• In this article, we review evidence for the existence of osteosarcopenic obesity including the current operational definition of osteosarcopenic obesity, prevalence, pathophysiology, outcomes and exploratory approaches to the management of components. (springer.com)
  • 3-Adrenergic receptor ( 3-AR) and uncoupling protein 1 (UCP1) are involved in energy expenditure of the adipocytes, and the polymorphism of these genes has been reported to be associated with the prevalence of obesity and type 2 diabetes. (hindawi.com)
  • Available evidence clearly indicates a rapid progression in the prevalence of obesity worldwide. (researchgate.net)
  • Genetic, physiological and psychological factors, as well as dietary habits, physical activity, lifestyle and social and environmental factors are responsible for the significant increase in the prevalence of obesity and its consequences [ 1 - 4 ]. (medsci.org)
  • To evaluate the prevalence of general and abdominal obesity and the concomitant presence of both outcomes and their determinants among adults living in a rural area. (scielosp.org)
  • U.S. Army body fat standards may offer practical and reasonable health guidelines suitable for all active Americans that might help stem the increasing prevalence of obesity that is predicted to increase the prevalence of Type 2 diabetes. (nih.gov)
  • There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
  • However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)
  • The prevalence of obesity in Brazil is progressively increasing among children. (bvsalud.org)
  • 447 preschool children showed a prevalence of the indicators of adiposity in the diagnosis of excess weight of 28.9%, concluding that the overweight and obesity, without the need to population of children aged two and three years of determine body composition6,7. (bvsalud.org)
  • age is already showing a high prevalence of It is known that central obesity, i.e., overweight1. (bvsalud.org)
  • Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
  • The prevalence has increased significantly with the current obesity epidemic and is estimated to be between 20% and 30% in the general adult population [ 1 ] and ~10% in children. (medscape.com)
  • Novel risk factors may be may have been studied extensive- the rise in the prevalence of obesity identified in newly studied popula- ly in high-income countries (HICs), continues in LMICs, there may be an tions and regions. (who.int)
  • Recent research exploring the Index (HEI-1995 and HEI-2005), to mitigate the rising prevalence of effect of dietary patterns on mortality the Diet Quality Index-Internation- obesity in the study populations. (who.int)
  • Researchers suspect that visceral fat makes more of certain proteins that inflame your body's tissues and organs and narrow your blood vessels. (webmd.com)
  • Lipodystrophy , a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. (artandpopularculture.com)
  • however, it is either insufficient for the body's needs or is poorly used by the tissues. (picmonic.com)
  • Where other weight loss supplements are designed to target certain factors, Exipure targets the body's level of brown adipose tissue. (outlookindia.com)
  • Visceral fat, also known as organ fat or intra-abdominal fat, is located inside the peritoneal cavity, packed in between internal organs and torso, as opposed to subcutaneous fat, which is found underneath the skin, and intramuscular fat, which is found interspersed in skeletal muscle. (wikipedia.org)
  • Visceral fat is composed of several adipose depots including mesenteric, epididymal white adipose tissue (EWAT), and perirenal fat. (wikipedia.org)
  • Visceral fat is fat that wraps around your abdominal organs deep inside your body. (webmd.com)
  • The volume of subcutaneous fat (fat under the skin) and visceral fat were measured using abdominal MRI. (kget.com)
  • Dermal white adipose tissue (dWAT) was recently recognized for its potential to modify whole body metabolism. (jci.org)
  • Although this lipid layer has been frequently grouped together with s.c. white adipose tissue (sWAT), it is now recognized as a distinct depot that responds to different stimuli. (jci.org)
  • Aerobic exercise is one of the major strategies in the prevention and the treatment of obesity and type 2 diabetes [ 1 ]. (hindawi.com)
