Indicated as adjunctive therapyReported in patients with hepaticImpairmentCirrhosisSevereTherapyAcuteMonotherapyPartial seizuresAsterixisEncephalopathySeizuresRenal diseaseDoseHyperglycemiaDosesTreatmentConfusionLiverAdverseDrugStoresGlasgow ComaImpairmentPatientsAcuteCYP3A4AbnormalitiesCardiacIncludeEvidenceManagementPortalDrugCasesEffects
Indicated as adjunctive therapy2
- Hydrochlorothiazide tablets are indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. (entirelypetspharmacy.com)
- Epiron Milpharm is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation. (pillintrip.com)
Reported in patients with hepatic1
- An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
Impairment3
- If the calculated dose of lamotrigine (for example for treatment of children with epilepsy or patients with hepatic impairment) does not equate to whole tablets, the dose to be administered is that equal to the lower number of whole tablets. (medicines.org.uk)
- Dosing adjustments are recommended in geriatric patients and in patients with moderate or severe renal or hepatic impairment. (drugs.com)
- At baseline, 35% had evidence of cerebral malaria and 17% had severe hepatic impairment. (cdc.gov)
Cirrhosis6
- Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. (msdmanuals.com)
- It is caused most often by cirrhosis (in North America), schistosomiasis (in endemic areas), or hepatic vascular abnormalities. (msdmanuals.com)
- Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
- The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
- It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy. (drugcite.com)
- Triiodothyronine (T3) levels are low in the fetus and newborn, in old age, in chronic caloric deprivation, hepatic cirrhosis, renal failure, surgical stress, and chronic illnesses representing what has been called the "T3 thyronine syndrome. (neotypestation.com)
Severe2
- Symptoms include severe drowsiness, incoordination, weakness of muscles, slow breathing, or it may even lead to coma and death. (pharmastores.com)
- FDA granted Qualified Infectious Disease Product (QIDP) Designation and Fast Track Designation for CAL02, a novel first-in-class anti-toxin drug candidate, being developed to treat severe community-acquired bacterial pneumonia (SCABP) as an adjunctive therapy to standard of care, entitling Eagle to an additional five years of marketing exclusivity upon approval. (eagleus.com)
Therapy5
- management of hepatic coma-as adjunctive therapy. (nih.gov)
- Lamotrigine is given as adjunctive therapy but may be the initial antiepileptic drug (AED) to start with in Lennox-Gastaut syndrome. (medicines.org.uk)
- Adjunctive therapy should be used as clinically indicated. (infectweb.com)
- Adjunctive therapy-See Table 1 for patients older than 12 years and Tables 2 and 3 for patients aged 2 to 12 years. (genesight.com)
- The recommended total daily dose of TOPAMAX ® as adjunctive therapy in adults with partial onset seizures is 200 to 400 mg/day in two divided doses, and 400 mg/day in two divided doses as adjunctive treatment in adults with primary generalized tonic-clonic seizures. (druggenius.com)
Acute3
- Paromomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. (drugbank.com)
- For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. (nih.gov)
- These reactions may be associated with other organ involvement, such as hepatitis, hepatic failure, blood dyscrasias, or acute multiorgan failure. (genesight.com)
Monotherapy1
- Adjunctive or monotherapy treatment of partial seizures and generalised seizures, including tonic-clonic seizures. (medicines.org.uk)
Partial seizures1
- Adjunctive treatment of partial seizures and generalised seizures, including tonic-clonic seizures and the seizures associated with Lennox-Gastaut syndrome. (medicines.org.uk)
Asterixis1
- Findings on physical examination in hepatic encephalopathy include asterixis and fetor hepaticus. (medscape.com)
Encephalopathy3
- Portosystemic encephalopathy better describes the pathophysiology than hepatic encephalopathy or hepatic coma, but all 3 terms are used interchangeably. (msdmanuals.com)
- Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
- Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)
Seizures2
- Signs of an overdose include GI distress, coma, or seizures. (entirelypetspharmacy.com)
- POTIGA is a potassium channel opener indicated as adjunctive treatment of partial-onset seizures in patients aged 18 years and older who have responded inadequately to several alternative treatments and for whom the benefits outweigh the risk of retinal abnormalities and potential decline in visual acuity. (drugs.com)
Renal disease2
- Hydrochlorothiazide should be used with extreme caution if your pet also suffers from abnormalities in electrolyte or water balance, diabetes mellitus, hepatic function issues, hyperuricemia, lupus, or renal disease. (entirelypetspharmacy.com)
- Adjunctive treatment of active pulmonary and extra-pulmonary tuberculosis (including renal disease) where first line therapies have failed. (medscape.co.uk)
