Adipose tissue of obese. Medical search. Frequent questions

Excess adipose tissue, resulting in obesity, is currently one of the most serious threats to human health on a global level. (europa.eu)
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. (ejournals.ca)
Brown adipose tissue (BAT) dissipates chemical energy as heat via thermogenesis and protects against obesity by increasing energy expenditure. (ttu.edu)
Objective:Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. (hal.science)
Background: Predicting relapses of post-operative complications in obese patients who undergo cardiac surgery is significantly complicated by persistent metabolic maladaptation associated with obesity. (illinois.edu)
Objective: We interrogated whether BCAA catabolic changes precipitated by obesity in the heart and adipose tissue can be reliable prognosticators of adverse outcomes following cardiac surgery. (illinois.edu)
BMI, indices of tissue dysfunction and duration of hospital stay following surgery correlated with BCAA metabolizing enzyme expression and metabolite levels in AA and SAT. Conclusion: This study proposes that in a setting of obesity, dysregulated BCAA catabolism could be an effective surrogate to determine cardiac surgery outcomes and plausibly predict premature re-hospitalization. (illinois.edu)
Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
In this study, we examined the expression pattern of IL-1Ra and showed that it is highly expressed not only in liver and spleen, but also in white adipose tissue (WAT), where it is upregulated in obesity. (diabetesjournals.org)
Finally, lipopolysaccharide administration induced a long-lasting expression of IL-1Ra in mouse WAT, suggesting that adipose tissue is an important source of IL-1Ra in both obesity and inflammation. (diabetesjournals.org)
Obesity elicits immune cell infiltration of adipose tissue provoking chronic low-grade inflammation. (diabetesjournals.org)
We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity. (hindawi.com)
In addition, the mean abundance of BGCs was positively correlated with obesity, consistent with the lower taxonomic diversity in the gut microbiota of obese individuals. (hindawi.com)
For example, some studies report an increased Firmicutes to Bacteroidetes ratio in obese patients [ 6 , 7 ], whereas others found no association between the above phyla and obesity [ 8 , 9 ]. (hindawi.com)
In this study, we analyzed the differences in the BGCs of nonobese and obese individuals using human fecal metagenomic data, in order to identify obesity-associated BGCs. (hindawi.com)
LIkewise, children from ages 7 to 17 today are becoming more and more obese which is only going to increase that 36.5% of adults with obesity. (ipl.org)
The WHO factsheet on obesity and overweight reports 13% of the world's adult population to be obese, i.e. 11% of men and 15% of women, and 39% of the population aged over 18 to be overweight (38% of men and 40% of women) in 2014. (ipl.org)
Obesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue.To elucidate the effects of natural dietary components on the inflammatory and metabolic consequences of obesity, we examined the effects of unripe, ripe and industrial acerola juice (Malpighia emarginata DC. (ironmagazine.com)
on the relevant inflammatory and lipolysis proteins in the adipose tissue of mice with cafeteria diet-induced obesity. (ironmagazine.com)
Vitamin D accumulates in adipose tissue (AT), and vitamin D deficiency is frequent in obesity. (medscape.com)
The high prevalence of vitamin D deficiency in obese subjects [ 3 ] suggests that adipose tissue (AT) has a major role in the body distribution of vitamin D, but the causal relationship between obesity and low levels of circulating 25(OH)D has not been completely elucidated yet. (medscape.com)
lion adults are obese and 2.1 bil ion attributed to obesity. (who.int)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20ß-dihydrocorticosterone (20ß-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to cardiometabolic complications of obesity . (bvsalud.org)
Mice lacking one Cbr1 allele and mice overexpressing Cbr1 in their adipose tissue underwent metabolic phenotyping before and after induction of obesity with high-fat feeding . (bvsalud.org)

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. (ejournals.ca)
The enhancement of insulin secretion resulted from the down-regulation of stearoyl-CoA desaturase-1 (SCD1) in white adipose tissue and a consequently reduced level of oxidative stress. (wikipedia.org)
The data indicates an example of cross talk between white adipose tissue and pancreatic β cells mediated through modulation of oxidative stress. (wikipedia.org)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Alpha-Linolenic Acid Supplementation Prevents Exercise-Induced Improvements in White Adipose Tissue Mitochondrial Bioenergetics and Whole-Body Glucose Homeostasis in Obese Zucker Rats. (uoguelph.ca)
White adipose tissue is associated with elevated levels of TNF [tumor necrosis factor]-alpha. (medpagetoday.com)

Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-γ agonism. (ejournals.ca)
Adipose tissue metabolism of obese mice on standard and high-fat diets" by S Lochaya, N Leboeuf et al. (jax.org)
Adipose tissue metabolism of obese mice on standard and high-fat diets. (jax.org)
KLF15 levels in both humans and mice increase two to three times in response to exercise and control the ability of muscle tissue to burn fat and generate force. (wikipedia.org)
KLF15 in adipose tissue is downregulated in obese mice. (wikipedia.org)
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report researchers. (sciencedaily.com)
We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)
Treating obese mice with CST inhibited the recruitment of monocyte-derived macrophages to the liver and decreased inflammation, suggesting CST is an anti-inflammatory peptide. (sciencedaily.com)
Administering CST had no effect on insulin or glucose tolerance in control lean mice, showing that the effect of CST is restricted to obese animals. (sciencedaily.com)
This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals. (sciencedaily.com)
Scientists looked at microenvironments of lean, obese and formerly obese lab mice during the study. (newsweek.com)
Although formerly obese fat models had more and larger tumors than in mice with lean microenvironments, the number and size of tumors did decrease after weight loss, leading researchers to speculate that the risks of developing cancer could be mitigated by weight loss. (newsweek.com)
juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet. (ironmagazine.com)
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. (bvsalud.org)
20ß-DHB activated both the glucocorticoid and mineralocorticoid receptor in adipose tissue and systemic administration to wild-type mice induced glucose intolerance , an effect that was ameliorated by both glucocorticoid and mineralocorticoid receptor antagonism. (bvsalud.org)
Cbr1 haploinsufficient lean male mice had lower fasting glucose and improved glucose tolerance compared with littermate controls, a difference that was abolished by administration of 20ß-DHB and absent in female mice with higher baseline adipose 20ß-DHB concentrations than male mice . (bvsalud.org)
Conversely, overexpression of Cbr1 in adipose tissue resulted in worsened glucose tolerance and higher fasting glucose in lean male and female mice . (bvsalud.org)
Carbonyl reductase 1 is a novel regulator of glucocorticoid and mineralocorticoid receptor activation in adipose tissue that influences glucose homeostasis in lean mice . (bvsalud.org)

More recent studies suggest that inflammation in adipose tissue could be a key factor leading to these illnesses. (bu.edu)
Increasingly, evidence implicates localized inflammation in adipose tissue , which in turn stimulates systemic low-grade inflammation, as a primary force contributing to the development of these diseases. (medscape.com)

The current proposal aims to determine the dynamics of human adipose tissue maintenance and investigate any differences in regulation of the fat mass in lean and obese individuals. (europa.eu)
By comparing the BGCs of known SM between obese and nonobese samples, we found that menaquinone produced by Enterobacter cloacae showed the highest correlation with BMI, in agreement with a recent study on human adipose tissue composition. (hindawi.com)

At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. (hal.science)
Methods: Male and female patients of ages between 44 and 75 were stratified across different body mass index (BMI) (non-obese = 17, pre-obese = 19, obese class I = 14, class II = 17, class III = 12) and blood, atrial appendage (AA), and subcutaneous adipose tissue (SAT) collected during cardiac surgery. (illinois.edu)

Empirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values. (plos.org)
Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
There are a number of risk factors for insulin resistance, including being overweight or obese or having a sedentary lifestyle . (wikipedia.org)
More than one third of the world's population is overweight or obese. (medscape.com)

In humans the generation of fat cells (adipocytes) is a major factor behind the growth of adipose tissue during childhood. (europa.eu)
Recently I developed a method that is based on the incorporation of 14C from nuclear bomb tests into genomic DNA, which allows for the analysis of cell and tissue turnover in humans. (europa.eu)
In WAT of obese humans, IL-1Ra was also markedly increased. (diabetesjournals.org)
Although SFAs have been shown to affect the epigenome in whole blood, pancreatic islets, and adipose tissue in humans, and genome-wide DNA methylation studies have linked epigenetic changes to NAFLD and NASH, studies focusing on the association of SFAs and DNA methylation in human liver are missing. (lu.se)