  • Citing the strong overlap between heart disease, kidney disease, type 2 diabetes , and obesity, the American Heart Association (AHA) has for the first time formally defined what they are calling cardiovascular-kidney-metabolic (CKM) syndrome. (medscape.com)
  • Obesity and its consequent dysregulation, as important risk factors for type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), cardiovascular diseases, and various types of cancer, represent significant threats to global health ( 1 , 2 ). (diabetesjournals.org)
  • ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
  • Obesity is a major risk for developing type 2 diabetes, especially abdominal and visceral adipose tissue. (picmonic.com)
  • Separate effects of exercise amount and intensity on adipose tissue and skeletal muscle mass in adults with abdominal obesity. (psychologytoday.com)
  • 1 ]. A central fat pattern has adverse health - abdominal fat), abdominal subcutaneous implications in both children and adults. (who.int)
  • In 2014, an estimated 600 million adults were obesity according to the World Health Organization. (medsci.org)
  • According to Claudio Pagano, M.D., Ph.D., an associate professor of internal medicine at Italy's University of Padova who has studied this issue, "Weight loss in adults and children with obesity greatly improves migraine headache by improving all the main features that worsen migraineurs' quality of life. (drweil.com)
  • It has the Recent studies in children showed that a ability to act as a surrogate for abdominal greater deposition of central fat correlates fat [ 9 ]. (who.int)
  • Post-mortem analyses of coronary arteries have indicated that obesity (associated with a high accumulation of abdominal fat measured at autopsy) was predictive of earlier and greater extent of large vessels atherosclerosis as well as increase of coronary fatty streaks. (researchgate.net)
  • The aim of this thesis was to investigate the associations between fatty acid (FA) biomarkers, carbohydrate intake, and abdominal obesity (AO) and related anthropometric measures in a population-based cohort of men and women in Stockholm County. (avhandlingar.se)
  • The aim of the study was to assess whether the diagnostic lipid parameters for metabolic syndrome and short-chain fatty acids (SCFAs) are related to the immunoexpression of interleukins in prostate tissue with benign hyperplasia. (bvsalud.org)
  • Researchers first started to focus on abdominal obesity in the 1980s when they realized it had an important connection to cardiovascular disease, diabetes, and dyslipidemia. (wikipedia.org)
  • It has been shown that traditional cardiovascular risk factors such as hypertension, obesity, diabetes, dyslipidemia and metabolic syndrome modify the structural and functional characteristics of arteries reducing their compliance and increasing arterial stiffness. (dovepress.com)
  • and data to study the association between abdominal fat distribution and other health conditions and risk factors, such as cardiovascular disease, diabetes, hypertension, and activity and dietary patterns. (cdc.gov)
  • Weight, fat, and regional fat placement, specifically in the abdominal site, may each have distinctly different associations with diabetes risk. (nih.gov)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • Replication studies identify several genetic variants in Arabs with obesity- linked diabetes. (who.int)
  • For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
  • Gaps exist in our information about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)
  • In morbidly obese women region-specific variations in mean adipocyte size are associated with metabolic complications but not systemic or adipose inflammation. (nih.gov)
  • The researchers reported that abdominal obesity "may be of particular interest in migraine, as this adipose tissue produces multiple substances potentially involved in migraine pathophysiology, including markers of systemic inflammation. (drweil.com)
  • A low-grade inflammation is suggested to contribute to the disease development, often accompanied by obesity. (avhandlingar.se)
  • The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. (biomedcentral.com)
  • Furthermore, the independent association of systemic adipokine levels with knee osteoarthritis severity supports a role for adipose-associated inflammation in the molecular pathogenesis of obesity-induced osteoarthritis. (biomedcentral.com)
