• The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
  • Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
  • alone and evaluate its activity in combinatio n with pegylated liposomal doxorubicin (PLD). (researchgate.net)
  • Because of the vesicant activity of doxorubicin, microparticles made of biodegradable polymer poly(lactide-co-glycolide) or PLGA can safely deliver doxorubicin intratumorally and are effective vaccine adjuvants, (ii) enhancing T-cell activation using anti-OX40 and (iii) sustaining T-cell responses by checkpoint blockade using anti-CTLA-4. (aacrjournals.org)
  • He was treated with liposomal doxorubicin 40 mg/m(2) every 4-6 weeks up to now with a total dose of 800 mg. (curehunter.com)
  • Partial remission has been achieved after 17 months of treatment with liposomal doxorubicin. (curehunter.com)
  • As a result, Dr Tolaney said that "we don't use a lot of anthracyclines in the metastatic setting, but sometimes I will use liposomal doxorubicin in a patient who didn't have an adjuvant anthracycline. (cancertherapyadvisor.com)
  • 2008). Influence of drug-to-lipid ratio on drug release properties and liposome integrity in liposomal doxorubicin formulations. (ubc.ca)
  • Although there have been a number of efforts to extend the duration of action such as the use of various adjuvants and liposomal formulations, the magnitude of block prolongation is still limited. (asra.com)
  • 2006). Therapeutically Optimized Rates of Drug Release can be Achieved by Varying the Drug-to-Lipid Ratio in Liposomal Vincristine Formulations. (ubc.ca)
  • 2005). Preparation, Physical Characterization and Biological Analysis of Liposomal Formulations of Vincristine. (ubc.ca)
  • The lipopolysaccharide (LPS) from A. salmonicida, a major factor in determining bacterial virulence, was incorporated into liposomes to determine the ability of these formulations to function as delivery vehicles and immunological adjuvants in rainbow trout (Oncorhynchus mykiss). (mun.ca)
  • Several aspects were considered important in examining the potential of liposomal LPS formulations as vehicles and adjuvants. (mun.ca)
  • These results propose that liposomal LPS formulations are worthy of farther investigation in terms of potential and application in rainbow trout. (mun.ca)
  • Adjuvants are vaccine ingredients that can help induce a strong immune response in certain formulations. (crodapharma.com)
  • Our selection of aluminium-based and liposomal adjuvants, such as our newly available CAF range, can help improve the effectiveness of your vaccine formulations. (crodapharma.com)
  • Formulations of the liposomal vaccines with other potent adjuvants can promote long-term immunological memory when delivered via human administrable routes. (ntd-network.org)
  • In order to minimize the drug-related toxicities, we have also developed liposomal drug formulations for single-shot therapy, providing dual protection by its antileishmanial and immunomodulatory functions at lower doses. (ntd-network.org)
  • The program in CVR currently has two TB vaccines in late stage clinical testing and different liposomal adjuvant formulations and a novel Chlamydia trachomatis vaccine in phase 1 trials. (ssi.dk)
  • Adjuvant 65 (based on peanut oil) was tested in influenza vaccines in the 1970s, but was never released commercially. (wikipedia.org)
  • Aluminium salts are the most commonly-used adjuvants in human vaccines. (wikipedia.org)
  • An adjuvant is an ingredient used in some vaccines that helps create a stronger immune response in people receiving the vaccine. (cdc.gov)
  • In other words, adjuvants help vaccines work better. (cdc.gov)
  • Some vaccines that are made from weakened or killed germs contain naturally occurring adjuvants and help the body produce a strong protective immune response. (cdc.gov)
  • Adjuvants have been used safely in vaccines for decades. (cdc.gov)
  • In all cases, vaccines containing adjuvants are tested for safety and effectiveness in clinical trials before they are licensed for use in the United States, and these vaccines are continuously monitored by CDC and FDA once they are approved. (cdc.gov)
  • Several different adjuvants are used in U.S. vaccines. (cdc.gov)
  • Aluminum-containing adjuvants are vaccine ingredients that have been used in vaccines since the 1930s. (cdc.gov)
  • We support you with immuostimulators and adjuvant systems that fulfill the needs of your vaccines. (crodapharma.com)
  • Well-established as a common component in a variety of vaccines, Adju-Phos is an aluminium-based adjuvant that induces strong Th2 immune responses. (crodapharma.com)
  • One of the most widely used vaccine adjuvants, Alhydrogel is an aluminium-based adjuvant used in clinically-approved vaccines that can elicit effective Th2 immune responses. (crodapharma.com)
  • Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant. (newtbvaccines.org)
  • Alternatives to Mineral Oil Adjuvants in Vaccines Against Aeromonas salmonicida subs. (ku.dk)