Even if guidelines are already available to manage anesthesia and surgery of obese patients, the assessment of the perioperative morbidity and mortality from heart and brain disorders in morbidly obese surgical patients will be challenging in the next years. (benthamscience.com)
The present review will recapitulate the new mechanisms underlying the Heart-brain Axis (HBA) vulnerability during the perioperative period in healthy and morbidly obese patients. (benthamscience.com)

UPR in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. (endocrine-abstracts.org)

Epicardial fat reflects intraabdominal visceral fat, and the echocardiographic assessment of this tissue is an easy and reliable marker of visceral adiposity. (qxmd.com)
The presence of overweight in men (BMI 25, 84 kg/m 2 ) and even normal body weight in women (BMI 21,62 kg/m 2 ) corresponds to an increased volume of visceral tissue in the abdomen. (hindawi.com)

Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). (mdpi.com)

Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. (ejournals.ca)

The researchers found that 50 of the subjects had an inflamed adipose phenotype characterized by tissue macrophage accumulation in crown-like structures. (massagemag.com)
In addition, macrophage retention in fat was associated with upregulated tissue CD68 and tumor necrosis factor mRNA expression and with increased plasma high sensitivity C-reactive protein. (massagemag.com)
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. (ejournals.ca)
Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women. (hal.science)

In this study we evaluated whether epicardial adipose tissue is related to insulin sensitivity and glucose metabolism in obese subjects. (qxmd.com)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
This study tested the hypothesis that Cbr1-mediated glucocorticoid metabolism influences glucocorticoid and mineralocorticoid receptor activation in adipose tissue and impacts glucose homeostasis in lean and obese states. (bvsalud.org)

Dr. Gokce of Boston University School of Medicine and colleagues studied subcutaneous abdominal fat samples from 77 obese subjects. (massagemag.com)
In obese individuals, the concentration of fat in the abdominal region is a predictive marker for future health problems. (bvsalud.org)
Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal adipose tissue), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (msdmanuals.com)

Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)

The cellular character of the adipose tissue of 21 nonobese and 78 obese patients has been examined. (jci.org)
Our study specifically clarified the correlation between BCAA catabolizing enzymes, cellular BCAAs and branched-chain keto acids (BCKAs) with the severity of cardiometabolic outcomes in obese patients pre and post cardiac surgery. (illinois.edu)
In SAT, from class III obese patients, mRNA and protein expression of BCAA catabolic enzymes and BCKA dehydrogenase (BCKDH) enzyme activity was decreased. (illinois.edu)
We previously showed that this cytokine antagonist is upregulated in the serum of obese patients, correlating with BMI and insulin resistance. (diabetesjournals.org)
The number of obese patients undergoing cardiac and noncardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular disorders. (benthamscience.com)
Our review provides current insights into the mechanisms underlying HBA response in obese surgical patients and how they are modulated by epigenetically active food constituents. (benthamscience.com)
Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)
It is our goal to establish an ARC focused on understanding the relationship between metabolic disorders and Adipose Tissue Biology by studying adipose tissues from insulin sensitive and insulin resistant patients obtained during and after Bariatric Surgery. (bu.edu)
Conclusion: Microalbuminuria may not be present in obese patients without diabetes and/hypertension. (scirp.org)
1996) Microalbuminuria in obese patients with or without hypertension. (scirp.org)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)

Each subject underwent a transthoracic echocardiogram to evaluate epicardial adipose tissue thickness, a euglycemic hyperinsulinemic clamp to estimate insulin sensitivity, and an oral glucose tolerance test to evaluate glucose tolerance. (qxmd.com)

Macrophages are specialized immune cells that promote tissue inflammation by secreting inflammatory molecules, which can lead to insulin resistance and metabolic disease. (sciencedaily.com)

Viral DNA was isolated from brain, lung, liver, muscle, and adipose tissue of monkeys 7 months after initial infection, long after the active virus has disappeared from blood and feces ( 3 ). (cdc.gov)
We, therefore, investigated whether human liver SFA content associates with DNA methylation and tested if SFA-linked alterations in DNA methylation associate with NAFLD-related clinical phenotypes in obese individuals. (lu.se)