  • Here, we review these societal and structural factors and then link them with biological processes such as telomere shortening, allostatic load, oxidative stress, and tissue inflammation. (frontiersin.org)
  • We propose that racial residential segregation and discrimination increases tissue inflammation and cytokine production, resulting in dysregulated immune signaling, which promotes plaque formation and cardiovascular disease. (frontiersin.org)
  • The researchers looked at data that included measurements of lean muscle, abdominal fat and subcutaneous fat (the type of fat you can see and grab hold of) from more than 4,000 middle-to-older-aged men and women and compared that data to reported changes in fluid intelligence over a six-year period. (psychologytoday.com)
  • The NAFLD group had higher hepatic fat ( P ±0.001) lower skeletal muscle IS ( P = 0.01), hepatic IS ( P = 0.01), and adipose tissue IS ( P = 0.04). (medscape.com)
  • The co-existence of impaired bone health (osteopenia/osteoporosis), reduced muscle mass and strength (sarcopenia), and increased adiposity (obesity) in middle-aged and older people has been identified in recent studies, leading to a proposal for the existence of "osteosarcopenic obesity" as a distinct entity. (springer.com)
  • Routine evaluation of an expression of weight not adiposity [ 11 ] regional fat distribution on a wide scale and it provides no information on body fat requires methods that are simpler than distribution, so it can mask true obesity- dual-energy X-ray absorptiometry (DXA), related risk in children [ 3 ]. (who.int)
  • These results indicate that diet-induced obesity increases the risk of symptomatic features of osteoarthritis through changes in musculoskeletal function and pain-related behaviors. (biomedcentral.com)
  • Although obesity is a powerful risk factor for developing metabolic syndrome (MetS), it is not present in all obese individuals. (endocrine-abstracts.org)
  • While not all obese individuals develop high blood pressure, scientific evidence supports that several pathophysiological mechanisms contribute to obesity-induced hypertension. (withings.com)
  • In obese individuals, the concentration of fat in the abdominal region is a predictive marker for future health problems. (bvsalud.org)
  • However, whether the concurrent existence of sarcopenia, osteoporosis and obesity leads to an increased risk of adverse musculoskeletal outcomes and mortality above and beyond the risks associated with the sum of the component parts remains to be proven and is a question of research interest. (springer.com)
  • While CKM syndrome is a public health emergency, there is also great potential for improving CKM health in the population, with an increasing number of therapies that favorably impact metabolic risk factors, risk for adverse kidney events, or both, which also protect against CVD," added Ndumele, director of obesity and cardiometabolic research in the division of cardiology at Johns Hopkins University in Baltimore. (medscape.com)
  • At this stage, excess weight, abdominal obesity, or dysfunctional adipose tissue (clinically manifest as impaired glucose tolerance or prediabetes) is present without other metabolic risk factors or CVD. (medscape.com)
  • High-fat (HF) diets, when compared to high-carbohydrate (HC) diets, are more at risk to induce body weight gain because of the large storage capacities of adipose tissue and the low satiating effects of high fat diets, as compared to the low capacities of the glycogen stores and of the de novo lipogenesis cost ( 6 ). (frontiersin.org)
  • It is suggested that until the epidemic progression of obesity is stopped and obesity prevented or at least properly managed, cardiologists will be confronted to an evolving contribution of risk factors where smoking, hypercholesterolemia and hypertension may be relatively less prevalent but at the expense of a much greater contribution of abdominal obesity and related features of the metabolic syndrome. (researchgate.net)
  • 35 inches for women) has been shown to be an independent predictor of risk factors for obesity and increased morbidity. (psychiatrist.com)
  • Obesity increases the risk of a number of health problems, including coronary disease, particular types of carcinoma, respiratory system complications and osteoarthritis of small and large joints [ 1 ]. (medsci.org)
  • We don't know for sure what puts you at risk of migraine , but obesity is clearly associated with some cases. (drweil.com)