  • Using rainbow trout ( Oncorhynchus mykiss ) as recipients, injection vaccines based on formalin-inactivated Aeromonas salmonicida subspecies salmonicida were formulated with CpG oligodeoxynucleotides, the liposomal cationic adjuvant formulation 01 (CAF01) or with Freund's incomplete adjuvant and administered intraperitoneally. (ku.dk)
  • Furthermore, the induced protection appears similar to that of the benchmark formulation, thus introducing viable, potential alternative types of adjuvants for use in future fish vaccines. (ku.dk)
  • Patient who undergo upfront surgery can qualify for adjuvant chemotherapy based on gene expression profiling such as the Oncotype DX, MammaPrint, or Prosigna. (medscape.com)
  • Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
  • Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (uci.edu)
  • High-risk features such as stage IC, higher grade, or clear-cell histology should prompt consideration of adjuvant chemotherapy. (medscape.com)
  • For their study, they assigned patients with early-stage (T0) KS to combined antiretroviral (cART) therapy alone, and those with advanced-stage (T1) KS to cART plus liposomal anthracycline chemotherapy. (medscape.com)
  • Of those with advanced-stage KS, 140 (84%) were treated with cART plus liposomal anthracycline chemotherapy, 14 (8%) were treated with cART alone, 9 (5%) were treated with cART and radiotherapy for localized ulcerating tumors, and 3 (2%) were treated with cART plus complete excision. (medscape.com)
  • Interesting study showing a strong difference in EFS with neoadjuvant + adjuvant vs. adjuvant alone for stage III/IV melanoma. (fcshemoncreview.com)
  • M.S. Webb, N.L. Boman, D. Masin, D. Yapp, E. Ramsay, P.R. Cullis and M.B. Bally, "A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity", Biochim. (ubc.ca)
  • Part of our new generation of adjuvants, CAF01 is a liposomal adjuvant formulation that offers excellent long-term stability and drives both humoral and cellular immune responses. (crodapharma.com)
  • Quantification of the lipid content in liposomal adjuvants for subunit vaccine formulation is of extreme importance, since this concentration impacts both efficacy and stability. (precisionnanosystems.com)
  • Polyethylenimine: An Intranasal Adjuvant for Liposomal Peptide-Based Subunit Vaccine against Group A Streptococcus . (bvsalud.org)
  • Liposomal encapsulation helps to cross the intestinal barrier, providing a non-animal source of iron with high bioavailability. (sunday.de)
  • 2007). Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. (ubc.ca)
  • Objective(s)CpG oligodeoxynucleotides (CpG ODNs) have been shown to have potent immunostimulatory adjuvant activity for a wide range of antigens. (civilica.com)
  • A versatile immunostimulatory saponin that's widely used as a potent veterinary adjuvant, Quil-A can work against both intra- and extra-cellular pathogens, stimulating innate and Th-mediated adaptive immune. (crodapharma.com)
  • Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy-by the use of adjuvants. (mdpi.com)
  • A novel liposomal adjuvant used in cancer immunotherapy trials, CAF09b has the capacity to facilitate the production of CD8+ T-cells. (crodapharma.com)
  • Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544. (universiteitleiden.nl)
  • 2009) Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. (ubc.ca)
  • 2007) Characterization of the Drug Retention Properties and Pharmacokinetic Properties of Liposomal Nanoparticles Containing Dihydrosphingomyelin. (ubc.ca)
  • In this study, according to some recently reported drawbacks with PS CpG, the adjuvant potential of liposomal PO CpG as a substitute for PS CpG was evaluated.Materials and MethodsSoluble Leishmania antigens (SLA) as a model antigen and distearoylphosphatidylcoline (DSPC) as a neutral lipid were employed to prepare liposomes. (civilica.com)
  • In this paper, we outline a high performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) method that allows for the rapid and simultaneous quantification of lipid concentrations within liposomal systems prepared by three liposomal manufacturing techniques (lipid film hydration, high shear mixing, and microfluidics). (precisionnanosystems.com)
  • For the production of our genuine liposomal, water-soluble iron, we use iron saccharate. (sunday.de)
  • A South Korean study showing the superiority of 5FU/LV + liposomal irinotecan vs. 5FU/LV alone. (fcshemoncreview.com)
  • This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). (uci.edu)
  • Patients also receive leucovorin IV over 90-120 minutes and liposomal irinotecan IV over 90 minutes on day 1. (uci.edu)
  • Plant saponins from Quillaia (the bark of a soap bark tree), soybean, Polygala senega Cytokines: IL-1, IL-2, IL-12 CpG oligonucleotides Combinations: Freund's complete adjuvant, Freund's incomplete adjuvant, AS01 (combining MPL and Quillaia saponins), Matrix-M (combining Quillaia saponins and two types of fat) There are many adjuvants, some of which are inorganic, that carry the potential to augment immunogenicity. (wikipedia.org)
  • Freund's complete adjuvant is a solution of inactivated Mycobacterium tuberculosis in mineral oil developed in 1930. (wikipedia.org)