This study intends to find the occurrence of microal-buminuria in non-diabetic normotensive obese individuals. (scirp.org)
Objectives: To estimate urinary albumin creatinine ratio (UACR) in non-diabetic normotensive obese individuals. (scirp.org)
Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)

The gut metagenomic data was extracted from the European Bioinformatics Institute-Sequence Read Archive database using the accession number ERP003612, which initially was used to analyze the correlation between the colonic microbiota and metabolic disorders in a Danish cohort of 123 nonobese and 169 obese individuals [ 15 ]. (hindawi.com)

Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)

Accumulation of inflammation factors such as monocytes chemoattractant protein-1 (MCP1) in adipose tissue is a factor in the development of MetS. (ejournals.ca)
However, the inflammatory mediators that play a role in the accumulation of macrophages are still unclear, so this study aims to determine the expression of MCP-1 in perivascular adipose tissue (PVAT). (ejournals.ca)
Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)

The aim of this study was to examine whether novel malabsorptive or bypass bariatric surgery in obese women with T2DM leads to reduction in UPR. (endocrine-abstracts.org)

With collective efforts of faculty representing different expertise and disciplines, we are posed to begin the development at BUMC of a unique center of knowledge in the field of adipose tissue biology pre- and -post bariatric surgery. (bu.edu)

Massive adipose tissue depositions in the abdomen and thorax sufficient to interfere with respiration developed in a patient with multiple medical problems. (cdc.gov)

Adipose cell size (lipid per cell) was determined in three different subcutaneous and deep fat depots in each patient and the total number of adipose cells in the body estimated by division of total body fat by various combinations of the adipose cell sizes at six different sites. (jci.org)

Because adipose inflammation was linked to impaired arterial endothelial function, Dr. Gokce pointed out, "that may identify obese individuals at increased cardiovascular risk. (massagemag.com)
Moreover, it can be speculated that IL-1Ra, whose production is markedly increased in WAT in obese individuals, contributes further to weight gain because of its endocrine and paracrine effects on the hypothalamus and adipocytes, respectively. (diabetesjournals.org)
Finally, we will describe the nutrigenomics approach, an emerging noninvasive dietary tool, to maintain a healthy body weight and to minimize the HBA propensity to injury in obese individuals undergoing all types of surgery by personalized intake of plant compounds that may regulate the switch from health to disease in an epigenetic manner. (benthamscience.com)
It has long been established that obese individuals are typically insulin resistant and predisposed to such disorders as type 2 diabetes, atherosclerotic cardiovascular disease, NAFLD and certain cancers. (bu.edu)
for these reasons supplementation with 25-hydroxyvitamin-D3 is more effective in obese individuals. (medscape.com)

Methods: Twenty overweight/obese volunteer employees were recruited by convenience sampling. (cdc.gov)

Now in America there is 78.6 million obese adults and counting (CDC). (ipl.org)
23 kg/m2 were taken as cases and 41 age and sex matched healthy non-obese adults with Body Mass Index (scirp.org)
Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)

In obese adolescents, prediabetes may be transient (with reversion to normal in 2 years in 60%) or progress to diabetes, especially in adolescents who persistently gain weight. (msdmanuals.com)

It does not provide any information on the distribution of the adipose tissue in the organism. (hindawi.com)
The conducted studies have revealed that it is necessary to determine the adipose tissue distribution in the organism. (hindawi.com)

Echocardiographic epicardial adipose tissue was significantly correlated with whole-body glucose uptake index from the clamp and with all indices of insulin resistance and glucose intolerance measured, except the 120-min plasma glucose level after an oral glucose tolerance test. (qxmd.com)
Tumors found in obese microenvironments were significantly larger and more prevalent than those found in lean models. (newsweek.com)

However, neither Cbr1 haploinsfficiency nor adipose overexpression affected glucose dyshomeostasis induced by high-fat feeding . (bvsalud.org)

Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)

Plasma and intracellular BCAAs and BC ketoacids (BCKAs), tissue mRNA and protein expression and activity of BCAA catabolizing enzymes were assessed and correlated with clinical parameters. (illinois.edu)
in both IR cells and obese SAT, protein expression of β 2 -adrenergic receptor was reduced. (medscape.com)

Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)

The adipose tissue participates in numerous endocrine functions via the secretion of bioactive molecules, such as adipokines [ 10 ]. (plos.org)
Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)

A veterinarian can perform a fine needle aspiration of cells or a biopsy (which removes a small amount of tissue from a tumor) for evaluation. (merckvetmanual.com)
If malignancy is suspected, tissue surrounding the tumor will also be removed to increase the chance that none of the tumor cells are left behind. (merckvetmanual.com)

The number of overweight/obese employees with healthy waist circumferences increased from 3 to 8 post-intervention. (cdc.gov)

We postulate that these abnormal adipose tissue deposits were caused by Adv 36 infection. (cdc.gov)

1995) Direct measurement of high-density lipoprotein in cho-lesterol in serum with polyethylene GLYCOL-modified en-zymes and sulfated α-Cyclodextrin. (scirp.org)
[ 5 , 6 ] An alternative hypothesis considers low serum 25(OH)D in obese as a result of volumetric dilution of vitamin D in the large adipose stores. (medscape.com)

Biopsy of adipose tissue identified human adenovirus 36 (Adv 36) DNA. (cdc.gov)

As senior investigator Dr. Noyan Gokce told Reuters Health, "Our data demonstrate that obese subjects exhibit varying degrees of inflammation in their fat tissue, and increased inflammatory activity in fat was associated with systemic metabolic abnormalities including insulin resistance. (massagemag.com)

Within adipose tissue, the expression of lipolytic and lipogenic enzymes was higher, while those related to lipid oxidation were lower in the NDh group compared to the NDo group. (frontiersin.org)

Regulatory T cells (Tregs) are specifically reduced in adipose tissue of obese animals. (diabetesjournals.org)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
A study by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center found cancer cells grow more rapidly in "fatty, obese tissue," particularly cells that cause breast cancer. (newsweek.com)

Following 18 weeks of diet regimen, the NDo group exhibited reduced body weight and peri-gonadal adipose-to-body weight ratio, paralleled to lesser food consumption. (frontiersin.org)
ratio in the adipose tissue, compared with the control lean group. (ironmagazine.com)
ratio in adipose tissue. (ironmagazine.com)

Epicardial adipose tissue has been recently recognized as a source of bioactive molecules as well as free fatty acids, adiponectin, and inflammatory cytokines. (qxmd.com)
In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. (cambridge.org)
In breast cancer, we know that the cancer is embedded in very fatty tissue, because the breast is made up largely of adipose tissue. (newsweek.com)
Although instances of cancer increased in fatty microenvironments, when researchers analyzed gene expression patterns within the tumors specifically, they found only "extremely subtle" changes were produced between obese, lean and formerly lean models. (newsweek.com)
If you fatten animals they get inflammations in their fatty tissue, which speed up the growth of their fat reserves even more. (ironmagazine.com)

However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)
In summary, we demonstrated that WAT is one of the most important sources of IL-1Ra quantitatively, suggesting that this tissue could represent a novel target for anti-inflammatory treatment. (diabetesjournals.org)

Anatomy32

Organisms13

Diseases31

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology3

Phenomena and Processes54

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science1

Health Care4

Geographicals1

Obesity27

White adipos6

Mice18

Inflammation in adipose tissue2

Human adipose tissue2

Subcutaneous adipose tissue2

Overweight or obese4

Humans4

Morbidly obese2

Type 2 diabet1

Visceral2

Antilipolytic effect of insulin1

Severely obese1

Macrophage4

Metabolism3

Abdominal3

Excess2

Patients11

Insulin sensitivity1

Metabolic disease1

Liver2

Diabetic3

Nonobese1

Associated with insulin resistance1

Accumulation4

T2DM1

Bariatric1

Abdomen1

Depots1

Individuals5

Methods1

Adults3

Diabetes1

Organism2

Significantly2

Overexpression1

Phenotype1

Protein2

Homeostasis1

Adipokines2

Tumor2

Intervention1

Abnormal1

Serum2

Biopsy1

Systemic1

Lipid1

Cells4

Ratio3

Fatty5

Inflammatory2