  • 11 , 12 Visceral obesity is associated with hyperleptinemia, leptin-resistance and hypoadiponectinemia configuring a high cardiovascular risk phenotype. (dovepress.com)
  • We performed crude and adjusted Poisson regression analyses for each obesity outcome and multinomial logistic regression for metabolic risk. (scielosp.org)
  • The risk of general and abdominal obesity and concomitant outcomes increased significantly with age in both sexes. (scielosp.org)
  • A study to be presented at the RSNA meeting shows that higher levels of visceral abdominal fat in midlife are linked to an increased risk of developing Alzheimer's disease. (scitechdaily.com)
  • Obesity is strongly associated with osteoarthritis, and in particular a dose dependent relationship has been found to exist between BMI and risk of developing osteoarthritis of the knees. (laparoscopic.md)
  • Excessive osteoarthritis of otherwise healthy joints is known to contribute towards osteoarthritis, but obesity is also a risk factor for developing osteoarthritis in non-weight-bearing joints, and current research indicates a more complex relationship exists between osteoarthritis and obesity than can be explained by biomechanical stress alone. (laparoscopic.md)
  • For classifying children with excess weight (risk of overweight, overweight or obesity), or with overweight or obesity the cut-off points of the Z-scores of Body Mass Index (zBMI), proposed by the Ministry of Health (2009), were used, from the point of view of the World Health Organization. (bvsalud.org)
  • Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. (biomedcentral.com)
  • One of the most significant risk factors is obesity. (biomedcentral.com)
  • however, there is currently no comprehensive explanation for why obesity increases the risk of osteoarthritis at different sites throughout the body. (biomedcentral.com)
  • Liver, muscle, and intestine tissue samples were taken to measure mRNA expression of key genes involved in glucose, lipid, and protein metabolism. (frontiersin.org)
  • Using a quantitative and sensitive reverse transcription (RT)-competitive polymerase chain reaction (PCR) assay, we determined the distribution and relative mRNA expression of the four PPARs (α, β, γ1, and γ2) and liver X receptor-α (LXRα) in the main tissues implicated in lipid metabolism. (diabetesjournals.org)
  • PPARα and LXRα were mainly expressed in liver, while PPARγ1 predominated in adipose tissue and large intestine. (diabetesjournals.org)
  • After 11 weeks, body weight, serum biochemical indices and the mRNA expressions of the liver tissue, as well as the outward appearance, weight and histopathological analysis of liver and adipose tissues were evaluated. (medsci.org)
  • There is an abundance of ev- and mortality, for which the incidence cancer, liver cancer, and oesopha- idence that obesity and/or weight is expected to increase over the next geal squamous cell carcinoma. (who.int)
  • Moreover, HC diets have been proposed as a way to fight against obesity ( 7 - 9 ), and recent dietary guidelines insist on reducing fat intake and maintaining 45-65% of intake as carbohydrate based on whole grain, vegetables, and fruits ( 10 ). (frontiersin.org)
  • Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)
  • Here we reveal that endostatin inhibits adipogenesis and dietary-induced obesity. (diabetesjournals.org)
  • The overall hypothesis was that dietary fat quality assessed by serum and adipose tissue FA composition, and dietary intake of especially carbohydrates is associated with AO. (avhandlingar.se)
  • High susceptibility to dietary obesity was associated with increased osteoarthritic changes in the knee and impaired musculoskeletal force generation and motor function compared with controls. (biomedcentral.com)
  • Which new data are needed to explore the relationships of diet and dietary patterns to obesity and weight gain? (who.int)
  • the literature on dietary patterns and components were included and However, obese subjects are more obesity as part of a larger review scored negatively in most of the di- likely to underreport intake of all ma- of dietary patterns and several out- etary guidelines indices. (who.int)
  • Since skin-embedded adipocytes may provide natural insulation, they provide an important counterpoint to the activation of thermogenic brown and beige adipose tissues, whereby these distinct depots are functionally interrelated and require simultaneous assay. (jci.org)
