com)
Previous studies suggest that screening for early detection and improved treatment, including adjuvant therapy, have contributed to about one-half of the decline in breast cancer-related mortality 3 . (nature.com)
PRINCIPLES: It is crucial for aging societies to evaluate trends in cancer mortality rates of older adults. (smw.ch)
This study examined socio-demographic and regional characteristics specifically focused on the cancer mortality experience of older adults in Switzerland. (smw.ch)
65, 65-74, 75-84, 85+ years) mortality rates were calculated as observed (cancer deaths/person years) and expected from Poisson models adjusted for changes in death record coding over follow-up. (smw.ch)
RESULTS: Cancer mortality, except for lung cancer, increased with advancing age. (smw.ch)
Younger old women living alone or in suburban areas had the most sharpest increase in lung cancer mortality rates. (smw.ch)
CONCLUSION: This comprehensive epidemiological analysis of cancer mortality trends in older adults provides further evidence that in Switzerland (like other developed countries) cancer is a disease of aging with important gender-age-specific variations representing major public health challenges for aging societies. (smw.ch)
Switzerland statistics of cancer mortality 1984-2008. (smw.ch)
Levi F, Lucchini F, La Vecchia C. Trends in cancer mortality in Switzerland, 1980-2001. (smw.ch)
Levi F, Lucchini F, Negri E, La Vecchia C. Trends in mortality from major cancers in the European Union, including acceding countries, in 2004. (smw.ch)
Estimates of cancer incidence and mortality in Europe in 1995. (smw.ch)
Doria-Rose VP, Marcus PM. Death certificates provide an adequate source of cause of death information when evaluating lung cancer mortality: an example from the Mayo Lung Project. (smw.ch)

Personally, when I have a patient with multisite disease and I'm going to keep their breasts, that to me is one indication that I would consider an MRI, to make sure that I wasn't missing intervening disease between the two sites - that there wasn't something else that would change my mind about doing a two-site lumpectomy," Barrio said. (medscape.com)
Linda M. Pak, MD, a breast cancer surgeon and surgical oncologist at NYU Langone's Breast Cancer Center, New York, NY, who was not involved in the study, commented that it the new study provides "importation information regarding the oncologic safety" of lumpectomy. (medscape.com)

Despite having lower incidence rates, black women had a 41% higher breast cancer death rate. (cdc.gov)
Despite significant progress in breast cancer detection and treatment, black women experience higher death rates even though they have a lower incidence of breast cancer compared to white women. (cdc.gov)
The age-adjusted incidence of cancer in the US is 3 times higher than that in Asian countries, with immigrants to the US having increased risk for this condition [ 4 , 5 ]. (mdpi.com)
In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome. (cdc.gov)

Fourteen randomized controlled trials (RCTs) comprising eight extended adjuvant ETs for HR + breast cancer and 38,070 patients were analyzed. (bvsalud.org)
Researchers require further evidence from human studies and randomized controlled trials to find out whether it could be an effective treatment for breast cancer. (medicalnewstoday.com)