  • A version without the bacteria, that is only oil in water, is known as Freund's incomplete adjuvant. (wikipedia.org)
  • Our data suggests that liposomally-incorporated LPS can safely be administered to rainbow trout and function as delivery vehicles and immunological adjuvants. (mun.ca)
  • A study looking at the immunogenicity and protective efficacy of an influenza split vaccine with the GI-101 adjuvant has been completed and confirmational experiments are ongoing. (ivi.int)
  • Long-Term Immunogenicity and In Vitro Prophylactic Protective Efficacy of M. tuberculosis Fusion Protein DR2 Combined with Liposomal Adjuvant DIMQ as a Boosting Vaccine for BCG. (newtbvaccines.org)
  • An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens. (wikipedia.org)
  • Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called pathogen-associated molecular patterns, which include liposomes, lipopolysaccharide, molecular cages for antigens, components of bacterial cell walls, and endocytosed nucleic acids such as RNA, double-stranded RNA, single-stranded DNA, and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
  • No matter what the mechanism is, alum is not a perfect adjuvant because it does not work with all antigens (e.g. malaria and tuberculosis). (wikipedia.org)
  • Adjuvants have been used for decades to help enhance the immune response to vaccine antigens. (crodapharma.com)
  • Among women with advanced-stage disease, optimal debulking surgery, as well as platinum/taxane-based adjuvant therapy prolongs disease-free and median survival. (cancernetwork.com)
  • Some factors that are considered when selecting the specific agent include what they received as adjuvant therapy and their disease-free interval. (cancertherapyadvisor.com)
  • It consists of addressing the underlying risk factors, removing necrotic tissues, commencing antifungal medication, and providing adjuvant therapy. (relainstitute.com)
  • There has been increasing interest in dexamethasone as an adjuvant to local anesthetic solutions based on clinical reports of extended duration when added to intermediate-acting local anesthetics (28,29). (edmariano.com)
  • Finally, TZ lipids were used to lipidate peptides in a liposomal peptide vaccine where they induced similar anti-peptide titers as a CHEMS conjugate. (uky.edu)
  • There are many known adjuvants in widespread use, including aluminium salts, oils and virosomes. (wikipedia.org)
  • Towards an understanding of the adjuvant action of aluminium. (smw.ch)
  • Today, aluminium salts are the most widely used adjuvants, whilst scientists and vaccine manufacturers are continuously innovating to expand the repertoire of available adjuvant options. (crodapharma.com)
  • Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease. (wikipedia.org)
  • Patients at high risk for recurrence should be evaluated for adjuvant treatment with CDK4/6 inhibitors. (medscape.com)
  • Postmenopausal women at high risk for recurrence can be evaluated for adjuvant treatment with a bisphosphonate. (medscape.com)
  • In this review we use influenza vaccine as a model in a discussion of the different mechanisms of action of the available adjuvants. (smw.ch)
  • To develop an efficient liposomal vaccine delivery system, the size of liposomes is critical to their adjuvant activities. (hal.science)
  • We are conducting early-stage clinical trials, establishing vaccine evaluation systems and developing COVID-19 vaccine adjuvants in addition to epidemiological studies. (ivi.int)
  • Of the available adjuvants, clonidine has been demonstrated in clinical studies and systematic reviews to extend the duration of analgesia for intermediate-acting local anesthetics (e.g., mepivacaine) with few side effects in doses up to 150 mcg but probably do not extend long-acting local anesthetics (25,27). (edmariano.com)
  • In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. (wikipedia.org)
  • Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells, lymphocytes, and macrophages by mimicking a natural infection. (wikipedia.org)
  • Adjuvants help the body to produce an immune response strong enough to protect the person from the disease he or she is being vaccinated against. (cdc.gov)
  • Newer adjuvants have been developed to target specific components of the body's immune response, so that protection against disease is stronger and lasts longer. (cdc.gov)
  • However, recent research indicates that alum formulated in a nanoparticle form rather than microparticles can broaden the utility of alum adjuvants and promote stronger adjuvant effects. (wikipedia.org)
  • In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection. (ku.dk)
  • These data provide evidence for continued evaluation of TZ lipids as gene delivery vectors and as potential vaccine adjuvants. (uky.edu)
  • Stimulator of IFN genes (STING) is becoming an exciting target for therapeutic adjuvants. (jci.org)
  • We show that liposomal nanoparticle-delivered cGAMP (cGAMP-NP) activates STING more effectively than soluble cGAMP. (jci.org)
  • Our comprehensive portfolio of components accelerates the production of complete adjuvant systems. (crodapharma.com)