Dose2
- Caution is advised for patients receiving concomitant high-dose aspirin and acetaZOLAMIDE, as anorexia, tachypnea, lethargy, coma and death have been reported. (drugcite.com)
- A patient who ingested a dose between 96 and 110 g topiramate was admitted to a hospital with a coma lasting 20 to 24 hours followed by full recovery after 3 to 4 days. (druggenius.com)
Hyperglycemia1
- Diabetes is a metabolic disorder that affects different parts of the body, with short- and long-term consequences, such as ketoacidosis due to hyperglycemia or diabetic coma. (jabonline.in)
Doses1
- Adjunctive treatment where high pharmacological doses are needed. (who.int)
Treatment1
- IV Glucagon (Choice A) is useful as an adjunctive treatment in both calcium channel blocker and beta blocker overdose. (iem-student.org)
Confusion1
- 12 mg/dL) is associated with confusion, delirium, stupor and coma. (sdrugs.com)
Liver2
- Evaluation of the Patient With a Liver Disorder History and physical examination often suggest a cause of potential liver disorders and narrow the scope of testing for hepatic and biliary disorders. (msdmanuals.com)
- Because amiloride HCl is not metabolized by the liver, drug accumulation is not anticipated in patients with hepatic dysfunction, but accumulation can occur if the hepatorenal syndrome develops. (drugcentral.org)
Adverse1
- Chemotherapeutic agents interact with vitamin A in various ways, from adjunctive vitamin A for nutritive support and amelioration of adverse drug effects to cotherapy using retinoids as chemotherapeutic agents. (interactionsguide.com)
Drug1
- Concomitant use may enhance drug efficacy by mobilizing hepatic stores and elevating plasma concentrations, particularly in very-low-birth-weight (VLBW) neonates with bronchopulmonary dysplasia. (interactionsguide.com)
Stores1
- 1 Other factors that can contribute to EDKA are 1) the decrease in hepatic glucose production during a fasting state when glycogen stores are already depleted and 2) the increased urinary excretion of glucose. (uspharmacist.com)
Glasgow Coma1
- Various scoring systems help to monitor critically ill patients, such as the Animal Trauma Triage score, Modified Glasgow Coma Scale (MGCS), and the Glasgow Composite Measure Pain Scale. (merckvetmanual.com)
Impairment1
- No dose adjustment is required for patients with hepatic impairment (see section 5.2). (medthority.com)
Patients1
- In patients with schizophrenic or other psychotic illnesses, use of benzodiazepines is recommended only for adjunctive, i.e. not for primary treatment. (medicines.org.uk)
Acute1
- Molecular adsorbent recirculating system effectively replaces hepatic function in severe acute liver failure. (umaryland.edu)
CYP3A43
- abametapir will increase the level or effect of felbamate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- apalutamide will decrease the level or effect of felbamate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- clarithromycin will increase the level or effect of felbamate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Abnormalities1
- Hydrochlorothiazide should be used with extreme caution if your pet also suffers from abnormalities in electrolyte or water balance, diabetes mellitus, hepatic function issues, hyperuricemia, lupus, or renal disease. (entirelypetspharmacy.com)
Cardiac1
- The purpose of this study was to investigate the competence of N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and cardiac index (C.I) as adjunctive diagnostic tools for BCI. (biomedcentral.com)
Include2
- Common variations include a replaced right hepatic artery, which originates from the superior mesenteric artery, a replaced left hepatic artery, which is derived from the left gastric artery, or a completely replaced common hepatic artery, which can originate from the superior mesenteric artery or the aorta. (medscape.com)
- Signs of an overdose include GI distress, coma, or seizures. (entirelypetspharmacy.com)
Evidence1
- The first syndrome is hyperammonemia with minimal or no evidence of hepatic injury. (nih.gov)
Management1
- Current international vaccination strategies for hepatitis B virus (HBV), and advances in the management of hepatitis C virus (HCV) infections, promise to have a major impact on the incidence of HCC, but their benefit will be realized slowly because of the very long latency period-20-30 years-from hepatic damage to HCC development. (medscape.com)
Portal1
- During angiography, a catheter is placed selectively via either the transjugular or transfemoral route into the hepatic vein to measure portal pressure. (medscape.com)
Drug1
- Do not use oral thyroid hormone drug products to treat myxedema coma. (pfizermedicalinformation.com)
Cases1
- Atypical antipsychotics have been associated with hyperglycemia, some cases of which have been associated with ketoacidosis, hyperosmolar coma, or death. (medscape.com)
Effects1
- felbamate decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism. (medscape.com)