Women with breast cancer have more treatment options and a better chance of surviving their disease than ever before. (pharmexec.com)
Among 8,769 women who filled at least one prescription for HT, 2,761 (31%) discontinued therapy. (springer.com)
Patient-reported discontinuation of endocrine therapy and related adverse effects among women with early-stage breast cancer. (ons.org)
The study involved 1,711 women identified from the linked Missouri Cancer Registry and Medicaid claims data set. (ascopost.com)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432992/all/Exercise_for_women_receiving_adjuvant_therapy_for_breast_cancer. (unboundmedicine.com)
Breast cancer is the most common type of cancer in the UK, experienced by around one in eight women. (cromwellhospital.com)
We developed our breast care diagnostic pathway to provide women with rapid access to diagnostic services in suspected cases of breast cancer. (cromwellhospital.com)
The survey confirmed pathological nodal status, tumour grade, tumour size and ER status as the most clinically important factors for consideration when selecting women with early breast cancer for adjuvant systemic therapy in the UK. (ox.ac.uk)
But triple negative breast cancer can develop in women of any age and ethnicity. (macmillan.org.uk)
Most women with triple negative breast cancer have no strong history of breast cancer in their family (hereditary breast cancer). (macmillan.org.uk)
But some women with triple negative breast cancer have an altered BRCA1 gene . (macmillan.org.uk)
RESULTS: We identified 1,837 women having operations for stage I or II breast cancer. (healthpartners.com)
For every 100 breast cancers diagnosed, black women had nine more deaths than white women (27 deaths per 100 breast cancers diagnosed among black women compared with 18 per 100 among white women). (cdc.gov)
At the individual level, the maximal effectiveness of screening for breast cancer can only be achieved when all women have timely follow-up to breast cancer exams and state-of-the-art treatment. (cdc.gov)
It is the most commonly diagnosed cancer among US women. (cdc.gov)
Although breast cancer deaths have declined over the last 2 decades, it remains the second leading cause of cancer deaths among women ( 1 ). (cdc.gov)
The maximum benefit of breast cancer screening will only be achieved if women of all racial groups receive not only optimal screening, but also timely follow-up and state-of-the-art treatment. (cdc.gov)
The objective of this systematic review was to identify the effects of different training methods in women who have survived breast cancer (WSBC). (frontiersin.org)
Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women. (curehunter.com)
For example, a 2021 study found that most women experienced an average weight gain of 1.2 kg (2.64 lb) during treatment for early-stage breast cancer. (healthline.com)
The women with higher BMIs had breast cancer cells with more inflammation and different mutations. (healthline.com)
Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)
Breast cancer is the number one cancer diagnosed amongst South African women with a 1 in 29 lifetime risk [ 2 , 3 ], while prostate cancer is the most prevalent in men [ 4 ]. (hindawi.com)
From a long-term quality of life standpoint, this is a big deal for women moving forward who really want to keep their breasts. (medscape.com)
Barrio did highlight, however, that "not everybody routinely does MRI" in women with breast cancer, including her institution, although generally she feels that "our standard imaging has gotten better," with screening ultrasound identifying more lesions than previously. (medscape.com)
Women with stage I-III, hormone receptor-positive/negative, HER2-negative breast cancer treated with adjuvant FEC-D chemotherapy from 2007 through 2014 in Alberta, Canada, were included. (jnccn.org)
Breast cancer is the 2nd leading cause of cancer death (the most common is lung cancer) in the overall female population but is the leading cause of cancer death in Black women. (msdmanuals.com)
Asian and Pacific Islander women have the lowest death rate from breast cancer. (msdmanuals.com)
White, Asian, and Pacific Islander women are more likely to be diagnosed with localized breast cancer than Black, Hispanic, American Indian, and Alaska Native women. (msdmanuals.com)
The ACS updated its guidelines for breast cancer screening in average-risk women in October 2015. (medscape.com)
[ 1 ] At this time, the ACS is in the process of updating the breast cancer screening guidelines for women at high risk, which were last updated in 2007. (medscape.com)
It is acceptable for women to choose not to do breast self-examination (BSE) or to do BSE regularly (monthly) or irregularly. (medscape.com)
Background: Breast cancer is the most common malignancy in women in Nigeria. (bvsalud.org)