  • Osteoporosis, a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility, occurs frequently, particularly in older women. (springer.com)
  • Magriplis E, Andrea E, Zampelas A. Nutrition in the Prevention and Treatment of Abdominal Obesity (Second Edition, 2019) The Mediterranean Diet: What it is and its effect on abdominal obesity. (psychologytoday.com)
  • Thus, our findings reveal that endostatin has a potential application for antiobesity therapy and the prevention of obesity-related metabolic syndromes. (diabetesjournals.org)
  • Abdominal obesity has been strongly linked to cardiovascular disease, Alzheimer's disease, and other metabolic and vascular diseases. (wikipedia.org)
  • Abdominal obesity was more closely related with metabolic dysfunctions connected with cardiovascular disease than was general obesity. (wikipedia.org)
  • Abdominal obesity is linked with higher cardiovascular events among South Asian ethnic population. (wikipedia.org)
  • Increased body fat can be present either as an overt overweight/obesity or fat redistributed into visceral organs and/or fat infiltrated into bone and muscle, which occurs especially with age and some chronic diseases [ 3 , 4 ]. (springer.com)
  • Fat tissue constitutes 20 to 25% of human body weight being an energy storage container, in the form of triglycerides. (sciencedaily.com)
  • Body fat is then calculated based on accepted values for the density of fat and lean tissue to identify the percentage of body fat that will produce the overall measured density 6,34 . (bodybuilding.com)
  • DEXA uses a three compartment model dividing the body into total body mineral, mineral-free lean tissue, and fat mass 14,26,30 . (bodybuilding.com)
  • Since fat tissue has a distinct resistance compared to lean tissue (due to its different water content), the percentage of fat tissue can be determined from the overall body resistance and total weight. (bodybuilding.com)
  • An earlier study from Johns Hopkins concluded that people with a high body mass index (BMI) indicating overweight or obesity were 81 percent more likely to have episodic migraines (those that occur up to 14 days per month) than were people with a lower body mass index. (drweil.com)
  • Migraine, obesity and body fat distribution- a population-based study. (drweil.com)
  • In that case, the study also provides a first step toward aiming treatments at specific regions of the body, especially those that contribute most to the complications of obesity. (disabled-world.com)
  • The main reasons for completed but invalid whole body scans were implants, excessive X-ray "noise" due to obesity, and jewelry not removed. (cdc.gov)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • The NAFLD (n = 23) and non-NAFLD (n = 13) groups were of similar age, sex, glycemic status, body mass index, % body fat and abdominal fat. (medscape.com)
  • [ 1 , 5 ] Hispanic children are disproportionately affected by the obesity epidemic with 38.1% of Hispanic children and adolescents 12 to 19 years of age found to be overweight/obese according to the 2011-2012 National Health and Nutrition Examination data. (medscape.com)
  • We observed high prevalences of general and abdominal obesity in this population, which is consistent with the values found in urban populations. (scielosp.org)
  • These results set up the stage for developing novel anti-obesity therapies. (sciencedaily.com)
  • These results, published in the latest issue of the journal Cell , set up the stage for developing novel anti-obesity therapies. (sciencedaily.com)
  • Ms A, a 49-year-old woman with a history of severe obesity, bipolar disorder, anxiety, and multiple medical problems, was admitted to the hospital with severe anasarca and a chronic pleural effusion. (psychiatrist.com)
  • Activation of the sympathetic nervous system has been considered to have an important function in the pathogenesis of obesity-related hypertension. (withings.com)
  • In the United States, obesity and its complications cause as many as 300,000 premature deaths each year, making it second only to cigarette smoking as a preventable cause of death. (msdmanuals.com)
  • They found that middle-aged people with higher measures of abdominal fat scored worse on measures of fluid intelligence as the years went by. (psychologytoday.com)
  • We previously reported that rats prone to obesity exhibit an exaggerated increase in glucose oxidation and an exaggerated decline in lipid oxidation under a low-fat high-carbohydrate (LF/HC) diet. (frontiersin.org)
  • We also noticed a relationship between tissue expression of IL-6 and IL-18 and lipid parameters (TG and HDL). (bvsalud.org)
  • The clinical manifestations of this syndrome may include hypertension , hyperglycemia, hypertriglyceridemia, reduced high-density lipoprotein cholesterol (HDL-C), and abdominal obesity . (medscape.com)
  • The aim of this study was to determine whether the mean size of fat cells in either visceral or subcutaneous adipose tissue has an impact on the metabolic and inflammatory profiles in morbid obesity. (nih.gov)
  • Airway difficulties may be encountered in numerous scenarios, including head and neck trauma, traumatic airway injury, morbid obesity with or without respiratory distress, thermal injury, upper-airway pathology (eg, Ludwig angina), and term pregnancy (to name only a few examples). (medscape.com)
  • Values of 0.52 and 0.54 of the WHR were the cut-off points for optimization of Sensitivity/Specificity respectively for excess weight or overweight or obesity. (bvsalud.org)
  • Obesity-related cancers of particular in developing countries than in de- concern in LMICs include colorec- veloped countries [5]. (who.int)
  • A variety of scores were includ- of cultural determinants of obesity ty of settings to evaluate the major ed in the USDA review, including the in LMICs is presented in Chapter 2. (who.int)
  • In this case, fat mass is still one compartment, but the lean tissue is divided into three discrete compartments, bone, muscle, and everything else. (bodybuilding.com)
  • Obesity is a condition when fat accumulation is excessive to the extent that it produces adverse health consequences [ 1 ]. (medsci.org)
  • CHICAGO , Nov. 20, 2023 /PRNewswire/ -- Higher amounts of visceral abdominal fat in midlife are linked to the development of Alzheimer's disease, according to research being presented next week at the annual meeting of the Radiological Society of North America ( RSNA ). (kget.com)
  • Osteoarthritis is a common degenerative condition affecting the joints and surrounding tissues. (laparoscopic.md)
  • The knees are common sites for osteoarthritis in obesity. (laparoscopic.md)
  • BACKGROUND AND OBJECTIVES There is a lack of studies on obesity measured by outer abdominal fat (OAF), which describes abdominal subcutaneous adipose tissue thickness with regard to spino-pelvic parameters. (uzh.ch)
  • the MRI technique we describe uses an advanced fat-specific method to measure the thickness of dWAT, together with the total volume of WAT and the relative activation/fat depletion of brown adipose tissues (BAT). (jci.org)
  • Additionally, studies should assess whether the clinical outcomes associated with osteosarcopenic obesity are worse than the mere addition of those linked with its components. (springer.com)
  • However, rural activities were a protective factor for obesity outcomes. (scielosp.org)
  • Metabolic syndrome linked to abdominal obesity is also predictive of recurrent coronary events both in post-myocardial infarction patients and among coronary artery disease men who underwent a revascularization procedures. (researchgate.net)
  • concentration of fat in the abdominal region has a Obesity and even overweight are generally higher predictive sensitivity for diseases and health not difficult to recognise, but a more accurate problems. (bvsalud.org)
  • This agglomeration of abnormalities has been referred to as the metabolic syndrome which can be identified by the presence of three of the five following variables: abdominal obesity, elevated triglyceride concentrations, low HDL-cholesterol levels, increased blood pressure and elevated fasting glucose. (researchgate.net)
  • Obesity causes decreased tidal volumes due to reduced in chest expansion that is caused both by the weight on the chest itself and the effect of abdominal obesity on flattening the diaphragms. (wikipedia.org)
  • The ac- and is the best indicator of changes in the intra- cumulation of both types of fat is affected abdominal fat during weight loss [ 8 ]. (who.int)
  • Most research on obesity and can- to weight gain in postmenopausal cohol consumption, drinking hot tea, cer has focused on Caucasians in women [3]. (who.int)
  • Although weight gain and obesity use, white race, and obesity [8]. (who.int)