Results: In SweBCG91-RT, 454 patients were node-negative, postmenopausal, and systemically untreated with ER-positive, HER2-negative cancers, which constitutes a low-risk subgroup and potential candidates for therapy omission. (lu.se)
Within the MET141 low-risk subgroup (lowest 25th percentile of scores), 95% of patients were free of metastasis at 15 years, even in the absence of adjuvant endocrine therapy. (lu.se)
In a clinically low-risk subgroup of the METABRIC cohort not treated with systemic therapy, no breast cancer death occurred among the MET141 low-risk patients. (lu.se)
Who is at risk of developing breast cancer? (cromwellhospital.com)
The causes of breast cancer aren't fully understood, but there are several risk factors that can increase your likelihood of developing it. (cromwellhospital.com)
The data were used to estimate directly a parametric regression-based risk equation, from which a prognostic index was developed, and prognosis-specific estimates of the baseline breast cancer hazard could be observed. (ox.ac.uk)
Published estimates of treatment effects, health service treatment costs and utilities were used to construct a decision analytic framework around this risk equation, thus enabling simulation of the effectiveness and cost-effectiveness of adjuvant therapy for all possible combinations of prognostic factors included in the model. (ox.ac.uk)
Would you use single agent adjuvant HER2 directed therapy for patients with low risk HER2+ breast cancer who are not candidates for chemotherapy? (themednet.org)
Benign microscopic breast changes known as atypical hyperplasia may increase a woman's risk of developing breast cancer. (ucsfhealth.org)
But your gender identity may not align with your breast cancer risk. (healthline.com)
Your doctor can help you better understand how your specific circumstances will translate into breast cancer risk factors and symptoms. (healthline.com)
But the risk of it coming back depends on the same factors as any other type of breast cancer. (macmillan.org.uk)
The risk factors for triple negative breast cancer are not clear. (macmillan.org.uk)
But triple negative breast cancer does not seem to share these risk factors. (macmillan.org.uk)
The value of the scientific research produced by third party sponsors is key to complementing Novartis-sponsored research by helping us to better understand the benefit/risk profile of our therapies, as well as enabling us to explore new opportunities addressing unmet medical needs. (novartis.com)
Among the different risk factors, it is estimated that sedentary behavior, obesity, and physical inactivity in particular account for 20-40% of all cancer cases. (frontiersin.org)
Additionally, someone's risk of breast cancer-related death also increases if they gain weight during or after breast cancer treatment, per the same study. (healthline.com)
Why is overweight and obesity a risk factor for breast cancer? (healthline.com)
Higher body weight is associated with a higher risk of a number of different kinds of cancer. (healthline.com)
Research suggests that obesity is a well-established risk factor for breast cancer. (healthline.com)
While many factors are involved in the etiology of cancer, it has been clearly established that diet significantly impacts one's risk for this disease. (mdpi.com)
More recently, specific food components have been identified which are uniquely beneficial in mitigating the risk of specific cancer subtypes. (mdpi.com)
Plant sterols are well known for their effects on blood cholesterol levels, however research into their potential role in mitigating cancer risk remains in its infancy. (mdpi.com)
Despite the results of recent studies failing to demonstrate a large inverse association between produce consumption and overall cancer risk [ 6 ], the benefits of key nutrition components unique to plant foods, may still prove beneficial in reducing individual risk and may mitigate the risk of specific cancer subtypes. (mdpi.com)
Family history remains one of the major risk factors that contribute to cancer, and recent studies have identified several genes whose germline mutations are associated with cancer. (nature.com)
[ 147 ] In addition, a physician reminder in conjunction with a patient risk assessment strategy can result in a reduction in patient fractures and an increase in osteoporosis therapy. (medscape.com)
Screening patients at high risk for pancreatic cancer-Is it time for a paradigm shift? (cdc.gov)
BRCA1/2 mutation carriers treated with BCT have a high risk of LR, many of which are new primary breast cancers. (lu.se)

An altered BRCA 1 gene can cause breast cancer to run in families. (macmillan.org.uk)

Early Breast Cancer Trialists' Collaborative Group. (springer.com)

She has a special interest in treating HER2 amplified (over-expressed), hormone receptor-positive breast cancer, and treatment modalities for optimal bone health in breast cancer patients. (rochester.edu)

Anatomy12

Organisms3

Diseases45

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Psychiatry and Psychology2

Phenomena and Processes47

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups2

Health Care32

Geographicals2

Receiving adjuvant endocrine therapy1

Recurrence23

Radiotherapy10

Trastuzumab12

Clinical34

Tamoxifen19

Endocrine therapy in postmenopausal2

Hormonal10

Metastatic breast7

Adherence10

Chemotherapy for breast cancer1

20232

Invasive15

Ovarian4

Tumors9

Neoadjuvant chemotherapy2

Mastectomy8

Oncology5

Radiation therapy11

Receive adjuvant1

Systemic adjuvant1

Aromatase1

Outcomes8

Survival14

Diagnosis15

HER2-Positive Breast Cancer1

Doxorubicin1

Cyclophosphamide1

Anthracycline1

Human epidermal growth f2

Efficacy7

20191

Patients with metastatic1

20181

Docetaxel2

Inhibitor1

Surgery10

20224

Treatment Protocols1

Survivors3

Regimen1

Lapatinib1

Mortality16

Lumpectomy2

Incidence5

Colorectal Cancer1

Trials2

Women33

Risk28

BRCA1

Early Breast Cancer Trialists1

Hormone receptor-positive brea1